American Journal of Reproductive Immunology and Microbiology

ABSTRACT: Prostaglandins, steroids, and their metabolites that are known to be produced by the conceptus, maternal endometrium, and placenta of the cow and sheep were tested for their ability to inhibit in vitro blastogenesis of bovine and ovine lymphocytes. Prostaglandin E 2 (PGE 2 ) suppressed PHA‐ and mixed lymphocyte reaction‐induced blastogenesis in a log‐linear, concentration‐dependent manner, exerting its inhibitory effect at a final concentration of 10 −8 M and higher. PGE 2 also inhibited IL‐2 ‐dependent proliferation of lymphocytes, but to a lesser degree than for PHA‐treated cultures. Progesterone and estradiol‐17β also inhibited [ 3 H] thymidine incorporation into PHA‐stim‐ulated lymphocytes, but only at a pharmacological concentration of 10 −5 M. No synergy between PGE 2 and progesterone in inhibiting lymphocyte proliferation was observed. Estrone, PGF 2α , 15‐keto‐13,14‐dihydro‐PGF 2α , and two metabolites of progesterone (5β‐preg‐nane‐3,20‐dione and 5β‐pregnane‐3,20‐diol) had no effect on lymphocyte proliferation. By virtue of its continual production at the fetal‐maternal interface throughout pregnancy, PGE 2 may be an important local immunoregulatory agent to protect the allogeneic fetus from maternal immunological attack in the cow and ewe.

B.G. LOW

P.J. HANSEN

American Journal Of Reproductive Immunology

Actions of Steroids and Prostaglandins Secreted by the Placenta and Uterus of the Cow and Ewe on Lymphocyte Proliferation In Vitro

牛和绵羊胎盘及子宫分泌的类固醇和前列腺素对体外淋巴细胞增殖的作用

American Journal of Reproductive Immunology and MicrobiologyVolume 18, Issue 4 p. 131-131 The Physiology of Reproduction, Edited by Ernst Knobil, Jimmy D. Neill Stephen A. Myers, Stephen A. Myers Director Division of Maternal/Fetal Medicine Mount Sinai Hospital Medical Center of Chicago California Avenue at 15th Street Chicago, IL 60608Search for more papers by this author Stephen A. Myers, Stephen A. Myers Director Division of Maternal/Fetal Medicine Mount Sinai Hospital Medical Center of Chicago California Avenue at 15th Street Chicago, IL 60608Search for more papers by this author First published: December 1988 https://doi.org/10.1111/j.1600-0897.1988.tb00249.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume18, Issue4December 1988Pages 131-131 RelatedInformation

Stephen A. Myers

<i>The Physiology of Reproduction</i>, Edited by Ernst Knobil, Jimmy D. Neill

《生殖生理学》，由恩斯特·克努比尔和吉米·D·尼尔编辑

ABSTRACT: Antigenic differences between mother and fetus (i.e., blood group incompatibilities) were traditionally considered deleterious for viviparous reproduction. Recently, evidence has accumulated suggesting that maternal response to paternally derived fetal antigens, paradoxically, may facilitate maintenance of pregnancy. Thus, fetuses whose paternally derived antigens do not differ from maternal antigens (i.e., histocompatible pregnancies) may be at a selective disadvantage during pregnancy. Parents sharing histocompatibility antigens (i.e., HLA) may produce compatible fetuses and show overall reduced fertility. Indeed, increased HLA sharing has been reported in some couples experiencing repetitive spontaneous abortion. However, the effects of HLA sharing in couples not selected because of previous pregnancy losses have not been assessed. To elucidate the reproductive effects of maternal‐fetal histocompatibility, we initiated prospective population‐based studies of parental HLA sharing and reproductive outcome in the Hutterites, a population isolate that lives communally and proscribes contraception. The relationship between HLA‐A, ‐B, and ‐DR sharing and reproductive outcome was examined in 111 Hutterite couples. Intervals from marriage to each birth were no longer among couples sharing antigens; differences were significant at the second birth and remained significant through the sixth birth (P &lt; .05). When the effects of sharing at individual loci were examined, HLA‐DR was the only individual locus that was a significant predictor of birth interval length (P = .025). Completed family sizes were 6.5 and 9.0 among couples sharing and not sharing HLA‐DR, respectively (P = .082, 2‐tailed). However, recognized fetal loss rates did not differ among couples sharing and not sharing antigens. We interpret these results as evidence for reduced fertility among some Hutterite couples sharing HLA, as a result of maternal‐fetal compatibility for HLA‐DR, per se, or alleles at an undefined, HLA‐DR‐linked locus. Our data further suggest that longer intervals associated with HLA‐DR sharing may result from losses occurring early in gestation, before Hutterites would recognize pregnancy.

