Advanced Biomedical Research

Hysteroscopy is known as the gold standard for endometrial polyps diagnosis and its findings on vascularity, size, and number of polyps can indicate malignancy, but it is a relatively expensive method with some complications. Ultrasound is a common part of the gynecological examination, and with technological advances, its ability to predict pathological outcomes has increased. This study aimed to determine the accuracy of ultrasound in diagnosing the characteristics of endometrial polyps.

Safoura Rouholamin

Parisa Irannezhad

Maryam Hashemi

Comparison of Endometrial Polyp Characteristics in Transvaginal Sonography and Hysteroscopy in Predicting Endometrial Malignancies in Premenopausal and Postmenopausal Women

经阴道超声与宫腔镜检查中子宫内膜息肉特征比较：预测围绝经期和绝经后妇女子宫内膜恶性肿瘤

One of the well-known causes of subfertility is polycystic ovary syndrome (PCOS). Genetic components play a critical role in the etiology of PCOS. The recognition of differentially expressed genes in PCOS patients might provide a better understanding of the pathophysiology of this syndrome and paves the way for novel therapeutics. Gene expression profiles in cumulus cells (CCs) could be used as biological criteria for embryo competence and their analysis might lead to important molecular information about embryo quality. CALM1, PSMD6, and AK124742 are three well-known genes associated with embryo development. Therefore, the objective of this study was to compare the expression of CALM1, PSMD6, and AK124742 genes in the CCs of infertile PCOS patients with their expression in the CCs of the donor fertile group.CCs were collected from the follicular fluid of 33 patients with PCOS as the experimental group and 33 cumulus donor women who were referred to the infertility center for egg donation as the control group. CCs were frozen until genetic testing. The expression of CALM1, PSMD6, and AK124742 genes was detected by real-time polymerase chain reaction.CALM1 and AK124742 gene expressions significantly increased (CALM1 P = 0.003) (AK124742 P = 0.000) and PSMD6 expression significantly decreased (P = 0.002) in the PCOS group compared to the cumulus donor (control) group.Therefore, our research findings suggest that the potential impact of Polycystic Ovary Syndrome (PCOS) on fertility could be attributed to modifications in the expression levels of genes that affect the reproductive.

Fatemesadat Mostafavi

Ali Akbari

Roshanak Aboutorabi

Mohammad Kazemi

Zahra Borzouie

Awat Feizi

Elham Naghshineh

Differential gene expressions of CALM1, PSMD6, and AK124742 long noncoding RNA in cumulus cells from polycystic ovary syndrome patients versus normal control women

多囊卵巢综合征患者与正常对照女性卵丘细胞中CALM1、PSMD6及AK124742长链非编码RNA的差异基因表达

Background: Morphine withdrawal usually results in undesired outcomes , despite partial benefits of alternative medication such as methadone, because of the lack of mental sedation during the withdrawal period, may not lead to the desired result. In this study, forced exercise by treadmill is used to manage morphine dependence in animal model. Materials and Methods: Forty adult male mice were divided into 5 groups, from which 4 groups became dependent by increasing daily doses of morphine for 6 days (20-45 mg/kg, SC). Afterwards, the animals were treated for 21 days by either of the following protocol: Positive control (dependent) received once daily 45 mg/kg of morphine sulfate (SC) for 21 day, group under treatment by clonidine (0.4 mg/kg, SC) for 21 day group under treatment by forced exercise by treadmill for 21 day, group under treatment by combination of clonidine (0.4 mg/kg, SC) and forced exercise by treadmill for 21day and the negative control group(independent) received saline injection like other groups. Each of this administration was injected at 8 AM. Finally, in the test day (day 28), all animals received a single dose of naloxone (3 mg/kg, SC) at 8 AM and then were observed for withdrawal signs, and Total Withdrawal Score (TWS) was determined as described previously. After withdrawal sign evaluation for evaluation of stress level of dependent mice, blood cortisol and glucose level were measured in non-fasting situations well. Results: This study showed that TWS significantly decreased in all treatment groups in comparison with positive control group (P < 0.001). Moreover, blood cortisol and glucose level significantly decreased in group under treatment by clonidine (0.4 mg/kg) and group under treatment by combination of clonidine (0.4 mg/kg) and forced exercise by treadmill groups in comparison with control positive (dependent) (P < 0.05). Conclusion: This study suggested that forced exercise can be useful as adjunct therapy in dependent people and can ameliorate side effects and stress situation of withdrawal syndrome periods.

