MACEDONIAN JOURNAL OF CHEMISTRY AND CHEMICAL ENGINEERING (MACED. J. CHEM. CHEM. ENG.) 是马其顿化学家和技术人员协会的官方出版物。这是一本每年出版两次的非盈利性开放获取期刊。该杂志发表来自化学、化学工程、食品技术、生物技术和材料科学、冶金及相关领域的所有领域的原创科学论文、短通讯、评论和教育论文。发表在期刊上的论文在化学文摘中进行了总结。

The Macedonian Journal of Chemistry and Chemical Engineering (MACED. J. CHEM. CHEM. ENG.) is the official publication of the Association of Chemists and Technologists of Macedonia. This is a non-profit open-access journal published biannually. The journal publishes original scientific papers, short communications, reviews, and educational papers from all fields related to chemistry, chemical engineering, food technology, biotechnology, materials science, metallurgy, and related areas. All papers published in the journal are summarized in Chemical Abstracts.

《Macedonian Journal of Chemistry and Chemical Engineering》（马其顿化学与化学工程杂志）是马其顿化学家和技术人员协会的官方出版物。这是一份每年出版两次的非盈利开放获取期刊，致力于发表来自化学、化学工程、食品技术、生物技术、材料科学、冶金及相关领域的原创科学论文、短通讯、评论和教育论文。所有发表在该期刊上的论文均在化学文摘中进行了总结。

Macedonian Journal of Chemistry and Chemical Engineering

This research highlights the specificity of the new stability-indicating method developed to evaluate the impurity profile of Atorvastatin film-coated tablets. The proposed method has the ability to capture any possible changes that may occur during the stability studies over time and under different stress factors, and is selective enough to enable quality control of finished product from different suppliers of active pharmaceutical ingredient (API)/excipients. Satisfactory critical peak resolution between specified and unspecified impurities was achieved using the fused-core shell technology and extensively endcapped diisopropyl-cyanopropylsilane stationary phase (Halo ES-CN 150 mm × 4.6 mm, 2.7 µm), with a 10 mM ammonium formate buffer pH 3.5 and acetonitrile as mobile phase. A potential worse case impurity profile was assumed by using retained samples combined with the data obtained for samples manufactured with APIs from different suppliers exposed to the forced degradation study. The mass balance for stressed samples demonstrated the stability-indicating capability of the proposed method.

Elena Trajchova Kovachovska

Jelena Acevska

Katerina Brezovska

Stefan Trajkovic

Ivana Mitrevska

Sonja Ugarkovic

Aneta Dimitrovska

Development of a stability-indicating method for evaluation of impurity profile of Atorvastatin film-coated tablets using cyano column based on core-shell technology

基于核壳技术采用氰基柱的阿托伐他汀薄膜包衣片杂质谱评价的稳定性指示方法的开发

A novel electrochemical sensor for testosterone detection has been prepared by the chemical modification of a gold electrode (AuE). For the electrode modification, specific polyurethane (PU) films were synthesized from hexamethylene diisocyanate, olivetol, polyethylene glycol-100 (PEG100) and β-cyclodextrin. The synthesized PUs were investigated as selective films, and were used to coat a AuE surface at different concentrations and thicknesses. The testosterone responses of the modified electrodes were investigated by square-wave voltammetry (SWV). One separated cathodic SWV peak was obtained for testosterone at –0.390 V, with the prepared PU-modified AuE in 0.1 M phosphate buffer (PB) (pH 7.2). The linearity of testosterone responses of the prepared PU modified electrode was obtained over a concentration range of 0.1–1.0 µM (R2 = 0.995). It was observed that the response of the electrode increased regularly and sensitively with increasing testosterone amount. The detection limit, relative standard deviation and sensitivity of modified electrode were found to be approximately 5.69 nM, 1.669 % and 98.331 %, respectively. The PU-modified AuE exhibited good selectivity and a low response time for testosterone. Therefore, the prepared testosterone sensor offers a good alternative for fast and practical testosterone determination in clinical or biomedical studies.

