BMC Nutrition

Gallstones are a common digestive disorder that threatens human health. Iron deficiency may be related to the formation of gallstones, but there is limited current epidemiological research. The objective of this study was to investigate the relationship between iron status and gallstones. The datasets from the National Health and Nutrition Examination Survey (NHANES) 2017–2020 were used in a cross-sectional investigation. Gallstones were determined by using the 2007–2010 NHANES questionnaire. Multivariate linear regression models were used to examine the association between serum iron, serum ferritin and iron intake with the risk for gallstones. Subgroup analysis based on gender, age, race, and diabetes were performed. Fitted smoothing curves were used to describe the linear relationship. The research involved 7847 participants aged 20 and above, among whom 845 were identified as having gallstones. Participants with higher serum iron levels tended to have a lower gallstones prevalence. A negative relationship between serum iron and gallstones prevalence was observed (OR = 0.979, 95% CI:0.965–0.992). The group with the highest serum iron tertile had a 23.7% lower risk of gallstones compared to the lowest tertile (OR = 0.763, 95% CI:0.628‒0.929). Gallstone prevalence was inversely correlated with iron intake in model 1. The negative association between serum iron and gallstones remained stable in stratifications, including gender, age, race, and diabetes. Elevated serum iron was associated with a decreased prevalence of gallstones. However, to confirm the impact of long-term iron metabolism on gallstone formation, additional prospective research is necessary.

Si-Hua Wen

Xin Tang

Tao Tang

Zheng-Rong Ye

Association between serum iron and gallstones in US adults: a cross-sectional study

美国成年人血清铁与胆结石之间的关联：一项横断面研究

Abstract Background Malnutrition is a significant concern reported in adult critically ill patients, yet there is no gold standard to assess nutritional status in this population. This study examines the association between nutritional status and clinical outcomes in intensive care unit (ICU) patients using nutritional risk assessment tools and aims to look for the best tool. Method In a single-center prospective cohort study among 165 patients, the predictive performance of high or low malnutrition risk assessed by Nutritional Risk Screening (NRS), Modified Nutrition Risk in Critically Ill (m-NUTRIC), Mini-Nutritional-Assessment Short-Form (MNA-SF), Controlling Nutritional status (CONUT), and Prognostic Nutritional Index (PNI) were evaluated and compared for mortality, organ failure, length of hospitalization, and mechanical ventilation (MV). Results Different assessment tools showed various nutritional statuses. m-NUTRIC and NRS-2002 were found to be associated more strongly relative to other tools with mortality (RR = 1.72; 95% CI, 1.42–2.08) and (RR = 1.37; 95% CI, 1.08–1.72), organ failure (RR = 1.69; 95% CI, 1.44–1.96) and (RR = 1.22; 95% CI, 0.99–1.48), MV (RR = 1.46; 95% CI, 1.27–1.65) and (RR = 1.21; 95% CI, 1.04–1.39) respectively. There was no correlation between malnutrition levels assessed by mentioned tools except for NRS-2002 and length of hospitalization. In predicting mortality or illness severity, the cut points were different for some tools like NUTRIC-score and all assessed outcomes (3.5), MNA-SF and mortality (6.5), CONUT with mortality, and MV (6.5). Conclusions A considerable proportion of patients admitted to the ICU are at high risk for malnutrition. Compared to other tools, m-NUTRIC and NRS-2002 proved superior in predicting clinical outcomes in critically ill patients. Other tools overestimated the risk of malnutrition in the ICU so couldn’t predict clinical outcomes correctly.

Omid Moradi Moghaddam

Masoumeh Hosseinzadeh Emam

Pardis Irandoost

Mahdi Hejazi

Zeinab Iraji

Leila Yazdanpanah

Seyedeh Farnaz Mirhosseini

Abolfazl Mollajan

Mohammad Niakan Lahiji

Relation between nutritional status on clinical outcomes of critically ill patients: emphasizing nutritional screening tools in a prospective cohort investigation

