AJP Reports

Lacosamide [Vimpat® Harris FRC Corporation. © 2022 UCB, Inc. Smyrna, GA 30080] is an antiseizure medication which acts through blockage of voltage-gated neuronal sodium channels. Its recent implementation in the neonatal population has been extrapolated from adult and pediatric data suggesting a favorable safety profile. (1) Of note, preterm infants have unique developmental characteristics that may predispose them to increased risk of adverse reactions. We present a case of a preterm neonate who developed left ventricular (LV) dysfunction coinciding with the initiation of lacosamide.

Trassanee Chatmethakul

Amy Stanford

Danielle Rios

Adrianne Rahde Bischoff

Theresa Czech

Patrick McNamara

American Journal of Perinatology Reports

Cardiac dysfunction associated with lacosamide in a premature infant with Hypoxic Ischemic Encephalopathy: A case report.

早产儿缺氧缺血性脑病伴拉科酰胺相关心脏功能障碍：一例报告。

Pregnancies complicated by midtrimester painless cervical dilation are known to have associations with preterm birth. In situations where fetal amniotic membranes are exposed, the risk of perinatal morbidity and mortality increases dramatically in this particularly high-risk population. Multifetal gestations further increase the risk of preterm birth, yet there remains a paucity of data supporting therapeutic intervention for these patients. We report a case series of 12 multifetal gestations with painless cervical dilation and exposed fetal membranes that underwent emergency cerclage placement. Pregnancy prolongation was achieved on average 60.25 days with 76.9% neonatal survival. These findings are suggestive that emergency cerclage may be a beneficial treatment in this unique patient population.

Kirk Ramin

Ruby Nguyen

Lauren Giacobbe

Jessica Swartout

Marijo Aguilera

Emergency Cerclage Placement in Multifetal Pregnancies with a Dilated Cervix and Exposed Membranes: Case Series

多胎妊娠宫颈扩张、羊膜暴露情况下的紧急环扎术安置：病例系列

In recent times, atypical antipsychotics are increasingly being used in the neonatal intensive care unit (NICU) for the management of neonatal delirium. As the recognition of delirium in NICU infants increases, caution should be exercised with use of antipsychotics for management, given associated adverse effects. Neuroleptic malignant syndrome (NMS) is a rare adverse drug reaction associated with exposure to anti-dopaminergic medications. Most reported cases of NMS in pediatric patients have been in older children on antipsychotic medications. We present a case of a 10-month-old former preterm infant who developed clinical signs suggestive of neuroleptic malignant syndrome after exposure to olanzapine for treatment of delirium. Our case report details the clinical course of this infant, delves into the condition, and outlines some useful lessons for the clinician in the identification and management of this rare but life-threatening adverse effect.

Gloria Akuamoah-Boateng

Kayla A Buttafuoco

Courtney C Sutton

Brian Paul Hackett

NEUROLEPTIC MALIGNANT SYNDROME IN A 10-MONTH-OLD EX-PRETERM INFANT WITH DELIRIUM

10个月大早产儿并发谵妄的神经安定恶性综合征

Gestational alloimmune liver disease (GALD) is a rare autoimmune syndrome in which maternal antibodies lead to in utero fetal hepatocyte destruction, often presenting as neonatal liver failure and hemochromatosis. Antenatal intravenous immunoglobulin (IVIG) is generally accepted to be safe in pregnancy with demonstrable benefit for reducing GALD recurrence risk in subsequent pregnancies. Here we present a case of a 33-year-old woman with a prior neonatal demise due to GALD who received multiple prophylactic IVIG infusions in a subsequent twin pregnancy complicated by maternal jaundice and acute hepatitis. Liver biopsy demonstrated hepatocellular injury with bridging necrosis and cholestatic features consistent with drug-induced liver injury (DILI). This case demonstrates the importance of close clinical monitoring during IVIG therapy and the need for further research into alternative prophylaxis options for GALD.

