Nanomedicine Journal

Objective(s): In this study, drug loaded electrospun nanofibrous mats were prepared and drug release and mechanism from prepared nanofibers were investigated.  Materials and Methods: Paclitaxel (PTX) loaded polylactic acid (PLA) nanofibers were prepared by electrospinning. The effects of process parameters, such as PTX concentration, tip to collector distance, voltage, temperature and flow rate on the mean diameter of electrospun PTX loaded PLA nanofibers were investigated. Scanning electron microscopy (SEM) was used to investigate the fiber morphology and mean fiber diameter of prepared nanofibers. Response surface methodology was used to model the average diameter of electrospun PLA/PTX nanofibers. Results: The predicted fiber diameter was in good agreement with the experimental result. In Vitro drug release in phosphate buffer solution (PBS) and acetate buffer for the produced samples showed that diffusion is the dominant drug release mechanism for PTX loaded ubers. Conclusion: Electrospinning was shown to be very promising approach to the formulation of Paclitaxel in order to enhance its release in a sustained and prolonged manner.

Amir Doustgani

Nanomedicine journal

Investigation of drug release from paclitaxel loaded polylactic acid nanofibers

负载紫杉醇的聚乳酸纳米纤维药物释放研究

This paper provides an overview of how the surface properties of ferromagnetic nanoparticles dispersed in fluids is modified by natural and biocompatible polymers. Among common magnetic nanoparticles, magnetite (Fe3O4) and maghemite (g-Fe203) are popular candidates because of their biocompatibility. Natural polymeric coating materials are the most commonly used biocompatible magnetic nanoparticle coatings. In this paper, recent progresses in the methods of ferrofluids surface modification by the common natural polymers consisting of dextran, chitosan, gelatin and starch are reviewed.

Mahyar Ebrahimi

Abst Ract

A short review on Ferrofluids surface modification by natural and biocompatible polymers

天然和生物相容性聚合物对铁磁流体表面改性的简要综述

Objective(s): Binary hybrids of chitosan-zeolite have many interesting applications in separation and bacteriostatic activity. Materials and Methods: Template free ZSM-5 zeolite was synthesized by hydrothermal method, physical hydrogels of nano chitosan in the colloidal domain were obtained in the absence of toxic organic solvent and then nano chitosan/ZSM-5 hybrid composites with nano chitosan contents of 0.35%, 3.5%, 35% wt.% were prepared. The as prepared hybrid composites were ion-exchanged with Ag cations. Results: XRD and FT-IR results revealed a good crystalinity of as synthesized template frees ZSM-5 with BET surface area of 307 m2g-1. Presence of chitosan in composites was confirmed by XRD patterns and FT-IR spectroscopic analysis, the chitosan content in composite was obtained with TG analysis. SEM analysis of composites shows that chitosan particles were dispersed within the nanometer scale. The antimicrobial activity of different samples was investigated and the results showed that the Ag+-exchanged samples have the highest antibacterial properties. Cancer cell line A549 cell line were cultured in designated medium treated with Ag+-exchanged samples at the concentration of 0.01 to 0.5 mg/ml. After 24 and 48 hours incubation, the efficacy of Ag+-exchanged samples to treat cancer cell lines were measured by means of cell viability test via MTT assay. Concentrations of 0.05 and 0.1 mg/ml of Ag+-exchanged samples induced a very low toxicity. Conclusion: These hybrid composite materials have potential applications on tissue engineering and antimicrobial food packaging.

