NUTRIENTS (ISSN 2072-6643) 是一个国际性的、同行评审的开放获取高级论坛，用于与人类营养相关的研究。它发表评论、定期研究论文和简短的交流。我们的目标是鼓励科学家尽可能详细地发表他们的实验和理论结果。论文的长度没有限制。必须提供完整的实验细节，以便重现结果。

NUTRIENTS (ISSN 2072-6643) is an international, peer-reviewed open-access journal that focuses on research related to human nutrition. The journal publishes comments, regular research articles, and brief communications. Our aim is to encourage scientists to share their experimental and theoretical findings in as much detail as possible. There is no limit on the length of the papers, and complete experimental details must be provided to allow for the reproducibility of results.

NUTRIENTS (ISSN 2072-6643) 是一个国际性的、同行评审的开放获取期刊，专注于与人类营养相关的研究。期刊发表评论、定期研究论文和简短的交流文章。我们的目标是鼓励科学家尽可能详细地分享他们的实验和理论结果。论文长度没有限制，要求提供完整的实验细节，以便他人能够重现结果。

Nutrients

The aim of this study was to assess the effect of the level of adherence to the DASH diet on hypertension risk by conducting a systematic review and meta-analysis. A systematic literature search was performed. Two independent investigators performed the study selection, data abstraction, and assessment of the included studies. The meta-analysis was performed separately with the adjusted hazard (HR) or incident rate ratios (IRR) and the odds ratios (OR) of the highest compared to the lowest DASH diet adherence scores using a random effects model. A total of 12 studies were included in the qualitative and quantitative synthesis. When cohort studies reporting HR were pooled together, high adherence to the DASH diet was associated with a lower risk of hypertension (HR: 0.81, 95% CI 0.73-0.90,

Xenophon Theodoridis

Michail Chourdakis

Lydia Chrysoula

Violeta Chroni

Ilias Tirodimos

Konstantina Dipla

Eugenia Gkaliagkousi

Areti Triantafyllou

Adherence to the DASH Diet and Risk of Hypertension: A Systematic Review and Meta-Analysis

Obesity is a major risk factor for the development of insulin resistance and type 2 diabetes. The exact mechanism by which adipose tissue induces insulin resistance is still unclear. It has been demonstrated that obesity is associated with the adipocyte dysfunction, macrophage infiltration, and low-grade inflammation, which probably contributes to the induction of insulin resistance. Adipose tissue synthesizes and secretes numerous bioactive molecules, namely adipokines and cytokines, which affect the metabolism of both lipids and glucose. Disorders in the synthesis of adipokines and cytokines that occur in obesity lead to changes in lipid and carbohydrates metabolism and, as a consequence, may lead to insulin resistance and type 2 diabetes. Obesity is also associated with the accumulation of lipids. A special group of lipids that are able to regulate the activity of intracellular enzymes are biologically active lipids: long-chain acyl-CoAs, ceramides, and diacylglycerols. According to the latest data, the accumulation of these lipids in adipocytes is probably related to the development of insulin resistance. Recent studies indicate that the accumulation of biologically active lipids in adipose tissue may regulate the synthesis/secretion of adipokines and proinflammatory cytokines. Although studies have revealed that inflammation caused by excessive fat accumulation and abnormalities in lipid metabolism can contribute to the development of obesity-related insulin resistance, further research is needed to determine the exact mechanism by which obesity-related insulin resistance is induced.

Iwona Kojta

Marta Chacińska

Agnieszka Błachnio-Zabielska

Obesity, Bioactive Lipids, and Adipose Tissue Inflammation in Insulin Resistance

Spinal muscular atrophy (SMA), the main genetic cause of infant death, is a neurodegenerative disease characterized by the selective loss of motor neurons in the anterior horn of the spinal cord, accompanied by muscle wasting. Pathomechanically, SMA is caused by low levels of the survival motor neuron protein (SMN) resulting from the loss of the SMN1 gene. However, emerging research extends the pathogenic effect of SMN deficiency beyond motor neurons. A variety of metabolic abnormalities, especially altered fatty acid metabolism and impaired glucose tolerance, has been described in isolated cases of SMA; therefore, the impact of SMN deficiency in metabolic abnormalities has been speculated. Although the life expectancy of these patients has increased due to novel disease-modifying therapies and standardization of care, understanding of the involvement of metabolism and nutrition in SMA is still limited. Optimal nutrition support and metabolic monitoring are essential for patients with SMA, and a comprehensive nutritional assessment can guide personalized nutritional therapy for this vulnerable population. It has recently been suggested that metabolomics studies before and after the onset of SMA in patients can provide valuable information about the direct or indirect effects of SMN deficiency on metabolic abnormalities. Furthermore, identifying and quantifying the specific metabolites in SMA patients may serve as an authentic biomarker or therapeutic target for SMA. Here, we review the main epidemiological and mechanistic findings that link metabolic changes to SMA and further discuss the principles of metabolomics as a novel approach to seek biomarkers and therapeutic insights in SMA.

