AIMS Neuroscience is an international Open Access journal devoted to publishing peer-reviewed, high quality, original papers from all areas in the field of neuroscience. The primary focus is to provide a forum in which to expedite the speed with which theoretical neuroscience progresses toward generating testable hypotheses. In the presence of current and developing technology that offers unprecedented access to functions of the nervous system at all levels, the journal is designed to serve the role of providing the widest variety of the best theoretical views leading to suggested studies. Single blind peer review is provided for all articles and commentaries.

AIMS Neuroscience is an international Open Access journal dedicated to publishing high-quality, peer-reviewed original papers from all areas of neuroscience. The primary aim is to provide a forum that accelerates the progression of theoretical neuroscience towards generating testable hypotheses. In the context of current and emerging technologies that offer unprecedented access to the functions of the nervous system at all levels, the journal is designed to present a wide variety of the best theoretical perspectives that lead to suggested studies. All articles and commentaries undergo single-blind peer review.

AIMS Neuroscience 是一本国际开放获取期刊，专注于发表来自神经科学各个领域的高质量、经过同行评审的原创论文。期刊的主要目标是提供一个论坛，以加速理论神经科学向可测试假设的进展。在当前和发展中的技术提供前所未有的神经系统各个层面的功能访问的背景下，该期刊旨在提供最广泛的最佳理论观点，以引导后续研究。所有文章和评论均经过单盲同行评审。

AIMS Neuroscience

Over the years, several interventions have been implemented, including Lego® Therapy, with the aim of supporting and implementing social and communication skills impairments in Autism Spectrum Disorders (ASD). Although recent studies have shown that the ability to learn implicitly is preserved in ASDs, no study related to Lego® Therapy has analyzed whether and how this training can also affect aspects not directly treated. In this study, we report a first attempt of assessment of Lego® Therapy's effect on the specific area of cognitive skills in an ASD child. Over a period of 12 months, a child with ASD had weekly meetings with an expert operator of Lego® aiming to improve the child's ability to communicate, reduce impulsiveness and hyper verbalism, and encourage pro-social behavior. The intervention resulted in positive outcomes that were assessed after 12 months.

Nicoletta Vegni

Caterina D'Ardia

Gloria Di Filippo

Francesco Maria Melchiori

AIMS neuroscience

The impact of Lego® Therapy on cognitive skills in Autism Spectrum Disorders: a brief discussion

乐高®疗法对自闭症谱系障碍认知技能的影响：简要讨论

&lt;p&gt;Transcranial alternating current stimulation (tACS) at 5-Hz to the right hemisphere can alleviate anxiety symptoms. We aimed to explore the connectivity changes following the treatment. We collected electroencephalography (EEG) data from 24 participants with anxiety disorders before and after the tACS treatment during a single session. Electric stimulation was applied over the right hemisphere, with 1.0 mA at F4, 1.0 mA at P4, and 2.0 mA at T8, following the 10-10 EEG convention. With eLORETA, the scalp signals were transformed into the cortex's current source density. We assessed the connectivity changes at theta frequency between the centers of Brodmann area (BA) 6/8 (frontal), BA 39/40 (parietal), and BA 21 (middle temporal). Functional connectivity was indicated by lagged coherences and lagged phase synchronization. Paired t-tests were used to quantify the differences statistically. We observed enhanced lagged phase synchronization at theta frequency between the frontal and parietal regions (&lt;italic&gt;P&lt;/italic&gt; = 0.002) and between the parietal and temporal regions (&lt;italic&gt;P&lt;/italic&gt; = 0.005) after Bonferroni correction. Applying tACS 5-Hz over the right hemisphere enhanced inter-regional interaction, which was spectrum-specific and mainly mediated by phase rather than power synchrony. The potential neural mechanisms are discussed.&lt;/p&gt;

Tien-Wen Lee

Gerald Tramontano

Connectivity changes following transcranial alternating current stimulation at 5-Hz: an EEG study

5-Hz经颅交流电刺激后连接性变化：一项脑电图研究

&lt;p&gt;The purpose of the present study was to investigate the effects of neuromodulation techniques, including transcranial direct current stimulation, transcranial magnetic stimulation, and deep brain stimulation, on the treatments of nicotine dependence. Specifically, our objective was to assess the existing evidence by conducting an umbrella review of systematic reviews. The quality of the included studies was evaluated using the standardized tools designed to evaluate systematic reviews. The PubMed/MEDLINE database was queried for systematic reviews, and yielded 7 systematic reviews with a substantial sample size (N = 4,252), some of which included meta-analyses. A significant finding across these studies was the effectiveness of neuromodulation techniques to reduce nicotine cravings and consumption, through the evidence remains not yet conclusive. A significant efficacy of transcranial direct current stimulation and repetitive transcranial magnetic stimulation that targeted the dorsolateral prefrontal cortex was found, as well as the lateral prefrontal cortex and insula bilaterally, on smoking frequency and craving. Moreover, smoking behaviors may also be positively affected by the use of deep brain stimulation (DBS) targeting the nucleus accumbens. In conclusion, neuromodulation approaches hold promise as effective treatments for tobacco use disorder. Nonetheless, further research is required to comprehensively understand their effectiveness and to determine if combining them with other treatments can aid individuals to successfully quit smoking.&lt;/p&gt;

