AIDS Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies focused on all aspects of HIV and AIDS, from the molecular basis of disease to translational and clinical research. In addition, articles relating to prevention, education, and behavior change will be considered

AIDS Research and Treatment is a peer-reviewed, open access journal that publishes original research articles, review articles, and clinical studies focused on all aspects of HIV and AIDS, ranging from the molecular basis of the disease to translational and clinical research. Additionally, articles related to prevention, education, and behavior change will also be considered for publication.

《AIDS Research and Treatment》是一本经过同行评审的开放获取期刊，专注于HIV和艾滋病的各个方面，发表原创研究文章、综述文章和临床研究。期刊内容涵盖从疾病的分子基础到转化医学和临床研究。此外，关于预防、教育和行为改变的文章也将被考虑发表。

AIDS Research and Treatment

Background: Overweight and obesity have arisen as major public health challenges, affecting not just the general population but also people living with human immunodeficiency virus (HIV) (PLWH). Obesity and being overweight are both risk factors for heart disease and other related complications. However, little is known in our setting. As a result, this study was conducted to evaluate the prevalence of overweight and obesity and its associated factors among PLWH on dolutegravir (DTG)‐ and efavirenz (EFV)‐based therapies. Methods: An institution‐based comparative cross‐sectional study was carried out from June 30, 2021, to August 30, 2021. We purposively recruited 128 participants who have been on DTG ( n = 64)‐ and EFV ( n = 64)‐based regimens for ≥ 6 months. Demographic, anthropometric, laboratory, and clinical data were collected using a structured questionnaire. The data were entered into EpiData Version 4.6 and analyzed using SPSS Version 26.0. Multivariable logistic regression was utilized to identify the factors that are associated with being overweight or obese, and the significance level was set at p &lt; 0.05. Result: The prevalence of overweight and obesity was 28.1% in the DTG‐prescribed participants and 15.6% in the EFV‐prescribed participants. Age ≥ 40 years (adjusted odd ratio (AOR) = 3.86; 95% confidence interval (CI): 1.08–13.73; and p = 0.037), cluster of differentiation 4 (CD4) T‐cell counts ≥ 500 cells/mm 3 (AOR = 2.95; 95% CI: 1.01–8.59; and p = 0.029), and insufficient physical activity (AOR = 4.6; 95% CI: 1.53–13.84; and p = 0.007) were predictors of overweight and obesity. Conclusion: Overweight and obesity are not uncommon among PLWH on ART. While the difference was statistically insignificant, the prevalence of overweight and obesity was higher in patients treated with DTG compared with those treated with EFV. Older age, higher CD4 cell counts, and insufficient physical activity were associated with overweight and obesity. As a result, healthcare providers must understand the health implications of obesity and consider incorporating targeted weight control programs into standard HIV treatment.

Mohammed Jemal

Adane Adugna

Mamaru Getinet

Temesgen Baylie

Nuredin Chura Waritu

Overweight and Obesity Among People Living With HIV on Dolutegravir‐ and Efavirenz‐Based Therapies: A Comparative Cross‐Sectional Study

基于多替拉韦和依非韦伦治疗的HIV感染者中超重和肥胖的比较横断面研究

Despite access to antiretroviral therapy (ART), South Africa has a high human immunodeficiency virus (HIV) burden. Treatment outcomes among individuals on highly active ART (HAART) in KwaZulu‐Natal, with a higher incidence of HIV, are not fully known. This study evaluated the impact of HAART outcomes and identified and analyzed the factors associated with the outcomes in people living with HIV and AIDS (PLWHA) in the high‐incidence region of KwaZulu‐Natal Province, South Africa. This retrospective medical record review was conducted at King Edward VIII Hospital in South Africa. Data analysis was performed using STATA software Version 18.0 and Microsoft Excel 2021. The estimates used were 95% confidence intervals, and a p value &lt; 0.05 was considered statistically significant. A total of 707 clinical records of PLWHA were examined and analyzed; less than half of them (44.98%, n = 318) achieved the benchmark of two consecutive instances of suppressed viral loads. The CD4 greater than or equal to 500 cells/mm 3 at baseline average of 22.91% ( n = 162) registered an increase to 48.94% ( n = 346) in the 6 th month and further escalated to 79.49% ( n = 562) by the 12 th month following ART initiation. A total of 160 deaths (mortality rate of 22.63%) were recorded within the study period. The percentage of HIV‐infected patients attaining viral suppression at 6 and 12 months after initiating the treatment was respectively 44.98% and 67.04%, below the 90% target established by the Joint United Nations Program on HIV/AIDS (UNAIDS). The proportion of favorable immunological responses for individuals on ART increased over time.

