伤口护理的进展迅速分享了从工作台到床边的研究，包括烧伤、重大创伤、爆炸伤、手术和糖尿病溃疡的伤口护理应用。该杂志为组织损伤和修复领域提供了一个重要的、同行评议的论坛，重点是急性和慢性伤口。伤口护理的进展探索了新的研究方法和实践，以提供最新的科学发现和发展。伤口方面的进展护理范围包括：皮肤生物工程、皮肤和组织再生、急性、慢性和复杂伤口、敷料、抗疤痕策略、炎症、烧伤和愈合、生物膜、氧气和血管生成、严重肢体缺血、军事伤口护理、新设备和技术。

Advances in Wound Care is a journal dedicated to the field of wound care, rapidly sharing research findings from the laboratory to the bedside, including applications for burns, major trauma, blast injuries, surgical wounds, and diabetic ulcers. This journal provides an important peer-reviewed forum for the field of tissue injury and repair, focusing on both acute and chronic wounds. It explores new research methodologies and practices to present the latest scientific discoveries and advancements. The scope of research in wound care includes skin bioengineering, skin and tissue regeneration, acute, chronic, and complex wounds, dressings, anti-scarring strategies, inflammation, burns and healing, biofilms, oxygen and angiogenesis, severe limb ischemia, military wound care, and new devices and technologies.

《Advances in Wound Care》是一本专注于伤口护理领域的期刊，迅速分享从实验室到临床的研究成果，涵盖烧伤、重大创伤、爆炸伤、手术和糖尿病溃疡等伤口护理应用。该杂志为组织损伤和修复领域提供了一个重要的同行评议论坛，重点关注急性和慢性伤口的研究。期刊探索新的研究方法和实践，以提供最新的科学发现和发展。伤口护理的研究范围包括皮肤生物工程、皮肤和组织再生、急性、慢性和复杂伤口、敷料、抗疤痕策略、炎症、烧伤和愈合、生物膜、氧气和血管生成、严重肢体缺血、军事伤口护理以及新设备和技术。

Advances in Wound Care

Significance: Only a few decades ago, the primary focus of nutritional supplementation was to prevent deficiencies of essential nutrients. It is now recognized that, at higher than essential levels, selected nutrients can have a pharmacologic effect to prevent or treat disease. Recent Advances: Two of the most important pharmaconutrients, arginine, and the omega-3 polyunsaturated fatty acids in fish oil, have been shown to have profound effects on wound healing and infections. Critical Issues: Both arginine and fish oils have independent benefits, but the combination appears to be much more effective. This combination has been shown to affect outcomes involving wound healing and infections, as reviewed here, and can also affect incidence and outcomes in cardiovascular disease, diabetes, organ transplant rejection, and other inflammatory conditions. These possibilities have not yet progressed to widespread clinical application. Future Directions: The optimal combinations of immunonutrients, timing of administration, and the doses needed for best results need to be determined in preclinical and clinical studies. Also, the mechanisms involved in the administration of pharmaconutrients need to be established.

J. Wesley Alexander

Dorothy M. Supp

Role of Arginine and Omega-3 Fatty Acids in Wound Healing and Infection

精氨酸和Omega-3脂肪酸在伤口愈合与感染中的作用

Significance: Healthy skin provides a barrier to contaminants. Breaches in skin integrity are often encountered in the patient health care journey, owing to intrinsic health issues or to various procedures and medical devices used. The time has come to move clinical practice beyond mere awareness of medical adhesive-related skin injury and toward improved care and outcomes. Recent Advances: Methods developed in research settings allow quantitative assessments of skin damage based on the measurement of baseline skin properties. These properties become altered by stress and over time. Assessment methods typically used by the cosmetic industry to compare product performance could offer new possibilities to improve clinical practice by providing better information on the status of patient skin. This review summarizes available skin assessment methods as well as specific patient risks for skin damage. Critical Issues: Patients in health care settings may be at risk for skin damage owing to predisposing medical conditions, health status, medications taken, and procedures or devices used in their treatment. Skin injuries come as an additional burden to these medical circumstances and could be prevented. Technology should be leveraged to improve care, help maintain patient skin health, and better characterize functional wound closure. Future Directions: Skin testing methods developed to evaluate cosmetic products or assess damage caused by occupational exposure can provide detailed, quantitative information on the integrity of skin. Such methods have the potential to guide prevention and treatment efforts to improve the care of patients suffering from skin integrity issues while in the health care system.

