PATHOGENS AND GLOBAL HEALTH 是一本传染病和公共卫生期刊，专注于将分子、免疫学、基因组学和流行病学知识转化为应对全球健康威胁的控制措施。该杂志发表原创的创新研究论文、评论文章并就具有国际意义的健康主题采访政策制定者和意见领袖。它为控制和根除传染病的新创新解决方案提供科学、伦理和政治讨论的论坛，特别强调影响世界最贫困地区的疾病。

Pathogens and Global Health is a journal focused on infectious diseases and public health, dedicated to translating research findings in molecular biology, immunology, genomics, and epidemiology into effective control measures against global health threats. The journal publishes original innovative research papers and review articles, and conducts interviews with policymakers and opinion leaders on health topics of international significance. It provides a forum for scientific, ethical, and political discussions on new innovative solutions for controlling and eradicating infectious diseases, with a particular emphasis on diseases affecting the world's poorest regions.

《Pathogens and Global Health》是一本专注于传染病和公共卫生的期刊，致力于将分子生物学、免疫学、基因组学和流行病学的研究成果转化为应对全球健康威胁的有效控制措施。该期刊发表原创的创新研究论文和评论文章，并对具有国际意义的健康主题进行政策制定者和意见领袖的采访。它为控制和根除传染病提供了一个科学、伦理和政治讨论的论坛，特别强调影响世界最贫困地区的疾病。

Pathogens and Global Health

Antimicrobial resistance (AMR) is one of the most serious global public health threats in this century. The first World Health Organization (WHO) Global report on surveillance of AMR, published in April 2014, collected for the first time data from national and international surveillance networks, showing the extent of this phenomenon in many parts of the world and also the presence of large gaps in the existing surveillance. In this review, we focus on antibacterial resistance (ABR), which represents at the moment the major problem, both for the high rates of resistance observed in bacteria that cause common infections and for the complexity of the consequences of ABR. We describe the health and economic impact of ABR, the principal risk factors for its emergence and, in particular, we illustrate the highlights of four antibiotic-resistant pathogens of global concern - Staphylococcus aureus, Klebsiella pneumoniae, non-typhoidal Salmonella and Mycobacterium tuberculosis - for whom we report resistance data worldwide. Measures to control the emergence and the spread of ABR are presented.

Francesca Prestinaci

Patrizio Pezzotti

Annalisa Pantosti

Antimicrobial resistance: a global multifaceted phenomenon

抗菌药物耐药性：一个全球多方面的现象

Diphtheria is a reemerging vaccine-preventable infection of public health concern. Pooled estimates of serum IgG anti-diphtheria antibody levels can assist in estimating the susceptible population. The objective was to estimate pooled estimate of protective IgG anti-diphtheria antibodies in population globally. We searched three databases until May 2023. We included studies reporting serum anti-diphtheria antibody titre > 0.1 IU/ml as seroprotection. NHLBI checklist was used for quality assessment. Heterogeneity was explored and resolved by statistical methods. 1720 articles were retrieved out of which 51 articles were included. The pooled seropositivity rate against diphtheria was 57%. After removal of two influential outlier studies, pooled seropositivity became 51%. The meta-regression results for age depicted that seroprevalence significantly decreased with increasing age. Subgroup analysis done on basis of geographical distribution significantly reduced heterogeneity and revealed that the Western Pacific region and African regions had lower seroprotectivity compared to other regions. Subgrouping done based on year of sample collection revealed seroprotection was lower (55.63%) between 1986 and 2005 which increased to 67.11% between 2006 and 2015 and again dropped to 45.75% between 2016 and 2023. We concluded that after 2015, the disease has reemerged globally, with seroprotection level below 50% (45.75%) and overall only half of the population being seroprotected against diphtheria. So, there is a need for reinforcement of immunity against diphtheria (supplementary vaccination) after screening for antibody titre. PROSPERO registration number CRD42023458131.

Amit Kumar Mital

Priyanka Choudhary

Bijaya K. Padhi

Muhammad Aaqib Shamim

Aravind Gandhi P

Mayuri Raul

None Sruthi

Prakasini Satapathy

Mapping anti-diphtheria toxin antibody: a systematic review and meta-analysis with multi-level meta-regression

抗白喉毒素抗体图谱：一项多层次元回归的系统综述与Meta分析

Dengue virus (DENV) remains one of the most common arboviral infections threatening humans. This study was conducted to systematically review the available literature and provide an updated overview of the overall prevalence of DENV infection in Saudi Arabia. The prevalence data was pooled from 21,891 participants recruited in 17 studies. Using random-effects model, the overall prevalence of DENV infection in Saudi Arabia was calculated as 30.8% (95% CI: 20.8-49.8%). The pooled IgM and IgG seroprevalence rates were 17.7% and 26.6%, respectively. Furthermore, the detection of DENV-NS1 antigen and viral RNA revealed pooled estimates of 16.4% and 37.0%, respectively. This study reports a relatively high burden of DENV infection in Saudi Arabia. The findings of this SRMA provide valuable information on the epidemiology of DENV infections in the country, highlighting the need for additional epidemiological investigations to assess the current situation of DENV infection in the country.

