The Dark Knight: Functional Reprogramming of Neutrophils in the Pathogenesis of Colitis-Associated Cancer

2024-9-13

Inflammation mediated by gut microbiome alterations promotes lung cancer development and an immunosuppressed tumor microenvironment

2024-9-13

CD91 and its ligand gp96 confer cross-priming capabilities to multiple APCs during immune responses to nascent, emerging tumors

2024-9-13

PTPRZ1-targeting RNA CAR T cells exert antigen-specific and bystander antitumor activity in glioblastoma

2024-9-13

Integrated germline and somatic features reveal divergent immune pathways driving response to immune checkpoint blockade

2024-9-10

Spatially resolved whole-transcriptomic and proteomic profiling of lung cancer and its immune-microenvironment according to PD-L1 expression

2024-9-5

Cannabidiol enhances Atezolizumab efficacy by upregulating PD-L1 expression via the cGAS–STING pathway in triple-negative breast cancer cells

2024-9-3

A Sampling of Highlights from the Literature

2024-9-3

CAR T cells engineered to secrete IFN-κ induce tumor ferroptosis via an IFNAR/STAT1/ACSL4 axis

2024-8-26

Age-associated contraction of tumor-specific T cells impairs antitumor immunity

2024-8-24

CD36+ pro-inflammatory macrophages interact with ZCCHC12+ tumor cells in papillary thyroid cancer promoting tumor progression and recurrence

2024-8-23

A single-cell analysis of the NK-cell landscape reveals that dietary restriction boosts NK cell antitumor immunity via Eomesdermin

2024-8-16

Tumor-Associated Antigen Burden Correlates with Immune Checkpoint Blockade Benefit in Tumors with Low Levels of T-cell Exhaustion

2024-8-13

The CCR6–CCL20 axis promotes regulatory T cell glycolysis and immunosuppression in tumors

2024-8-12

Blocking CX3CR1+ Tumor-associated Macrophages Enhances the Efficacy of Anti-PD-1 Therapy in Hepatocellular Carcinoma

2024-8-8

The spatial structure of the tumor immune microenvironment can explain and predict patient response in high-grade serous carcinoma

2024-8-8

An engineered self-biomineralized oncolytic adenovirus induces effective antitumor immunity and synergizes with immune checkpoint blockade

2024-8-5

A Sampling of Highlights from the Literature

2024-8-1

Blockade of IL1β and PD1 with Combination Chemotherapy Reduces Systemic Myeloid Suppression in Metastatic Pancreatic Cancer with Heterogeneous Effects in the Tumor

2024-8-1

Organ-specific immune setpoints underlie divergent immune profiles across metastatic sites in breast cancer

2024-7-25

Machine Learning–Directed Conversion of Glioblastoma Cells to Dendritic Cell–Like Antigen-Presenting Cells as Cancer Immunotherapy

2024-7-25

Transforming the Dark into Light: A Siglec-9 Switch

2024-7-22

Targeting Tumor-Associated Sialic Acids using Chimeric Switch Receptors based on Siglec-9 Enhances the Antitumor Efficacy of Engineered T Cells

2024-7-22

MR1 gene and protein expression are enhanced by inhibition of the extracellular signal-regulated kinase ERK

2024-7-19

Augmenting CAR T Cell Functions with LIGHT

2024-7-19

Engineered CAR-NK cells with tolerance to H2O2 and hypoxia can suppress postoperative relapse of triple-negative breast cancers

2024-7-18

Regulatory Considerations for Genome-Edited T-cell Therapies

2024-7-17

The E3 ubiquitin ligase FBXO38 maintains the antitumor function of natural killer cells by sustaining IL-15R signaling

2024-7-11

RNA-encoded interleukin-2 with extended bioavailability amplifies RNA vaccine–induced antitumor T-cell immunity

2024-7-11

Unveiling the Culprit: IL17 Signaling in the Pancreatic Epithelium Drives Tumorigenesis

2024-7-11

Iron boosts anti-tumor type 1 T-cell responses and anti-PD1 immunotherapy

2024-7-10

MerTK Induces Dysfunctional Dendritic Cells by Metabolic Reprogramming

2024-7-8

Nivolumab reaches brain lesions in patients with recurrent glioblastoma and induces T-cell activity and upregulation of checkpoint pathways

2024-7-8

Knocking out CD70 rescues CD70-specific nanoCAR T cells from antigen-induced exhaustion

2024-7-8

PlexinB1 inactivation reprograms immune cells in the tumor microenvironment, inhibiting breast cancer growth and metastatic dissemination

2024-7-8

“Couple’s Immunotherapy”: Is CXCL13 at the Heart of the Prescription?

2024-7-5

Unveiling Cellular Identities and Gene Expression Pathways in Overlapping Myocarditis and Myositis

2024-7-5

Endoplasmic reticulum stress potentiates the immunosuppressive microenvironment in hepatocellular carcinoma by promoting the release of SNHG6-enriched small extracellular vesicles

2024-7-3

A Sampling of Highlights from the Literature

2024-7-2

Do Not Forget the Granulocytic Compartment’s Role in T cell–Mediated Antitumor Immunity

2024-7-2

NK Receptor Signaling Lowers TCR Activation Threshold, Enhancing Selective Recognition of Cancer Cells by TAA-Specific CTLs

2024-7-1

Improvement of tumor neoantigen detection by high field asymmetric waveform ion mobility mass spectrometry

2024-7-1

Identification of core techniques that enhance genome editing of human T cells expressing synthetic antigen receptors

2024-6-28

Intracellular osteopontin promotes the release of TNFα by mast cells to restrain neuroendocrine prostate cancer

2024-6-28

Hypoxia-induced long non-coding RNA HIF1A‑AS2 regulates stability of MHC class I protein in head and neck cancer

2024-6-26

Atypical B Cells Promote Cancer Progression and Poor Response to Bacillus Calmette-Guérin in Non–Muscle Invasive Bladder Cancer

2024-6-25

Intermittent MEK inhibition with GITR co-stimulation rescues T-cell function for increased efficacy with CTLA-4 blockade in solid tumor models

2024-6-18

Pancreatic epithelial IL-17/IL-17RA signaling drives B7-H4 expression to promote tumorigenesis

2024-6-6

CLN-617 retains IL-2 and IL-12 in injected tumors to drive robust and systemic immune-mediated antitumor activity

2024-6-5

A Sampling of Highlights from the Literature

2024-6-4