Journal of Chemical Health Risks

Aim: The aim of the study is to evaluate mandibular posterior flexure's validity and predictive accuracy in gender determination on digital panoramic radiographs. The objective of the study is to correlate the flexure of the posterior border of the ramus with that of gender. Methods: The study was conducted on 200 digital panoramic images taken in the Department of Oral Medicine and Radiology. Each image was examined and analyzed by an individual observer based on Loth and Henneberg's 1996 criteria for the presence of mandibular ramus flexure on the posterior border of the ramus at the level of the occlusal plane. The scoring was assigned separately for the right and left mandibular ramus flexure and a total score was given for each panoramic radiograph obtained from adult male and female subjects. Results: In the present study, we observed the overall predictive accuracy using mandibular ramus flexure to be 80% in the gender determination. A Kappa value of 0.601 was obtained and the predictive accuracy was higher for females than males. Conclusion: Mandibular ramus flexure showed a substantial predictive accuracy, making it a viable tool for aiding gender determination in forensic dentistry. To enhance gender identification accuracy, it is advisable to incorporate a comprehensive set of parameters like maximum ramus breadth, maximum ramus height, coronoid height, projective ramus height, along with mandibular ramus flexure.

Turaga Amani

Shree Abiraami

Journal of chemical health risks

Gender Determination using Mandibular Ramus Flexure in Chennai Population - A Retrospective Study on Digital Panoramic Radiographs

使用下颌支弯曲度对金奈人群进行性别判定——一项关于数字全景X光片的回顾性研究

The research examined sixty implants in sixty patients who were 65 years old or older, with diameters of 3.5/4.0/4.5/5.0 mm and lengths of 8.5/10.0/11.5 mm. A, maxillary right-posterior; B, maxillary left-posterior; C, mandibular right-posterior; D, mandibular anterior; E, mandibular left-posterior; F, and a total of ten sections were used to split the implant placement locations. After the implant procedure, participants had to return to the hospital six times: once for stitch removal, twice for one month's follow-up, four times for two months' follow-up, five times before the final restoration was delivered, and six times after it was delivered. The Osstell Mentor, Periotest M, and Anycheck were used to assess the stability of the implants (IST). A significance level of 0.05 was used to assess the mean values of ISQ, PTV, and IST. Compared to 1V, 4V and 5V showed considerably greater ISQ, PTV, and IST findings (p < 0.05). In the E location, at 4V and 5V, the ISQ readings were the lowest (p < 0.05). The IST findings of 6V were noticeably greater than those of 1V, 2V, 3V, and 4V in all mandibular sites (p < 0.05). The findings of the ISQ showed a negative correlation with PTV and a positive correlation with IST, whereas the results of PTV showed a negative correlation with IST. DOI: https://doi.org/10.52783/jchr.v14.i01.2952

Nidhi Singh

Mahesh Suganna

Manisha Pathak

Sweta Yadav

Shikha Singh

Himanshu Sharma

Basal Implantologist

Evaluation of Implant Stability According to Implant Placement Site and Duration in Elderly Patients

老年患者种植体稳定性评估：根据种植部位和时间

Background - Low back pain is more common now a days. But there is limited evidence of efficiency of lumbar belt for treatment of low back pain1. There is also lack of methodology in the studies reported on the efficiency of the device. Objective - To evaluate the effectiveness of lumbar belt in chronic low back pain and to evaluate the mobility and disability of the trunk after using lumbar belt for chronic low back pain. Materials and Methods- 32 subjects were included in this study with age group between 25 to 45 years. Subjects was divided in to two groups through lottery method. Data collection sheet was used to obtain demographic details such as patients age, gender, address, contact details. Before the treatment (at day 0) and after treatment (at days 15), Pain of back was determined by Visual analogue scale (VAS), disabilities of the spine determined by modified Oswestry disability index (MODI) and spine mobility (ROM) measured by modified Schober's test (MST) in both groups. Both groups were treated by IFT (4P) and Hot pack over back for 15 mins and experimental group was advised to wear lumbar belt during the treatment period as daily minimum of 8 hours except during sleeping time. Result- Paired T – test and 2- tailed test was used to analyse the data, since the P-value of paired sample test for individual group (pre and post scores) of VAS and MODI is <0.01, so there is significant difference between pre and post scores. But, the P-value of pre and post score of MST for experimental (belt wearing) group is not <0.01, so, there is no significant difference of mobility of spine in experimental group. In 2 – tailed test the P- value of VAS and MODI is not < 0.01, so, there is no significant different in pain and disability after compared in between both groups. But, in 2- tailed test the p-value is < 0.01 in MST after compared in between both groups. Therefore, we can say that there is a significant difference in the amount of change in MST (cm) between the Experimental and control groups. Conclusion-The present study provided evidence to prove that use of lumbar belt in chronic low back pain reduce trunk mobility. DOI: https://doi.org/10.52783/jchr.v14.i01.3303

