The Brazilian Journal of Veterinary Pathology is the official electronic periodical of the Brazilian Association of Veterinary Pathology.    The purpose of the BJVP is to publish original full papers, short communications, case reports, letters, reviews (by invited experts) and abstracts of scientific meetings.    The preferable subjects  is natural and experimental pathology. All the articles are submitted to scientific reviewers.

The Brazilian Journal of Veterinary Pathology is the official electronic journal of the Brazilian Association of Veterinary Pathology. The purpose of the BJVP is to publish original full papers, short communications, case reports, letters, reviews (by invited experts), and abstracts of scientific meetings. The journal primarily focuses on natural and experimental pathology. All articles are subject to scientific review.

《Brazilian Journal of Veterinary Pathology》是巴西兽医病理学会的官方电子期刊。BJVP的目的是发表原创的完整论文、短篇通讯、病例报告、信件、专家邀请的综述以及科学会议的摘要。期刊主要关注自然病理学和实验病理学。所有文章均需经过科学审稿。

Brazilian Journal of Veterinary Pathology

An adult boa with acute epistaxis, without other clinical signs, was found dead in its terrarium. Macroscopic examination of the specimen revealed multiple yellow foci in the lung and liver. Microscopic findings included severe and multifocal granulomas as well as vasculitis, hemorrhages and thrombosis in liver and lungs, with the presence of intralesional Gram positive and acid-fast bacilli. PCR end point analysis and sequencing using total DNA extracted from formalin-fixed paraffin-embedded samples of liver and lungs identified Mycobacteroides abscessus subsp massiliense and Erysipelothrix rhusiopathiae. Mycobacteria are organisms that can affect a wide range of animals, including reptiles. In snakes, reports are rare and mycobacterial species are highly variable. Erysipelothrix rhusiopathiae is a pathogenic bacillus related to multiple organ disorders, which until now has not been reported in boas. This report describes the first case report of Mycobacteroides abscessus subsp. massiliense and Erysipelothrix rhusiopathiae detection in a boa.

Juan Pablo Velasco-Montes de Oca

Laura P. Romero-Romero

Rigoberto Hernández-Castro

Luary C Martínez-Chavarría

First report of Mycobacteroides abscessus subsp. massiliense and Erysipelothrix rhusiopathiae as causative agents of pneumonia and hepatitis in a boa (Boa constrictor)

首例报道：马赛分枝杆菌和红斑丹毒丝菌作为蟒蛇（Boa constrictor）肺炎和肝炎的致病原

Hemangiosarcoma (HSA) is a malignant tumor derived from the endothelium of vessels, and primary renal HSA is a rare variant of the disease. This study aimed to report a case of unilateral primary renal HSA with pulmonary and brain metastasis in a dog. A 10-year-old mixed-breed male dog was treated at the Hospital Professor Ricardo Alexandre Hippler from Universidade Vila Velha (HV-UVV) with signs of hematuria. A mass in the left kidney was detected by ultrasound, and no metastasis was detected on chest radiography. Unilateral nephrectomy was performed, and the material underwent histopathological examination, which was concluded as HSA. The animal died 48 days after surgery, and a necropsy was performed, showing marked hemothorax and multifocal metastasis of HSA in the lung and brain. The absence of nodules at other sites before surgery indicates a primary renal origin. The late diagnosis of the disease may have contributed to the spread of metastasis and, consequently, the development of hemothorax. Histopathological and necroscopic examinations were essential to confirm the diagnosis.