Maasoumeh Khatamiana

Baharak Divband

Mahdieh Daryana

Preparation, characterization and antimicrobial property of ag+- nano Chitosan/ZSM-5: novel Hybrid Biocomposites

Ag+纳米壳聚糖/ZSM-5的制备、表征及抗菌性能：新型混合生物复合材料

Objective(s): PEI based nanoparticle (NP) due to dual capabilities of proton sponge and DNA binding is known as powerful tool for nucleic acid delivery to cells. However, serious cytotoxicity and complicated conditions, which govern NPs properties and its interactions with cells practically, hindered achievement to high transfection efficiency. Here, we have tried to optimize the properties of PEI/ firefly luciferase plasmid complexes and cellular condition to improve transfection efficiency. Materials and Methods: For this purpose, firefly luciferase, as a robust gene reporter, was complexed with PEI to prepare NPs with different size and charge. The physicochemical properties of nanoparticles were evaluated using agarose gel retardation and dynamic light scattering.  MCF7 and BT474 cells at different confluency were also transfected with prepared nanoparticles at various concentrations for short and long times. Results: The branched PEI can instantaneously bind to DNA and form cationic NPs. The results demonstrated the production of nanoparticles with size about 100-500 nm dependent on N/P ratio. Moreover, increase of nanoparticles concentration on the cell surface drastically improved the transfection rate, so at a concentration of 30 ng/il, the highest transfection efficiency was achieved. On the other side, at confluency between 40-60%, the maximum efficiency was obtained. The result demonstrated that N/P ratio of 12 could establish an optimized ratio between transfection efficiency and cytotoxicity of PEI/plasmid nanoparticles. The increase of NPs N/P ratio led to significant cytotoxicity. Conclusion: Obtained results verified the optimum conditions for PEI based gene delivery in different cell lines.

Roya Cheraghi

Mohsen Alipour

Mahboobeh Nazari

Saman Hosseinkhani

Optimization of conditions for gene delivery system based on PEI

基于PEI的基因递送系统条件优化

Objective(s): Our previous studies have shown that MgO nanoparticles (MgO NPs) could improve anxiety and reduce pain in animals. In this study, the effect of co administration MgO NPs and vitamin C on anxiety like behavior and nociception in postpartum depression (PPD) model were investigated.Materials and Methods:  Female mice (27 ± 3 g) were divided into groups: two control groups, PPD groups:  saline or MgO NPs 1, 5, 10 mg/kg (acute/ chronic), vitamin C 5 and 25 mg/kg (acute) alone or co-injected with MgO NPs 5 (acute). For induction of PPD, chronic injection of progesterone for 5 days was used and three days after progesterone withdrawn (PWD), the depression behavior was evaluated by tail suspension test. Elevated plus maze and hot plate tests were used for evaluation of anxiety and pain perception, respectively. Results: PWD induced anxiety and acute injection of MgO NPs 5 reduced anxiety while chronic injection increased anxiety (P<0.05). Acute and chronic injections of MgO NPs 10 increased anxiety (P<0.05, PConclusion: Effects of MgO NPs on anxiety like behavior induced by PWD, is depends on dose and usage duration. Probably usage of antioxidant can improve efficacy of MgO NPs on anxiety reduction and nociception.

Mahnaz Kesmati

Farzaneh Zadehdarvish

Zahra Jelodar

Mozhgan Torabi

Vitamin C potentiate sedative effect of magnesium oxide nanoparticles on anxiety and nociception in the postpartum depression model