Faiznur Ahmed

Lopa Das

Saurav Sarma

Effectiveness of Lumbar Belt on Pain and Lumbar Mobility in Patients with Chronic Low Back Pain- An Experimental Study

慢性腰痛患者使用腰带对疼痛和腰椎活动度的影响——一项实验研究

Introduction: This study aims to investigate allied health professionals' perceptions and knowledge regarding various aspects of artificial intelligence (AI) in healthcare. Objectives: The primary objective is to explore healthcare professionals' understanding of AI concepts, applications, ethical considerations, and strategies for continuous learning about AI. Methods: A comprehensive survey was conducted to assess general awareness of AI applications, understanding of core AI concepts, ethical considerations surrounding AI use, practical applications of AI in healthcare, and preferred strategies for continuous learning. Results: The survey yielded nuanced insights into respondents' recognition of common AI applications in healthcare, their concerns regarding AI implementation, preferred frameworks for AI education, and the prioritization of ethical principles. Additionally, the study explored participants' understanding of different AI types, tools for personalizing interventions, strategies for ensuring fairness in AI diagnostics, and the essential skill sets required for allied health professionals to navigate the evolving landscape of AI-driven healthcare. Conclusions:The findings emphasize the need for targeted educational programs, increased awareness of ethical considerations, and the development of a multidimensional skill set to prepare allied health professionals for the evolving landscape of AI in healthcare. DOI: https://doi.org/10.52783/jchr.v14.i2.3660

Sherafin Jancy Vincy

Shagun Agarwal

Chandrasekar Mathialagan

Kumar Shantanu

S Subramanian

Darla Rao

Paramita Dey

Exploring Allied Health Professionals' Perceptions and Knowledge of Artificial Intelligence in Healthcare

探索医疗辅助专业人员对人工智能在医疗领域的认知与知识

Postpartum depression (PPD) presents as a major episode of depression occurring during pregnancy or within the initial weeks following childbirth. Despite varying opinions on the specific onset defining PPD, its symptoms significantly impair maternal-infant bonding, breastfeeding, and maternal function. Alongside typical depressive symptoms, anxiety and sleep disturbances often co-occur, leading to prolonged suffering and challenges in diagnosis. The pathophysiology involves dysregulation in neuroactive steroid levels, particularly allopregnanolone (ALLO), and disrupted GABA signaling post-delivery. This dysregulation is linked to altered stress response and has an association in PPD. Current pharmacologic treatments for PPD, primarily selective serotonin reuptake inhibitors (SSRIs), lack rapid response and specificity for PPD symptoms. Brexanolone, the first FDA-approved PPD treatment, mimics ALLO and has shown efficacy in reducing depressive symptoms, but with limitations in administration and potential side effects. Recent focus has turned to zuranolone, a synthetic neuroactive steroid GABAA receptor modulator that is distinct in that it can be taken once daily and is bioavailable orally. Preclinical studies demonstrated its potency in modulating GABAA receptors, highlighting its promise as a novel PPD treatment. Clinical trials on zuranolone showcased its safety, tolerability, and efficacy in improving depressive symptoms, anxiety, insomnia, and functional health among women with PPD. Notably, zuranolone's holistic benefits beyond targeting depression offer a promising breakthrough in the PPD treatment landscape. These findings emphasize the necessity for tailored interventions to enhance maternal mental health post-delivery. Continued research and development are crucial to expand treatment options and promote the well-being of mothers experiencing PPD. DOI: https://doi.org/10.52783/jchr.v14.i2.3484

Milan Prabhakar

Aarti Sati

Sengar Yashwardhan

Pratap Singh

Pawan Verma

Deeksha Vishwakarna

A Comprehensive Review of Zuranolone's Clinical Efficacy and Safety as a Fast-Acting Oral Postpartum Depression (PPD) Treatment