CAROLE OBER

SHERMAN ELIAS

ELIZABETH O'BRIEN

DONNA D. KOSTYU

WALTER W. HAUCK

ALLEN BOMBARD

HLA Sharing and Fertility in Hutterite Couples: Evidence for Prenatal Selection Against Compatible Fetuses

Hutterite夫妇中的HLA共享与生育力：对兼容胎儿产前选择的证据

ABSTRACT: Investigators testing for antisperm antibodies have recently focused on tests that detect the Ig classes of the sperm‐bound antibodies. The aim of this study was to compare the sensitivity of two of these tests, viz. the immunobead binding technique (IBT) and the mixed antiglobulin reaction (MAR). Twenty‐one male or female sera were tested for IgG and IgA antisperm antibodies with the IBT and the MAR. The sera were selected on the basis of the IBT results, and the MAR was carried out without knowledge of these results. For IgG antisperm antibodies, there was a highly significant correlation between the two tests ( P = 0.0043), whereas, for IgA antisperm antibodies, the correlation was poor ( P = 0.2951), because the IBT revealed a positive reaction for IgA in sera in which no such antibodies could be detected by the MAR.

HELLE MEINERTZ

RICHARD BRONSON

Detection of Antisperm Antibodies on the Surface of Motile Spermatozoa. Comparison of the Immunobead Binding Technique (IBT) and the Mixed Antiglobulin Reaction (MAR)

活动精子表面抗精子抗体的检测：免疫珠结合技术（IBT）与混合抗球蛋白反应（MAR）的比较

American Journal of Reproductive Immunology and MicrobiologyVolume 18, Issue 4 p. 140-140 EDITORIAL NORBERT GLEICHER M.D., NORBERT GLEICHER M.D. Editor-in-Chief, AJRIM Department of Obstetrics/Gynecology Mount Sinai Hospital Medical Center of ChicagoSearch for more papers by this author NORBERT GLEICHER M.D., NORBERT GLEICHER M.D. Editor-in-Chief, AJRIM Department of Obstetrics/Gynecology Mount Sinai Hospital Medical Center of ChicagoSearch for more papers by this author First published: December 1988 https://doi.org/10.1111/j.1600-0897.1988.tb00251.xCitations: 1AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume18, Issue4December 1988Pages 140-140 RelatedInformation

NORBERT GLEICHER

EDITORIAL

社论

G. Wienrich

H.-C. Schuppe

M. Schon

M.P. Schon

LEEP-CAM (LYMPHOCYTE ENDOTHELIAL EPITHELIAL-CELL ADHESION MOLECULE) - DETECTION OF A NEW CELL ADHESION MOLECULE IN HUMAN TESTIS

LEEP-CAM（淋巴细胞内皮细胞粘附分子）- 在人睾丸中发现的一种新型细胞粘附分子

U. Paasch

S. Grunewald

H.-J. Glander.

Sperm with damaged membranes are profoundly at risk to have caspases 8, 9 and 3 activated

膜受损的精子极易激活胱天蛋白酶8、9和3

Gerard Chaouat

Natalie Ledee

Sylvie Dubanchet

Sandrine Zourbas

Olivier Sandra

Jacques Martal

Rene Frydman

Cytokines in pregnancy and implantation/early abortion: re-examining the TH1/TH2 paradigm

妊娠与着床/早期流产中的细胞因子：重新审视TH1/TH2范式

Justine S. Fitzgerald

Tobias Pohlmann

Rita Neundorf

Udo R. Markert

Trophoblast derived indoleamine-dioxygenase induced regulation of stat3 expression in allogeneic lymphocytes

滋养层来源的吲哚胺-双加氧酶诱导的异基因淋巴细胞中STAT3表达的调控

Gabriela Gutierrez

Adriana Sarto

Luciana Berod

Teresa Gentile

R.A. Margni

S. Pasqualini

Up-Regulation of TH2 feto-placental levels could be involved in the protective effect of low-molecular-weight heparin treatment on spontaneous abortion in mice

低分子量肝素治疗对小鼠自然流产的保护作用可能与TH2胎盘水平的升高有关

Publication Information	Publisher: Wiley-Blackwell Publishing Ltd，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 1994，Proportion of original research papers: ，Self Citation Rate:， Gold OA Rate:

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