Graziella Orrù

Marina Baroni

Ciro Conversano

Angelo Gemignani

Exploring the therapeutic potential of tDCS, TMS and DBS in overcoming tobacco use disorder: an umbrella review

探索tDCS、TMS和DBS在克服烟草使用障碍中的治疗潜力：一项伞形综述

&lt;sec&gt;&lt;title&gt;Purpose&lt;/title&gt;&lt;p&gt;The cyclic AMP response element–binding protein (CREB) and nerve growth factor (NGF) have been proposed as key modulators of brain health and are involved in synaptic plasticity. The study investigates how combined water-based training affects hippocampal neuron plasticity and memory function in old rats.&lt;/p&gt;&lt;/sec&gt;&lt;sec&gt;&lt;title&gt;Methods&lt;/title&gt;&lt;p&gt;16 Wistar male rats 24-month-old were randomly divided into two groups: combined training (n = 8) and control (n = 8). Four sessions were performed per week for 10 weeks, and consisted of resistance and endurance training in water. The control group was placed in a water container during training for 30 minutes to be homogenized in terms of the stress conditions. The.NGF and CREB genes in the hippocampus were evaluated and the working memory was measured using real-time PCR and Y-maze tests. The SPSS 26 software was utilized in which independent t-tests were used to analyze the genes and the Mann-Whitney U test was used to analyze functional memory with a significant level of (P &amp;lt; 0.05).&lt;/p&gt;&lt;/sec&gt;&lt;sec&gt;&lt;title&gt;Results&lt;/title&gt;&lt;p&gt;The combined training resulted in a significant rise in NGF and CREB gene expression in the hippocampus tissue of elderly rats compared to the control group (P &amp;lt; 0.05); however, there was no notable difference in the Y maze performance test between the two groups (P &amp;lt; 0.05).&lt;/p&gt;&lt;/sec&gt;&lt;sec&gt;&lt;title&gt;Conclusions&lt;/title&gt;&lt;p&gt;These findings suggest that water-based combined training has beneficial effects on gene expression of NGF and CREB; however, it is necessary to conduct more studies to comprehend the effects of combined training on memory function.&lt;/p&gt;&lt;/sec&gt;

Roya. Askari

Mohadeseh. NasrAbadi

Amir Hossein. Haghighi

Mohammad Reza. Jahanmahin

Rajabi Somayeh

Matteo. Pusceddu

Effect of combined training in water on hippocampal neuronal Plasticity and memory function in healthy elderly rats

水环境中联合训练对健康老年大鼠海马神经可塑性和记忆功能的影响

&lt;sec&gt;&lt;title&gt;Background&lt;/title&gt;&lt;p&gt;Older individuals are at a particular risk of sleep disorders, a loss of cognitive and emotional control, and a poor quality of life. Pharmaceutical therapy for these conditions is commonplace but has not been particularly effective, and relatively little research exists for their treatment using non-pharmacological approaches. The effectiveness of Physical Activity plus selected components of Amygdala and Insula Retraining (PAAIR) was tested to improve sleep quality, depression, working memory, and emotion regulation among older males.&lt;/p&gt;&lt;/sec&gt;&lt;sec&gt;&lt;title&gt;Methods&lt;/title&gt;&lt;p&gt;This was a parallel, randomized control trial. The study was conducted in-person among 40 older Iranian men (&lt;italic&gt;M&lt;/italic&gt;&lt;sub&gt;age&lt;/sub&gt;: 65.78, &lt;italic&gt;SD&lt;/italic&gt; = 2.41). The participants were randomly assigned with equal allocation to either the PAAIR or a control condition. Both interventions were conducted in-person over 12 weeks. The participants met twice weekly for 45-minute sessions at a local elderly training and rehabilitation center. All participants completed measurements for sleep quality, depressive symptoms, working memory, and emotion regulation at baseline, 12 weeks (immediately after the intervention), and 8 weeks later.&lt;/p&gt;&lt;/sec&gt;&lt;sec&gt;&lt;title&gt;Results&lt;/title&gt;&lt;p&gt;Among the 36 individuals who finished the study, their sleep quality, working memory, and emotion regulation improved, and their depressive symptoms were reduced from baseline to 12 weeks (post-intervention) and 8 weeks later; these effects were seen even more so for the PAAIR group compared to the control group, with large to extremely large effect sizes.&lt;/p&gt;&lt;/sec&gt;&lt;sec&gt;&lt;title&gt;Conclusion&lt;/title&gt;&lt;p&gt;The findings suggest that PAAIR has the potential to enhance sleep quality, cognitive function, and emotion regulation and reduce depressive symptoms among older men, thus contributing to their quality of life and mental health.&lt;/p&gt;&lt;/sec&gt;

