REGENERATIVE THERAPY 是日本再生医学会的官方同行评审在线期刊。REGENERATIVE THERAPY 是一本多学科期刊，发表关于基础研究、临床转化、工业发展和监管问题的原创文章和评论，重点关注干细胞生物学、组织工程和再生医学。

Regenerative Therapy is the official peer-reviewed online journal of the Japanese Society for Regenerative Medicine. This multidisciplinary journal publishes original articles and reviews on fundamental research, clinical translation, industrial development, and regulatory issues, with a focus on stem cell biology, tissue engineering, and regenerative medicine.

《Regenerative Therapy》是日本再生医学会的官方同行评审在线期刊。该期刊涵盖多个学科，发表关于基础研究、临床转化、工业发展和监管问题的原创文章和评论，重点关注干细胞生物学、组织工程和再生医学领域。

Regenerative Therapy

Activation of skeletal progenitors upon tissue injury and the subsequent cell fate specification are tightly coordinated in the bone repair process. Although known osteoimmunological signaling networks play important roles in the microenvironment of the bone defect sites, the molecular mechanism underlying the bone repair process has not been fully understood. To better understand the behavior of the skeletal progenitors and the heterogeneity of the cells during bone repair at the microenvironmental level, we performed a combinatorial analysis consisting of lineage tracing for skeletal progenitors using the Sox9-CreERT2;R26RtdTomato mouse line followed by single-cell RNA sequencing (scRNA-seq) analysis using a mouse model of calvarial bone repair. To identify a therapeutic target for bone regeneration, further computational analysis was performed focusing on the identification of the cell–cell interactions, followed by pharmacological assessments with a critical-size calvarial bone defect mouse model. Lineage tracing analysis showed that skeletal progenitors marked by Sox9 were activated upon bone injury and contributed to bone repair by differentiating into osteoblasts. The scRNA-seq analysis characterized heterogeneous cell populations at the bone defect sites; the computational analysis predicted a bifurcated lineage from skeletal progenitors toward osteogenic and adipogenic lineages. Chemokine C–C motif ligand 9 (Ccl9) was identified as a signaling molecule that regulates bone regeneration in the mouse model, possibly through the regulation of adipogenic differentiation at the bone defect site. Multipotential skeletal progenitors and the direction of the cell differentiation were characterized at single cell resolution in a mouse bone repair model. The Ccl9 signaling pathway may be a key factor directing osteogenesis from the progenitors in the model and may be a therapeutic target for bone regeneration.

Mika Nakayama

Hiroyuki Okada

Masahide Seki

Yutaka Suzuki

Ung-il Chung

Shinsuke Ohba

Hironori Hojo

Single-cell RNA sequencing unravels heterogeneity of skeletal progenitors and cell–cell interactions underlying the bone repair process

单细胞RNA测序揭示骨骼祖细胞异质性及细胞间相互作用在骨修复过程中的作用

Skeletal muscle injuries have bothered doctors and caused great burdens to the public medical insurance system for a long time. Once injured, skeletal muscles usually go through the processes of inflammation, repairing and remodeling. If repairing and remodeling stages are out of balance, scars will be formed to replace injured skeletal muscles. At present, clinicians usually use conventional methods to restore the injured skeletal muscles, such as flap transplantation. However, flap transplantation sometimes needs to sacrifice healthy autologous tissues and will bring extra harm to patients. In recent years, stem cells-based tissue engineering provides us new treatment ideas for skeletal muscle injuries. Stem cells are cells with multiple differentiation potential and have ability to differentiate into adult cells under special condition. Skeletal muscle tissues also have stem cells, called satellite cells, but they are in small amount and new muscle fibers that derived from them may not be enough to replace injured fibers. Bone marrow mesenchymal stem cells (BM-MSCs) could promote musculoskeletal tissue regeneration and activate the myogenic differentiation of satellite cells. Biomaterial is another important factor to promote tissue regeneration and greatly enhance physiological activities of stem cells in vivo. The combined use of stem cells and biomaterials will gradually become a mainstream to restore injured skeletal muscles in the future. This review article mainly focuses on the review of research about the application of BM-MSCs and several major biomaterials in skeletal muscle regeneration over the past decades.

Yu-hao Wang

Dian-ri Wang

Yu-chen Guo

Ji-yuan Liu

Jian Pan

The application of bone marrow mesenchymal stem cells and biomaterials in skeletal muscle regeneration

骨髓间充质干细胞与生物材料在骨骼肌再生中的应用

Decellularized extracellular matrix (dECM) is widely used in regenerative medicine as a scaffold material due to its unique biological activity and good biocompatibility. Hydrogel is a three-dimensional network structure polymer with high water content and high swelling that can simulate the water environment of human tissues, has good biocompatibility, and can exchange nutrients, oxygen, and waste with cells. At present, hydrogel is the ideal biological material for tissue engineering. In recent years, rapid development of the hydrogel theory and technology and progress in the use of dECM to form hydrogels have attracted considerable attention to dECM hydrogels as an innovative method for tissue engineering and regenerative medicine. This article introduces the classification of hydrogels, and focuses on the history and formation of dECM hydrogels, the source of dECM, the application of dECM hydrogels in tissue engineering and the commercial application of dECM materials.