Jessica A Meyer

Jenna S Silverstein

Kristen Thomas

Sara Brubaker

Judith Chervenak

Drug-Induced Liver Injury From Intravenous Immunoglobulin For Prevention Of Recurrent Gestational Alloimmune Liver Disease: A Clinical Catch-22

静脉免疫球蛋白预防复发性妊娠同种免疫性肝病所致药物性肝损伤：临床困境

Amniotic fluid and amnion membranes have been used in surgery specialties to improve wound healing. The objective was to determine if amniotic fluid could be collected at cesarean delivery and then reapplied to the layers of the closure using the CeaLogic Specimen Collection and Ratio Applicator Kit. Autologous amniotic fluid from 20 subjects was collected at cesarean delivery using the collection kit, and then transferred to the applicator kit, mixed with calcium chloride solution, and applied directly to each of the surgical repair layers during closure. The Modified Hollander Cosmesis Score was used to assess wound appearance from photographs of the incision taken in the postpartum setting. The median (IQR) Modified Hollander Cosmesis Score (range 0-best, to 6-worst) at the one week and four-week postpartum visits was 0 (0,1) and 0 (0,2), respectively. There were no wound complications nor surgical site infections. The CeaLogic Specimen Collection and Ratio Applicator Kits can be used to collect and reapply autologous amniotic fluid at cesarean delivery. Future studies can determine if the application of autologous amniotic fluid to cesarean delivery closure can improve cosmesis and wound healing, as well as decrease the risk for the development of intraabdominal adhesions.

Chad Grotegut

Kristin Weaver

Lena Fried

Sarah Dotters-Katz

Jennifer Gilner

The collection and application of autologous amniotic fluid to cesarean delivery closure – a feasibility study

自体羊水收集与应用于剖宫产切口闭合的可行性研究

Background: The incidence of uterine leiomyomas, or fibroids, affecting pregnant individuals is estimated to be 10%, but there are no guidelines or recommendations for fetal or maternal surveillance in pregnancies affected by them. Risks associated with fibroids during pregnancy include potential for pain, preterm birth, fetal growth restriction, higher cesarean delivery rate, fetal malpresentation, placenta abruption, and postpartum hemorrhage. Case presentation: This case describes a 26-year-old gravida 1 para 0 who presented at early term for severe abdominal pain and was found to have acute abdomen accompanied by a non-reassuring fetal heart rate tracing. With emergent cesarean delivery, it was found that the patient was hemorrhaging from a ruptured vessel of a pedunculated fibroid and myomectomy was subsequently performed. Conclusion: While rare, hemorrhage from a uterine fibroid should be considered a part of the differential diagnosis of abdominal pain in pregnant patients with fibroids, particularly when accompanied by concurrent indicators such as free fluid, hypotension/tachycardia, or concerning changes in fetal heart rate especially in a patient without risk factors for uterine rupture.

Nicholas William Racchi

Lisa Bird

Samantha Mullan

William Schnettler

Nanci Billock

Hemorrhaging uterine fibroid leading to emergent early term Cesarean Delivery: A Case Report

子宫肌瘤出血致紧急早期剖宫产：一例报告

短名	AJP Rep
Journal Impact	0.60
国际分区	PEDIATRICS(Q4)

ISSN	2157-6998, 2157-7005
h-index	14

涉及主题	医学生物遗传学内科学怀孕外科病理产科胎儿心理学儿科放射科精神科妊娠期内分泌学化学生物化学数学
出版信息	出版商: Thieme Medical Publishers, Inc.，出版周期: ，期刊类型: journal，开源期刊: 是
基本数据	创刊年份: 2014，原创研究文献占比: 87.50%，自引率:0.00%， Gold OA占比: 100.00%
期刊费用	$2300详情
平均审稿周期	网友分享经验：12 Weeks

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Cardiac dysfunction associated with lacosamide in a premature infant with Hypoxic Ischemic Encephalopathy: A case report.

Emergency Cerclage Placement in Multifetal Pregnancies with a Dilated Cervix and Exposed Membranes: Case Series

NEUROLEPTIC MALIGNANT SYNDROME IN A 10-MONTH-OLD EX-PRETERM INFANT WITH DELIRIUM

Drug-Induced Liver Injury From Intravenous Immunoglobulin For Prevention Of Recurrent Gestational Alloimmune Liver Disease: A Clinical Catch-22

The collection and application of autologous amniotic fluid to cesarean delivery closure – a feasibility study

Cardiac dysfunction associated with lacosamide in a premature infant with Hypoxic Ischemic Encephalopathy: A case report.

The collection and application of autologous amniotic fluid to cesarean delivery closure – a feasibility study

Drug-Induced Liver Injury From Intravenous Immunoglobulin For Prevention Of Recurrent Gestational Alloimmune Liver Disease: A Clinical Catch-22

NEUROLEPTIC MALIGNANT SYNDROME IN A 10-MONTH-OLD EX-PRETERM INFANT WITH DELIRIUM

Hemorrhaging uterine fibroid leading to emergent early term Cesarean Delivery: A Case Report