Cell Adhesion and Migration

Research on the function of HGH1 in breast cancer remains lacking.

Zeyu Wang

Taiyuan Liu

Kang He

Longyun Wang

Xiaoxuan Ma

Zhaoyun Yang

Yingchao Zhang

Lijing Zhao

Cell Adhesion & Migration

Knockdown of HGH1 in breast cancer cell lines can inhibit the viability, invasion and migration of tumor cells

敲低HGH1可抑制乳腺癌细胞系的活力、侵袭和迁移能力

The research endeavors to expound the role of ORM1 in bladder cancer (BCa) and the implied response mechanism. RT-qPCR and Western blotting examined ORM1 and S100A12 expression. Functional experiments assessed the cellular phenotypes. HDOCK and Co-IP confirmed the interaction of ORM1 and S100A12. Western blotting tested apoptosis- and ERK signaling-associated proteins. ORM1 and S100A12 were abundant in the BCa cells. ORM1 or S100A12 loss impaired cell proliferation, migration, and invasion, and aggravated cell apoptosis. ORM1 interacted with S100A12. ORM1 knockdown down-regulated S100A12 expression and inactivated ERK signaling.S100A12 overexpression or ERK activator reversed the impacts of ORM1 interference on ERK signaling and BCa cells. ORM1 mightdrive BCa via binding to S100A12 and activating ERK signaling.

Zhe Liu

Xiaofeng Pu

Orosomucoid 1 interacts with S100A12 and activates ERK signalling to expedite the advancement of bladder cancer

血清类黏蛋白1与S100A12相互作用并激活ERK信号通路以加速膀胱癌进展

The potential of adult adipose-derived stromal cells (ADSCs) to differentiate into astrocytes holds promise for future cell transplantation therapies. However, the growth of differentiated astrocytes is unstable, and their survival rate is low. Endoplasmic reticulum (ER) pathway mediated apoptosis is one of the causes of cell death, but whether there is ER stress response in the differentiation of ADSCs into astrocytes is still unclear. In this study, the expression of protein factors related to endoplasmic reticulum stress (ERS) and apoptosis, including GRP78, ATF6, PERK, CHOP, Caspase12, and Caspase3, was detected in cells. It was found that the expression of ERS pro-survival factors was highest in the ADSCs group and decreased with prolonged induction time. Conversely, the expression levels of pro-apoptotic factors increased with the extension of induction time. Thus, ERS occurs during the differentiation of ADSCs into astrocytes, and ERS can mediate apoptosis of ADSC-derived astrocytes.

Pingshu Zhang

Wen Li

Ya Ou

Qi Yan

Qi Wu

Xiaodong Yuan

The relationship between endoplasmic reticulum stress and apoptosis in the process of adipose-derived stromal cells differentiating into astrocytes

内质网应激与脂肪源性基质细胞向星形胶质细胞分化过程中凋亡的关系

This research aims to study the effect of magnetic nanoparticles of Fe3O4 (MNP Fe3O4) containing gambogic acid (GA-MNP Fe3O4) on colorectal cancer (CRC). MNP Fe3O4 enhanced the antitumor effect of GA by inhibiting the malignant behavior of CRC cells. RORB was a target of GA, and GA activated RORB expression to inhibit metastasis of CRC. Knockdown of RORB impaired the effect of GA-MNP Fe3O4 on CRC metastasis. EMILIN1 was a target of RORB, and RORB promoted transcription of EMILIN1. Overexpression of EMILIN1 reversed the effect of knockdown of RORB on GA-MNP Fe3O4 and inhibited metastasis in CRC. These findings revealed that MNP Fe3O4 enhanced the antitumor effect of GA and activated RORB to promote EMILIN1 transcription and inhibit CRC metastasis.

