Cosmetics

Abstract: Introduction: Gold threads became widely used in esthetic surgery in the early 1990s. Produced in Spain, these threads consisted of a gold thread (5/0) with a diameter of 0.1 mm, composed of 99.99% pure gold, which was combined with a polyglycolic thread. Since then, discussions about their effectiveness have continued, which is the focus of our study. Patients and Methods: Gold thread implantation was performed on 11,062 patients in four clinics in Moscow over the course of 28 years. This study used a comparative analysis of photo collages created for the visual representation of data and changes before and after the procedure, as well as patient satisfaction assessments using the Patient Satisfaction Scale (PSS). We examined the results of 492 patients who underwent gold thread implantation in the face between 1996 and 2024. Of these patients, 86% were women aged 30 to 60 years, 11% were women aged 20 to 30 years, and 3% were men aged 25 to 60 years. Results: One year after thread implantation, the PSS assessment showed a 91% success rate with minimal complications. Patient satisfaction was high, with an average score of 4.8 out of 5 after one month, 4.7 after six months, and 4.6 after one-year post-procedure. Discussion: Gold thread implantation is a minimally invasive procedure that has demonstrated a high level of safety, making it an effective option for facial rejuvenation. Histological studies have shown that gold threads stimulate the production of collagen and elastin and activate angiogenesis, thereby improving skin nourishment and hydration, as well as enhancing the skin tone, elasticity, and turgor. To improve the qualitative characteristics of the skin, it is necessary to work in the subcutaneous layer. Conclusions: Gold thread implantation strengthens the connective tissue framework at the implantation site, thus improving skin nourishment and hydration. Gold threads provide a long-term rejuvenating effect, slowing the ptosis of the soft tissue of the face and neck. Gold thread implantation does not interfere with tissue dissection during surgical interventions or the performance of any cosmetic procedures, including hardware-based treatments.

Alexey E. Avdeev

Valentin I. Sharobaro

Arslan A. Penaev

Anastasia S. Borisenko

Elena V. Mitish

Anna S. Bairamova

Facial Gold Reinforcement: 28 Years of Experience in the Use of Gold Threads

面部黄金强化：28年黄金线使用经验

Acne vulgaris, the most prevalent skin disorder among teenagers and young adults, is often perceived as a moderate skin condition; however, it imposes a substantial economic and psychological burden on individuals and society. Microneedling emerges as a valuable therapeutic option for acne vulgaris. The procedure involves using fine needles to create controlled micro-injuries in the skin, stimulating collagen production and enhancing the skin’s natural healing processes. This minimally invasive technique effectively reduces acne lesions, improves skin texture, and increases collagen production with minimal adverse effects and downtime. This narrative review evaluates the efficacy and safety of microneedling procedures in treating acne vulgaris. A comprehensive research strategy was employed across various databases (PubMed, Google Scholar, Cochrane Library) to identify relevant studies. Inclusion criteria encompassed studies investigating microneedling procedures for acne, including controlled trials and case studies. Outcomes such as reduced acne lesions, improved skin texture, adverse effects, and patient satisfaction were analyzed. While further well-designed studies are warranted to elucidate optimal treatment protocols and long-term outcomes, current evidence supports the integration of microneedling into managing acne-prone skin. Moreover, the long-term consequences of microneedling in acne management remain an area for future research.

Șoimița Emiliana Măgerușan

Gabriel Hancu

Aura Rusu

Current Understanding of Microneedling Procedures for Acne Skin: A Narrative Review

痤疮皮肤微针治疗现状：一项叙述性综述

This article describes a technique for gluteal augmentation using cross-linked hyaluronic acid (HA) filler, with a focus on long-term patient follow-up. The rising demand for buttock enhancement driven by esthetic preferences has led to the exploration of minimally invasive alternatives to traditional surgical methods. Ultrasound imaging was utilised to evaluate the presence and distribution of HA filler over time. The patients reported satisfactory aesthetic improvements, with mild transient side effects. The findings highlight the technique’s effectiveness in achieving enhanced gluteal contour with a minimal volume of filler, demonstrating both safety and durability in the long term. This innovative approach may serve as a valuable option in aesthetic practises focused on body contouring.

Renato Pazzini

Renata Viana

Giseli Petrone

Long Term Follow-Up in Gluteal Augmentation Using Cross-Linked Hyaluronic Acid: Up to 20 Months Ultrasound Follow-Up

使用交联透明质酸进行臀部增大术的长期随访：长达20个月的超声随访

Animal venom and plant extracts have been used since ancient times in traditional medicine worldwide. Natural components, valued for their safety and effectiveness, have been consistently used in cosmetic and pharmaceutical applications. We propose a journey along the boulevard of active compounds from natural sources, where bee venom (BV), cobra venom (CV), and Ficus carica reveal their individual therapeutic and cosmetic properties. The originality of this review lies in exploring the synergy of these bioactive sources, an approach that has not been presented in the literature. Although BV, CV, and Ficus carica have different origins and compositions, they have multiple common pharmacological and cosmetic actions, which make them ideal for inclusion in various products that can be used for skin care and health in general. Their anti-inflammatory, antioxidant, immunomodulatory, antimicrobial, neuroprotective, and regenerative properties give them an essential role in the creation of potential innovative and effective products in the pharmaceutical and cosmetics industry. Although many plant extracts have antioxidant and anti-inflammatory properties, Ficus carica was chosen due to its complex biochemical composition, which provides valuable benefits in skin regeneration and protection against oxidative stress. According to the International Nomenclature of Cosmetic Ingredients (INCI), Ficus carica is used in the form of an extract of fruits, leaves, juice, bark or stem, each having specific applicability in topical formulations; due to the diversity of bioactive compounds, it can amplify the effectiveness of BV and CV, helping to enhance their beneficial effects and reducing the risk of adverse effects, due to its well-tolerated nature. Thus, this combination of natural ingredients opens up new perspectives in the development of innovative products, optimizing efficiency and maintaining a favorable safety profile. In this context, due to the reported experimental results, the three natural sources caught our attention, and we conceived the present work, which is a review made following the analysis of the current progress in the study of the bioactive compounds present in BV, CV, and Ficus carica. We focused on the novelties regarding pharmacological and cosmetic actions presented in the literature, and we highlighted the safety profile, as well as the modern approaches regarding the delivery and transport systems of the active substances from the three natural sources, and we evaluated their prospects in therapeutic and cosmetic use. This paper not only expands our knowledge of bioactive compounds, but it can also generate new ideas and motivations for the research and development of innovative treatments and skincare methods.

