Trem2-expressing multinucleated giant macrophages are a biomarker of good prognosis in head and neck squamous cell carcinoma

2024-9-13

NVL-655 Is a Selective and Brain-Penetrant Inhibitor of Diverse ALK-Mutant Oncoproteins, Including Lorlatinib-Resistant Compound Mutations

2024-9-13

Zongertinib (BI 1810631), an irreversible HER2 TKI, spares EGFR signaling and improves therapeutic response in preclinical models and patients with HER2-driven cancers

2024-9-9

Increased RNA and protein degradation is required for counteracting transcriptional burden and proteotoxic stress in human aneuploid cells

2024-9-9

Insights on Future Directions in Cancer Research from the AACR NextGen Stars

2024-9-4

Highlighted research articles

2024-9-4

Correction: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

2024-9-3

Tuning Responses to Polatuzumab Vedotin in B-cell Lymphoma

2024-9-3

Correction: <i>MACROD2</i> Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors

2024-9-3

If You Build It, Patients with Rare Cancers Will Come: A Successful Clinical Trial in Relapsed and Refractory JMML

2024-9-3

Correction: Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis

2024-9-3

Gene-Specific Machine Learning Models to Classify Driver Mutations in Clonal Hematopoiesis

2024-9-3

MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in Breast Cancer

2024-8-28

RNA shielding of P65 is required to potentiate oncogenic inflammation in TET2 mutated clonal hematopoiesis

2024-8-27

Chromothripsis-mediated small cell lung carcinoma

2024-8-26

TCR-engineered T-cells directed against Ropporin-1 constitute a safe and effective treatment for triple-negative breast cancer

2024-8-22

Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer

2024-8-20

The History of Chromosomal Instability in Genome-Doubled Tumors

2024-8-13

CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify KDM3B as a Genotype Specific Vulnerability in IDH2- and TET2-Mutant Cells

2024-8-13

Neuro-mesenchymal interaction mediated by a β2 adrenergic-nerve growth factor feedforward loop promotes colorectal cancer progression.

2024-8-13

The N6-methyladenosine Epitranscriptomic Landscape of Lung Adenocarcinoma

2024-8-13

Epigenetic and oncogenic inhibitors cooperatively drive differentiation and kill KRAS-mutant colorectal cancers

2024-8-9

T Cell Responses to Individualized Neoantigen Therapy mRNA-4157 (V940) Alone or in Combination With Pembrolizumab in the Phase 1 KEYNOTE-603 Study

2024-8-8

Disparate pathways for extrachromosomal DNA biogenesis and genomic DNA repair

2024-8-7

Lung Cancer Adoptive Cell Therapy: Inspiring TIL ACT Comes Center Stage

2024-8-2

The Interplay between Extracellular Matrix Remodeling and Cancer Therapeutics

2024-8-2

Iron: The Secret Ingredient Breaking PARPi Resistance

2024-8-2

WRN Helicase: Is There More to MSI-H than Immunotherapy?

2024-8-2

Highlighted research articles

2024-8-2

Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium

2024-7-31

Botensilimab, an Fc-enhanced anti-CTLA-4 antibody, is effective against tumors poorly responsive to conventional immunotherapy

2024-7-31

Identification and characterization of chemotherapy resistant high-risk neuroblastoma persister cells

2024-7-31

Preexisting Skin-Resident CD8 and γδ T-cell Circuits Mediate Immune Response in Merkel Cell Carcinoma and Predict Immunotherapy Efficacy

2024-7-26

MARK2/MARK3 kinases are catalytic co-dependencies of YAP/TAZ in human cancer

2024-7-26

A targetable secreted neural protein drives pancreatic cancer metastatic colonization and HIF1a nuclear retention

2024-7-19

The SCRUM-MONSTAR Cancer-Omics Ecosystem: Striving for a Quantum Leap in Precision Medicine

2024-7-18

D3S-001, a KRAS G12C inhibitor with rapid target engagement kinetics, overcomes nucleotide cycling and demonstrates robust preclinical and clinical activities

2024-7-10

Rational protein engineering to enhance MHC-independent T cell receptors

2024-7-10

Perivascular NOTCH3+ stem cells drive meningioma tumorigenesis and resistance to radiotherapy

2024-7-10

CHD2 Regulates Neuron-glioma Interactions in Pediatric Glioma

2024-7-9

Mechanisms of resistance to oncogenic KRAS inhibition in pancreatic cancer

2024-7-8

A classical epithelial state drives acute resistance to KRAS inhibition in pancreas cancer

2024-7-8

ROR2 Regulates Cellular Plasticity in Pancreatic Neoplasia and Adenocarcinoma

2024-7-8

Mechanisms of response and tolerance to active RAS inhibition in KRAS-mutant NSCLC

2024-7-8

Clonal Lineage Tracing with Somatic Delivery of Recordable Barcodes Reveals Migration Histories of Metastatic Prostate Cancer

2024-7-5

Single cell view of tumor microenvironment gradients in pleural mesothelioma

2024-7-5

Oncogenic KRAS-dependent stromal interleukin-33 directs the pancreatic microenvironment to promote tumor growth

2024-7-3

Highlighted research articles

2024-7-1

Precision Targeting of the Gut Microbiome for Cancer Immunotherapy

2024-7-1

Expression of Concern: Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Antitumor T-cell Immunity

2024-7-1