Clinical and Experimental Reproductive Medicine

With the advent of metagenomics and 16S ribosomal RNA sequencing, growing attention has been dedicated to the endometrial microbiome. Research involving a relatively large cohort of healthy female participants has reported Lactobacillus dominance (LD) in the endometrial microbiome. Multiple studies have also shown that the loss of LD and/or increased microbial diversity within the endometrium are associated with reproductive failure. This phenomenon may stem from the loss of the immunomodulatory effects of Lactobacillus and the rise of proinflammatory responses triggered by pathogenic proliferation. Recent research has employed personalized antibiotic therapy followed by probiotic supplementation, tailored to the endometrial microbial composition of women with repeated implantation failure. The findings suggest that metagenomic analysis of the endometrial microbiome could be a valuable tool in addressing reproductive failure.

Ae Ra Han

Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine

Endometrial microbiome in reproductive failure: The possibility of metagenomic analysis

生殖失败中的子宫内膜微生物组：宏基因组分析的可能性

Follicular fluid (FF) oxidation-reduction potential (ORP) has shown promise as a predictor for in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes has been demonstrated. This study aimed to determine the association between the ORP in FF and IVF/ICSI outcomes.

Minh Tam Le

Thai Thanh Thi Nguyen

Trung Van Nguyen

Quoc Huy Vu Nguyen

The impact of oxidation-reduction potential in follicular fluid on intracytoplasmic sperm injection outcomes

卵泡液氧化还原电位对卵胞浆内单精子注射结果的影响

The choice between utilizing testicular or ejaculatory sperm for intracytoplasmic sperm injection (ICSI) in men with severe oligozoospermia or cryptozoospermia is a crucial aspect of managing male infertility. This study aimed to identify a predictive factor that could guide this decision-making process.

Marzieh Derakhshan

Peyman Salehi

Maryam Derakhshan

Elham Naghshineh

Minoo Movahedi

Hatav Ghasemi Tehrani

Ensieh Salehi

Should testicular sperm retrieval be implemented for intracytoplasmic sperm injection in all patients with severe oligozoospermia or cryptozoospermia?

严重少精症或隐匿精子症患者进行卵胞浆内单精子注射时是否应实施睾丸精子提取？

For successful embryo implantation in women with high pulsatility, uterine vascular resistance and pulsatility must be reduced. We examined the effects of amlodipine on uterine pulsatility index (PI), resistance index (RI), and embryo transfer (ET) outcomes in women with prior implantation failure and at least one elevated uterine PI measurement (especially higher than 3).

Nazli Navali

Elham Eghbali

laya Farzadi

Aliyeh Ghasemzadeh

Kobra Hamdi

Parvin Hakimi

Hojat Ghasemnejad-Berenji

Sonia Sadeghpour

Impact of amlodipine on uterine artery resistance in women with prior implantation failure: A randomized controlled trial of hormone replacement therapy cycles for frozen embryo transfer

氨氯地平对既往胚胎植入失败妇女子宫动脉阻力的影响：一项针对冻融胚胎移植周期激素替代治疗的随机对照试验

Objective: This study was conducted to investigate the impact of previous delivery mode on pregnancy outcomes in patients with secondary infertility after frozen-thawed embryo transfer.Methods: This prospective observational study included 140 patients experiencing secondary infertility. Of these, 70 patients had a previous cesarean delivery (CD), while the remaining 70 patients had a previous normal vaginal delivery (NVD). The primary outcome was the implantation rate. The secondary outcomes included rates of clinical pregnancy, chemical pregnancy, miscarriage, and ectopic pregnancy.Results: The comparison of all fertility outcomes between the two groups revealed no statistically significant differences. The implantation rate was 40.4% in the CD group and 41.7% in the NVD group (&lt;i&gt;p&lt;/i&gt;=0.842). The clinical pregnancy rate was 50% in the CD group and 49.3% in the NVD group (&lt;i&gt;p&lt;/i&gt;=0.932), while the chemical pregnancy rate was 14.6% in the CD group and 19% in the NVD group (&lt;i&gt;p&lt;/i&gt;=0.591). The miscarriage rates in the CD and NVD groups were 20% and 17.6%, respectively (&lt;i&gt;p&lt;/i&gt;=0.803). One case of tubal ectopic pregnancy occurred in the NVD group (1.4%).Conclusion: The mode of prior delivery did not significantly impact pregnancy outcomes following frozen-thawed embryo transfer.