危重患者营养状况与临床结局的关系：一项前瞻性队列研究中营养筛查工具的强调

Feeding practices during infancy have a significant impact on a child's cognitive development and long-term health outcomes. Dietary diversity guidelines from the WHO and UNICEF recommend a diverse range of foods for children aged below 24 months for their optimal growth and development. However, in sub-Saharan Africa (SSA), little is known about the extent to which dietary diversity behaviour in children aged 6 to 24 months aligns with the recommendations and the factors associated with the differentials in dietary behaviour. This study aimed to fill this gap. This study employed an analytical cross-sectional approach, drawing on recent Demographic and Health Survey (DHS) data from 31 SSA countries. The study included a weighted sample of 44,071 children aged between 6 and 24 months, and their respective mothers aged 15–49 years. The primary outcome was Minimum Dietary Diversity (MDD) categorised per WHO recommendation. Multivariable logistic regression was used to examine the association of MDD with demographic and socio-economic characteristics. The pooled MDD intake among children aged 6–24 months in SSA was 11% ranging from as low as 1.3% in Burkina Faso to 32.9% in South Africa. Children of mothers aged 45–49 years had 52% significant higher likelihood of MDD compared to those aged 15–19 years (AOR = 1.52, 95% CI:1.03, 2.24). Higher maternal education levels also increased MDD odds in the children: 22% higher for mothers who had attained secondary education (AOR = 1.22, 95% CI:1.07, 1.39), and 36% higher for those with education beyond secondary level (AOR = 1.36, 95% CI:1.09, 1.71) compared to no education. Children of rich mothers had 44% higher odds of MDD than those with poor mothers (AOR = 1.44, 95% CI:1.27, 1.62). Increased antenatal visits, and urban residence also contributed to higher MDD odds. Based on the current global estimate of approximately 28% MDD rate, the reported 11% MDD intake among children in this study is relatively low. There is a positive association between MDD intake in children and several factors, including maternal education, antenatal visits, wealth index, and residency. These findings highlight the need for policymakers and other stakeholders to give urgent attention to empowering parents to ensure adequate nutrient intake among children for better child growth and development.

Heavenlight A. Paulo

John Andrew

Pankras Luoga

Huda Omary

Suleiman Chombo

Jackline Vicent Mbishi

Isaac Y. Addo

Minimum dietary diversity behaviour among children aged 6 to 24 months and their determinants: insights from 31 Sub-Saharan African (SSA) countries

6至24个月儿童最低膳食多样性行为及其决定因素：基于31个撒哈拉以南非洲国家的洞察

The Mediterranean diet (MD) has been considered one of the healthiest dietary patterns, and an excellent model of sustainability. Higher Education food services present an excellent scenario to encourage students healthy eating habits and modulate food choices. The purpose of this work was to develop an index to evaluate MD compliance with cafeteria menus. Three major axes were considered: MD key points, existing indexes on individual adherence to the MD and, existing indexes on menu assessment. The index includes four levels: (I) assesses the availability (IA), variety and frequency (IB) of food; (II) evaluates menu's nutritional quality; (III) assesses the menu's quality through information provided in the dishes' technical specifications and (IV) allows a more detailed evaluation through on-site visits and documentation consultation. The components receive a score between − 2 and 3, according to the given answers. The final score may vary between − 33.5 and 41.5 points depending on the degree of compliance with the MD key points. The index was applied to 60 menus from different contexts using complete assessments of each menu, performed independently by 3 researchers, using the same pre-prepared Microsoft Excel® spreadsheet. Inter-rater reliability was assessed using Cohen's Kappa and internal consistency with Cronbach's alpha. Assessment for level I) returned a Cohen's Kappa coefficient of 0.92 (p < 0.05) and a Cronbach's alpha coefficient of 0.88. Dimension I is mostly influenced by subdimension IB (r = 0,97). The availability of non-starchy vegetables and fresh fruits has a stronger correlation with IA (availability of foods), and higher availability of fish, pulses and fruit has a strong positive correlation with IB (variety and frequency of foods). Researchers believe that the index is a useful tool to assess compliance of menus to the MD and help identify the key points that need to be addressed and improved in cafeterias.

S. S. Silva

A. Rocha

L. Ferreira

B. Neto

D. Dikmen

S. Vidacek Filipec

Z. Satalic

C. Viegas

Development of a tool to assess the compliance of cafeteria menus with the Mediterranean Diet

开发一种评估自助餐厅菜单是否符合地中海饮食的工具

Recently, the number of patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and its more advanced condition, metabolic dysfunction-associated steatohepatitis (MASH), has been increasing. These patients are at a higher risk of cardiovascular events and thromboembolism. However, the direct impact of high-fat diet (HFD), a cause of MASLD, on liver coagulation function is not well understood. Previously, we demonstrated that a short-term, 4-day intake of a HFD exacerbates concanavalin A (Con A)-induced acute liver injury in mice by promoting coagulation and inflammation. This model demonstrates that the liver exposed to a short-term HFD is vulnerable even before disease onset. In this study, using this model, we elucidated the detailed mechanisms by which short-term HFD intake promotes coagulation, considering primary and secondary hemostasis. C57BL/6 mice normally fed a normal diet (ND) were subjected to a HFD for 4 days. Liver tissue and blood samples were collected before and 4 and 24 h after Con A administration. Histological analysis, flow cytometry for platelet analysis, and blood coagulation tests related to secondary hemostasis were performed. Even with short-term consumption of a HFD alone, platelet and fibrinogen levels increased in the peripheral blood and liver. Additionally, when Con A was administered to mice on a short-term HFD, an increase in P-selectin expression was observed in the liver, with no upregulation in peripheral blood platelets. Furthermore, in mice subjected to a short-term HFD and treated with Con A, prolonged prothrombin time (PT) and activated partial thromboplastin time (APTT) were observed. Consuming a HFD in short-term can enhance primary and secondary hemostasis, thereby increasing the risk of thrombosis. These conditions are presumed to be a risk factor that exacerbates Con A-induced liver injury. The findings provide insight into early intervention strategies for chronic liver diseases, such as MASLD and MASH.

