《生物活性材料》是一份国际性的、经过同行评审的研究出版物，涵盖了生物活性材料的各个方面。该杂志欢迎提交与与所有生物物种的细胞、组织或器官接触的下一代生物材料的科学和工程有关的研究论文、评论和快速交流。生物活性材料将具有对生物环境的适应性，旨在刺激和/或指导适当的细胞和组织反应，或控制与微生物物种的相互作用。

Bioactive Materials is an international, peer-reviewed research journal that covers all aspects of bioactive materials. The journal welcomes submissions of research papers, reviews, and rapid communications related to next-generation biomaterials that interact with cells, tissues, or organs of all biological species. Bioactive materials are designed to be adaptable to biological environments, aiming to stimulate and/or guide appropriate cellular and tissue responses, or to control interactions with microbial species.

《Bioactive Materials》是一份国际性的、经过同行评审的研究期刊，涵盖生物活性材料的各个方面。该杂志欢迎提交与所有生物物种的细胞、组织或器官接触的下一代生物材料相关的科学和工程研究论文、评论和快速交流。生物活性材料旨在适应生物环境，刺激和/或指导适当的细胞和组织反应，或控制与微生物物种的相互作用。

Bioactive Materials

Human adenovirus (HAdV) can cause severe respiratory infections in immunocompromised patients, but its clinical treatment is seriously limited by side effects of drugs such as poor efficacy, low bioavailability and severe nephrotoxicity. Trace element selenium (Se) has been found will affect the disease progression of pneumonia, but its antivirus efficacy could be improved by speciation optimization. Therefore, herein we performed anti-HAdV effects of different Se speciation and found that lentinan (LNT)-decorated selenium nanoparticles (SeNPs) exhibited low cytotoxicity and excellent anti-HAdV antiviral activity. Furthermore, SeNPs@LNT reduced the HAdV infection-induced mitochondrial damage and excessive production of reactive oxygen species (ROS). It was also involved in the repair of host cell DNA damage and inhibition of viral DNA replication. SeNPs@LNT inhibited HAdV-induced apoptosis mainly by modulating the p53/Bcl-2 apoptosis signaling pathway. In vivo, SeNPs@LNT replenished Se by targeting the infected site through the circulatory system and was involved in the synthesis of Glutathione peroxidase 1 (GPx1). More importantly, GPx1 played an antioxidant and immunomodulatory role in alleviating HAdV-induced inflammatory cytokine storm and alleviating adenovirus pneumonia in Se-deficient mice. Collectively, this study provides a Se speciation of SeNPs@LNT with anti-HAdV activity, and demonstrate that SeNPs@LNT is a promising pharmaceutical candidate for the treatment of HAdV.

Yinghua Li

Ting Liu

Ruilin Zheng

Jia Lai

Jingyao Su

Jiali Li

Bing Zhu

Tianfeng Chen

Translational selenium nanoparticles boost GPx1 activation to reverse HAdV-14 virus-induced oxidative damage

Abnormal proliferation of aggressive fibroblast-like synoviocytes (FLS) and perpetuate synovial inflammation can inevitably accelerate the progression of rheumatoid arthritis (RA). Herein, a strategy of simultaneously promoting FLS apoptosis and inhibiting inflammation as mediated by macrophages is proposed to restore synovial homeostasis for effective RA therapy. A hyaluronic acid-based dissolvable microneedle (MN) is fabricated for transdermal delivery of dual human serum albumin (HSA)-contained biomimetic nanocomplexes to regulate RA FLS and macrophages. Upon skin insertion, dual nanocomplexes are released rapidly from the MN and accumulate in RA joint microenvironment through both passive and active targeting as mediated by HSA. Thioketal-crosslinked fluorinated polyethyleneimine 1.8 K (TKPF) was constructed to bind the plasmid encoding pro-apoptotic gene PUMA with HSA coating layer (TKPF/pPUMA@HSA, TPH). TPH nanocomplexes can upregulate PUMA through RA FLS transfection to trigger efficient apoptosis. Also, HSA nanocomplexes encapsulating the classic anti-inflammatory natural product celastrol (Cel@HSA, CH) can inhibit inflammation of macrophages through blocking NF-κB pathway activation. TPH/CH MN can deplete RA FLS and inhibit M1 macrophage activation, suppress synovial hyperplasia as well as reduce bone and cartilage erosion in a collagen-induced arthritis (CIA) mouse model, demonstrating a promising strategy for efficient RA treatment.