Marina Possa dos Reys

Tayse Domingues de Souza

Adriano Stelzer Bindaco

Driéle Lutzke

Mayra Cunha Flecher

Primary renal hemangiosarcoma with brain and lung metastasis in a dog

犬原发性肾血管肉瘤伴脑和肺转移

A 9-year-old intact male Rottweiler with clinically suspected prostatic mass had difficulty climbing stairs.The dog was also favoring the left hind limb.The owners mentioned that he had started to act quieter and exhibit declining appetite with weight loss over the course of 2 weeks, in addition to having hematuria.Numerous pulmonary nodules and an abdominal mass with displaced urinary bladder and colon were evident on radiographs.In addition, lytic bone, with cortical bone disruption, was identified in the mid-diaphyseal region of the left femur.Marked lymphadenomegaly of the left popliteal and inguinal nodes was identified on physical examination.A year prior to the onset of these clinical signs, the patient had undergone amputation of digit 5 of its left hind limb due to a severely ulcerated lesion, diagnosed histologically as a subungual malignant neoplasm.An oral tumor between teeth 206 and 207 was also removed; however, this mass was not evaluated histologically.

de Cecco B

de Oca PVM

Langohr IM

Boudreaux B

Sasaki E

Subungual squamous cell carcinoma with metastasis to the femur, multiple lymph nodes, adrenal glands, and lungs

甲下鳞状细胞癌伴股骨、多处淋巴结、肾上腺及肺转移

Nocardiosis is a multi-systemic disease that has been reported in several species of birds. It is characterized by the development of granulomatous inflammation in several organs, mainly affecting the respiratory system. An adult male domestic canary (Serinus canaria domestica) weighing 14.5 g was received for examination. Multiple nodules were identified in the epicardium, air sacs, and lungs. Histologically these nodules corresponded to granulomas, in which numerous thin, filamentous branching bacteria were identified. Gram stains of the epicardium, air sacs, and lungs revealed many filamentous branching Gram-positive bacteria. These bacteria were also strongly acid-fast positive by Fite-Faraco stain. PCR end-point analysis and sequencing using total DNA extracted from formalin-fixed paraffin-embedded samples of lungs, heart, and air sacs confirmed the presence of Nocardia asteroides. To the best of the authors’ knowledge, this is the first case report of nocardiosis associated with Nocardia asteroides in a Domestic Canary (Serinus canaria domestica) in Mexico.

Rubén Arturo López-Crespo

Samantha Miroslava Torres-Cervantes

Jwerlly Tatiana Pico-Rodríguez

Manuel Arturo Moreno-Borjas

Luary Carolina Martínez-Chavarría

First report of nocardiosis due to Nocardia asteroides in a domestic canary (Serinus canaria domestica) in Mexico

墨西哥家养金丝雀（Serinus canaria domestica）中由星形诺卡菌（Nocardia asteroides）引起的诺卡氏菌病的首次报道

A 4-year-old Thoroughbred stallion suffered a fracture of the left thoracic limb while racing.Because of the poor prognosis, the horse was euthanized.

Espil JI

Quiroga MA

Uzal FA

Catastrophic scapular fracture in a stallion

种马的灾难性肩胛骨骨折

Reports on thyroid carcinomas in bovines are scarce. An 18-year-old Nellore cow was referred to a veterinary hospital due to lateral recumbency lasting one day after falling on irregular terrain. The patient was clinically diagnosed with spinal cord injury. Necropsy and histopathology revealed a thyroid tubule papillary carcinoma. Immunohistochemical analysis revealed discrete positive cells for calcitonin, moderately positive cells for thyroid transcription factor 1 (TTF-1), and strongly positive cells for thyroglobulin in the thyroid gland. Thus, this report describes a case of a mixed tubule papillary carcinoma derived from both medullary and follicular cells in a Nellore cow.