Majid Motaghinejad

Manijeh Motevalian

Majid Asadi-Ghalehni

Ozra Motaghinejad

Attenuation of morphine withdrawal signs, blood cortisol and glucose level with forced exercise in comparison with clonidine

强制运动与可乐定相比对吗啡戒断症状、血液皮质醇和血糖水平的影响

Background: The relationship between inborn errors of immunity (IEIs) and COVID-19 severity and incidence rates remains unclear due to limited and diverse data. This study aimed to address this gap by identifying specific IEIs associated with an increased risk of severe COVID-19 or a predisposition to severe disease before vaccination. Materials and Methods: Data were collected from the medical records of 15 patients with various IEIs, supplemented by interviews with individuals from an IEIs registry who had experienced COVID-19 before vaccination. Results: Among the participants, only three patients (20%) experienced severe-prolonged COVID-19. Notably, this severity was predominantly observed in two male patients with Bruton’s disease (BD) and one female patient with autosomal recessive hypogammaglobinemia. Moderate and severe COVID-19 cases were equally distributed (13.33%). In the female subgroup, one patient with common variable immunodeficiency and another with combined immunodeficiency experienced moderate and severe COVID-19, respectively. Conversely, both male patients with moderate and severe COVID-19 had BD. Conclusion: Despite the limited number of severe cases, the absence of cytokine storm manifestation suggests potential protective mechanisms, possibly due to intravenous immunoglobulin therapy and inherent deficiencies within cytokine-producing cells (B and T cells). While IEIs may not be significant risk factors for COVID-19, they offer promising avenues for further research into therapeutic strategies targeting specific immune system components to mitigate severe COVID-19.

Negin Salemi

Behrokh Shojaie

Paria Bolourinejad

Roya Sherkat

Aryana Zamanifar

Farhoodeh Ghaedrahmati

Mahdieh Azizi

Hamid Aria

Diversity in the Clinical Course and Outcome of COVID-19 in Patients with Different Inborn Errors of Immunity can be Associated with the Type of Error

不同先天性免疫缺陷患者中COVID-19临床过程和结局的多样性可能与缺陷类型相关

In the current century, air pollution is known as one of the most critical environmental problems and it is important to find the relations of air pollution and human health. Various air pollutants, such as volatile organic compounds (VOCs), can negatively affect women’s fertility. An exhaustive electronic search was done from 2013 until July 2023 in PUBMED and The Cochrane Central Register of Controlled Trials. The following keywords were combined using Boolean hints in the databases queried: air pollution AND (fertility OR miscarriage OR embryo quality OR embryo development OR pregnancy OR implantation OR live birth). The randomized controlled trials, case-control and cohort studies analyzing the impact of air pollutants on fertility were included in the review. In this systematic review, a significant relation was found between the increase in air pollution and the reduction of fertility health, live birth rates, embryo quality, fertility, implantation rates, and miscarriage in exposed women. These results suggest low fertility health rates are associated with traffic-related air pollution. This review has concluded four components (particulate matter, nitrogen dioxide, sulfur, and carbon monoxide) of traffic pollution that can impair women’s fertility. Air pollution harms women’s fertility. These effects affect gamete’s quality at the genetic and epigenetic level. These effects also alter fetal development. Studies have also reported an effect on fetal growth with increased miscarriages. Since air pollution is everywhere and has many sources, it seems necessary to increase the awareness of people and government officials, especially in hygiene and health, to limit air pollutants as much as possible.