Cemre Zeynep Harman

Öznur Güngör

Preparation of a polyurethane membrane testosterone sensor and its application using square-wave stripping voltammetry

制备聚氨酯膜睾酮传感器及其在方波剥离伏安法中的应用

Tetrapyridinesilver(I) perrhenate [Agpy4]ReO4 was synthesized, and its crystal structure and Raman spectra were elucidated at low temperatures. The crystal lattice is constructed from isolated tetrahedral cations and anions having no argentophilic interactions. Weak hydrogen bonds are formed between the oxygens of the disordered perrhenate anions and the ortho-hydrogens of the pyridine ligands. No parallel π…π stacking interactions are observed, but C-H…π interactions of the pyridine ligands within columns of cations and between the columns appeared. Correlation analysis for Ag+, pyridine ligands, and perrhenate ions was performed, and the perrhenate ion and some of the AgN4 skeleton vibrational modes and pyridine ligand modes in the Raman spectrum of [Agpy4]ReO4 were assigned.

Vladimir M. Petrushevski

Kende Attila Béres

Petra Bombicz

Attila Farkas

László Kótai

Laura Bereczki

Structural and Raman spectroscopic characterization of tetrapyridinesilver(I) perrhenate, [Agpy4]ReO4

四吡啶银(I)高铼酸盐[Agpy4]ReO4的结构和拉曼光谱表征

A different, reliable, and cost-effective strategy for the analysis of aflatoxins, ochratoxin A, and zearalenone in corn-based foods was proposed, including one multi-toxin immunoaffinity column (IAC) sample preparation and three different high-performance liquid chromatography fluorescence detection methods. The analytical procedures were tested and verified, keeping in mind their occurrence at trace levels in corn-based foods. With the validation of the proposed multi-toxin IAC methodology and comparison of the performance characteristics with methods using a single-toxin IAC, we confirmed the reliability of the multi-toxin IAC procedure versus the single-toxin IAC. The methods were validated by revealing satisfactory performance characteristics; for example, the obtained values of limit of detection were significantly lower than the maximum limits for all mycotoxins of concern. In addition, the recovery values were between 70.9 % and 106.1 % for all mycotoxins of interest, with precision values lower than 10.5 %.

Biljana Stojanovska Dimzoska

Zehra Hajrulai Musliu

Risto Uzunov

Aleksandra Angeleska

Katerina Blagoevska

Radmila Crceva Nikolovska

Gordana Ilievska

Elizabeta Dimitrieska Stojkovic

Study on the effectiveness of a multi-toxin immunoaffinity clean-up for reliable cost-effective HPLC-FLD analysis of mycotoxins in corn-based foods

基于玉米食品中多毒素免疫亲和净化对可靠成本效益的HPLC-FLD真菌毒素分析效果的研究

It is exactly one hundred years ago when the first paper about the development of polarography was published in 1922. Polarography is considered a predecessor of voltammetry, and this iconic electrochemical technique was designed by the Nobel laureate Jaroslav Heyrovsky. In this short review, the aim is to highlight some of the most important achievements of voltammetry so far. While hints are given to some of the most important theoretical works related to various electrode mechanisms in cyclic voltammetry and pulse voltammetric techniques, a critical part is written that should help to improve the communication between theoretical and experimental electrochemists. Since a main application of voltammetry is in the field of constructing biosensors, some of the major achievements and several drawbacks of applying voltammetric techniques in designing sensors are discussed. In a small part of this review, the role of nanomaterials in voltammetry is also considered. As scanning electrochemical microscopy (SECM) seems to be most promising instrumental system that will bring voltammetry a step closer to probing real biological systems, critical aspects about the weaknesses of this technique are also briefly discussed. In the final outlooks, we present a set of directions in which voltammetry will develop in the coming years. The paper is written in a way to motivate younger electrochemists to get more involved in exploring the voltammetry.