Tambwe Willy Muzumbukilwa

Riziki Ghislain Manimani

Aganze Gloire-Aime Mushebenge

Rajesh Vikram Vagiri

Manimbulu Nlooto

Evaluation of Treatment Outcomes Among Individuals on Highly Active Antiretroviral Therapy in KwaZulu‐Natal, South Africa

南非夸祖鲁-纳塔尔省接受高效抗逆转录病毒治疗个体治疗效果的评估

Background: Following the 2018 World Health Organization’s (WHO) guidelines on HIV treatment and management, the Zimbabwean government has embraced dolutegravir (DTG)‐based regimens as the preferred first‐line treatment for people living with HIV (PLWH). Despite this implementation, there remains a paucity of knowledge on the potential associations between DTG‐based regimens, body weight and blood lipid levels among PLWH in Zimbabwe. Thus, the aim of this study was to investigate variances in body weight and blood lipid levels at two distinct timepoints—baseline and 6‐month post‐DTG initiation. Methods: We conducted this study between November 2021 and April 2023 among ART‐naïve individuals initiating a DTG‐based regimen. Participants were recruited from a tertiary clinic in Zimbabwe. Body weight, standing height and blood lipid levels were measured at baseline and 6‐month post‐DTG. Changes in weight, body mass index (BMI) and lipids levels were assessed using the paired Student’s t ‐test and Wilcoxon signed rank test. Multivariable logistic and linear regression analysis was used to assess risk factors associated with changes in weight, BMI and lipid levels. Results: A cohort comprising 130 study participants, characterised by a mean (±SD) age of 40.0 (±11.0) years at baseline, was subjected to a 6‐month regimen of DTG‐based therapy. The outcomes revealed statistically significant alterations in various physiological parameters. Specifically, post the DTG‐based intervention, there were substantial increases observed in body weight ( p &lt; 0.001), BMI ( p = 0.003), total cholesterol (TC) levels ( p = 0.002) and high‐density lipoprotein cholesterol (HDL‐C) levels ( p &lt; 0.001) in comparison to their baseline values. Intriguingly, the corresponding triglyceride (TG) levels exhibited a noteworthy decrease ( p &lt; 0.001). Notably, individuals aged 40 years or older exhibited a positive association ( p = 0.022) with increased TC levels and concurrent weight gain. Furthermore, current employment emerged as another factor positively linked to increased TC levels and weight gain. Conclusions: Upon the initiation of DTG, discernible elevations were observed in body weight, BMI and lipid levels. This study represents the first comprehensive assessment of lipid profiles and weight gain among this population in Zimbabwe, filling a critical gap in the existing literature. These findings, while indicative of short‐term effects, underscore the imperative for further investigative efforts aimed at elucidating the prolonged consequences associated with DTG‐induced weight gain and increased lipid levels and its underlying mechanisms.

Rudo Chakanetsa

Raylton P. Chikwati

Itai Chitungo

Cuthbert Musarurwa

Donald M. Tanyanyiwa

Justen Manasa

Vinie Kouamou

Weight and Lipid Levels in People Living With HIV and Initiating a Dolutegravir‐Based Regimen in a Resource Limited Setting

资源有限地区开始使用多替拉韦为基础方案的HIV感染者体重与血脂水平

To analyze sociodemographic and behavioral factors associated with vulnerability to HIV according to sexual orientation.This is a cross-sectional study conducted using data on 3,818 people in the city of Imperatriz, Brazil, during 2015 and 2016. The survey's questionnaires addressed sociodemographic and behavioral variables. For the data analysis, association (chi-square test) and strength of association (odds ratio) were observed. A significance level of p < 0.05 and adjustment for age and gender were taken into consideration.A substantial portion of the sample stated they were heterosexual (88.8%). These individuals demonstrated a lower chance of HIV infection (p < 0.001), sexually transmitted infections (p < 0.001), alcohol use (p < 0.001) and condom use (p < 0.001), compared to men who have sex with men and/or bisexuals. In this group, after adjusting for confounding variables, the factors associated with HIV infection were being male (p < 0.001), unmarried (p < 0.001), having completed higher education (p < 0.001) and boasting multiple sexual partners (p < 0.001).Behavioral and sociodemographic factors of vulnerability to HIV are predominant among men who have sex with men and/or are bisexual.

Maria Aparecida A. O. Serra

Antoninho B. Milhomem

Samae B. Oliveira

Francisca Aline A. S. Santos

Roberta Araújo e Silva

Ana Cristina P. J. Costa

Maria da Conceição S. O. Cunha

Antônio Uelton A. Silva

Roberto Wagner J. F. Freitas

Márcio Flávio M. Araújo

Sociodemographic and Behavioral Factors Associated with HIV Vulnerability according to Sexual Orientation

社会人口学和行为因素与性取向相关的艾滋病易感性

The syndromic diagnosis of sexually transmitted infections (STIs) is widely recognized as the most practical, feasible, and cost-effective diagnostic tool in resource-limited settings. This study assessed the diagnostic accuracy of syndromic versus laboratory testing of STIs among 794 men randomly selected from the Moshi district of Tanzania. Participants were interviewed with a questionnaire that included questions on history of STIs symptoms. Blood and urine samples were taken from the participants for laboratory testing. Only 7.9% of the men reported any symptoms of STI; however, 46% of them tested positive for at least one STI. There was little agreement between syndromic and laboratory-confirmed diagnoses, with low sensitivity (0.4%–7.4%) and high specificity (96%–100%) observed for each individual symptom. The area under the receiver-operating curve was 0.528 (95% CI: 0.505–0.550), indicating that the syndromic approach has a 52.8% probability of correctly identifying STIs in study participants. In conclusion, whenever possible, laboratory diagnosis of STI should be favored over syndromic diagnosis.