Masoomeh Latifi

Forough Rahim

Mojtaba Ahmadlou

Nima Pouladian

Leili Allahbakhshian

How Can Outdoor Air Pollutants Adversely Affect the Women’s Fertility? Systematic Review

户外空气污染物如何对女性生育能力产生不利影响？系统综述

Background: Escitalopram, a pharmacological compound, and crocin, the active compound of saffron, influence brain functions and serotonin levels. This study examined the efficacy of escitalopram with and without crocin in restoring the input-output (I/O) functions and long-term potentiation (LTP) within the hippocampal cornu ammonis 1 (CA1) region of stressed rats. Materials and Methods: Rats were divided into six groups: control (Co), sham (Sh), stress-recovery (St-Rec), stress-escitalopram (St-Esc), stress-crocin (St-Cr), and stress-escitalopram-crocin (St-Esc-Cr) groups. They underwent 14 days of restraint stress (6 h/day). After being subjected to stress, they received 14 days of escitalopram (20 mg/kg) and crocin (30 mg/kg), as well as co-administration of these two compounds during the next 14 days. The field excitatory postsynaptic potential (fEPSP) slope and amplitude were measured using I/O functions and LTP induction in the CA1 region. Corticosterone (CORT) levels were also evaluated. Results: The fEPSPs slope and amplitude in the I/O functions and LTP induction significantly decreased in stressed rats without therapeutic intervention. These variables in the I/O functions declined in rats with escitalopram administration alone. All electrophysiological parameters showed an increase in rats treated with crocin alone compared to stressed subjects without any treatment. Serum CORT levels decreased only with crocin treatment for stressed rats. Conclusion: Neural excitability and memory within the CA1 region were severely disrupted among stressed rats without any treatment. Furthermore, administering crocin alone improved neural excitability and memory post-chronic stress. Treatment with escitalopram alone also impaired neural excitability within the CA1 region. The use of escitalopram with and without crocin did not enhance memory under chronic stress.

Mehran Joodaki

Maryam Radahmadi

Hojjatallah Alaei

Comparing the Efficacy of Escitalopram with and without Crocin in Restoring I/O Functions and LTP within the Hippocampal CA1 Region of Stressed Rats

比较艾司西酞普兰联合或不联合藏红花素对应激大鼠海马CA1区输入/输出功能及长时程增强的恢复作用

Background: Anterior cruciate ligament (ACL) injury has an incidence of 0.05–0.08 per thousand. An inappropriate treatment plan could lead to articular cartilage damage and early knee osteoarthritis. Some surgical reconstruction techniques use different graft types; all of them try to restore the patient’s preinjury activity levels. The current study aims to evaluate the efficacy of ACL reconstruction (ACLR) using an autologous hamstring tendon. Materials and Methods: This is a retrospective one-center cohort study performed on consecutive patients with an ACL injury who underwent ACLR using semitendinosus and gracilis autograft. The postsurgical activity and fear were measured using Marx scale and Tampa scale of kinesophobia, respectively, during a follow-up of 18 months. Results: From a total of 76 patients included in our study, 40.8% were female. The mean age of the participants was 26.25-year-old. Five patients from those with kinesophobia (12.5%) and 34 patients from those with no-kinesophobia (94%) returned to the preinjury activity level ( P value &lt; 0.001). Marx scale six months after the surgery was significantly lower than the score before the surgery, but as expected, it improved during the 18-month follow-up. Conclusion: The current study showed that kinesophobia reduces the rate of return to preinjury levels. Maybe, overcoming this fear will help these patients to reach better results. However, we suggest implementing further trials in larger sample sizes before reaching a solid conclusion.

