Acta Medica Academica

This study aimed to explore the efficacy of cinnamon extract as an anti-insomnia medication in experimental animals by evaluating the levels of hormones and neurotransmitters related to insomnia.A total of 30 male Wistar rats were divided into six groups. Induction of insomnia in animal models was done by administration of p-chloro-phenylalanine (PCPA) compounds. Estazolam was administrated to the positive control group. Cinnamon extract administration was divided into 3 doses, namely: 25 mg/kg BW, 50 mg/kg BW and 100 mg/kg BW. Evaluation of the organ coefficient was conducted to evaluate drug toxicity to the organs. The enzyme-linked-immunoassay method assessed hormones and neurotransmitters in the serum and hypothalamus related to insomnia.There was a decrease in the adrenal coefficient in the cinnamon extract group compared to the PCPA group (0.011+0.001, P<0.05). In addition, there was a decrease in the corticotropin-releasing hormone, adrenocorticotropin hormone, and corticosterone levels in the serum of animals who received cinnamon extract. Our study found a dose of cinnamon extract of 50 mg/kg BW was the best dose to balance neurotransmitter levels in insomniac rats.The cinnamon extract increased serotonin and melatonin levels and decreased norepinephrine levels in the insomnia-induced group. Cinnamon extract has potential as an anti-insomnia medication through hypothalamus-pituitaryadrenal axis improvement and brain neurotransmitter regulation in an animal model of insomnia.

Rachmat Hidayat

Patricia Wulandari

Muhammad Reagan

The Potential of Cinnamon Extract (Cinnamomum burmanii) as Anti-insomnia Medication through Hypothalamus Pituitary Adrenal Axis Improvement in Rats

肉桂提取物（阴香）通过改善大鼠下丘脑-垂体-肾上腺轴作为抗失眠药物的潜力

Objective. This cohort study aimed to examine the impact of the FLT3-ITD mutation on the downstream signaling pathway of PI3K/AKT pathway, the percentage of leukemia stem cells, and the survival of patients receiving D3A7 induction therapy. Method. Bone marrow mononuclear cells were collected from 20 adult AML patients who had completed D3A7 induction therapy at Cipto Mangunkusumo National General Hospital and Dharmais Cancer Hospital. FLT3-ITD gene mutation was examined by the PCR-sequencing method. Expression of phosphorylated PI3K and AKT was detected using the sandwich ELISA method. Flow cytometry was used for detecting the number of apoptosis and proliferation cells, and biomarkers of leukemia stem cells. Result. The expression levels of PI3K and AKT proteins were higher in FLT3-ITD, both in the mutant group compared to the non-mutation group, and in the patient group with treatment failure outcomes compared to the patient group with treatment response. The percentage of the leukemia stem cell population did not differ significantly between the FLT3-ITD mutation group and the wild type group, and between the treatment failure outcome group and the response outcome group. Conclusion. This study presents the important role of FLT3-ITD mutation via its downstream signaling (PI3K/AKT) in the outcome of D3A7 induction therapy. The FLT3-ITD mutation plays an important role in the 12-month survival of AML patients after D3A7 therapy. However, the outcome of D3A7 therapy and FLT3-ITD mutation were not associated with leukemia stem cells.

Elly Yanah Arwanih

Ikhwan Rinaldi

Septelia Inawati Wanandi

Melva Louisa

The Role of FLT3-ITD Mutation, PI3K/AKT Pathway, and Leukemia Stem Cells in D3A7 Induction therapy – the Outcomes of Adult Indonesian Patients with Acute Myeloid Leukemia

FLT3-ITD突变、PI3K/AKT通路及白血病干细胞在D3A7诱导治疗中的作用——印度尼西亚成人急性髓系白血病患者的治疗结果

Objective. A wide range of lesions, including a mesothelial cyst of the uterine round ligament, are included in the differential diagnosis of a groin mass. Our study emphasizes the rarity of this ailment and the significance of correct preoperative diagnosis in guiding our treatment approach. Case Report. A 43-year-old female patient, presented to our hospital with a five-year his- tory of swelling and slight discomfort in the right groin. A nonreducible inguinal mass with greater projection during a Val- salva maneuver was found. An abdominal CT scan revealed a well-defined lesion located near the right horn of the uterus and extending through the inguinal canal. The patient was brought to the operating room with the clinical suspicion of an inguinal hernia. A soft mass measuring 4.5×2×1.8cm was discovered in the right round ligament, and it was surgically removed. Histo- pathological examination confirmed a mesothelial cystic lesion. The patient’s condition, after a period of 12 months, continues to be satisfactory. Conclusion. Few cases of uterine round ligament mesothelial cysts have been reported worldwide. Their cause is unknown, and preoperative diagnosis is unreliable. Resection relieves symptoms, and histological examination of the surgical specimen confirms the diagnosis. Additional clinical cases are needed to create a systematic clinical approach.