Eri Nanizawa

Yuki Tamaki

Tomiko Yakura

Shun Otsuka

Naoyuki Hatayama

Munekazu Naito

The impact of a short-term high-fat diet on coagulation function in a mouse model and its role in exacerbating concanavalin A-induced liver injury

短期高脂饮食对小鼠模型凝血功能的影响及其在加重刀豆蛋白A诱导的肝损伤中的作用

Abstract Introduction Promotion of child health during the first thousand days from conception to the child’s second birthday is vital for survival, growth and development. Growth monitoring and promotion services are key to the early detection of growth faltering and preventing malnutrition and promoting child health. This study aimed to assess the utilization of Growth Monitoring and Promotion (GMP) services and its associated factors among young children in Gorkha district of Nepal. Methods A community-based cross-sectional study was conducted in the Gorkha district, involving 290 mother-child pairs, from April 2024 to June 2024. Multistage random sampling was used to select mothers. Data was collected through face-to-face interviews using structured questionnaires. Descriptive statistics and inferential statistics involving multivariate logistic regression analyses were performed to identify the factors associated with GMP service utilization. Results Only 5.5% of children had completed the recommended 24 GMP visits according to protocol, while 23.8% utilized GMP services more than 15 times, which represents the 75th percentile of service utilization. Mothers who had good knowledge had significantly higher (adjusted OR = 4.23, 95% CI: 2.070–8.650, p &lt; 0.001) GMP service utilization among their children than those counterpart mothers with poor knowledge about the GMP services. The main reasons for not regular utilizing GMP services included the time constraints and their household responsibilities (85%). Conclusion This study reported the low utilization of GMP services among children in Gorkha district. Maternal knowledge on GMP service emerged as the primary predictor of GMP service utilization and maternal engagement in the household activities explores as a leading barrier to GMP service utilization. Enhancing maternal knowledge through community engagement strategies and improving the monitoring mechanism within the health systems could increase GMP utilization.

Jagat Prasad Upadhyay

Damaru Prasad Paneru

Yam Prasad Sharma

Nava Raj Khadka

Utilization and associated factors of growth monitoring and promotion services among young children in Gorkha district of Nepal

尼泊尔廓尔喀地区幼儿生长监测与促进服务利用情况及其相关因素

The composition of maternal gut phylum in each trimester of pregnancy has been associated with fetal development, separately. Diet is a main effective factor on the gut composition of phylum. However, associations between dietary glycemic index (GI), load (GL) and total antioxidant capacity (TAC) not studied with the gut population of phylum in mothers at the first trimester of pregnancy.

Navid Momeni

Seyedeh Neda Mousavi

Hossein Chiti

Siamak Heidarzadeh

BMC Nutr

A maternal sweet diet is associated with the gut dysbiosis in the first trimester of pregnancy

母体甜食摄入与妊娠早期肠道菌群失调相关

Abbreviation	BMC Nutr.
Journal Impact	1.78
Quartiles(Global)	NUTRITION & DIETETICS(Q3)

ISSN	2055-0928
h-index	31

Publication Information	Publisher: BioMed Central Ltd，Publishing cycle: ，Journal Type: journal，Open Access Journals: Yes
Basic data	Year of publication: 2015，Proportion of original research papers: 95.63%，Self Citation Rate:0.00%， Gold OA Rate: 100.00%
Journal Fees	$2190Details
Average review cycle	网友分享经验：15 Weeks

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Association between serum iron and gallstones in US adults: a cross-sectional study

Relation between nutritional status on clinical outcomes of critically ill patients: emphasizing nutritional screening tools in a prospective cohort investigation

Minimum dietary diversity behaviour among children aged 6 to 24 months and their determinants: insights from 31 Sub-Saharan African (SSA) countries

Development of a tool to assess the compliance of cafeteria menus with the Mediterranean Diet

The impact of a short-term high-fat diet on coagulation function in a mouse model and its role in exacerbating concanavalin A-induced liver injury

Utilization and associated factors of growth monitoring and promotion services among young children in Gorkha district of Nepal

Minimum dietary diversity behaviour among children aged 6 to 24 months and their determinants: insights from 31 Sub-Saharan African (SSA) countries

Development of a tool to assess the compliance of cafeteria menus with the Mediterranean Diet

The impact of a short-term high-fat diet on coagulation function in a mouse model and its role in exacerbating concanavalin A-induced liver injury

A maternal sweet diet is associated with the gut dysbiosis in the first trimester of pregnancy