Peng Hua

Ruifeng Liang

Suleixin Yang

Yanbei Tu

Meiwan Chen

Microneedle-assisted dual delivery of PUMA gene and celastrol for synergistic therapy of rheumatoid arthritis through restoring synovial homeostasis

The pore architecture of porous scaffolds is a critical factor in osteogenesis, but it is a challenge to precisely configure strut-based scaffolds because of the inevitable filament corner and pore geometry deformation. This study provides a pore architecture tailoring strategy in which a series of Mg-doped wollastonite scaffolds with fully interconnected pore networks and curved pore architectures called triply periodic minimal surfaces (TPMS), which are similar to cancellous bone, are fabricated by a digital light processing technique. The sheet-TPMS pore geometries (s-Diamond, s-Gyroid) contribute to a 3‒4-fold higher initial compressive strength and 20%-40% faster Mg-ion-release rate compared to the other-TPMS scaffolds, including Diamond, Gyroid, and the Schoen's I-graph-Wrapped Package (IWP) in vitro. However, we found that Gyroid and Diamond pore scaffolds can significantly induce osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). Analyses of rabbit experiments in vivo show that the regeneration of bone tissue in the sheet-TPMS pore geometry is delayed; on the other hand, Diamond and Gyroid pore scaffolds show notable neo-bone tissue in the center pore regions during the early stages (3-5 weeks) and the bone tissue uniformly fills the whole porous network after 7 weeks. Collectively, the design methods in this study provide an important perspective for optimizing the pore architecture design of bioceramic scaffolds to accelerate the rate of osteogenesis and promote the clinical translation of bioceramic scaffolds in the repair of bone defects.

Miaoda Shen

Yifan Li

Fengling Lu

Yahui Gou

Cheng Zhong

Shukun He

Chenchen Zhao

Guojing Yang

Lei Zhang

Xianyan Yang

Zhongru Gou

Sanzhong Xu

Bioceramic scaffolds with triply periodic minimal surface architectures guide early-stage bone regeneration

Wenhan Tian

Yuzeng Liu

Bo Han

Fengqi Cheng

Kang Yang

Weiyuan Hu

Dongdong Ye

Sujun Wu

Jiping Yang

Qi Chen

Yong Hai

Robert O. Ritchie

Guanping He

Juan Guan

Mechanically robust surface-degradable implant from fiber silk composites demonstrates regenerative potential

机械强度高且表面可降解的丝纤维复合材料植入物展示出再生潜力

Radiation-induced heart disease (RIHD), characterized by severe oxidative stress and immune dysregulation, is a serious condition affecting cancer patients undergoing thoracic radiation. Unfortunately, clinical interventions for RIHD are lacking. Selenium (Se) is a trace element with excellent antioxidant and immune-modulatory properties. However, its application in heart radioprotection remains challenging. Herein, we developed a novel bioactive Cordyceps militaris-based Se oral delivery system (Se@CM), which demonstrated superior radioprotection effects in vitro against X-ray-induced damage in H9C2 cells through suppressing excessive ROS generation, compared to the radioprotectant Amifostine. Moreover, Se@CM exhibited exceptional cardioprotective effects in vivo against X-ray irradiation, reducing cardiac dysfunction and myocardial fibrosis by balancing the redox equilibrium and modulating the expression of Mn-SOD and MDA. Additionally, Se@CM maintained immuno-homeostasis, as evidenced by the upregulated population of T cells and M2 macrophages through modulation of selenoprotein expression after irradiation. Together, these results highlight the remarkable antioxidant and immunity modulation properties of Se@CM and shed light on its promising application for cardiac protection against IR-induced disease. This research provides valuable insights into developing effective strategies for preventing and managing RIHD.