Stéphanie F. Bernatchez

Jens Bichel

The Science of Skin: Measuring Damage and Assessing Risk

皮肤科学：测量损伤与评估风险

Chronic skin wounds are one of the most devastating complications in diabetic patients due to the formation of advanced glycation end-products (AGEs) resulting from nonenzymatic glycation of proteins and lipids in hyperglycemia. AGEs, upon binding their receptors (RAGEs), trigger proinflammatory signals that impair wound healing in diabetes and contribute to the pathology of chronic skin wounds.

Hwan June Kang

Suneel Kumar

Biraja C. Dash

Henry C. Hsia

Martin L. Yarmush

François Berthiaume

Multifunctional Elastin-Like Polypeptide Fusion Protein Coacervates Inhibit Receptor-Mediated Proinflammatory Signals and Promote Angiogenesis in Mouse Diabetic Wounds

多功能弹性蛋白样多肽融合蛋白凝聚物抑制小鼠糖尿病伤口中的受体介导的促炎信号并促进血管生成

Diabetic foot ulcerations have devastating complications, including amputations, poor quality of life, and life-threatening infections. Diabetic wounds can be protracted, take significant time to heal, and can recur after healing. They are costly consuming health care resources. These consequences have serious public health and clinical implications. Debridement is often used as a standard of care. Debridement consists of both nonmechanical (autolytic, enzymatic) and mechanical methods (sharp/surgical, wet to dry debridement, aqueous high-pressure lavage, ultrasound, and biosurgery/maggot debridement therapy). It is used to remove nonviable tissue, to facilitate wound healing, and help prevent these serious outcomes. What are the various forms and rationale behind debridement? This article comprehensively reviews cutting-edge methods and the science behind debridement and diabetic foot ulcers.

David Dayya

Owen J. O'Neill

Tania B. Huedo-Medina

Nusrat Habib

Joanna Moore

Kartik Iyer

Debridement of Diabetic Foot Ulcers

糖尿病足溃疡的清创术

Hard-to-heal diabetic foot ulcers (DFUs) are associated with higher mortality rates and an increased medical burden for patients. ON101, a new topical cream, exhibited better healing efficacy than the control dressing in a Phase III trial. In this

Shun-Cheng Chang

Ching-Wen Lin

Jui-Ching Chen

Yi-Hsin Wu

Shyi-Gen Chen

Yu-Yao Huang

Nai-Chen Cheng

Shawn M. Cazzell

Hsin-Han Chen

Kuo-Feng Huang

Kwang-Yi Tung

Hsuan-Li Huang

Cherng-Kang Perng

Bimin Shi

Chang Liu

Yujin Ma

Yemin Cao

Yanbing Li

Yaoming Xue

Fang Gao

Ying Cao

Li Yan

Qiu Li

David G. Armstrong

Guang Ning

Effects of ON101 for Hard-to-Heal Diabetic Foot Ulcers in A Randomized Phase III Trial: A Post hoc Analysis

ON101对难愈性糖尿病足溃疡的随机III期试验效果：事后分析

Diabetes and smoking are frequently co-morbid conditions leading to arterial insufficiency, significantly increasing the risk of non-healing wounds and subsequent major amputation. Autologous patient-specific mesenchymal stem cells (MSCs) present a novel tool for regenerative therapy to treat advanced stages of arterial insufficiency. The regenerative performance of cells from diabetics with impaired arterial perfusion is known to be reduced, but the impact of additional patient factors such as smoking remains poorly understood.