Christos Vrysis

Vasileios Gkatziolis

Nicole Demetriou

Konstantinos Geroulis

Rodanthi Mastrogianni

Alexandros Dais

Dimitrios Giovanitis

Marios Ponirakos

Konstantinos Papadimitropoulos

A Round Ligament Mesothelial Cyst Imitating an Inguinal Hernia in a Woman of Reproductive Age

生育年龄女性中拟似腹股沟疝的圆韧带间皮囊肿

In the current molecular review, we describe the mechanisms of TP53/MDM2 deregulation and their impact on the colon adenocarcinoma molecular substrate and phenotype. Among the genes that are critically altered in carcinogenesis, the TP53 tumor suppressor gene is of major importance. The TP53 gene (gene locus: 17p13.1) regulates the cell cycle by controlling the G1/S and G2/M checkpoints securing the normal sequence of cell cycle phases. Furthermore, it is involved in apoptosis programmed cell death. The gene is mutated or epigenetically altered in all epithelial malignancies, including colon adenocarcinoma. Additionally, Mouse Double Minute 2 Homolog (MDM2), a proto-oncogene (12q14.3), acts as a major negative regulator for p53 expression in the p53-MDM2 auto-regulatory pathway. MDM2 binds directly to p53 and represses its transcriptional activity, promoting p53 degradation. CONCLUSION: In colon adenocarcinoma, MDM2 oncogene overexpression directly influences p53 oncoprotein expression levels.

Athanasios Niotis

Evangelos Tsiambas

Dimitrios Dimitroulis

Helen Sarlanis

Evangelos Falidas

Nikolaos Kavantzas

Constantinos A. Constantinides

P53/MDM2 Complex-Based Targeted Strategies in Colon Adenocarcinoma

基于P53/MDM2复合物的结肠腺癌靶向策略

Objective. We aimed to investigate the causes and factors predictive of in-hospital death among patients with systemic lupus erythematosus (SLE) admitted to a tertiary care hospital in Thailand.&#x0D; Materials and Methods. We retrospectively reviewed the records of patients with SLE admitted between 2017 and 2021. We collected data related to age, sex, body mass index, comorbidities, disease duration, medication usage, clinical symptoms, vital signs, laboratory results, evidence of infection, presence of systemic inflammatory response syndrome, quick sepsis-related organ assessment scores, and SLE disease activity on the date of admission. The length of hospitalization, treatment administered, and subsequent clinical outcomes (including in-hospital complications and death) were also recorded.&#x0D; Results. Among 267 enrolled patients, the overall in-hospital mortality rate was 25.5%, and infection was the most common cause of death (75.0%). Multivariate analysis revealed that prior hospitalization within 3 months (odds ratio [OR]: 2.311; 95% confidence interval [CI]: 1.002–5.369; P=0.049), initial infection on admission (OR: 2.764; 95% CI: 1.006–7.594; P=0.048), use of vasopressor drugs (OR: 2.940; 95% CI: 1.071–8.069; P=0.036), and mechanical ventilation (OR: 5.658; 95% CI: 2.046–15.647; P=0.001) were independent risk factors for in-hospital mortality.&#x0D; Conclusion. Infection was the major cause of mortality in patients with SLE. Prior hospitalization within 3 months, initial infection on admission, vasopressor use, and mechanical ventilation during admission are independent risk factors for in-hospital mortality in patients with SLE.

Sujin Lertwises

Attapon Rattanasupar

Arunchai Chang

Factors Predictive of In-Hospital Mortality in Patients with Systemic Lupus Erythematosus: A Single-Centre Retrospective Analysis

系统性红斑狼疮患者住院死亡率的预测因素：一项单中心回顾性分析

Background. Paraneoplastic Neurological Syndromes (PNS) constitute a heterogeneous cluster of disease manifestations related to various cancers. Small Cell Lung Cancer (SCLC) is strongly related to PNS. This narrative review conducted a survey in the available PubMed literature to highlight the appearance of PNSs in SCLC cases and discuss published research highlights on the subject so that general practitioners can be acquainted with the medical phenomenon present in SCLC patients. Method. A narrative review of the medical literature was conducted as documentary informative research in the PubMed medical database, combined with a survey of the online e-library Google Books. The key words used were: “Paraneoplastic Neurological Syndromes” and “Small Cell Lung Cancer”. Results. Paraneoplastic syndromes are related to the presence of a malignancy and are not secondary to treatment. Paradoxally, both a malignancy and its therapeutic approach may cause a series of PNSs. Paraneoplastic cerebellar degeneration, motor neuron disorders, peripheral neuropathies, hyponatremia, and syndromes such as myasthenic Lambert-Eaton, ectopic Cushing’s, Stiffman, and Opsoclonus-myoclonus syndrome may also appear in SCLC cases. Diagnosis follows specific criteria, and they are caused by tumor-directed antibodies known as onconeural antibodies. Immunosuppressants, intravenous immunoglobulins, plasma exchange, rituximab, cyclophosphamide, azathioprine, and tocilizumab could be considered as treatment agents. Conclusions. Most patients demonstrate poor PNS treatment results with common relapse. The time for beginning treatment of PNS is discussed. A multidisciplinary team is needed for potentially earlier diagnosis and PNS improvement, better prognosis, and increased overall survival and quality of life.