Ali A. Rabaan

Amer Alshengeti

Hayam A Alrasheed

Maha F. Al-Subaie

Maha H. Aljohani

Yahya A. Almutawif

Amjad A. Yousuf

Shahab A. Alsuliman

Jumana M. Al-Jishi

Fareed Almalki

Maha A. Alshiekheid

Hejji E. Alahmed

Ameen M. Alramadan

Safaa Abdulrahman Turkistani

Khalid Hajissa

Dengue virus infection in Saudi Arabia from 2003 to 2023: a systematic review and meta-analysis

2003年至2023年沙特阿拉伯登革病毒感染：系统综述与荟萃分析

Antibiotic resistance in typhoid fever poses a critical public health problem due to the emergence of extensively drug-resistant (XDR)

Aisha Bisola Bello

Ridwan Olamilekan Adesola

Ibrahim Idris

Godfred Yawson Scott

Suleiman Alfa

Favour Akinfemi Ajibade

Combatting extensively drug-resistant Salmonella : a global perspective on outbreaks, impacts, and control strategies

抗击广泛耐药性沙门氏菌：全球视角下的疫情、影响及控制策略

Li-Ta Keng

Chen-Chieh Lin

Chang-Wei Wu

Chia-Jung Liu

Lih-Yu Chang

Meng-Rui Lee

Jung-Yueh Chen

Jann-Yuan Wang

Clinical applications of immunoglobulin G against different individual Aspergillus species for the diagnosis of chronic pulmonary aspergillosis among at-risk populations

不同个体曲霉种属特异性免疫球蛋白G在慢性肺曲霉病高危人群诊断中的临床应用

Hepatic schistosomiasis is a neglected parasitosis that affects millions of people each year worldwide and leads to high healthcare costs and increased morbidity and mortality in infected humans. It is a disease that has been widely studied in terms of its pathophysiology; therefore, the signaling pathways that lead to liver damage, with the consequent development of liver fibrosis, are now better understood. Research has elucidated the role of soluble egg antigen in the development of hepatic granulomas and liver fibrosis, the signal transducer and activator of transcription 3 and its participation in liver damage, the role of heat shock protein 47 and its involvement in liver fibrosis, the anti-inflammatory effects caused by interleukin-37, and the role of natural killer and natural killer T cells in the development of the disease. Hepatic schistosomiasis can range from simple hepatomegaly to the development of portal hypertension combined with hepatic fibrosis. For diagnostic purposes, a microscopic examination of excreta remains the gold standard; however, abdominal ultrasound has recently taken on an important role in the assessment of liver lesions produced by the parasite. Praziquantel is considered the management drug of choice, and has been associated with a potential preventive antifibrotic effect.

Lara-Cano R

Castañeda-Méndez P.F.

Uribe-Esquivel M

Barbero-Becerra V.J.

Hepatic schistosomiasis as a determining factor in the development of hepatic granulomas and liver fibrosis: a review of the current literature

肝吸虫病作为肝肉芽肿和肝纤维化发展的决定因素：当前文献综述

Abbreviation	Pathog. Glob. Health.
Journal Impact	4.76
Quartiles(Global)	TROPICAL MEDICINE(Q1)

ISSN	2047-7724, 2047-7732
h-index	80

Publication Information	Publisher: Maney Publishing，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2012，Proportion of original research papers: 77.94%，Self Citation Rate:2.00%， Gold OA Rate: 15.79%
Average review cycle	网友分享经验：较慢,6-12周
Average recruitment ratio	网友分享经验：容易

Pathogens and Global Health

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Antimicrobial resistance: a global multifaceted phenomenon

Mapping anti-diphtheria toxin antibody: a systematic review and meta-analysis with multi-level meta-regression

Dengue virus infection in Saudi Arabia from 2003 to 2023: a systematic review and meta-analysis

Combatting extensively drug-resistant Salmonella : a global perspective on outbreaks, impacts, and control strategies

Clinical applications of immunoglobulin G against different individual Aspergillus species for the diagnosis of chronic pulmonary aspergillosis among at-risk populations

Mapping anti-diphtheria toxin antibody: a systematic review and meta-analysis with multi-level meta-regression

Dengue virus infection in Saudi Arabia from 2003 to 2023: a systematic review and meta-analysis

Combatting extensively drug-resistant Salmonella : a global perspective on outbreaks, impacts, and control strategies

Clinical applications of immunoglobulin G against different individual Aspergillus species for the diagnosis of chronic pulmonary aspergillosis among at-risk populations

Hepatic schistosomiasis as a determining factor in the development of hepatic granulomas and liver fibrosis: a review of the current literature