Yang-Jean Li

Tai-Heng Chen

Yan-Zhang Wu

Yung-Hao Tseng

Metabolic and Nutritional Issues Associated with Spinal Muscular Atrophy

Hesperetin (HT) is a type of citrus flavonoid with various pharmacological activities, including anti-tumor, anti-inflammation, antioxidant, and neuroprotective properties. However, the role and mechanism of HT in ulcerative colitis (UC) have been rarely studied. Our study aimed to uncover the beneficial effects of HT and its detailed mechanism in UC. Experimental colitis was induced by 2.5% dextran sodium sulfate (DSS) for seven days. HT ameliorated DSS-induced colitis in mice, showing marked improvement in weight loss, colon length, colonic pathological severity, and the levels of TNFα and IL6 in serum. A combination of informatics, network pharmacology, and molecular docking identified eight key targets and multi-pathways influenced by HT in UC. As a highlight, the experimental validation demonstrated that PTGS2, a marker of ferroptosis, along with other indicators of ferroptosis (such as ACSL4, Gpx4, and lipid peroxidation), were regulated by HT in vivo and in vitro. Additionally, the supplement of HT increased the diversity of gut microbiota, decreased the relative abundance of Proteobacteria and Gammaproteobacteria, and restored beneficial bacteria (Lachnospiraceae_NK4A136_group and Prevotellaceae_UCG-001). In conclusion, HT is an effective nutritional supplement against experimental colitis by suppressing ferroptosis and modulating gut microbiota.

Jinzhi Wang

Yuanyuan Yao

Ting Yao

Qingmiao Shi

Yifan Zeng

Lanjuan Li

Hesperetin Alleviated Experimental Colitis via Regulating Ferroptosis and Gut Microbiota

橙皮素通过调节铁死亡和肠道菌群缓解实验性结肠炎

Dysphagia is a syndrome of abnormal eating function resulting from a variety of causative diseases, and is associated with malnutrition. To date, the swallowing function has been difficult to examine without the use of invasive and expensive methods, such as the videofluorographic swallowing study or fiberoptic endoscopic evaluation of swallowing. In recent years, progress has been made in the clinical application of ultrasound equipment for the evaluation of body compositions near the body surface, including the assessment of nutritional status. Ultrasound examination is a noninvasive procedure and relatively inexpensive, and the equipment required is highly portable thanks to innovations such as wireless probes and tablet monitoring devices. The process of using ultrasound to visualize the geniohyoid muscle, digastric muscle, mylohyoid muscle, hyoid bone, tongue, masseter muscle, genioglossus muscle, orbicularis oris muscle, temporalis muscle, pharynx, esophagus, and larynx, and the methods used for evaluating these structures, are provided in this study in detail. This study also aims to propose a protocol for the assessment of swallowing-related muscles that can be applied in real-world clinical practice for the diagnosis of sarcopenic dysphagia, which can occur in elderly patients with sarcopenia, and has received much attention in recent years.

Keisuke Maeda

Motoomi Nagasaka

Ayano Nagano

Shinsuke Nagami

Kakeru Hashimoto

Masaki Kamiya

Yuto Masuda

Kenichi Ozaki

Koki Kawamura

Ultrasonography for Eating and Swallowing Assessment: A Narrative Review of Integrated Insights for Noninvasive Clinical Practice

Background: Keto analogues in combination with a (very) low-protein diet significantly reduces the progression to end-stage kidney disease. The question of their benefit and safety for kidney transplant recipients remains. This study aimed to show the renoprotective effect and safety of the use of this method in patients with chronic kidney disease and a kidney transplantation. Materials: This was a retrospective monocentric study conducted by the transplant nephrology department in Martin, in which patients with chronic kidney disease, with or without kidney transplant therapy, who received a low-protein diet and supplementation with keto analogues were included (n = 59). The changes in their glomerular filtration rate, proteinemia, calcaemia, weight, and glycaemia and the side effects associated with a low-protein diet and keto analogue use were studied in the patients with chronic kidney disease with or without kidney transplantation. Results: The kidney transplant recipients had a significantly more advanced stage of chronic kidney disease (p = 0.0001) than the non-transplanted patients at the time of the prescription of the keto analogues (p = 0.0001). Furthermore, the kidney transplant recipients had a significantly longer follow-up period (p = 0.0001), with a difference of 27 months within subgroups. During the observed period, we recorded a decrease in glomerular filtration, but without statistical significance. In our group, we did not confirm a significant occurrence of adverse effects associated with a low-protein diet and keto analogues. Conclusion: Keto analogues reduce the progression of chronic kidney disease and stabilise glomerular filtration in patients with chronic kidney disease. Based on our analysis, treatment with keto analogues is effective and safe for kidney transplant recipients after kidney transplantation.