Hossein Akbari Aghdam

Seyedeh Ghazal Shahrokh

Omid Ahmadi

Koushan Rostami

Mohammad M. Najafi

Amirhossein Sadeghian

Zahra Hosseini

Kasra Talebi Anaraki

Evaluation of the Relative Frequency of Preinjury Activity Recovery in Anterior Cruciate Ligament Replacement Patients: A Cohort Study

前交叉韧带置换患者术前活动恢复的相对频率评估：一项队列研究

Background: It is essential to maintain the quality of the stored blood, because various factors affect the stored red blood cells (RBCs) over time, some red blood cell storage lesions (RCSL) develop during storage, and it could reduce the function of the RBCs. The present study aimed to evaluate the effects of glutathione monoethyl ester on different biochemical changes, oxidant, and antioxidant levels in the leukoreduced RBCs (LR-RBCs) during storage. Materials and Methods: About 10 units of LR-RBC were collected, processed and stored according to the standard operating procedures (SOPs) of the Iranian Blood Transfusion Organization. Each unit divided into 2 equal parts; LR-RBC treated with glutathione monoethyl ester and a control group. Exposure of phosphatidylserine (PS), reactive oxygen species (ROS) and microvesicle derived from the RBCs (RBC-MVs), were measured by the flow cytometry method. ELISA was used to measure the level of glutathione, and 2, 3-diphosphoglycerate (2,3-DPG). Glucose-6-phosphate dehydrogenase (G6PD) enzyme activity was measured with a chemistry autoanalyzer. Results: The levels of glutathione reduced the initial value in the treated group (80%), and the control group (60%), respectively. Exposure of surface PS, ROS and RBC-MVs increased significantly during storage time for consecutive weeks to the amount of GSH. The levels of 2,3-DPG decreased with increasing storage time. Conclusions: Overall, The study suggest that glutathione monoethyl ester is effective to reduce the oxidative stress and the quality of RBCs can be improved.

Behrooz Ghezelbash

Mohammadreza Deyhim

Azita Azarkeivan

Ali Akbar Pourfathollah

Nahid Eskandari

The Effects of Glutathione Monoethyl Ester on Different Biochemical, Oxidant, and Antioxidant Levels During Storage in Leukoreduced Red Blood Cells

谷胱甘肽单乙酯对白细胞减少红细胞储存期间不同生化、氧化剂和抗氧化剂水平的影响

Abbreviation	Adv. Biomed. Res.
Journal Impact	0.80
Quartiles(Global)	MEDICINE, RESEARCH & EXPERIMENTAL(Q4)

ISSN	2277-9175
h-index	14

Publication Information	Publisher: Wolters Kluwer Medknow Publications，Publishing cycle: ，Journal Type: journal，Open Access Journals: Yes
Basic data	Year of publication: 2019，Proportion of original research papers: 90.83%，Self Citation Rate:0.00%， Gold OA Rate: 92.74%
Journal Fees	$300Details
Average review cycle	网友分享经验：53 Weeks

Advanced Biomedical Research

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Comparison of Endometrial Polyp Characteristics in Transvaginal Sonography and Hysteroscopy in Predicting Endometrial Malignancies in Premenopausal and Postmenopausal Women

Differential gene expressions of CALM1, PSMD6, and AK124742 long noncoding RNA in cumulus cells from polycystic ovary syndrome patients versus normal control women

Attenuation of morphine withdrawal signs, blood cortisol and glucose level with forced exercise in comparison with clonidine

Diversity in the Clinical Course and Outcome of COVID-19 in Patients with Different Inborn Errors of Immunity can be Associated with the Type of Error

How Can Outdoor Air Pollutants Adversely Affect the Women’s Fertility? Systematic Review

Diversity in the Clinical Course and Outcome of COVID-19 in Patients with Different Inborn Errors of Immunity can be Associated with the Type of Error

How Can Outdoor Air Pollutants Adversely Affect the Women’s Fertility? Systematic Review

Comparing the Efficacy of Escitalopram with and without Crocin in Restoring I/O Functions and LTP within the Hippocampal CA1 Region of Stressed Rats

Evaluation of the Relative Frequency of Preinjury Activity Recovery in Anterior Cruciate Ligament Replacement Patients: A Cohort Study

The Effects of Glutathione Monoethyl Ester on Different Biochemical, Oxidant, and Antioxidant Levels During Storage in Leukoreduced Red Blood Cells