Iolanda Simões Braga

Pedro Pol Ximenes

Fernando Carmona Dinau

Fernanda Barthelson Carvalho de Moura

Isabeli Joaquim Contel

Giovanna Gati de Souza

Isadora Fernanda Pelaquim

Noeme Sousa Rocha

Histopathological and immunohistochemical characterization of a mixed tubule papillary thyroid carcinoma in a Nellore cow

Nellore牛混合型管状乳头状甲状腺癌的组织病理学和免疫组织化学特征

Oral squamous cell carcinoma is a common malignant tumor of epithelial cells in dogs. This tumor metastasizes slowly and primarily affects the gingiva. Despite its importance, few studies document this cancer in wild canids. A young adult female hoary fox (Lycalopex vetulus) kept in captivity at Associação Mata Ciliar (Jundiaí, SP, Brazil) exhibited clinical signs such as weakness, prostration, and severe oral bleeding. After anesthetizing the animal, a reddish, friable verrucous formation was observed on the upper and lower lip, as well as on the maxillary and mandibular gingiva on the right side of the mouth, extending towards the bony palate. A biopsy of this mass was performed, followed by histopathological and immunohistochemical evaluation. Histopathology indicated an atypical squamous proliferation with inflammatory features suggestive of poorly differentiated squamous cell carcinoma, which was confirmed by immunohistochemistry through the positive expression of antibodies AE1AE3, p63, and CK14. The proliferation marker ki67 was used to assess the aggressiveness and malignancy of the tumor, and it was found in approximately 80% of the neoplastic cells. Because of the poor prognosis, the hoary fox was euthanized, and a necropsy was performed. Histopathological analysis of the tissues revealed lung metastasis, suppurative bronchopneumonia, and renal metastasis associated with neutrophilic interstitial nephritis and tubular necrosis. The present report describes this type of neoplasm for the first time in a hoary fox and one of the few observed in wild canids. The scarcity of research on neoplasm incidence in wild canids in Brazil emphasizes the need for further investigations to understand tumor development in these species better

Isabela Coelho Zanoti

Bethânia Almeida Gouveia

Fernanda Ramalho Ramos

Mariana Klein

Claudia Momo

Oral squamous cell carcinoma with lung and kidney metastases in a hoary fox (Lycalopex vetulus)

白狐（Lycalopex vetulus）口腔鳞状细胞癌伴肺和肾转移

With the aim of evaluating the effects of caffeine on the expression of gene transcripts related to osteogenesis and chondrogenesis, during zebrafish embryonic development the embryos were divided into five groups: control (without caffeine), 0.25 mM caffeine, 0.5 mM caffeine, 1.0mM caffeine, and 2.0mM caffeine. Embryos were placed in cell culture plates with aquarium water at 280 C for 72 hours post-fertilization (hpf). Embryonic development was followed at times of six, 12 hpf, 24 hpf, 30 hpf, 48 hpf, 54 hpf, and 72 hpf. At 72 hpf, the expression of Sox9a, runx2b, osteocalcin, osteopontin, collagen 2a1, and bmp2a was analyzed using real-time RT-PCR. The 0.25mM caffeine group showed embryonic development that was visually similar to the control group despite having a significantly lower relative expression of bmp2a, runx2b, and collagen 2a1. In the 0.5mM and 1mM caffeine groups, morphological alterations such as tail folding, pericardial edema, and yolk sac deformation were observed, and the relative expression levels of bmp2a, runx2b, and collagen 2a1 were significantly lower. In contrast, osteocalcin expression was significantly higher than in the control group. In the 2mM caffeine group, the embryos did not hatch until 72 hpf and showed tail docking and pericardial and yolk sac edema. The relative expression of bmp2a and runx2b was significantly lower, whereas that of osteocalcin, osteopontin, and collagen 2a1 did not differ from that of the control group. We conclude that caffeine altered the expression of gene transcripts related to osteogenesis and chondrogenesis in zebrafish embryos, even in embryos without visible morphological changes.