Emmanouel Georgiannakis

Theoni Zougou

Evaggelos Mavrommatis

Paraneoplastic Syndromes of the Nervous System in Patients Suffering from SCLC. A Review of the Recent Literature

小细胞肺癌患者神经系统副肿瘤综合征的最新文献综述

Objective. This study aims to develop and create a specialized acute kidney injury (AKI) predictor score for the intensive care unit (ICU) patients in Padang, Indonesia. Patients and Methods. This study was a prospective observational study on 352 ICU patients at three specialized hospitals in Padang City; Dr. M. Djamil General Hospital, Dr. Rasidin General Hospital, and Siti Rahmah Islamic Hospital. Data regarding demographics, clinical characteristics, laboratory results, and outcomes related to AKI were gathered. The factors that predict AKI were identified using multivariate logistic regression analysis to determine independent factors. The predictor scores were created using regression coefficients and then internally confirmed. Results. Out of a total of 352 patients, 128 individuals (36.4%) suffered from AKI. Factors that independently predict the occurrence of AKI include age over 60 years old, having a history of chronic kidney disease, having sepsis, need for vasopressors, and having creatinine level 1.3 mg/dL (IQR 1.0-1.8) upon admission to ICU. An area under the curve (AUC) of 0.85 (95% CI 0.80-0.90) indicated the strong performance of the constructed predictor score. Conclusion. The constructed AKI predictor score a scale factor of 10, resulting in a range of 0–10 for the AKI predictor score. It demonstrates a good level of accuracy in predicting AKI in ICU patients in Padang. This score can be used by healthcare professionals to quickly identify and categorize individuals based on their risk level, facilitating timely intervention and personalized treatment.

Liliriawati Ananta Kahar

Development of Acute Kidney Injury Predictor Score in Intensive Care Unit Patients in Padang, Indonesia

印度尼西亚巴东重症监护病房急性肾损伤预测评分的发展

Objective. We present the case of a ruptured heterotopic pregnancy after natural conception and its management during hospi- talization. Case Report. The patient presented to the emergency department of our hospital with symptoms of lower abdominal pain and vaginal blood loss. She reported a confirmed intrauterine pregnancy at 8 weeks’ gestation following natural concep- tion. The patient was admitted to the hospital with the diagnosis of a ruptured ovarian cyst. Due to hemodynamic instability, an urgent exploratory laparotomy was performed. The histological review showed an ectopic fallopian pregnancy, confirming the final diagnosis of an heterotopic pregnancy. Conclusion. Heterotopic pregnancy is a very rare condition, even more so if it happens spontaneously. As a result, it has been insufficiently studied in relation to proper management and timely diagnosis.

Dionysios Galatis

Christos Benekos

Konstantina Kalaitzi

Panagiotis-Konstantinos Karachalios

Ioannis Chatzipanagiotis

Ippokratis Diamantakis

Foteini Anifantaki

Vasileios Batsakoutsas

Nikolaos Kiriakopoulos

A Rare Case of Ruptured Heterotopic Pregnancy after Natural Conception Demanding Immediate Attention

自然受孕后异位妊娠破裂的罕见病例需立即关注

ISSN	1840-1848, 1840-2879
h-index	19

涉及主题	医学生物内科学心理学病理外科遗传学物理政治学精神科放射科化学数学法学
出版信息	出版商: Academy of Sciences and Arts of Bosnia and Herzegovina，出版周期: ，期刊类型: journal，开源期刊: 是
基本数据	创刊年份: 2012，原创研究文献占比: 0.00%，自引率:N.A.， Gold OA占比: 0.00%
平均审稿周期	网友分享经验：15 Weeks

Acta Medica Academica

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The Potential of Cinnamon Extract (Cinnamomum burmanii) as Anti-insomnia Medication through Hypothalamus Pituitary Adrenal Axis Improvement in Rats

The Role of FLT3-ITD Mutation, PI3K/AKT Pathway, and Leukemia Stem Cells in D3A7 Induction therapy – the Outcomes of Adult Indonesian Patients with Acute Myeloid Leukemia

A Round Ligament Mesothelial Cyst Imitating an Inguinal Hernia in a Woman of Reproductive Age

P53/MDM2 Complex-Based Targeted Strategies in Colon Adenocarcinoma

Factors Predictive of In-Hospital Mortality in Patients with Systemic Lupus Erythematosus: A Single-Centre Retrospective Analysis

The Role of FLT3-ITD Mutation, PI3K/AKT Pathway, and Leukemia Stem Cells in D3A7 Induction therapy – the Outcomes of Adult Indonesian Patients with Acute Myeloid Leukemia

A Round Ligament Mesothelial Cyst Imitating an Inguinal Hernia in a Woman of Reproductive Age

Paraneoplastic Syndromes of the Nervous System in Patients Suffering from SCLC. A Review of the Recent Literature

Development of Acute Kidney Injury Predictor Score in Intensive Care Unit Patients in Padang, Indonesia

A Rare Case of Ruptured Heterotopic Pregnancy after Natural Conception Demanding Immediate Attention