The American Journal of Translational Research is a journal dedicated to translational medicine research, aiming to bridge the gap between basic research and clinical applications.

《American Journal of Translational Research》是一本专注于转化医学研究的期刊，旨在促进基础研究与临床应用之间的桥梁。

American Journal of Translational Research

Background: Mitochondrial flashes (mitoflashes) are transient signals from transient bursts of reactive oxygen species (ROS) and changes in pH that occur in certain physiological or pathological conditions. Mitoflashes are closely related to metabolism, cell differentiation, stress response, diseases, and aging. Sepsis can trigger mitochondrial dysfunction in myocardial cells, which leads to ROS overproduction, while uncoupling protein 2 (UCP2) can reduce ROS production. This study aims to observe whether UCP2 overexpression can regulate the frequency of mitoflashes in cardiomyocytes during sepsis and thereby play a protective role. Methods: A cell model for sepsis-induced myocardial damage was established using lipopolysaccharide (LPS). UCP2 overexpression in cardiomyocytes was achieved by adenovirus transfection. Creatinine kinase (CK), lactate dehydrogenase (LDH), tumor necrosis factor (TNF-α), and interleukin (IL-6) activities were detected, and mitochondrial membrane potentials (MMP) were measured. The frequency of mitoflashes in cardiomyocytes was observed. Results: With LPS stimulation, mitoflashes in cardiomyocytes increased significantly, and the MMP was damaged. Additionally, significant increases in CK, LDH, TNF-α, and IL-6 expression levels were observed. UCP2 overexpression can significantly reverse myocardial cell injuries that result from LPS stimulation. Compared with the LPS group, the LPS+UCP2 overexpression group showed a decrease in mitoflash frequency, an improved MMP, and decreases in CK, LDH, TNF-α, and IL-6 expression levels. Conclusion: This study is the first to demonstrate the function of UCP2 overexpression in protecting the myocardium by regulating mitoflash frequency and reversing sepsis-induced myocardial injuries.

Wen-bo Chen

Shiyu Luo

P. Xie

Tingting Hou

Tian Yu

Xiaoyun Fu

American journal of translational research

Overexpressed UCP2 regulates mitochondrial flashes and reverses lipopolysaccharide-induced cardiomyocytes injury.

过表达的UCP2调控线粒体闪烁并逆转脂多糖诱导的心肌细胞损伤。

To investigate the efficacy of a feedforward control-based intervention strategy for preventing hypothermia among trauma patients during pre-hospital emergency care.

Ting-Li Xu

Yan-Lin Jiang

Gui-Xiu Zhou

Chang-Hua Wu

Application of a feedforward control-based intervention for preventing hypothermia in trauma patients in a pre-hospital emergency setting

基于前馈控制的干预措施在院前急救环境中预防创伤患者低体温的应用

Xinghao Wang

Effects of high-intensity interval training on lipid metabolism, tumor necrosis factor-&amp;#x3B1;, and C-reactive proteinin overweight children

高强度间歇训练对超重儿童脂代谢、肿瘤坏死因子-α和C反应蛋白的影响

Acute lung injury (ALI) is defined as the acute onset of diffuse bilateral pulmonary infiltration, leading to PaO

Qin Juan Wu

Qian Li

Ping Yang

Lei Du

Itaconate to treat acute lung injury: recent advances and insights from preclinical models

衣康酸盐治疗急性肺损伤：从临床前模型中获得的最新进展与见解

To investigate the diagnostic significance of immune cells and biochemical markers in the cerebrospinal fluid and blood of patients with brucella meningitis.

Xiaoyan He

Yu Ma

None Aynur

Hongyan Li

Immune cell and biochemical marker levels in the cerebrospinal fluid and blood of patients with brucella meningitis and their clinical significance

布鲁氏菌脑膜炎患者脑脊液和血液中免疫细胞及生化标志物水平及其临床意义

To evaluate the clinical efficacy of open versus arthroscopic rotator cuff repair in treating moderate rotator cuff tears.

Binjie Zou

Xinhua Dong

Siliang Cheng

Short-term efficacy of open surgery versus arthroscopic rotator cuff repair in moderate rotator cuff tears

开放手术与关节镜下修复中度肩袖撕裂的短期疗效比较

Metastatic spread to the pancreas from renal cell carcinoma is a relatively rare event. Even rarer is the metachronous occurrence of clear cell renal cell carcinoma (ccRCC) and pancreatic ductal adenocarcinoma (PDAC). Our case report contributes to the existing literature by documenting the unusual occurrence of metachronous ccRCC and PDAC in a 69-year-old patient, and we review the literature.

Ye-Li Zhu

Chun-Hui Zhou

Fan-Chuang Kong

Xiao-Lin Liu

Xiao-Guang Wang

Jing Chen

Yan-Hua Huang

A rare metachronous primary clear cell renal cell carcinoma and pancreatic ductal adenocarcinoma: case report and literature review

肾透明细胞癌与胰腺导管腺癌罕见异时性原发癌：病例报告与文献综述

To investigate the implications of serum hsa_circ_0007534 levels in ovarian cancer (OC) patients.

Mingyue Cao

Yunchao Gu

Beidi Lv

Shouqian Liu

Yuanming Shen

Serum hsa_circ_0007534 as a diagnostic biomarker for ovarian cancer

血清hsa_circ_0007534作为卵巢癌的诊断生物标志物

To evaluate the efficacy of FOLFOX regimen combined with cetuximab in the treatment of advanced colon cancer.

Yang Zhang

Hong Qian

Xiaofei Cheng

Ting Zhou

Cheng Zhong

Feng Tian

Qi Sun

Effect of FOLFOX regimen combined with cetuximab treatment on the efficacy and tumor markers of advanced colon cancer patients

FOLFOX方案联合西妥昔单抗治疗对晚期结肠癌患者疗效及肿瘤标志物的影响

To explore the effect of humanized nursing interventions on rectal cancer patients undergoing chemotherapy.

Yan Zhang

Hui Wang

Wenjing Shan

Jia Cao

Yan Huang

Effects of humanized nursing interventions on psychological well-being and quality of life in rectal cancer patients undergoing chemotherapy

人文化护理干预对接受化疗的直肠癌患者心理健康和生活质量的影响

Abbreviation	Am. J. Transl. Res.
Journal Impact	1.52
Quartiles(Global)	ONCOLOGY(Q4)

ISSN	1943-8141
Early Warning Journal	中国科学技术大学 2023 年预警期刊, 中科院 2023 年预警期刊

Publication Information	Publisher: E-Century Publishing Corporation，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2009，Proportion of original research papers: 92.38%，Self Citation Rate:5.90%， Gold OA Rate: 0.07%

American Journal of Translational Research

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