Patrícia Kleinová

Tímea Blichová

Karol Graňák

Andrej Kollár

Matej Vnučák

Ivana Dedinská

Keto Analogues in Patients with Chronic Kidney Disease with or Without Kidney Transplantation

慢性肾脏病患者（无论是否接受肾移植）中的酮体类似物

Obesity is one of the world’s major public health challenges. Its pathogenesis and comorbid metabolic disorders share common mechanisms, such as mitochondrial or endoplasmic reticulum dysfunction or oxidative stress, gut dysbiosis, chronic inflammation and altered autophagy. Numerous pro-autophagy dietary interventions are being investigated for their potential obesity-preventing or therapeutic effects. We summarize current data on the relationship between autophagy and obesity, and discuss various dietary interventions as regulators of autophagy-related genes in the prevention and ultimate treatment of obesity in humans, as available in scientific databases and published through July 2024. Lifestyle modifications (such as calorie restriction, intermittent fasting, physical exercise), including following a diet rich in flavonoids, antioxidants, specific fatty acids, specific amino acids and others, have shown a beneficial role in the induction of this process. The activation of autophagy through various nutritional interventions tends to elicit a consistent response, characterized by the induction of certain kinases (including AMPK, IKK, JNK1, TAK1, ULK1, and VPS34) or the suppression of others (like mTORC1), the deacetylation of proteins, and the alleviation of inhibitory interactions between BECN1 and members of the Bcl-2 family. Significant health/translational properties of many nutrients (nutraceuticals) can affect chronic disease risk through various mechanisms that include the activation or inhibition of autophagy. The role of nutritional intervention in the regulation of autophagy in obesity and its comorbidities is not yet clear, especially in obese individuals.

Martyna Bednarczyk

Nicola Dąbrowska-Szeja

Dariusz Łętowski

Sylwia Dzięgielewska-Gęsiak

Dariusz Waniczek

Małgorzata Muc-Wierzgoń

Relationship Between Dietary Nutrient Intake and Autophagy—Related Genes in Obese Humans: A Narrative Review

肥胖人群饮食营养摄入与自噬相关基因的关系：叙述性综述

Background/Objectives: Malnutrition significantly hinders recovery in patients undergoing convalescent rehabilitation. Proper nutritional management can improve rehabilitation outcomes. This study aimed to develop a novel nutritional screening method (J-Method) specifically in patients undergoing convalescent rehabilitation and compare it with the widely used Mini Nutritional Assessment Short Form (MNA-SF). Methods: We developed the J-Method for convalescent rehabilitation settings and compared its results with that of the MNA-SF. The J-Method comprised six items derived from various nutritional screening methods and obtained solely from medical records, without patient interviews. Data from 148 patients aged &gt; 65 years with cerebrovascular diseases admitted to a convalescent rehabilitation ward (CRW) were collected. Nutritional status was evaluated using the J-Method and MNA-SF, after which the results were compared. Results: It is possible that the J-Method more precisely identified patients as malnourished than did the MNA-SF (J-Method: MNA-SF = 36/148 (24.3%): 111/148 (75.0%)). In detail, 75 (50.4%) were classified as having malnutrition by the MNA-SF but as non-malnutrition by the J-Method; however, no patients were in the opposite scenario. In addition, the results of nutritional screening using the J-Method identified patients in need of nutritional management intervention and suggested that to improve the rehabilitation effect, nutritional management should be initiated in an acute hospital before admission to a CRW. Conclusions: The J-Method may be more effective than the MNA-SF for nutritional screening in convalescent rehabilitation settings, as it provides a more accurate assessment of malnutrition without requiring patient interviews.

Kozue Okamoto

Miho Kogirima

Yoshiro Tsuji

Shinsuke Ishino

Hiromasa Inoue

Establishment of a Rapid and Precise Nutritional Screening Method for Convalescent Rehabilitation Patients: A Preliminary Study

康复期患者快速精准营养筛查方法的建立：一项初步研究

Alzheimer’s disease (AD) is a complex multifactorial neurodegenerative disease. With the escalating aging of the global population, the societal burden of this disease is increasing. Although drugs are available for the treatment of AD, their efficacy is limited and there remains no effective cure. Therefore, the identification of safe and effective prevention and treatment strategies is urgently needed. Functional factors in foods encompass a variety of natural and safe bioactive substances that show potential in the prevention and treatment of AD. However, current research focused on the use of these functional factors for the prevention and treatment of AD is in its initial stages, and a complete theoretical and application system remains to be determined. An increasing number of recent studies have found that functional factors such as polyphenols, polysaccharides, unsaturated fatty acids, melatonin, and caffeine have positive effects in delaying the progression of AD and improving cognitive function. For example, polyphenols exhibit antioxidant, anti-inflammatory, and neuroprotective effects, and polysaccharides promote neuronal growth and inhibit inflammation and oxidative stress. Additionally, unsaturated fatty acids inhibit Aβ production and Tau protein phosphorylation and reduce neuroinflammation, and melatonin has been shown to protect nerve cells and improve cognitive function by regulating mitochondrial homeostasis and autophagy. Caffeine has also been shown to inhibit inflammation and reduce neuronal damage. Future research should further explore the mechanisms of action of these functional factors and develop relevant functional foods or nutritional supplements to provide new strategies and support for the prevention and treatment of AD.

