Biomedicine and Aging Pathology

Abdel-Tawab H. Mossa

Tarek M. Heikal

Enayat Abdel Aziz Omara

Biomedicine & Aging Pathology

Corrigendum to ‘Liver damage associated with exposure to aspirin and diazinon in male rats and the ameliorative effect of selenium”

“对‘阿司匹林和二嗪农暴露导致雄性大鼠肝损伤及硒的缓解作用’一文的勘误”

The effect of Shakrino, a herbomineral medicine (HMM)) on early diabetic nephropathy in rats was evaluated. The occurrence of early diabetic nephropathy (DN) in rats treated with streptozotocin was revealed by hyperglycemia, depleted liver glycogen, decreased glucose uptake by peripheral tissue, impaired renal function, increased lipid peroxidation and decreased antioxidants in kidney. These changes were associated with increased total urine output, urinary albumin excretion rate, urinary albumin to creatinine ratio, increased relative kidney weight, increased arterial blood pressure, decreased glomerular filtration rate and urinary creatinine in DN rat. HMM treatment (200 and 400 mg/kg, p.o., 4 weeks) lowered blood glucose, glycosylated haemoglobin, creatinine, blood urea nitrogen, lipid profiles, serum albumin and total urine output, urinary albumin excretion rate, urinary albumin to creatinine ratio, relative kidney weight, increased urinary creatinine and GFR, and also restored depleted antioxidants, decreased malonolaldehyde formation in kidney of DN rats. Histoarchitecture study showed dense mesangial matrix in glomeruli of DN rats, which were improved by HMM treatment. The protective effect of HMM may be due to the presence of antioxidants like gallic acid, quercetin, β-sitosterol, Jamboline, ellagic acid, gymnemic acid B, α-amyrin and polyphenols.

Suresh Ramnath Naik

Nazneen Shaikh

Rajesh R. Patil

Rahul S. Somani

Abhijit S. Mali

Protective activity profile of herbomineral medicine in early diabetic nephropathy rats: Restoration of kidney antioxidants, hemodynamics and suppression of proinflammatory mediators

草本矿物药对早期糖尿病肾病大鼠的保护作用特征：肾脏抗氧化剂、血液动力学恢复及抑制促炎介质的抑制

Camel urine has traditionally been used to treat cancer, but this practice awaits scientific scrutiny, in particular its role in tumor angiogenesis, the key step involved in tumor growth and metastasis. We aimed to investigate the effects of camel urine on key components of inflammatory angiogenesis in the murine cannulated sponge implant angiogenesis model. Polyester-polyurethane sponges, used as a framework for fibrovascular tissue growth, were implanted in Swiss albino mice and camel urine (25, 50 and 100 mg/kg/day) was administered for 14 days through installed cannula. The implants, collected at day 14 post-implantation, were processed for the assessment of hemoglobin (Hb), myeloperoxidase (MPO), N-acetylglucosaminidase (NAG) and collagen, which were used as indices for angiogenesis, neutrophil and macrophage accumulation and extracellular matrix deposition, respectively. Relevant inﬂammatory, angiogenic and ﬁbrogenic cytokines were also determined. Camel urine treatment attenuated the main components of the ﬁbrovascular tissue, wet weight, vascularization (Hb content), macrophage recruitment (NAG activity), collagen deposition and the levels of vascular endothelial growth factor (VEGF), interleukin (IL)-1β, IL-6, IL-17, tumor necrosis factor (TNF)-α and transforming growth factor (TGF-β). A regulatory function of camel urine on multiple parameters of the main components of inflammatory angiogenesis has been revealed giving insight into the potential therapeutic benefit underlying the anti-cancer actions of camel urine.

Abdulqader A. Alhaider

Abdel Galil M. Abdel Gader

Nawaf Almeshal

Sarita Saraswati

Camel urine inhibits inflammatory angiogenesis in murine sponge implant angiogenesis model

