The journal will cover technical and clinical studies related to health, ethical and social issues in field of Gynecology and Obstetrics. Articles with clinical interest and implications will be given preference.

The Asian Pacific Journal of Reproduction will cover technical and clinical studies related to health, ethical, and social issues in the field of Gynecology and Obstetrics. Articles with clinical interest and implications will be given preference.

《Asian Pacific Journal of Reproduction》期刊将涵盖与妇产科领域相关的健康、伦理和社会问题的技术性和临床研究。我们优先考虑具有临床兴趣和影响的文章。

Asian Pacific Journal of Reproduction

Objective: To assess the protective effects of 70% ethanolic extract of Moringa ( M. ) oleifera leaves on fertility and epididymal dysfunctions in diabetic rats. Methods: Thirty-six male Wistar rats were divided into six groups, each with six rats. Group I was the normal control group receiving vehicle (0.5 mL of distilled water/rat/day) orally; group II, III, IV, V and VI were injected intraperitoneally with 60 mg/kg of streptozotocin once to induce type I diabetes. Then, the diabetic rats in group II receiving vehicle (0.5 mL of distilled water /rat/day) orally; the diabetic rats in groups III, IV and V were orally treated with M. oleifera leaf extract at dose of 100, 250, and 500 mg/kg body weight (b.wt.)/day, respectively; the diabetic rats in group VI were administrated with reference drug glibenclamide (5 mg/kg b.wt./day). The treatment lasted for 60 days. Sperm parameters (sperm count, motility and viability), fertility index, litter size, lipid peroxidation and antioxidative defense markers ( i.e. superoxide dismutase, catalase, glutathione, and ascorbic acid) in the epididymal tissue were determined. Histopathological changes in epididymis were also evaluated. Results: Administration of different doses of M. oleifera leaf extract in diabetic rats induced a remarkable dose dependent improvement in sperm parameters, fertility index, litter size, epididymal antioxidant status and also restored histopathological changes as compared to the diabetic control group. These findings were comparable with reference drug. Conclusions: M. oleifera leaf extract possesses significant antioxidant activities as well as beneficial effects on epididymal dysfunctions in diabetic male rats.

Ram Niwas Jangir

Gyan Chand Jain

Assessment of ameliorative effects of Moringa oleifera Lam. on epididymal dysfunctions and fertility in streptozotocin–induced diabetic rats

评估辣木（Moringa oleifera Lam.）对链脲佐菌素诱导的糖尿病大鼠附睾功能障碍和生育能力改善作用的研究

Objective: To explore the potential therapeutic impact of an alcoholic extract derived from the sea cucumber ( Holothuria parva ) on letrozole-induced polycystic ovary syndrome (PCOS) in adult female Sprague-Dawley rats. Methods: Sixteen female rats, aged 8 to 10 weeks, with a mean weight of (200±20) g, were randomly assigned to four groups: the control, PCOS, and two treatment groups receiving sea cucumber extract and metformin, respectively. PCOS was induced by administering letrozole at a dose of 1 mg/kg to initiate the treatment period at 60 days of age. The study spanned four weeks, during which ovarian and uterine tissues were collected for histological examination, and blood samples were collected for hormonal levels. Results: Significant decreases in luteinizing hormone/follicle stimulating hormone (LH/FSH) and testosterone and increases progesterone levels among groups treated with sea cucumber extract were observed. While no significant differences were observed in follicle-stimulating hormone (FSH) and testosterone levels, the distinctive variations in key hormones suggested a potential role for sea cucumber alcoholic extract in ameliorating PCOS symptoms. Conclusions: This research highlights the moderate efficacy of sea cucumber extract as a therapeutic intervention for PCOS, providing a novel perspective in the search for effective remedies. The observed hormonal alterations, particularly in LH, estradiol, and progesterone, underscore the need for further exploration into the underlying mechanisms and for optimizing the application of sea cucumber extract in PCOS management.

Samaneh Askari

Mohammad Reza Jafarzadeh Shirazi

Masoumeh Ahmadi

Arezoo Khoradmehr

Nadiar M. Mussin

Asset A. Kaliyev

Farzad Mohammad Rezazadeh

Mohammad Dadpasand Taromsari

Ali Bustani

Nader Tanideh

Kulyash R. Zhilisbayeva

Amin Tamadon

Impact of alcoholic extract from sea cucumber (Holothuria parva) on letrozole–induced polycystic ovary syndrome in adult female rats