维生素C增强氧化镁纳米颗粒对产后抑郁症模型中焦虑和痛觉的镇静作用

Objective(s)Paclitaxel (PTX) and docetaxel (DTX) belong to the family of taxanes drugs which have been employed for treatment of ovarian, breast, lung, head, neck, gastric, pancreatic, bladder, prostate and cervical cancer. Controlled drug release systems improve the effectiveness of drug therapy by modifying the release profile, biodistribution, stability and solubility, bioavailability of drugs and minimize the side effects of anticancer drugs. So, the purpose of the present study was to synthesize the modified nanocomposite for the controlled releases of these drugs.Materials and MethodsMagnetic magnesium iron oxide nanoparticles were synthesized via the co-precipitation chemical method and then composited with graphene oxide and modified by polyvinyl alcohol. The physicochemical characterization of the prepared nanocomposites was investigated by scanning electron microscope (SEM),  X-ray powder diffraction (XRD) , Fourier-transform infrared spectroscopy and vibrating-sample magnetometer.ResultsSpecific characteristics such as adsorption capacity, monodispersity, stability and hydrophilicity of magnetic nanomaterials were studied in the controlled release of anticancer drugs. Drug loading content and drug loading efficiency and release rate of drugs were investigated in vitro at different pH with ultraviolet-visible spectroscopy (UV-Vis). DLE and DLC of PTX and DTX in the modified magnetic nanocomposites were calculated  as 85.2 ± 2.7% and 7.74 ± 0.24% , 89.4 ± 1.2% and 8.12 ± 0.11% of, respectively. The cumulative release amount of PTX and DTX from magnetic modified nanocomposites at pHs 5.8, 7.4 over 100 h were 58 % and 40 % and 54 % and 37 %, respectively.ConclusionThe potential of modified nanocomposite in drug delivery systems from the intrinsic properties of the magnetic core combined with their drug loading capability and the biomedical properties of modified nanocomposite generated by different surface coatings. The generally sustained and controlled release profile of DTX (or PTX) facilitates the application of modified nanocomposite for the delivery of anticancer drugs.

Ahmad Gholami

Biuck Habibi

Amir Abbas Matin

Naser Samadi

Controlled release of anticancer drugs via the magnetic magnesium iron nanoparticles modified by graphene oxide and polyvinyl alcohol: Paclitaxel and docetaxel

通过氧化石墨烯和聚乙烯醇修饰的磁性镁铁纳米颗粒控制释放抗癌药物：紫杉醇和多西他赛

Exosomes, which are one of the extracellular vesicles, are considered necessary tools of intracellular communication that abundant in our body in physiological and pathological conditions with a diameter of 30-150 nm. The nanotubes, dendrimeric, metallic, nanoparticles have been used in the medical area.  However, these nano-based systems are lack of standardized manufacturing methods and therefore, it has toxic effects on cells. The delivery methods of growth factors, exosomes, cells, and engineered tissues have notably advanced in the medical area. The fact that they contain bioactive molecules such as protein, lipid, RNA and DNA revealed that these structures may play an important role in the treatment of cancer. Here, we review work on the contribution exosomal mediated cancer treatment in two main topics as exogenous molecule carrier and self-use. We also emphasize the development of exosome-based systems by referring to the advantages and disadvantages of using exosomes and future perspectives in cancer therapy.

Fatma Kubra Ata

Serap Yalcin

Exosomes as delivery tools in cancer therapy: Future perspectives

外泌体作为癌症治疗中的递送工具：未来展望

Objective(s) Quercetin antioxidant properties could play an important role in various fields of health. However, its use has been limited because of several disadvantages such as very low solubility in water and high instability in the presence of air, light and heat. Encapsulation of quercetin in nanostructure systems such as liposome may lead to decrease the adverse effects and protect this molecule against degradation. The aim of this study was preparation and in-vitro and in-vivo evaluation of liposomes for topical delivery of quercetin to improve the pressure ulcers.Materials and Methods Liposomal formulations were prepared by fusion method and characterized. The amount of drug retained in and penetrated through mouse skin after 8 hours were determined. Also microscopic and macroscopic examination of laboratory animals was performed.Results  Encapsulation efficacy of liposomes was in range 64.66-77.83%. Formulation F4 showed maximum drug release in 8 hours and the remaining drug in the skin layers was more than 46%. Histological investigation suggested that F4 and phenytoin 1% cream have the healing effect on the pressure ulcer during 28 day-treatment.Conclusion Quercetin liposomes due to its natural structure and minimal systemic absorption and side effects can be a suitable candidate for the treatment of pressure ulcers.