Monireh Asadi Ghaleni

Forouzan Fattahi Masrour

Narjes Saryar

Alexandra J. Bratty

Ebrahim Norouzi

Matheus Santos de Sousa Fernandes

Georgian Badicu

Effects of an intervention combining physical activity and components of Amygdala and Insula Retraining (AIR) on sleep and working memory among older male adults

干预结合身体活动与杏仁核和岛叶再训练（AIR）成分对老年男性睡眠和工作记忆的影响

&lt;sec&gt;&lt;title&gt;Background&lt;/title&gt;&lt;p&gt;Schizophrenia is characterized by significant cognitive impairments and affects up to 98% of patients. Neurofeedback (NF) offers a means to modulate neural network function through cognitive processes such as learning and memorization, with documented structural changes in the brain, most notably an increase in grey matter volume in targeted regions.&lt;/p&gt;&lt;/sec&gt;&lt;sec&gt;&lt;title&gt;Methods&lt;/title&gt;&lt;p&gt;The present 2-week, open-label, preliminary study aims to evaluate the efficacy on cognition of an adjunctive short and intensive (8 daily sessions lasting 30 minutes) alpha/theta NF training in a sample of subjects affected by schizophrenia on stabilized treatment with atypical antipsychotic drugs. The efficacy was measured at baseline and at the end of the study by the Brief Neuropsychological Examination 2 (ENB 2), the Mini Mental State Examination (MMSE), and the Stroop color-word interference test; the clinical symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS).&lt;/p&gt;&lt;/sec&gt;&lt;sec&gt;&lt;title&gt;Results&lt;/title&gt;&lt;p&gt;A final sample of nine patients completed the study. Regarding the cognitive performance, at the final assessment (week 2), the NF treatment significantly improved the performance in the “Story Recall Immediate” (p = 0.024), “Story Recall Delayed” (p = 0.007), “Interference Memory 30 s” (p = 0.024), “Clock Test” (p = 0.014) sub-tests, and the ENB2 Total Score (p = 0.007). Concerning the clinical symptoms, no significant changes were observed in the PANSS subscales and the PANSS Total score.&lt;/p&gt;&lt;/sec&gt;&lt;sec&gt;&lt;title&gt;Conclusions&lt;/title&gt;&lt;p&gt;NF could represent an adjunctive treatment strategy in the therapeutic toolbox for schizophrenia cognitive symptoms.&lt;/p&gt;&lt;/sec&gt;

Fabrizio Turiaco

Fiammetta Iannuzzo

Giovanni Genovese

Clara Lombardo

Maria Catena Silvestri

Laura Celebre

Maria Rosaria Anna Muscatello

Antonio Bruno

Cognitive effects of brief and intensive neurofeedback treatment in schizophrenia: a single center pilot study

精神分裂症短期与强化神经反馈治疗的认知效果：一项单中心初步研究

acBWQ6	AIMS Neurosci.
Journal Impact	2.93
mbqgSu	NEUROSCIENCES(Q2)

ISSN	2373-7972, 2373-8006
h-index	18

u9zg3I	心理学生物医学神经科学精神科内科学计算机科学化学内分泌学生物化学认知遗传学认知心理学病理物理哲学人工智能数学
+5d/bs	e+/GRg: AIMS Press，uzYam8: ，dxwaWB: journal，8x2mMQ: Xn96QY
ak9yM6	A7IHrH: 2014，sQJ/D8: 66.67%，sE9og+:3.20%， wzlKC/: 100.00%
OtlFwL	$5008By/Hf
JrpmBe	网友分享经验：8 Weeks

AIMS Neuroscience

uM3Gfz

sZFHBm

sZFHBm

sZFHBm

sZFHBm

Hi2Sc4

e7MLUV

XjnQ+b

Kq5Kd6

LB2xFn

XmiM++

The impact of Lego® Therapy on cognitive skills in Autism Spectrum Disorders: a brief discussion

Connectivity changes following transcranial alternating current stimulation at 5-Hz: an EEG study

Exploring the therapeutic potential of tDCS, TMS and DBS in overcoming tobacco use disorder: an umbrella review

Effect of combined training in water on hippocampal neuronal Plasticity and memory function in healthy elderly rats

Effects of an intervention combining physical activity and components of Amygdala and Insula Retraining (AIR) on sleep and working memory among older male adults

Connectivity changes following transcranial alternating current stimulation at 5-Hz: an EEG study

Exploring the therapeutic potential of tDCS, TMS and DBS in overcoming tobacco use disorder: an umbrella review

Effect of combined training in water on hippocampal neuronal Plasticity and memory function in healthy elderly rats

Effects of an intervention combining physical activity and components of Amygdala and Insula Retraining (AIR) on sleep and working memory among older male adults

Cognitive effects of brief and intensive neurofeedback treatment in schizophrenia: a single center pilot study