海参（Holothuria parva）乙醇提取物对成年雌性大鼠来曲唑诱导的多囊卵巢综合征的影响

Spermatozoa are recognized as foreign cells by both male and female immune systems, leading to the production of antisperm antibodies (ASAs) when sperm are exposed to immune system due to a breach in the mucosal barrier. ASAs can be found in both sexes, though concentrations vary by individual and sex. This review examines ASAs production, their specific binding locations on sperm, and how ASAs may impair key sperm functions, including motility, viability, acrosome reaction, and capacitation. While ASAs are known to potentially interfere with sperm quality and sperm binding to zona pellucida in both humans and livestock, their impact on fertility remains debated, as ASAs are also detected in a significant number of fertile individuals. Furthermore, the practical relevance of ASAs screening in fertility assessment lacks consensus, with some findings suggesting that ASAs might even aid fertilization under certain conditions. By compiling the information on ASAs and their effects on semen quality and fertility, this review aims to provide a comprehensive understanding of the role of ASAs in infertility.

Channareddi Kuntareddi

Kamaraj Elango

Pradeep Nag

Arumugam Kumaresan

Impact of antisperm antibodies on sperm functions and fertility in livestock: A narrative review

抗精子抗体对家畜精子功能及生育力的影响：叙述性综述

Objective: To describe the various options available for preserving female and/or male fertility, taking into account both social and medical aspects, and to identify the effects of different natural products on male infertility extracted from plants. Methods: We reviewed the literature and included full-text publications in English provided by international biomedical databases, including Sciences Direct, Google Scholar, OVID, PubMed, and MEDLINE between 2016 and 2023. Search terms, such as fertility preservation, in vitro maturation, cryopreservation, plants for the treatment of male infertility, were taken from Medical Subject Headings (MeSH) and Boolean operators were used to improve sensitivity. Results: 112 papers were identified in the initial search, of which 18 were excluded due to duplication. After reviewing titles and abstracts, 70 papers were finally included. The main findings of this study are presented under three key themes: gametogenesis, fertility preservation techniques, and plant-based alternatives. Regarding gametogenesis, significant progress has been made in understanding oocyte and sperm maturation, with optimized conditions improving maturation rates and motility. For fertility preservation, techniques such as rescue in vitro maturation and cryopreservation have shown the enhanced outcomes, particularly in maintaining gamete quality. Lastly, plant-based alternatives, including extracts and essential oils, have demonstrated potential in reducing oxidative stress, improving sperm motility, and supporting oocyte development, thus providing a promising complementary approach to conventional methods. Conclusions: Fertility preservation is achieved in a variety of ways, including oocyte and embryo vitrification and sperm cryopreservation, and the use of plant-based treatment of male infertility.

Chaimaa Hilali

Chafika Nadifi

Modou Mamoune Mbaye

Nouama Bouanani

Kettani Halabi Mohamed

Noureddine Louanjli

Moncef Benkhalifa

Fatima Azzahra Lahlou

Assessing fertility preservation strategies: A scoping review

评估生育力保存策略：范围综述

Pallav Sengupta

Sulagna Dutta

Muhjah Falah Hassan

Combating ovarian hyperstimulation syndrome in polycystic ovary syndrome: Lessons from clinical case reports and research

抗多囊卵巢综合征中的卵巢过度刺激综合征：临床病例报告与研究的启示

Abbreviation	Asian Pac. J. Reprod.
Journal Impact	0.44
Quartiles(Global)	REPRODUCTIVE BIOLOGY(Q4)

ISSN	2305-0500, 2305-0519
h-index	27

Publication Information	Publisher: Wolters Kluwer Medknow Publications，Publishing cycle: ，Journal Type: journal，Open Access Journals: Yes
Basic data	Year of publication: 2012，Proportion of original research papers: 0.00%，Self Citation Rate:0.00%， Gold OA Rate: 92.73%
Average review cycle	27 weeks

Asian Pacific Journal of Reproduction

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Assessment of ameliorative effects of Moringa oleifera Lam. on epididymal dysfunctions and fertility in streptozotocin–induced diabetic rats

Impact of alcoholic extract from sea cucumber (Holothuria parva) on letrozole–induced polycystic ovary syndrome in adult female rats

Impact of antisperm antibodies on sperm functions and fertility in livestock: A narrative review

Assessing fertility preservation strategies: A scoping review

Combating ovarian hyperstimulation syndrome in polycystic ovary syndrome: Lessons from clinical case reports and research

Assessment of ameliorative effects of Moringa oleifera Lam. on epididymal dysfunctions and fertility in streptozotocin–induced diabetic rats

Impact of alcoholic extract from sea cucumber (Holothuria parva) on letrozole–induced polycystic ovary syndrome in adult female rats

Impact of antisperm antibodies on sperm functions and fertility in livestock: A narrative review

Assessing fertility preservation strategies: A scoping review

Combating ovarian hyperstimulation syndrome in polycystic ovary syndrome: Lessons from clinical case reports and research