Dylan McLaughlin

Maiko Sasaki

Carson Hoffmann

Luke Brewster

Katherine E. Hekman

Smoking Status Impacts Mitochondrial Function and Synthetic Function in Mesenchymal Stem Cells Derived from Diabetics with Arterial Insufficiency

吸烟状况影响源自动脉功能不全糖尿病患者的间充质干细胞的线粒体功能和合成功能

Impairments in the differentiation and migratory capacity of epidermal stem cells (ESCs) are pivotal factors contributing to delayed wound healing. High mobility group box1 (HMGB1) has recently emerged as a potential target for tissue repair. Therefore, we aimed to investigate the role and molecular mechanisms of HMGB1 in ESCs during the wound-healing process.

Miao Zhen

Yongkang Zhu

Peng Wang

Xiaogang Liu

Junyou Zhu

Hengdeng Liu

Jingting Li

Jingling Zhao

Bin Shu

HMGB1 Accelerates Wound Healing by Promoting the Differentiation of Epidermal Stem Cells via the “HMGB1-TLR4-Wnt/Notch” Axis

HMGB1通过“HMGB1-TLR4-Wnt/Notch”轴促进表皮干细胞分化加速伤口愈合

Management of infection is a critical aspect of wound care. It involves the application of various interventions to treat the wound and prevent the infection from spreading to other parts of the body, which may lead to serious complications, including sepsis. Local treatment of skin wound infections is the favored route of administration, reducing the risk of adverse systemic effects while providing very high therapeutic concentrations at the target site. The purpose of this article was to review clinical trials from 2013 and onward, focusing on local treatment of acute wounds and burns as well as chronic wounds as their primary outcome measurement.

David Larson

Jamie Neelon

S. L. Rajasekhar Karna

Kristo Nuutila

Local Treatment of Wound Infections: A Review of Clinical Trials from 2013 to 2024

伤口感染的局部治疗：2013年至2024年临床试验综述

Alginate, sourced from seaweed, holds significant importance in industrial and biomedical domains due to its versatile properties. Its chemical composition, primarily comprising β-D-mannuronic acid and α-L-guluronic acid, governs its physical and biological attributes. This polysaccharide, extracted from brown algae and bacteria, offers diverse compositions impacting key factors such as molecular weight, flexibility, solubility, and stability.

Louai Alrata

Dahlia Abdulsattar

Sabrina Madrigal

Sophia R. Pyeatte

Mohamed Zaghloul

Wahid Abu-Amer

Batool Arif

Tarek Alhamad

Maria Remedi

Yiing Lin

Mohamed A. Zayed

Alginate Formulation for Wound Healing Applications

海藻酸盐制剂在伤口愈合中的应用

Autologous platelet-rich plasma (PRP) has shown promising outcomes in treating wounds, but the profile of patients benefiting most from this therapy is not known. This study aimed to identify influential variables in the success of this therapy, analyzing its personalized therapeutic potential for complex wounds.

Verónica Salgado-Pacheco

Ramon Oller

Marta Ferrer-Solà

Clara Masó-Albareda

Marta Casals-Zorita

Elisabet Sarri

Emma Puigoriol-Juvanteny

Joan Espaulella-Panicot

Marta Otero-Viñas

A Prospective Observational Study to Evaluate the Effectiveness of Platelet-Rich Plasma Therapy for Complex Wounds: Influential Clinical Variables on Wound Healing Outcomes

一项前瞻性观察性研究评估富血小板血浆疗法对复杂伤口的有效性：影响伤口愈合结果的临床变量

Abbreviation	Adv. Wound. Care. (New. Rochelle).
Journal Impact	5.69
Quartiles(Global)	DERMATOLOGY(Q1)

ISSN	2162-1918, 2162-1934
h-index	41

Publication Information	Publisher: Mary Ann Liebert Inc.，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2015，Proportion of original research papers: 71.43%，Self Citation Rate:1.70%， Gold OA Rate: 19.05%

Advances in Wound Care

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