Rong-Zu Nie

Huo-Min Luo

Ya-Ping Liu

Shuang-Shuang Wang

Yan-Jie Hou

Chen Chen

Hang Wang

Hui-Lin Lv

Xing-Yue Tao

Zhao-Hui Jing

Hao-Kun Zhang

Pei-Feng Li

Food Functional Factors in Alzheimer’s Disease Intervention: Current Research Progress

阿尔茨海默病干预中的食物功能因子：当前研究进展

Objectives: This study aimed to assess malnutrition and muscle mass depletion risk in gastrointestinal cancer patients, exploring the differences between gastric and colorectal cancer, with a focus on gender0specific variations and dietary intake. It also examined whether muscle depletion mediates the relationship between dietary intake and malnutrition risk. Methods: A sample of 100 Jordanian pre-operative gastrointestinal cancer patients (60 male, 40 female) with gastric or colorectal cancer were assessed for malnutrition risk using the malnutrition universal screening tool (MUST) and for muscle depletion using fat-free mass index (FFMI) and mid-upper arm muscle area (MUAMA). Results: The study found that 80% (95% CI: 0.708–0.873) of patients were at high risk of malnutrition, with over 60% experiencing severe muscle loss. Gastric cancer patients showed higher, though not statistically significant, malnutrition risk (90.2% vs. 72.9%) and muscle depletion compared to colorectal cancer patients. Advanced cancer stages were associated with significantly higher risk of malnutrition and muscle depletion. Significant gender-specific differences in muscle depletion via FFMI (p = 0.012) and via MUAMA (p = 0.028) were also noted, especially in females with gastric cancer. Additionally, males exhibited a significantly higher malnutrition risk (p &lt; 0.001) based on cancer stage. Patients’ dietary intake was significantly (p &lt; 0.001) below the recommended levels for energy, protein, carbohydrates, fiber, and essential fatty acids, which was associated with higher malnutrition risk, muscle depletion, low BMI (&lt;18.5 kg/m2), and significant weight loss (&gt;10%). Low dietary intake was strongly linked to increased malnutrition risk and muscle depletion, with muscle loss partially mediating (b = 0.4972, p &lt; 0.0001) the relationship between poor dietary intake and malnutrition risk. Additionally, higher muscle mass was protective against malnutrition (OR = 16.0, 95% CI: 1.706–150.507), and cancer type was a significant predictor of malnutrition risk (OR = 14.4, 95% CI: 1.583–130.867). Conclusions: Malnutrition risk and significant muscle loss are common in GI cancer patients, highlighting the urgent need for tailored nutrition care plans and lifestyle modifications.

Nahla Al-Bayyari

Marah Hailat

Ana Baylin

Gender-Specific Malnutrition and Muscle Depletion in Gastric and Colorectal Cancer: Role of Dietary Intake in a Jordanian Cohort

约旦人群中胃癌和结直肠癌的性别特异性营养不良和肌肉消耗：饮食摄入的作用

短名
Journal Impact	4.88
国际分区	NUTRITION & DIETETICS(Q1)
期刊索引	SCI Q1中科院 2 区

ISSN	2072-6643
h-index	209
国内分区	医学(2区)医学营养学(2区)

涉及主题	医学生物内科学化学病理内分泌学生物化学遗传学有机化学心理学食品科学环境卫生社会学数学精神科统计肥胖人口学
出版信息	出版商: Multidisciplinary Digital Publishing Institute (MDPI)，出版周期: ，期刊类型: journal，开源期刊: 是
基本数据	创刊年份: 2009，原创研究文献占比: 82.47%，自引率:14.60%， Gold OA占比: 99.13%
期刊费用	$详情
平均审稿周期	期刊官网数据：平均16.74天网友分享经验：偏慢,4-8周

Nutrients

期刊引文格式

有 1 位以上作者的期刊

有 2 位作者的期刊

有 3 位作者的期刊

有 5 位以上作者的期刊

书籍引用格式

学位论文引用格式

网页引用格式

专利引用格式

手工熬夜修改参考文献？研飞自动匹配期刊，一键轻松成稿，支持 Word/WPS

投稿经验分享