骆驼尿抑制小鼠海绵植入血管生成模型中的炎症性血管生成

To enhance the efficiency of biological, chemical and physical properties like antibacterial activity, wash durability, air-permeability and biocompatibility, cotton fabric materials were finished with chitosan and herbal nanocomposites. Extracts of Senna auriculata and Achyranthes aspera with chitosan solution was bulk finished on 40 cotton fabrics. To increase the functional properties, chitosan and herbal extract nanocomposites were finished on to another set of fabrics (nanocomposite finishing). Different functional properties were carried out for both the sets of fabrics and comparatively analyzed. Antibacterial activity was carried out using standard EN ISO 20645 method and durability of finished fabrics was done using a standard AATCC–124 test method. Physical properties like tensile strength, abrasion resistance and air-permeability were analyzed using the standards, ASTM D 5035-2006, AATCC 119-2004 and ASTM D 737-1996 respectively. Biocompatible properties of the finished fabric were determined by HET-CAM to ensure that material do not cause irritation points on skin surface. Antibacterial activity of nanocomposite finished fabrics showed more inhibitory zones of 31 mm for E. coli and 29 mm for S. aureus when compared to bulk finished fabrics. Nanocomposite finished fabrics showed good durable properties and physical properties than bulk finished fabrics. Bulk and nanocomposite finished fabrics showed good biocompatible properties when analyzed using a standard HET-CAM test. The study concludes that, nanocomposites could provide better functional properties than the bulk finished fabrics. The nano-sized particles in the composites was considered significant for its functional applications in hospital based fabrics to prevent the transmission of nosocomial infections.

S. Chandrasekar

S. Vijayakumar

R. Rajendran

Application of chitosan and herbal nanocomposites to develop antibacterial medical textile

壳聚糖与中草药纳米复合材料在开发抗菌医用纺织品中的应用

Diabetes mellitus is one of the major problems. In developing as well as developed countries. Uncontrolled blood glucose level and oxidative stress plays a vital role in pathogenesis of the diabetic cardiomyopathy. The present study was aimed to investigate the effect of Ficus religiosa in STZ-induced diabetic cardiomyopathy in rats. Streptozotocin (90 mg/kg i.p.), administered to 2 days old neonates (10–12 g), resulted in significant increase in fasting blood glucose, HbA1c, cardiac hypertrophic index, TGF-β1, TNFα, malondialdehyde, LDH, CK-MB, BNP and caspase-3, blood pressure. It caused significant reduction in plasma insulin, heart rate and superoxide dismutase. The eight-week treatment of F. religiosa started after induction of six weeks of diabetes, the treatment significantly improved diabetic markers, oxidative stress, inflammatory and cardiac markers. Results of the present study suggest that the cardioprotective effect of F. religiosa may be mediated through the control of diabetes, modulation of oxidative marker and cytokine (TGF-β1, TNFα).

Raman Sharma

Ashok Kumar

Bharatur Parthasarathy Srinivasan

Anisha Chauhan

Kiran Dubey

Cardioprotective effects of Ficus religiosa in neonatal streptozotocin-induced diabetic cardiomyopathy in rats

菩提树对新生链脲佐菌素诱导的糖尿病大鼠心肌病的心脏保护作用

Recently, considerable attention has been paid to utilize biofriendly and ecofriendly plant-based products for the prevention, cure and treatment of neurodegenerative disease. This article reviews herbs that have been documented to have a neuroprotective effect in vitro and in vivo Parkinson's disease (PD) model systems. We summarized the anti-Parkinsonian activities of herbs according to their genera. Plants corresponding to 47 genera were included in this review. These herbal medicines can be a substitute and precious source for anti-Parkinsonian drug discovery. The plant species in these families and genera whose pharmacological actions have been well characterized could possibly be good candidates for further studies to assess its ability to protect against neurodegenerative disease and potentially extend lifespan.

Sibi P. Ittiyavirah

Jahanara Hameed

Herbs treating Parkinson's disease

治疗帕金森病的草药

In the context of the discovery of new potential antidepressant candidates and in the light of promising antidepressant action of pyrazoline nucleus, a new series of thiophene bearing pyrazoline carboxamides were synthesized and examined for their antidepressant effect by two behavioural models viz. Forced Swim Test (FST) and Tail Suspension Test (TST). Neurotoxicity of the compounds were accessed by rotarod test. The titled compounds were characterized by IR, 1H NMR, 13C NMR and mass and elemental analyses. The preclinical evaluation the compounds were predicted by in silico toxicity, blood-brain barrier and human oral absorption. In this series, 5-(3-nitrophenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carboxamide (TSe) reduced immobility time 60.43 and 63.47% in both FST and TST, respectively at 10 mg/kg dose level when compared to the standard imipramine. Moreover, it was observed that the compounds possessing electron-releasing groups such as dimethyl amino, methoxy and electron-withdrawing chlorine in the 4th position of aromatic rings of the scaffold showed good antidepressant activity when compared to the pyrazolines having no substituents on the phenyl rings. All the compounds in the series have passed neurotoxicity test.

