American Journal of Stem Cells

Yi-Xian Li

The treatment and outcome prediction analysis of pediatric acquired severe aplastic anemia

儿童获得性重型再生障碍性贫血的治疗及预后预测分析

Bu-Sheng Tong

Study on the role of otological endoscopic technique in otology teaching

耳内镜技术在耳科学教学中作用的研究

Age-related hearing loss (ARHL) represents one of the most prevalent chronic sensory deficits experienced by the elderly, significantly diminishing their quality of life and correlating with various medical and psychological morbidities. This condition arises from the cumulative effects of aging on the auditory system, implicating intricate interactions between genetic predispositions and environmental factors. Aging entails a progressive decline in immune system functionality, termed immunosenescence, leading to a chronic low-grade inflammation known as inflammaging. This phenomenon potentially serves as a common mechanism underlying ARHL and other age-related pathologies. Recent research suggests that rejuvenating immunosenescence could mitigate inflammaging and ameliorate age-related functional declines, offering promising insights into anti-aging therapies. Consequently, this review endeavors to elucidate the role of immunosenescence-mediated inflammaging in ARHL progression and discuss its therapeutic implications.

Ke Qiu

Minzi Mao

Wendu Pang

Di Deng

Jianjun Ren

Yu Zhao

The emerging roles and therapeutic implications of immunosenescence-mediated inflammaging in age-related hearing loss

免疫衰老介导的炎症衰老在年龄相关性听力损失中的新兴作用及治疗意义

Dentin-pulp regeneration through stem/progenitor cell transplantation represents a promising frontier in regenerative endodontics. This systematic review meticulously evaluates animal studies to investigate the efficacy of stem cell therapy in repairing/regenerating the dentine-pulp complex in mature/immature animal teeth. Employing a comprehensive electronic search of PubMed and Scopus databases up to October 2023, relevant English studies were identified/assessed. Evaluation parameters encompassed radiographic and histological assessments of dentin-pulp complex formation. Outcome measures included pulp-like and dentin-like tissues regeneration, apical healing, dentin thickening, apical closure, and dentinal bridge formation. The risk-of-bias assessment adhered to the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) guidelines. Out of 3250 identified articles, 23 animal experiments were included, categorized into regenerative procedures in mature teeth (n=11), regenerative procedures in immature teeth (n=4), and vital pulp therapy (n=8). Despite the promising potential, the bias in the included studies was high. Notably, Various scaffolds, and growth factors were employed, highlighting the heterogeneity across the studies. Dental pulp stem cells (DPSCs) and bone marrow stem cells, especially specific subfractions, demonstrated notable regenerative potential: hypoxic conditions and extracellular vesicles from preconditioned DPSCs enhanced regeneration, with considerations of cell fate. Donor age impacted regeneration, and challenges persisted in pulpotomy and direct pulp capping. Scaffold and growth factor choices influenced outcomes, underscoring the need for standardized strategies. Despite the promise, clinical viability faces hurdles, necessitating further investigation into adverse effects, optimized scaffolds, and regulatory considerations. This systematic review illuminates the potential of stem cell transplantation for dentin-pulp complex regeneration. The overall evidence quality, influenced by study heterogeneity and biases, underscores the need for cautious interpretation of findings. Future studies should refine methodologies and establish reliable histological parameters for meaningful advancements in dentin-pulp regeneration.

Saeed Asgary

Mohammad Jafar Eghbal

Sayna Shamszadeh

American journal of stem cells

Advancements and challenges in stem/progenitor cell transplantation for dentin-pulp regeneration: a systematic review of animal studies (part I)

牙髓再生中干细胞/祖细胞移植的进展与挑战：动物研究的系统综述（第一部分）

Recent studies demonstrated that mesenchymal stem cells (MSCs) are important for the cell-based therapy of diseased or injured lung due to their immunomodulatory and regenerative properties as well as limited side effects in experimental animal models. Preclinical studies have shown that MSCs have also a remarkable effect on the immune cells, which play major roles in the pathogenesis of multiple lung diseases, by modulating their activity, proliferation, and functions. In addition, MSCs can inhibit both the infiltrated immune cells and detrimental immune responses in the lung and can be used in treating lung diseases caused by a virus infection such as Tuberculosis and SARS-COV-2. Moreover, MSCs are a source for alveolar epithelial cells such as type 2 (AT2) cells. These MSC-derived functional AT2-like cells can be used to treat and diminish serious lung disorders, including acute lung injury, asthma, chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis in animal models. As an alternative MSC-based therapy, extracellular vesicles that are derived from MSC-derived can be employed in regenerative medicine. Herein, we discussed the key research findings from recent clinical and preclinical studies on the functions of MSCs in treating some common and well-studied lung diseases. We also discussed the mechanisms underlying MSC-based therapy of well-studied lung diseases, and the recent employment of MSCs in both the attenuation of lung injury/inflammation and promotion of the regeneration of lung alveolar cells after injury. Finally, we described the role of MSC-based therapy in treating major pulmonary diseases such as pneumonia, COPD, asthma, and idiopathic pulmonary fibrosis (IPF).

Dailin Yuan

Yufei Bao

Ahmed El-Hashash

Mesenchymal stromal cell-based therapy in lung diseases; from research to clinic

间充质基质细胞疗法在肺部疾病中的应用：从研究到临床

短名	Am. J. Stem Cells
Journal Impact	1.66
国际分区	CELL BIOLOGY(Q4)

出版信息	出版商: E-Century Publishing Corporation，出版周期: ，期刊类型: journal，开源期刊: 否
基本数据	创刊年份: 2012，原创研究文献占比: 71.43%，自引率:0.00%， Gold OA占比: 0.00%

American Journal of Stem Cells

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The treatment and outcome prediction analysis of pediatric acquired severe aplastic anemia

Study on the role of otological endoscopic technique in otology teaching

The emerging roles and therapeutic implications of immunosenescence-mediated inflammaging in age-related hearing loss

Advancements and challenges in stem/progenitor cell transplantation for dentin-pulp regeneration: a systematic review of animal studies (part I)

Mesenchymal stromal cell-based therapy in lung diseases; from research to clinic

The treatment and outcome prediction analysis of pediatric acquired severe aplastic anemia

Study on the role of otological endoscopic technique in otology teaching

The emerging roles and therapeutic implications of immunosenescence-mediated inflammaging in age-related hearing loss

Advancements and challenges in stem/progenitor cell transplantation for dentin-pulp regeneration: a systematic review of animal studies (part I)

Mesenchymal stromal cell-based therapy in lung diseases; from research to clinic