Wenhui Zhang

Aoling Du

Shun Liu

Mingyue Lv

Shenghua Chen

Research progress in decellularized extracellular matrix-derived hydrogels

脱细胞细胞外基质衍生水凝胶的研究进展

Compared to bioactive glass 45S5, bioactive glass 1393 has shown greater potential in activating tissue cells and promoting angiogenesis for bone repair. Nevertheless, the effect of bioactive glass 1393 in the context of wound healing remains extensively unexplored, and its mechanism in wound healing remains unclear. Considering that angiogenesis is a critical stage in wound healing, we hypothesize that bioactive glass 1393 may facilitate wound healing through the stimulation of angiogenesis. To validate this hypothesis and further explore the mechanisms underlying its pro-angiogenic effects, we investigated the impact of bioactive glass 1393 on wound healing angiogenesis through both in vivo and in vitro studies. The research demonstrated that bioactive glass 1393 accelerated wound healing by promoting the formation of granulation, deposition of collagen, and angiogenesis. The results of Western blot analysis and immunofluorescence staining revealed that bioactive glass 1393 up-regulated the expression of angiogenesis-related factors. Additionally, bioactive glass 1393 inhibited the expression of ROS and P53 to promote angiogenesis. Furthermore, bioactive glass 1393 stimulated angiogenesis through the P53 signaling pathway, as evidenced by P53 activation assays. Collectively, these findings indicate that bioactive glass 1393 accelerates wound healing by promoting angiogenesis via the ROS/P53/MMP9 signaling pathway.

Xuenan Chen

Xinyu Ran

Xuebo Wei

Lifei Zhu

Shaodong Chen

Zhiyong Liao

Ke Xu

Weidong Xia

Bioactive glass 1393 promotes angiogenesis and accelerates wound healing through ROS/P53/MMP9 signaling pathway

生物活性玻璃1393通过ROS/P53/MMP9信号通路促进血管生成并加速伤口愈合

Tihui Wang

Shujing Feng

Hao Zhou

Wenhua Mao

Ruijun Bai

Yuan Xia

Jianghu Huang

Rui Zhang

Feiyue Lin

PIEZO1 activation enhances myogenesis and mitigates muscle degeneration in rotator cuff tear

PIEZO1激活增强肌生成并减轻肩袖撕裂中的肌肉退化

Chaofan Wang

Yimei Du

Changpei Lu

Lingbo Bi

Yunbu Ding

Weixin Fan

The role of SFRP1 in human dermal papilla cell growth and its potential molecular mechanisms as a target in regenerative therapy

SFRP1在人类真皮乳头细胞生长中的作用及其作为再生治疗靶点的潜在分子机制

Makoto Shiraishi

Yoshihiro Sowa

Ataru Sunaga

Kenta Yamamoto

Mutsumi Okazaki

Bioengineering strategies for regeneration of skin integrity: A literature review

皮肤完整性再生的生物工程策略：文献综述

Elahe Tahmasebi

Sareh Azadi

Samira Hajisadeghi

Hamidreza Barikani

Masoud Salehi

Mahdi Shafikhani

Fateme Mozaffari

Edris Nazarpour

Arman Torabizadeh

Ahad Khoshzaban

Self-assembling peptide nanofibers and nanoceramics in a model of alveolar bone repair: Insights from in vivo experiments and clinical trial

自组装多肽纳米纤维与纳米陶瓷在牙槽骨修复模型中的应用：来自体内实验与临床试验的启示

Kunbin Li

Liming Lu

Xianli Yao

Zhiyuan Wu

Pingge Sun

Xiaopeng Wen

Xiaoxing Li

Kai Wang

Xiran Yin

The NFATC2/Nrf2 cascade regulates spinal cord ischemia-reperfusion injury by controlling inflammation, apoptosis and oxidative stress

NFATC2/Nrf2级联通过调控炎症、凋亡和氧化应激调节脊髓缺血-再灌注损伤

Abbreviation	Regen. Ther.
Journal Impact	3.36
Quartiles(Global)	ENGINEERING, BIOMEDICAL(Q2)

ISSN	2352-3204
h-index	31

Publication Information	Publisher: Japanese Society of Regenerative Medicine，Publishing cycle: ，Journal Type: journal，Open Access Journals: Yes
Basic data	Year of publication: 2015，Proportion of original research papers: 87.96%，Self Citation Rate:2.90%， Gold OA Rate: 90.88%
Journal Fees	$1100Details
Average review cycle	网友分享经验：25 Weeks

Regenerative Therapy

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Single-cell RNA sequencing unravels heterogeneity of skeletal progenitors and cell–cell interactions underlying the bone repair process

The application of bone marrow mesenchymal stem cells and biomaterials in skeletal muscle regeneration

Research progress in decellularized extracellular matrix-derived hydrogels

Bioactive glass 1393 promotes angiogenesis and accelerates wound healing through ROS/P53/MMP9 signaling pathway

PIEZO1 activation enhances myogenesis and mitigates muscle degeneration in rotator cuff tear

The role of SFRP1 in human dermal papilla cell growth and its potential molecular mechanisms as a target in regenerative therapy

Bioengineering strategies for regeneration of skin integrity: A literature review

PIEZO1 activation enhances myogenesis and mitigates muscle degeneration in rotator cuff tear

Self-assembling peptide nanofibers and nanoceramics in a model of alveolar bone repair: Insights from in vivo experiments and clinical trial

The NFATC2/Nrf2 cascade regulates spinal cord ischemia-reperfusion injury by controlling inflammation, apoptosis and oxidative stress