Chang Liu

Weiyi Wang

Haoqiang Lai

Yikang Chen

Lvyi Li

Haiwei Li

Meixiao Zhan

Wenqiang Cao

Xiaoling Li

Biosynthesis of fungus-based oral selenium microcarriers for radioprotection and immuno-homeostasis shaping against radiation-induced heart disease

This review paper explores the cutting-edge advancements in hydrogel design for articular cartilage regeneration (CR). Articular cartilage (AC) defects are a common occurrence worldwide that can lead to joint breakdown at a later stage of the disease, necessitating immediate intervention to prevent progressive degeneration of cartilage. Decades of research into the biomedical applications of hydrogels have revealed their tremendous potential, particularly in soft tissue engineering, including CR. Hydrogels are highly tunable and can be designed to meet the key criteria needed for a template in CR. This paper aims to identify those criteria, including the hydrogel components, mechanical properties, biodegradability, structural design, and integration capability with the adjacent native tissue and delves into the benefits that CR can obtain through appropriate design. Stratified-structural hydrogels that emulate the native cartilage structure, as well as the impact of environmental stimuli on the regeneration outcome, have also been discussed. By examining recent advances and emerging techniques, this paper offers valuable insights into developing effective hydrogel-based therapies for AC repair.

Fariba Hashemi-Afzal

Hooman Fallahi

Fatemeh Bagheri

Maurice N. Collins

Mohamadreza Baghaban Eslaminejad

Hermann Seitz

Advancements in hydrogel design for articular cartilage regeneration: A comprehensive review

关节软骨再生水凝胶设计的进展：综合评述

Changjian Lin

Chenting Ying

Yibo Xu

Yuxuan Zou

Ruihan Chen

Kaicheng Xu

Xiaoxiao Ji

Qihua Cao

Jiahui Weng

Lifeng Jiang

Chenyi Ye

Kai Xu

Yuzhe He

Weijun Li

Lidong Wu

Jisheng Ran

Yan Xiong

Xiaohua Yu

Jiapeng Bao

Synergizing adaptive immunity and regenerative signals to enhance osteochondral defects repair

协同适应性免疫与再生信号以增强骨软骨缺损修复

Chaoxiong Wu

Xinyu Yang

Kaiyue Yang

Qingyu Yu

Chenlu Huang

Fangzhou Li

Linhua Zhang

Dunwan Zhu

Compensatory effect-based oxidative stress management microneedle for psoriasis treatment

基于补偿效应的氧化应激管理微针用于银屑病治疗

Changjiang Liu

Kun Liu

Dong Zhang

Yuting Liu

Yifeng Yu

Haifei Kang

Xianzhen Dong

Honglian Dai

Aixi Yu

Dual-layer microneedles with NO/O2 releasing for diabetic wound healing via neurogenesis, angiogenesis, and immune modulation

用于糖尿病伤口愈合的含NO/O2双层微针：通过神经发生、血管生成和免疫调节

Abbreviation	Bioact. Mater.
Journal Impact	18.17
Quartiles(Global)	MATERIALS SCIENCE, BIOMATERIALS(Q1)

ISSN	2097-1192, 2452-199X
h-index	90
Top Journals	Yes

Publication Information	Publisher: KeAi Communications Co.，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2016，Proportion of original research papers: ，Self Citation Rate:， Gold OA Rate:

Bioactive Materials

Journal Citation Format

A journal article with 1 author

A journal article with 2 authors

A journal article with 3 authors

A journal article with 5 or more authors

Books Citation Format

Thesis Citation Format

Web sites Citation Format

Patent Citation Format

Staying up late manually editing references? ivySCI automatically matches journals and helps you generate references with a single click.

Share Submission Experience

Translational selenium nanoparticles boost GPx1 activation to reverse HAdV-14 virus-induced oxidative damage

Microneedle-assisted dual delivery of PUMA gene and celastrol for synergistic therapy of rheumatoid arthritis through restoring synovial homeostasis

Bioceramic scaffolds with triply periodic minimal surface architectures guide early-stage bone regeneration

Mechanically robust surface-degradable implant from fiber silk composites demonstrates regenerative potential

Biosynthesis of fungus-based oral selenium microcarriers for radioprotection and immuno-homeostasis shaping against radiation-induced heart disease

Mechanically robust surface-degradable implant from fiber silk composites demonstrates regenerative potential

Advancements in hydrogel design for articular cartilage regeneration: A comprehensive review

Synergizing adaptive immunity and regenerative signals to enhance osteochondral defects repair

Compensatory effect-based oxidative stress management microneedle for psoriasis treatment

Dual-layer microneedles with NO/O2 releasing for diabetic wound healing via neurogenesis, angiogenesis, and immune modulation