Rubin Gulaboski

Future of Voltammetry

伏安法的未来

As an emerging technology, smart textiles can bring solutions to many problems, but also create new ones, especially related to their disposal and their impact on the environment. That is why it is important to address this problem at this stage of technological development when smart textiles have not yet pervaded the mass markets. In this article, first, an attempt is made to understand the chronological development of smart textiles: the reasons for a weak breakthrough in the commercial markets throughout the decades, starting from the 1990s until today, but also the emergence of new driving forces that should inevitably lead to a bright future for smart textiles. In addition, we explore the contemporary possibilities for sustainable materials, manufacturing techniques, and end-of-life solutions for developing sustainable smart textiles based on a broad literature review, online sources, and a questionnaire survey among textile experts. Finally, an overview of the latest developments related to the standardization of smart textiles is given. This research was spurred by participation in CONTEXT COST Action (CA17107 - European Network to connect research and innovation efforts on advanced Smart Textiles).

Aleksandra Ivanoska-Dacikj

Lutz Walter

Karin Eufinger

Ariadna Detrell

Yesim Oguz Gouillart

Enrico Venturini

Raul Fangueiro

Daniela Zavec

Paulo Cadeia

Vincent Nierstrasz

Bruno Mougin

Smart textiles: Paving the way to sustainability

智能纺织品：铺就可持续发展之路

In the last decade, the most investigated perovskite materials are the hybrid organic-inorganic perovskites (HOIPs) due to their optoelectronic properties and possible application in the production of photovoltaics. This interest has led to an ongoing search for new HOIP variants, alongside thorough investigations of the properties of existing HOIPs. That is why our research in the field of organic-inorganic perovskites is aimed at the synthesis, characterization, and investigation of the electrochemical properties of dimethylammonium lead iodide (DMAPbI3) using voltammetric studies. A modified synthesis of DMAPbI3, differing slightly from the one described in the literature, was performed by combining stoichiometric amounts of lead iodide (PbI2) and dimethylammonium iodide (DMAI) dissolved in acetonitrile. After conducting controlled evaporation, a yellow crystalline powder of DMAPbI3 was obtained. The identity and purity of the obtained compound were confirmed by powder X-ray diffraction (PXRD), infrared (IR) and Raman spectroscopy, and scanning electron microscopy (SEM) with energy dispersive X-ray spectroscopy (EDX). Investigations on the electrochemical properties of DMAPbI3 by cyclic voltammetry were performed with dichloromethane (DCM) and tetrabutylammonium chloride (TBAC) as the electrolyte. A paraffin-impregnated graphite electrode (PIGE) was used as a working electrode, on which the perovskite microparticles were immobilized. The electrochemical activity of DMAPbI3 is recognized through an intense, broad, and irreversible anodic peak attributed to the oxidation of the constituents to different possible products and the decomposition of the perovskite structure.

Jeta Sela

Leon Stojanov

Besarta Cheliku Ramadani

Miha Bukleski

Arianit Reka

Sandra Dimitrovska-Lazaova

Valentin Mirčeski

Slobotka Aleksovska

Synthesis, characterisation and voltammetric study of dimethylammonium lead iodide perovskite

二甲基铵铅碘钙钛矿的合成、表征及伏安特性研究

A series of mononuclear Cu(II) complexes were synthesized using a potential tetradentate hydrazone ligand obtained from the reaction between phenylhydrazine groups and 2,5-thiophenedicarboxaldehyde. The structures of ligands and complexes were elucidated through various spectroscopic techniques, confirming their composition. All complexes were found to adopt four-coordinated geometries, indicating the formation of stable structures. Spectroscopic analysis revealed that the hydrazone ligand coordinated with the Cu(II) metal ions as a dibasic tetradentate ligand by utilizing the phenolic oxygen and azomethine nitrogen atoms. The binding affinity of the complexes with calf thymus DNA (CT-DNA) was investigated using absorption and viscosity measurements, demonstrating their interaction through the intercalation mode. The binding studies showed that the Cu(II) complexes exhibited varying degrees of binding affinity, with Cu(L4) demonstrating the highest affinity, followed by Cu(L1), Cu(L2), and Cu(L3). Moreover, the DNA fragmentation properties of the Cu(II) complexes were evaluated, suggesting their potential utilization in pharmaceutical applications. The obtained results highlight the significance of these novel complexes in the field of medicinal chemistry.