Bruno Machado Bertassoli

Gilcinea de Cassia Santana

Julia Meireles Nogueira

Rayan Silva de Paula

Erika Cristina Jorge

Helder de Oliveira Guilherme

Endrigo Gabellini Leonel Alves

Amanda Maria Sena Reis

Rogéria Serakides

Natália Melo Ocarino

Caffeine exposure causes downregulation of the expression of genes related to osteogenesis and chondrogenesis in Zebrafish (Danio rerio)

咖啡因暴露导致斑马鱼（Danio rerio）中与成骨和软骨形成相关基因表达下调

Cardiovascular diseases are rarely reported in birds. Among pet birds, they are most documented in psittacine birds. Dilated cardiomyopathy is a myocardial disease frequently found in poultry but with few reports in both pet and wild birds. An elderly male green-winged saltator (Saltator similis) died suddenly after presenting intermittent clinical signs of dyspnea, weakness, and vocalization changes. A general increase in cardiac size with a bulging apex was observed at necropsy. The heart exhibited an enlarged left ventricular space and flaccid musculature on the cut section. The liver was diffusely enlarged with rounded edges. No other gross lesions were observed. Samples were collected in 10% formalin and routinely processed. Histologically, bundles of myocardial fibers were irregularly arranged, with markedly elongated myofibrils and irregular cell contours. Additionally, multifocal areas of disruption were observed between the myofibrils. Diffuse hepatic congestion of sinusoids and portal veins was observed, and diffuse edema in the interstitium and para bronchi was present in the lungs. The clinical signs observed were nonspecific and can be found in several diseases of the cardiovascular and respiratory systems of birds. The gross and histological findings are compatible with what has been described for dilated cardiomyopathy in birds; however, left ventricular dilatation is uncommon in avian patients. Heart diseases in pet birds are still underdiagnosed, and reports of cardiomyopathies are limited to psittacine birds. To the authors’ knowledge, this is the first report of a dilated cardiomyopathy in a passerine bird.

José Lucas Costa Duarte

Wellington Martins dos Santos

Hodias Sousa de Oliveira

Gabriel Forte Paranhos

Helder Carlos Costa Pereira

Jeann Leal de Araújo

Dilated cardiomyopathy in a green-winged saltator (Saltator similis)

绿翅盐鸟（Saltator similis）中的扩张型心肌病

Neoplasms are an important cause of morbidity and mortality in horses, with squamous cell carcinoma (SCC), also called squamous cell carcinoma, being the most common genital malignant tumor in the species and the most common neoplasm in horses in the State of São Paulo. Neoplasms frequently infiltrate the corpus cavernosum and can cause metastases in regional lymph nodes, generally having a guarded to poor prognosis due to local invasion and recurrence. Given the importance of the disease, the objective was to verify whether there is a difference in the expression pattern of immunomarkers of apoptosis and cell adhesion, according to the degree of cellular differentiation of the neoplasms. Twenty equine penile SCC samples from the Animal Pathology Service of the Veterinary Hospital of the Faculty of Veterinary Medicine and Animal Science of the University of São Paulo were histologically analyzed and classified according to their degree of differentiation. In addition, they were also subjected to the immunohistochemistry technique, with the immunomarkers Caspase-3 and E-cadherin. Data were analyzed using Kendall’s correlation and the Mann-Whitney test. It was found that there is a positive correlation between the expression of immunomarkers and that there is no statistically significant difference in the expression of immunomarkers according to the degree of differentiation.

Vitória Souza de Oliveira Nascimento

Gilmar de Oliveira Pinheiro

Immunohistochemical analysis of E-cadherin and Caspase-3 expression in equine penile squamous cell carcinoma

马阴茎鳞状细胞癌中E-钙粘蛋白和Caspase-3表达的免疫组织化学分析

ISSN	1983-0246
h-index	15

Publication Information	Publisher: Brazilian Association of Veterinary Pathology，Publishing cycle: ，Journal Type: journal，Open Access Journals: Yes
Basic data	Year of publication: 2010，Proportion of original research papers: 0.00%，Self Citation Rate:N.A.， Gold OA Rate: 0.00%
Journal Fees	$50Details
Average review cycle	9 weeks

Brazilian Journal of Veterinary Pathology

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