全面综述Zuranolone作为快速起效的口服产后抑郁症治疗药物的临床疗效与安全性

Tetramethylpyrazine (TMP) has low bioavailability due to its fast metabolism and short half-life, which is not conducive to transdermal treatment of atopic dermatitis (AD). Therefore, in this study, TMP was encapsulated into liposomes (Lip) by film dispersion method, and then the surface of Lip was modified by sodium alginate (ALG) and chitosan (CS). The tetramethylpyrazine-loaded liposomes in sodium alginate chitosan hydrogel called T-Lip-AC hydrogel. In vitro experiments, we found that T-Lip-AC hydrogel not only had the antibacterial effect of CS, but also enhanced the antiinflammatory and antioxidant effects of TMP. In addition, T-Lip-AC hydrogel could also provide a moist healing environment for AD dry skin and produce better skin permeability, and can also achieve sustained drug release, which is conducive to the treatment of AD. The lesions induced by 1-chloro- 2, 4-dinitrobenzene were used as the AD lesions model to test the therapeutic effect of the T-Lip-AC hydrogel on AD in vivo. The studies have showed that T-Lip-AC hydrogel could effectively promote wound healing. Therefore, we have developed a T-Lip-AC hydrogel as multifunctional hydrogel drug delivery system, which could become an effective, safe and novel alternative treatment method for treating AD.&nbsp

Kiran Singh

Mahendra Kumar Sahu

Deepa Thakur

Ume Kulsum

Lilima Baghel

Surabhi Sahu

Jhakeshwar Prasad

Therapeutic Potential of Hydrogel Based Sodium Alginate and Chitosan as A Multifunctional Drug Delivery System for Atopic Dermatitis

水凝胶基海藻酸钠和壳聚糖作为特应性皮炎多功能药物递送系统的治疗潜力

Rigid Pavement rehabilitation and reconstruction of concrete structures generate large quantities of Recycled Concrete Aggregate (RCA). These recycled aggregates could be used as material for subbase courses in pavement construction. The strength characteristics of RCA materials usually limit their application in road subbases. The high volume usage of RCA in subbase applications is better ensured by meeting the minimum standards set by the specification for material performance. When used as a substitute for natural aggregates in subbase applications, most RCA materials do not often meet the minimum requirements set by the specification. In such cases, stabilization with different stabilizers allows the use of these RCA's materials with the minimum required strength characteristics. In the present study, an attempt is made to evaluate the suitability of RCA as a subbase material using Ordinary Portland Cement (OPC) as a binding material. Concrete waste was pulverized and sieved to obtain the required gradation for the granular subbase (Gradation-II) as per MORT&H-V revision. RCA is treated with different dosages of cement and samples were prepared. The prepared samples were cured for 3, 7 & 28 days, and were tested. Compaction, California Bearing Ratio (CBR), Unconfined Compressive Strength (UCS), and permeability tests were conducted. From the laboratory studies conducted, it is observed that the Portland cement stabilized RCA mix exhibits an increase in strength, with an increase in the dosage of stabilizer and curing period.&nbsp

Vijay B. G

Raghavendra Sanganaikar

Neeraj S. N

Laboratory Analysis of Recycled Cement Stabilized Concrete Aggregates as Subbase Materials

再生水泥稳定混凝土骨料作为底基层材料的实验室分析

Normalizing inflamed soils including reactive oxygen species (ROS), nitric oxide (NO), cellfree DNA, and regulating inflammation-related seeds such as macrophages, neutrophils, fibroblasts, represent a promising strategy to maintain synovial tissue homeostasis for rheumatoid arthritis (RA) treatment. Herein, ROS scavenging amphiphilic block copolymer PEGylated bilirubin and NO-scavenging PEGylated o-phenylenediamine were fabricated to self-assemble into a dually responsive nanoparticle loaded with JAK inhibitor notopterol. The simultaneous ROS and NO depletion combined with JAK-STAT pathway inhibition could not only promote M2 polarization to reduce further ROS and NO generation, but also decrease cytokines and chemokines to prevent immune cell recruitment. Specifically, NBOP NPs responded to high level ROS and NO, and disintegrated to release notopterol in inflamed joints as the hydrophobic heads BR and oPDA were transformed into hydrophilic ones. The released notopterol could inhibit the JAK-STAT pathway of inflammatory cells to reduce the secretion of pro-inflammatory cytokines and chemokines. This strategy represented an effective way to regulate RA soils and seeds through breaking the positive feedback loop of inflammation aggravation, achieving an excellent anti-RA efficacy in a collagen-induced arthritis rat model. Taken together, our work offered a reference to adjust RA soils and seeds for enhanced RA treatment.