Bijo Mathew

Jerad Suresh

S. Anbazhagan

Synthesis, in silico preclinical evaluation, antidepressant potential of 5-substituted phenyl-3-(thiophen-2-yl)-4,5-dihydro-1h-pyrazole-1-carboxamides

5-取代苯基-3-(噻吩-2-基)-4,5-二氢-1H-吡唑-1-羧酰胺的合成、计算机辅助临床前评估及抗抑郁潜力

The key initiating process in atherogenesis is the subendothelial retention of apolipoprotein B-containing lipoproteins. Retained lipoproteins are chemically and enzymatically modified, inducing a chronic inflammatory response. Therapeutic approaches for atherosclerosis treatment have been focused on the control of risk factors, such as hypercholesterolemia, hypertension, and diabetes mellitus. Nonetheless, the efficacy of these strategies is limited and unfortunately the health problem persists. On the other hand, development of therapies targeting the interactions between low-density lipoproteins and components of the extracellular matrix has been poorly addressed. In this work, we review the response-to-retention hypothesis and the recent data on therapeutic approaches targeting the retentive process of proatherogenic low-density lipoproteins.

Livan Delgado-Roche

The response-to-retention hypothesis: From theory to the potential therapeutic approaches

反应-保留假说：从理论到潜在的治疗方法

Neuromuscular blocking drugs are used in anesthesia and intensive care to provide skeletal muscle relaxation. However, literature has revealed that the effects of these drugs on cancer have not been widely studied. We tested the effects of two non-depolarising neuromuscular blocking drugs, vecuronium bromide and cisatracurium besylate on lung cancer cells’ (A549) proliferation, migration and viability in the presence of a cytotoxic drug, cisplatin. We demonstrated in this study that both neuromuscular blocking agents inhibit lung cancer cells’ proliferation. In addition, the study revealed that vecuronium bromide and cisatracurium besylate was synergistic to cisplatin in reducing lung cancer cell proliferation. However, vecuronium inhibits lung cancer cells migration in vitro.

Iddrisu Baba Yabasin

Mohammed Mohammed Ibrahim

Abass Adam

Sam-Awortwi Wilfred

Juventus Benogle Ziem

Peng Gao

Silvanus Kampo

Wen Qingping

Anticancer effects of vecuronium bromide and cisatracurium besylate on lung cancer cells (A549), in vitro

维库溴铵和顺阿曲库铵苯磺酸盐对肺癌细胞（A549）的抗癌作用，体外研究

There is an unmet clinical need to develop neuroprotective agents for cerebrovascular procedures requiring transient cerebral artery occlusion. This study aims to investigate the effects of a single pre-treatment dose of 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (TDZD-8), a glycogen synthase kinase-3β (GSK-3β) inhibitor, in a transient focal cerebral ischemia model. Twenty-eight male adult Wistar rats were subjected to right middle cerebral artery (MCA) occlusion via intraluminal thread technique for 60 min under continuously cortical perfusion monitoring by laser-Doppler flowmetry. Rats were divided into two groups: control or treatment groups. In the treated group, TDZD-8 (5 mg/kg; intravenously) was administered 10 min before the onset of the MCA ischemia. At 24-h reperfusion, the following parameters were evaluated: neurological deficits, brain infarct volume, ipsilateral hemispheric oedema, neuron specific enolase (NSE) plasma levels, parenchyma histology (H–E staining), Fluoro-Jade positive neurons, p-Akt and total Akt expression by western blot analysis and p-Akt-positive nuclei by immunohistochemistry. Infarct volume (P < 0.001) and neurological deficits severity (P < 0.001) were reduced in TDZD-8 treated group. TDZD-8 attenuated hemispheric oedema (P < 0.001), prevented the NSE plasma level increase (P < 0.001) and diminished the number of degenerated neurons in the infarct area (P < 0.001), as shown by Fluoro-Jade staining. TDZD-8 treated rats showed few signs of perivascular oedema when compared to control group. No variations in total Akt and p-Akt expression were observed; instead immunohistochemistry showed increased p-Akt nucleus translocation in TDZD-8 treated rats (P < 0.05). TDZD-8 is a potential pre-treatment intraoperative drug to prevent neuronal injury induced by transitory artery occlusion during cerebrovascular procedures.

出版信息	出版商: Elsevier Masson s.r.l.，出版周期: ，期刊类型: journal，开源期刊: 否
基本数据	创刊年份: 2011，原创研究文献占比: ，自引率:， Gold OA占比:

Biomedicine and Aging Pathology

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