Neda Bavarsad

Neda Sistani Karampour

Golnaz Hemmati

Anahita Rezaie

The effect of topical quercetin loaded liposome on pressure ulcer healing in rats

局部应用槲皮素脂质体对大鼠压力性溃疡愈合的影响

Contrast agents (CAs) play a critical role in high-resolution magnetic resonance imaging (MRI) applications to enhance the low intrinsic sensitivity of MRI. Manganese oxide nanoparticles (MnO) have gotten developing consideration as substitute spinâ��lattice (T1) MRI CAs as a result of the Gd-based CAs which are related with renal i¬�brosis as well as the inherent dark imaging characteristics of superparamagnetic iron oxide NPs. In this review, previous developments in the usage of MnO nanoparticles as MRI CAs for cancer theranostic applications such as developments in toxicological properties, distribution and tumor microenvironment (TME)-responsive biomaterials were reviewed. A literature search was accomplished to discover distributed research that elaborates the use of MnO in multimodal imaging and therapy. In the current study, the electronic search including PubMed/Medline, Embase, ProQuest, Scopus, Cochrane and Google Scholar was performed dependent on Mesh key words. CAs can significantly improve the imaging contrast among the lesions and normal tissues. In this study we generally concentrate on typical advancements of MnO nanoparticles about properties, bimodal or multimodal imaging, and therapy. Numerous researches have demonstrated MnO-based nanostructure produce considerable biocompatibility with the lack of cytotoxicity. Therefore, remarkable features improved photothermal therapy, chemotherapy and Chemodynamic therapy.

Mehdi Khalilnejad

Tohid Mortezazadeh

Ramin Ghasemi Shayan

Application of Manganese Oxide (MnO) nanoparticles in multimodal molecular imaging and cancer therapy: A review

氧化锰（MnO）纳米颗粒在多模态分子成像与癌症治疗中的应用：综述

Objective(s): This study has investigated the effects of acute and chronic administration of MgO nanoparticles (NP), on the memory, serum magnesium ions level, total antioxidant capacity and histopathological changes of the rat hippocampus in the Alzheimer-like model induced by streptozotocin (STZ). Materials and Methods: Adult male Wistar rats divided into: control, sham (STZ+ saline) and MgO NP 1 and 5 mg/kg groups. To induce Alzheimer’s disease, all rats except control group, received STZ (3 mg/kg/ 5 µl of saline) into the lateral ventricles during anesthesia. One week after surgery, passive avoidance learning was started by shuttle box device and saline or MgO NP acutely and chronically was administered after training. Memory tests were done at 90 minutes and 24 hours after training and one week after chronic administration. Immediately after the memory test, serum magnesium levels and total antioxidant capacity were measured, also the brain hippocampus tissue was removed for histopathological evaluation. STZ significantly impairs memory up to a week after the training. Results: Acute and chronic administration of MgO NP significantly improved short and long-term memory in the Alzheimer’s rats. Serum magnesium level decreased in the Alzheimer’s rats and MgO NP increased it in a dose-dependent manner. MgO NP 1 mg/kg significantly increased serum total antioxidant capacity. MgO NP improved STZ-induced cell lesions in different parts of the hippocampus. Conclusions: It seems that MgO NP have the potential to improve brain lesions that have led to loss of memory and can be considered as an important component candidate for Alzheimer’s disease.

Norollah Tamoradi

Ali Shahriyari

Evaluating behavioral, biochemical and histopathological effects of the MgO nanoparticles administration on memory in the Alzheimer-like model of male rat

评估MgO纳米颗粒对雄性大鼠阿尔茨海默样模型记忆行为、生化和组织病理学的影响

短名
Journal Impact	1.30
国际分区	NANOSCIENCE & NANOTECHNOLOGY(Q4)

ISSN	2322-3049, 2322-5904
h-index	11

涉及主题	化学生物材料科学物理有机化学工程类纳米技术化学工程医学生物化学量子力学遗传学纳米颗粒内科学复合材料光学冶金核磁共振地质学药理学体外核化学古生物学病理
出版信息	出版商: Mashhad University of Medical Sciences，出版周期: ，期刊类型: journal，开源期刊: 是
基本数据	创刊年份: 2019，原创研究文献占比: 72.73%，自引率:14.30%， Gold OA占比: 0.00%
平均审稿周期	网友分享经验：12 Weeks

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