Monica Dinu

Carmen Galea

Ana Maria Chirilov

Alin Laurențiu Tatu

Lawrence Chukwudi Nwabudike

Olimpia Dumitriu Buzia

Claudia Simona Stefan

A Journey Along the Boulevard of Bioactive Compounds from Natural Sources, with Cosmetic and Pharmaceutical Potential: Bee Venom, Cobra Venom, Ficus carica

从天然来源探索具有化妆品和药用潜力的生物活性化合物之旅：蜂毒、眼镜蛇毒、无花果

Skin diseases are a common health problem affecting millions of people worldwide. Effective treatment often depends on the precise delivery of drugs to the affected areas. One promising approach is currently the transdermal drug delivery system (TDDS), whose significant challenge is the poor penetration of many compounds into the skin due to the stratum corneum (SC), which acts as a formidable barrier. To overcome this limitation, nanocarriers have emerged as a highly effective alternative. This review discusses the use of liposomes and ethosomes for transdermal drug delivery. Liposomes are micro- or nanostructures consisting of a lipid bilayer surrounding an aqueous core. They facilitate transdermal drug penetration and may be advantageous for site-specific targeting. Some methods of treating skin diseases involve incorporating drugs such as acyclovir, dithranol, and tretinoin or bioactive compounds such as fluconazole, melanin, glycolic acid, kojic acid, and CoQ10 into nanocarriers. The inability of liposomes to pass through the narrowed intercellular channels of the stratum corneum led to the invention of lipid-based vesicular systems such as ethosomes. They are structurally similar to conventional liposomes, as they are prepared from phospholipids, but they contain a high ethanol concentration. Ethosomes are noninvasive carriers that allow drugs to reach the deep layers of the skin. Examples of commonly used substances and drugs combined with ethosomes in cosmetics include methotrexate, ascorbic acid, vitamin A and E, and colchicine. A significant development in this area is the use of rutin-loaded ethosomes. Encapsulating rutin in ethosomes significantly improves its stability and enhances skin penetration, allowing more efficient delivery to deeper skin layers. In cosmetics, rutin–ethosome formulations are used to protect the skin from oxidative stress, reduce redness, and improve capillary strength, making it a valuable formulation in anti-aging and anti-inflammatory products. The results of the first clinical trial of the acyclovir–ethosome formulation confirm that ethosomes require further investigation. The work provides an update on recent advances in pharmaceutical and cosmetic applications, mentioning the essential points of commercially available formulations, clinical trials, and patents in the recent past.

Ewelina Musielak

Violetta Krajka-Kuźniak

Liposomes and Ethosomes: Comparative Potential in Enhancing Skin Permeability for Therapeutic and Cosmetic Applications

脂质体与乙醇化脂质体：在增强治疗和化妆品应用的皮肤渗透性方面的比较潜力

短名
Journal Impact	3.53
国际分区	DERMATOLOGY(Q2)

ISSN	2079-9284
h-index	44

涉及主题	生物化学医学有机化学生物化学病理遗传学物理工程类材料科学食品科学化妆品皮肤病科内科学地质学药理学
出版信息	出版商: Multidisciplinary Digital Publishing Institute (MDPI)，出版周期: ，期刊类型: journal，开源期刊: 是
基本数据	创刊年份: 2014，原创研究文献占比: 76.81%，自引率:8.80%， Gold OA占比: 99.30%
期刊费用	$详情
平均审稿周期	网友分享经验：8 Weeks

Cosmetics

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Facial Gold Reinforcement: 28 Years of Experience in the Use of Gold Threads

Current Understanding of Microneedling Procedures for Acne Skin: A Narrative Review

Long Term Follow-Up in Gluteal Augmentation Using Cross-Linked Hyaluronic Acid: Up to 20 Months Ultrasound Follow-Up

A Journey Along the Boulevard of Bioactive Compounds from Natural Sources, with Cosmetic and Pharmaceutical Potential: Bee Venom, Cobra Venom, Ficus carica

Liposomes and Ethosomes: Comparative Potential in Enhancing Skin Permeability for Therapeutic and Cosmetic Applications

A Journey Along the Boulevard of Bioactive Compounds from Natural Sources, with Cosmetic and Pharmaceutical Potential: Bee Venom, Cobra Venom, Ficus carica

Long Term Follow-Up in Gluteal Augmentation Using Cross-Linked Hyaluronic Acid: Up to 20 Months Ultrasound Follow-Up

Current Understanding of Microneedling Procedures for Acne Skin: A Narrative Review

Facial Gold Reinforcement: 28 Years of Experience in the Use of Gold Threads

Liposomes and Ethosomes: Comparative Potential in Enhancing Skin Permeability for Therapeutic and Cosmetic Applications