Nanofabrication

Increased oxidative stress in metabolic disorders has revealed promising alternatives for antioxidative therapeutics. Herein, we present synthesis and evaluations of Cerium oxide nanoparticles (CNPs) conjugated with Andrographolide (Ad-CNP). Characterization revealed a uniform particle size of 106 nm for bare CNP and 120 nm for Ad-CNP conjugates. UV-visible spectroscopy showed an absorbance peak at 230nm, indicating a high Ce³⁺/Ce⁴⁺ oxidation state. X-ray diffraction confirmed a pure cubic fluorite structure with a polycrystalline nature with peaks at 111, 200, 220, and 311. In terms of reactive oxygen species scavenging, bare CNPs demonstrated Catalase mimetic activity of 41.5%, whereas the Ad-CNP conjugates showed 47% scavenging activity. The Superoxide Dismutase mimetic activity was significantly increased due to synergy up to 77% of Ad-CNP whereas bare CNPs showed 57% activity. The CNPs exhibited notable antibacterial efficacy, diminishing microbial proliferation by 69% for bare CNPs and 82% for Ad-CNP. Biocompatibility testing with human skin keratinocytes validated the safety of the nanoparticles, and anti-inflammatory assays indicated decreased expression of pro-inflammatory cytokines IL-6 and TNF-α. The synergistic combination of CNPs with Andrographolide demonstrated significant potential as a potent antioxidant, antibacterial, and anti-inflammatory agent, making it a prospective candidate for antioxidative therapeutic research aimed at diminishing oxidative stress.

Sneha Kumari

Shivam Pandey

Leela Manohar Aeshala

Anuj Kumar

Sushant Singh

Examining the Synergism of Cerium Oxide Nanoparticle – Andrographolide Conjugate and Studying its Potential Role Towards Antioxidative Therapeutics

研究氧化铈纳米颗粒-穿心莲内酯偶联物的协同作用及其在抗氧化治疗中的潜在作用

Zheng Cui

Electron Beam Lithography

电子束光刻

Nanofabrication by Focused Ion Beam

聚焦离子束纳米加工

Nanofabrication by Self-Assembly

自组装纳米制造

Applications of Nanofabrication

纳米制造的应用

In this study, the compatibility of Quercetin (QC) nanocomposites with some selective food-grade pharmaceutical excipients was assessed using various thermal (DSC and TGA), non-thermal (P-XRD, FT-IR, and RAMAN spectroscopy, and FESEM) techniques. All the techniques were simultaneously used and correlated to detect the QC's compatibility with the selected excipients (CO, CCO, OA, T20, T60, and T80). DSC-TG studies showed that QC-CO and QC-T60 samples exhibited irregular degradation patterns, causing the drug's transformation from crystalline to amorphous. P-XRD results showed that the crystalline behavior of QC was retained in all the samples. However, the peak intensities were reduced and shifted in some samples. The Davg. value for all samples, including pure QC, was 26.80-76.07 nm. FT-IR and RAMAN studies demonstrated that bonds including –C=O stretching, C-C stretching (ring A), and -OH bonds (in ring A, B, and C) in pure QC play a crucial role in its interaction with excipients. Furthermore, the excipients' effect on QC's morphology using FESEM showed smoothening, fragmentation, and agglomeration of the drug. In conclusion, the possible drug-excipient incompatibility can be potentially determined with the help of these analytical methods. The physicochemical studies from this work may provide immense knowledge for the researchers and manufacturers involved in quercetin-based pharmaceutical and/or nutraceutical formulations.

Sabya Sachi Das

Priya Ranjan Prasad Verma

Sandeep Kumar Singh

Effect of Food-Grade Pharmaceutical Excipients on Physicochemical Behaviour of Quercetin Nanocomposites: Thermal and Non-Thermal Analysis

食品级药用辅料对槲皮素纳米复合物物理化学行为的影响：热分析与非热分析

In the present work, MWCNTs were used in wt.% of 0.075, 0.15, and 0.3 in epoxy resin, and then glass fabric/epoxy polymer (GF/EP) composites were fabricated using VARIM setup. The mechanical and wear properties of GF/EP composites were compared with and without the addition of MWCNTs. Maximum improvement in tensile and flexural performance were seen in GF/EP composites at 0.15 weight percent MWCNT addition when compared to a neat GF/EP one, based on static testing such as tensile and flexural tests. High-cycle fatigue test results show a relatively higher cycle count with 0.15 wt.% MWCNTs addition in the GF/EP composite compared to the GF/EP without the addition of MWCNTs. The wear performance also improved with a lower friction coefficient as well as a lower track depth and width for MWCNTs with added GF/EP than plain GF/EP composite. Therefore, in addition to decreasing surface softening and improving the wear performance of glass fabric epoxy composites, MWCNTs (0.15 weight percent) increased the interfacial adhesion at the fiber/matrix interface. This study establishes an optimum ratio of 0.15 wt.% of MWCNTs addition in glass fabric/epoxy polymer composites for enhancement in their mechanical and wear performance.