Suzan Atteya Gewida

Mohamed Salah Eldeen Abd Rabbo

Mohammed Abd Elmoety El Samra

Hesham Mahmoud Adel Abdel Moneim

Effect of prior cesarean delivery on the outcomes of intracytoplasmic sperm injection

既往剖宫产对卵胞浆内单精子注射结局的影响

Objective: This study investigated potential relationships between the kinetics of nucleolar precursor bodies (NPBs) in the pronucleus and developmental morphokinetics and euploidy in human preimplantation genetic testing for aneuploidy (PGT-A) cycles.Methods: The morphokinetic analysis of 200 blastocysts obtained from 53 PGT-A cycles was performed retrospectively in a time-lapse incubator. At the time of pronuclear breakdown (PNBD), we categorized the blastocysts into two groups based on the kinetic degree of clustering NPBs at the interface of the two pronuclei: clustered NPBs (CL) and non-clustered NPBs (NCL). We then compared morphokinetic parameters, abnormal behavioral events, and the rate of aneuploidy between the two groups.Results: Pronuclear fading and the first cleavage occurred earlier in the NCL group than in the CL group. However, the initiation of blastocyst formation and blastocyst expansion was delayed in the NCL group relative to the CL group. No differences were found in the rate of abnormal cleavage events, such as multinucleation at the 2-cell stage, direct cleavage from one to three cells, and from two to five cells between the CL and NCL groups. However, the fragmentation rate at the 8-cell stage was higher in the NCL group than in the CL group (10.3% vs. 1.9%, p&lt;0.05). Additionally, the euploid rate in the CL group was significantly higher than in the NCL group (37.9% vs. 12.4%, p&lt;0.05).Conclusion: These results demonstrate the effectiveness of combining NPB clustering at PNBD with morphokinetics as a parameter for selecting embryos with higher developmental potential in in vitro fertilization.

Hwa Soon Oh

Jung Mi Jang

Hye Jin Yoon

Chang Woo Choo

Kyung Sil Lim

Jin Ho Lim

Yong-Pil Cheon

The kinetics of nucleolar precursor bodies clustering at the pronuclei interface: Positive correlations with the morphokinetic characteristics of cleaving embryos and euploidy in preimplantation genetic testing programs

核仁前体体在原核界面聚集的动力学：与胚胎分裂形态动力学特征及植入前遗传学检测程序中的整倍体呈正相关

Abbreviation	Clin Exp Reprod Med
Journal Impact	1.82
Quartiles(Global)	REPRODUCTIVE BIOLOGY(Q4)

ISSN	2233-8233, 2233-8241
h-index	32

Publication Information	Publisher: Korean Society for Reproductive Medicine，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2011，Proportion of original research papers: 77.78%，Self Citation Rate:5.60%， Gold OA Rate: 100.00%

Clinical and Experimental Reproductive Medicine

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Endometrial microbiome in reproductive failure: The possibility of metagenomic analysis

The impact of oxidation-reduction potential in follicular fluid on intracytoplasmic sperm injection outcomes

Should testicular sperm retrieval be implemented for intracytoplasmic sperm injection in all patients with severe oligozoospermia or cryptozoospermia?

Impact of amlodipine on uterine artery resistance in women with prior implantation failure: A randomized controlled trial of hormone replacement therapy cycles for frozen embryo transfer

Effect of prior cesarean delivery on the outcomes of intracytoplasmic sperm injection

Endometrial microbiome in reproductive failure: The possibility of metagenomic analysis

The impact of oxidation-reduction potential in follicular fluid on intracytoplasmic sperm injection outcomes

Should testicular sperm retrieval be implemented for intracytoplasmic sperm injection in all patients with severe oligozoospermia or cryptozoospermia?

Impact of amlodipine on uterine artery resistance in women with prior implantation failure: A randomized controlled trial of hormone replacement therapy cycles for frozen embryo transfer

The kinetics of nucleolar precursor bodies clustering at the pronuclei interface: Positive correlations with the morphokinetic characteristics of cleaving embryos and euploidy in preimplantation genetic testing programs