Xiaodong Fan

Chunyang Lv

Meiling Xue

Peng Meng

Xiaoping Qian

Fe 3 O 4 nanoparticles containing gambogic acid inhibit metastasis in colorectal cancer via the RORB/EMILIN1 axis

含藤黄酸的Fe3O4纳米颗粒通过RORB/EMILIN1轴抑制结直肠癌转移

Epithelial cell adhesion molecule EpCAM is expressed on a subset of normal epithelia and overexpressed on malignant cells from a variety of different tumor entities. This overexpression is even more pronounced on so-called tumor-initiating cells (TICs) of many carcinomas. Taking this rather ubiquitous expression of EpCAM in carcinomas and TICs into account, the question arises how EpCAM can serve as a reliable marker for tumor-initiating cells and what might be the advantage for TICs to express this molecule. Furthermore, several approaches for therapeutic strategies targeting exclusively EpCAM on cancer cells were undertaken over the past decades and have recently been transferred to pre-clinical attempts to eradicate TICs. In the present review, we will depict potential functions of EpCAM in tumor cells with a special focus on TICs and therapeutic implications.

Sannia Imrich

Matthias Hachmeister

Olivier Gires

EpCAM and its potential role in tumor-initiating cells

EpCAM及其在肿瘤起始细胞中的潜在作用

Daphnetin, a coumarin derivative isolated from Daphne odorifera, has anti-tumor effects. The MAPK, STAT3, and NF-κB signaling pathways are closely related to the pathogenesis of lung cancer. To investigate the effect of daphnetin on anti-lung adenocarcinoma A549 cells and its mechanism. The anti-tumor effects of daphnetin on the proliferation, clone formation, migration, and invasion of A549 lung adenocarcinoma cells were investigated. The results showed that daphnetin inhibited the proliferation, colony formation, migration, and invasion of A549 cells through the MAPK/STAT3/NF-KB pathway, and mainly inhibited the clonal formation and migration of A549 cells through the JNK pathway. These results provide a new research direction and theoretical basis for the use of daphnetin in the inhibition of lung adenocarcinoma.

Zhe Lv

Yuna Du

Huiqing Zhang

Hui Fang

Yujie Guo

Lifeng Zeng

Yiguo Chen

Dan Li

Rong Li

Inhibition of JNK/STAT3/NF-KB pathway-mediated migration and clonal formation of lung adenocarcinoma A549 cells by daphnetin

瑞香素对肺腺癌A549细胞JNK/STAT3/NF-KB通路介导的迁移和克隆形成的影响

Abbreviation
Journal Impact	3.37
Quartiles(Global)	CELL BIOLOGY(Q3)

ISSN	1933-6918, 1933-6926
h-index	75

Publication Information	Publisher: Taylor and Francis Ltd.，Publishing cycle: ，Journal Type: journal，Open Access Journals: Yes
Basic data	Year of publication: 2007，Proportion of original research papers: 71.43%，Self Citation Rate:0.00%， Gold OA Rate: 100.00%
Journal Fees	$2990Details
Average review cycle	网友分享经验：较慢,6-12周
Average recruitment ratio	网友分享经验：较易

Cell Adhesion and Migration

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Knockdown of HGH1 in breast cancer cell lines can inhibit the viability, invasion and migration of tumor cells

Orosomucoid 1 interacts with S100A12 and activates ERK signalling to expedite the advancement of bladder cancer

The relationship between endoplasmic reticulum stress and apoptosis in the process of adipose-derived stromal cells differentiating into astrocytes

Fe ₃ O ₄ nanoparticles containing gambogic acid inhibit metastasis in colorectal cancer via the RORB/EMILIN1 axis

EpCAM and its potential role in tumor-initiating cells

Knockdown of HGH1 in breast cancer cell lines can inhibit the viability, invasion and migration of tumor cells

Orosomucoid 1 interacts with S100A12 and activates ERK signalling to expedite the advancement of bladder cancer

The relationship between endoplasmic reticulum stress and apoptosis in the process of adipose-derived stromal cells differentiating into astrocytes

Fe ₃ O ₄ nanoparticles containing gambogic acid inhibit metastasis in colorectal cancer via the RORB/EMILIN1 axis

Inhibition of JNK/STAT3/NF-KB pathway-mediated migration and clonal formation of lung adenocarcinoma A549 cells by daphnetin