Dikshant Malhotra

Mayank Agrawal

RT Durai Prabhakaran

Effect of MWCNTs on static, dynamic, and wear performance of Vacuum Assisted Resin Infusion Molding (VARIM) processed glass fabric/epoxy polymer composites

MWCNTs对真空辅助树脂灌注成型（VARIM）工艺玻璃纤维/环氧树脂聚合物复合材料静态、动态和磨损性能的影响

In this study, the detailed phytochemical composition of two medicinal plants was investigated and their importance in silver nanoparticles (AgNPs) synthesis was highlighted. Aqueous extracts from the leaves of both plants were used for various analytical techniques, including UV-vis spectroscopy, Gas chromatography-mass spectrometry (GC-MS), Fourier transform infrared spectroscopy (FTIR) and Thin layer chromatography (TLC). Quantification of total phenolics and flavonoids in different fractions of plant extracts revealed significant concentrations. TLC profiling showed a higher abundance of free phenolic and flavonoid compounds compared to bound forms in both plants, suggesting that they contribute significantly to total phenolic and flavonoid content. UV-vis spectra from 200 to 600 nm revealed the presence of aromatic rings and chromophores in leaf extracts. Furthermore, the GC-MS analysis identified several bioactive compounds, some of which were found to be common between these two species. The results demonstrate that various bioactive compounds such as phenols, flavonoids, alkaloids, carotenoids and terpenoids were present in these plant species. These compounds efficiently serve as both reducing and stabilizing agents during phytofabrication of AgNPs, consequently eliminating the need for the use of hazardous chemicals.

Preeti Sharma

Basudha Sharma

Screening of the Medicinal Plant-Based Metabolites Responsible for Silver Nanoparticle Phytofabrication

基于药用植物代谢物筛选银纳米颗粒植物合成的研究

Ketoconazole (KTZ) is a commonly prescribed antifungal drug used to treat several tropical and systemic fungus infections. The topical bioavailability of KTZ is limited due to extremely low water solubility and high molecular weight. The present investigation aimed to develop a ketoconazole nanocrystals formulation to improve the biomimetic attributes. The ketoconazole nanocrystals were prepared using a top-down media milling technique with a size of less than 800 nm and a narrow polydispersity index (PDI) of 0.434. The simplex lattice design was used to further investigate the effect of change in the proportion of different stabilizers on critical product attributes such as particle size and PDI. The result of the in vitro drug release and anti-fungal study proved the superiority of the optimized KTZ nanocrystal in inhibiting fungal infection and suspension of pure drug. The optimized nanocrystals entrapped within Carbopol-934P gel had higher permeability through cellulose membrane compared, to the marketed product (2 % ketoconazole % w/w Ketodoc Cream®) with sustained release for 24 h. Moreover, the release profile indicated diffusion-controlled release from gel following Korsmeyer-Peppas. The present investigation successfully demonstrated the application of simplex lattice design and desirability function in optimizing ketoconazole nanocrystals to improve its transdermal application.

短名
Journal Impact	3.32
国际分区	NANOSCIENCE & NANOTECHNOLOGY(Q3)

涉及主题	材料科学化学纳米技术物理工程类有机化学量子力学生物化学工程复合材料光学医学生物化学遗传学光电子学地质学古生物学物理化学冶金计算机科学病理纳米颗粒
出版信息	出版商: De Gruyter，出版周期: ，期刊类型: journal，开源期刊: 否
基本数据	创刊年份: ，原创研究文献占比: 65.00%，自引率:9.10%， Gold OA占比: 72.55%
平均审稿周期	网友分享经验：16 Weeks

Nanofabrication

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Examining the Synergism of Cerium Oxide Nanoparticle – Andrographolide Conjugate and Studying its Potential Role Towards Antioxidative Therapeutics

Electron Beam Lithography

Nanofabrication by Focused Ion Beam

Nanofabrication by Self-Assembly

Applications of Nanofabrication

Examining the Synergism of Cerium Oxide Nanoparticle – Andrographolide Conjugate and Studying its Potential Role Towards Antioxidative Therapeutics

Effect of Food-Grade Pharmaceutical Excipients on Physicochemical Behaviour of Quercetin Nanocomposites: Thermal and Non-Thermal Analysis

Effect of MWCNTs on static, dynamic, and wear performance of Vacuum Assisted Resin Infusion Molding (VARIM) processed glass fabric/epoxy polymer composites

Screening of the Medicinal Plant-Based Metabolites Responsible for Silver Nanoparticle Phytofabrication

Ketoconazole Nanocrystals Fortified Gel for Improved Transdermal Applications