Cansu Topkaya

Experimental biological studies of novel tetradentate hydrazone Cu(II) complexes for potential applications in medicinal chemistry

新型四齿席夫碱铜(II)配合物的实验生物学研究及其在药物化学中的潜在应用

Understanding energetics and electron behavior has been pivotal in elucidating numerous fundamental phenomena, including electricity, corrosion, respiration, energy generation in biological systems, intermolecular interactions within living organisms, organic synthesis, drug development, enzyme functions, and the design of biosensors, among others. As 2024 records the centennial anniversary of the completion of the first polarograph by Nobel laureate Jaroslav Heyrovský (awarded the Nobel Prize in Chemistry in 1959), it presents an opportune moment to pay tribute to several eminent electrochemists who have made significant contributions to the field of voltammetric techniques. Following our recent acknowledgment of the outstanding women who have made substantial contributions to voltammetry in a prior publication, this article aims to briefly highlight the major achievements of several distinguished male figures in the field (Jaroslav Heyrovský, Allen J. Bard, Christian Amatore, Richard Compton, Jean-Michel Savéant, Fraser Armstrong, Fritz Scholz, Joseph Wang, Milivoj Lovrić, Valentin Mirčeski, Alan M. Bond). Given that many of these remarkable personalities have contributed both as authors and referees for the Macedonian Journal of Chemistry and Chemical Engineering, this tribute serves as a fitting acknowledgment of their remarkable accomplishments on the occasion of the journal's 50th anniversary.

Visionary figures in the field of electrochemistry who revolutionized voltammetry

电化学领域中革新伏安法的先驱人物

Many analytical methods have been successfully employed for the study of minerals, in particular, vibrational infrared (FTIR) and Raman spectroscopies and X-ray powder diffraction (XRPD). The advantages of the vibrational spectroscopic techniques for identifying and characterizing minerals include: rapid and versatile use; qualitative and quantitative chemical signatures; distinctive chemical fingerprint of a material; indirect determination of the crystal features (polymorphism, isomorphism, coordination, degree of deformation of structural polyhedra); small sample quantity (area less than 1 μm2 for Raman); wide coverage of 4,000 – 50 cm−1 region in a single scan; in situ and direct measurements without sample preparation; nondestructive use; etc. On the other hand, XRPD is a destructive technique that, depending on the method used and the density of the material, requires from a few micrograms up to around 5 grams of sample quantity for analysis. In spite of that, it is a rapid and powerful technique used in mineral studies with relatively straightforward interpretation of the results. During the last decade, portable X-ray powder diffractometers for the nondestructive analysis of art and archeological materials have been developed along with the portable and hand-held vibrational spectroscopy instrument. Here, some advantages and limitations in the process of the complementary use of FTIR and Raman vibrational spectroscopy and XRPD for identification and characterization of minerals are outlined.

Petre Makreski

Ljupco Pejov

Gligor Jovanovski

Crossroads of vibrational (infrared and Raman) spectroscopy and X-ray powder diffraction in identification and characterization of some minerals – advantages and limitations. A review

振动光谱（红外和拉曼）与X射线粉末衍射在某些矿物鉴定与表征中的交叉应用——优势与局限。综述

Abbreviation	Maced. J. Chem. Chem. Eng.
Journal Impact	1.25
Quartiles(Global)	ENGINEERING, CHEMICAL(Q4)

ISSN	1857-5552, 1857-5625
h-index	20

Publication Information	Publisher: The Society of Chemists and Techonogists of Macedonia，Publishing cycle: Semiannual，Journal Type: journal，Open Access Journals: Yes
Basic data	Year of publication: 2008，Proportion of original research papers: 100.00%，Self Citation Rate:9.10%， Gold OA Rate: 96.77%
Average review cycle	网友分享经验：>12周，或约稿
Average recruitment ratio	网友分享经验：容易

Macedonian Journal of Chemistry and Chemical Engineering

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