Pushpa Prasad Gupta

Bishesar Sahu

Sunil Sahu

Akhilesh Kumar Sahu

Lalita Sandey

Trilok Nath Patel

In-Vitro And In-Vivo Characterization Of Nitric Oxide Scavenging Nanoparticles For Rheumatoid Arthritis

类风湿性关节炎一氧化氮清除纳米颗粒的体外和体内特性研究

Methotrexate (MTX) is a first-line drug for rheumatoid arthritis (RA). Targeting of MTX to inflamed joints is essential to the prevention of potential toxicity and improving therapeutic effects. Gold nanoparticles (GNPs) are characterized by controllable particle sizes and good biocompatibilities, therefore, they are promising drug delivery systems. We aimed at developing a GNPs drug delivery system incorporating MTX and folic acid (FA) with strong efficacies against RA. MTX-Cys-FA was synthesized through solid-phase organic synthesis. Then, it was coupled with sulfhydryl groups in GNPs, thereby successfully preparing a GNPs/MTX-Cys-FA nanoconjugate with targeting properties. Physical and chemical techniques were used to characterize it. Moreover, we conducted its stability, release, pharmacokinetics, biodistribution and cell cytotoxicity, cell uptake, cell migration, as well as its therapeutic effect on CIA rats. The histopathology was conducted to investigate anti-RA effects of GNPs/MTX-Cys-FA nanoconjugates. The GNPs/MTX-Cys-FA nanoconjugate exhibited a spherical appearance, had a particle size of 103.06 nm, a zeta potential of -33.68 mV, drug loading capacity of 11.04 %, and an encapsulation efficiency of 73.61%. Cytotoxicity experiments revealed that GNPs had good biocompatibilities while GNPs/MTX-Cys-FA exhibited excellent drug-delivery abilities. Cell uptake and migration experiment showed that nanoconjugates containing FA by LPS activated mouse mononuclear macrophages (RAW264.7) was significantly increased, and they exerted significant inhibitory effects on human fibroblast-like synoviocytes (HFLS) of RA (p<0.01). In addition, the nanoconjugate prolonged blood circulation time of MTX in collagen-induced arthritis (CIA) rats (p<0.01), enhanced MTX accumulation in inflamed joints (p<0.01), enhanced their therapeutic effects (p<0.01), and reduced toxicity to major organs (p<0.01). GNPs/MTX-Cys-FA nanoconjugates provide effective approaches for RA targeted therapeutic strategies.

Rinkee Verma

Prafull Jain

Rahul Singh

Pramila .

Alka Verma

Pharmacological Evaluation And Characterization Of Gold Nanoparticles Targeted Treatment For Rheumatoid Arthritis

金纳米颗粒靶向治疗类风湿性关节炎的药理学评价与表征

Hydrogels have been widely used in various biomedical applications, including skin regeneration and tissue repair. However, the capability of certain hydrogels to absorb exudate or blood from surrounding wounds, coupled with the challenge in their long-term storage to prevent bacterial growth, can pose limitations to their efficacy in biological applications. To address these challenges, the development of a multifunctional aloin-arginine-alginate (short for 3A) bio-patch capable of transforming into a hydrogel upon absorbing exudate or blood from neighboring wounds for cutaneous regeneration is proposed. The 3A bio-patch exhibits outstanding features, including an excellent porous structure, swelling properties, and biodegradability. These characteristics allow for the rapid absorption of wound exudates and subsequent transformation into a hydrogel that is suitable for treating skin wounds. Furthermore, the 3A bio-patch exhibits remarkable antibacterial and anti-inflammatory properties, leading to accelerated wound healing and scarless repair in vivo. This study presents a novel approach to the development of cutaneous wound dressing materials.

Divya Sahu

Manisha Chandrakar

In-vitro and In-vivo Characterization of Bio-Patch to Hydrogel on Skin Wounds for Efficient Scarless Wound Healing

生物贴片与水凝胶在皮肤伤口上的体外和体内特性研究：促进无痕伤口愈合

ISSN	2251-6719, 2251-6727
h-index	10

Publication Information	Publisher: Islamic Azad University，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2019，Proportion of original research papers: 0.00%，Self Citation Rate:N.A.， Gold OA Rate: 0.00%
Average review cycle	网友分享经验：3 Weeks

Journal of Chemical Health Risks

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