Yuwei Cheng

Elijah Paintsil

Musie Ghebremichael

Syndromic versus Laboratory Diagnosis of Sexually Transmitted Infections in Men in Moshi District of Tanzania

坦桑尼亚莫希区男性性传播感染的综合征诊断与实验室诊断比较

Introduction. Though people living with HIV/AIDS require a good combination of antiretroviral therapy and healthy dietary habits for a quality life and positive medical outcomes, little is, however, known regarding the dietary practices of HIV-positive patients who receive antiretroviral therapy (ART) in the Lawra Municipality. Objective. This study assessed the magnitude and factors associated with dietary diversity among HIV-positive patients on antiretroviral therapy (ART). Methods. This study was a facility-based cross-sectional study of 269 study participants recruited using a systematic random sampling technique. Bivariate and multivariable logistic regression analyses were performed to identify factors associated with their dietary diversity. Results. This study shows that only 36 (13.4%) of the sample consumed a diversified diet with a mean dietary diversity score of 3.7 ± 0.99. Starchy staple foods (96.7%) and flesh food (92.9%) were the most consumed foods. Being a nonfarmer employee (AOR = 10.76, 95% CI = 1.03–112.35), not taking cotrimoxazole prophylaxis (AOR = 3.76, 95% CI = 1.02–14.37) and adults of age 18–27 years (AOR = 5.95, 95% CI = 1.18–30.07) were significant predictors of high dietary diversity. Conclusion. This study revealed that dietary diversity was a significant nutritional problem among HIV-positive adults in Lawra Municipal Hospital. Starchy staple foods and flesh food were the most consumed foods, while organ meats, dairy products, and eggs were eaten less. Having a secured salary paid job, not taking cotrimoxazole prophylaxis, and being a young adult were strong predictors of a high dietary diversity score. Therefore, efforts should be made to strengthen and improve the economic status and to educate these vulnerable groups on the need to adhere to cotrimoxazole prophylaxis uptake.

Louis Nebayeng Mornah

Mahama Saaka

Diana Pireh

Magnitude and Predictors of Dietary Diversity among HIV-Infected Adults on Antiretroviral Therapy: The Case of North-Western, Ghana

加纳西北部接受抗逆转录病毒治疗的HIV感染成人饮食多样性的程度及预测因素

The primary objective of this study was to characterize women living with HIV (WLWH) in Belgium. The secondary objective was an exploratory analysis comparing women and men living with HIV (MLWH).

Abbreviation	AIDS. Res. Treat.
Journal Impact	1.03
Quartiles(Global)	INFECTIOUS DISEASES(Q4)

ISSN	2090-1240, 2090-1259
h-index	34

Publication Information	Publisher: Hindawi Publishing Corporation，Publishing cycle: ，Journal Type: journal，Open Access Journals: Yes
Basic data	Year of publication: 2010，Proportion of original research papers: 75.00%，Self Citation Rate:0.00%， Gold OA Rate: 100.00%
Journal Fees	$950Details
Average review cycle	网友分享经验：18 Weeks

AIDS Research and Treatment

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Overweight and Obesity Among People Living With HIV on Dolutegravir‐ and Efavirenz‐Based Therapies: A Comparative Cross‐Sectional Study

Evaluation of Treatment Outcomes Among Individuals on Highly Active Antiretroviral Therapy in KwaZulu‐Natal, South Africa

Weight and Lipid Levels in People Living With HIV and Initiating a Dolutegravir‐Based Regimen in a Resource Limited Setting

Sociodemographic and Behavioral Factors Associated with HIV Vulnerability according to Sexual Orientation

Syndromic versus Laboratory Diagnosis of Sexually Transmitted Infections in Men in Moshi District of Tanzania

Magnitude and Predictors of Dietary Diversity among HIV-Infected Adults on Antiretroviral Therapy: The Case of North-Western, Ghana

Overweight and Obesity Among People Living With HIV on Dolutegravir‐ and Efavirenz‐Based Therapies: A Comparative Cross‐Sectional Study

Evaluation of Treatment Outcomes Among Individuals on Highly Active Antiretroviral Therapy in KwaZulu‐Natal, South Africa

Weight and Lipid Levels in People Living With HIV and Initiating a Dolutegravir‐Based Regimen in a Resource Limited Setting

A Characterization of Women Living with HIV in Belgium