AIMS Biophysics is an international Open Access journal devoted to publishing peer-reviewed, high quality, original papers in the field of biophysics. We publish the following article types: original research articles, reviews, editorials, letters, and conference reports.    AIMS Biophysics welcomes, but not limited to, the papers from the following topics:    · Structural biology  · Biophysical technology  · Bioenergetics  · Membrane biophysics  · Cellular Biophysics  · Electrophysiology  · Neuro-Biophysics  · Biomechanics  · Systems biology

AIMS Biophysics is an international Open Access journal dedicated to publishing peer-reviewed, high-quality original papers in the field of biophysics. We publish various types of articles, including original research articles, reviews, editorials, letters, and conference reports. AIMS Biophysics welcomes papers on a wide range of topics, including but not limited to: structural biology, biophysical technology, bioenergetics, membrane biophysics, cellular biophysics, electrophysiology, neuro-biophysics, biomechanics, and systems biology.

《AIMS Biophysics》是一本国际开放获取期刊，致力于发表经过同行评审的高质量原创论文，涵盖生物物理学领域。我们接受以下类型的文章：原创研究文章、综述、社论、信件和会议报告。《AIMS Biophysics》欢迎但不限于以下主题的论文：结构生物学、生物物理技术、生物能量学、膜生物物理学、细胞生物物理学、电生理学、神经生物物理学、生物力学和系统生物学。

AIMS Biophysics

Photobiomodulation (PBM) also known as low-level level laser therapy is the use of red and near-infrared light to stimulate healing, relieve pain, and reduce inflammation. The primary chromophores have been identified as cytochrome c oxidase in mitochondria, and calcium ion channels (possibly mediated by light absorption by opsins). Secondary effects of photon absorption include increases in ATP, a brief burst of reactive oxygen species, an increase in nitric oxide, and modulation of calcium levels. Tertiary effects include activation of a wide range of transcription factors leading to improved cell survival, increased proliferation and migration, and new protein synthesis. There is a pronounced biphasic dose response whereby low levels of light have stimulating effects, while high levels of light have inhibitory effects. It has been found that PBM can produce ROS in normal cells, but when used in oxidatively stressed cells or in animal models of disease, ROS levels are lowered. PBM is able to up-regulate anti-oxidant defenses and reduce oxidative stress. It was shown that PBM can activate NF-kB in normal quiescent cells, however in activated inflammatory cells, inflammatory markers were decreased. One of the most reproducible effects of PBM is an overall reduction in inflammation, which is particularly important for disorders of the joints, traumatic injuries, lung disorders, and in the brain. PBM has been shown to reduce markers of M1 phenotype in activated macrophages. Many reports have shown reductions in reactive nitrogen species and prostaglandins in various animal models. PBM can reduce inflammation in the brain, abdominal fat, wounds, lungs, spinal cord.

Michael R Hamblin

1 Wellman Center for Photomedicine Massachusetts General Hospital BAR414 40 Blossom Street Boston MA 02114 USA

2 Department of Dermatology Harvard Medical School Boston MA 02115 USA

3 Harvard-MIT Division of Health Sciences and Technology Cambridge MA 02139 USA

Mechanisms and applications of the anti-inflammatory effects of photobiomodulation

光生物调节抗炎作用机制及应用

In the recent years microfluidic technology has affirmed itself as a powerful tool in medical and biological research. Among the different applications, cell manipulation has been widely investigated. Micro-flowcytometers, micromixers, cell sorters and analyzers are only few examples of the developed devices. Various methods for cell manipulation have been proposed, such as hydrodynamic, magnetic, optical, mechanical, and electrical, in this way categorized according to the manipulating force employed. In particular, when cells are manipulated by hydrodynamic effects, there is no needing of applying external forces. This brings to a simplification in the design and fabrication phase, and at the same time undesired effects on the biological sample are limited. In this paper, we will discuss the physics of the relevant hydrodynamic effects in microfluidics, and how they are exploited for cell manipulation.

Stefania Torino

Mario Iodice

Ivo Rendina

Giuseppe Coppola

Microfluidic technology for cell hydrodynamic manipulation

用于细胞流体动力学操控的微流控技术

&lt;p&gt;“Faster diagnosis, better outcomes: Biosensors pave the way for a brighter future for cancer patients”. As one of the top causes of death worldwide, cancer must be addressed with the help of innovative treatments and state-of-the-art diagnostic techniques. Due to stress, poor lifestyle choices, and environmental factors, cancer incidence is worryingly on the rise in India, especially among the younger generation. In India, 1 in 5 persons may receive a cancer diagnosis by 2025, potentially impacting 1.57 million people, even though 30–50% of cancers are preventable. Even though standard screening techniques are frequently too costly and impracticable for everyday use, early detection is vital. Alternatives that show promise include emerging biosensor technologies, which give quick, accurate, and customized diagnostic results. Due to its capacity to quickly and automatically identify biological changes, ultra-sensitive biosensing systems utilizing single chips have revolutionized cancer detection. Since they are more effective than conventional techniques, point-of-care (PoC) biosensors—such as innovative nano-sensing devices for exosomal micro-RNA analysis—are becoming increasingly popular. Developing sophisticated diagnostic instruments like bio-computers and resonant mirrors is made easier by these biosensors, which combine analytes, receptors, and electrical sensors to detect cancer biomarkers in biological samples. The accuracy and usability of detection are further improved by advancements in wearable technologies, microfluidics, and electrochemical and graphene-based sensors. BrCyS-Q and NanoLiposomes provide improved photodynamic treatment and targeted medication delivery, respectively. Improved patient outcomes and early intervention are anticipated using the i-Genbox, a colorimetric sensor based on LAMP technology, and DNA-SWCNT-based sensors that further improve biomarker identification for gynecologic tumors.&lt;/p&gt;

Dinesh Bhatia

Tania Acharjee

Monika Bhatia

Advancements in nanosensors for cancer detection

癌症检测用纳米传感器的发展

&lt;p&gt;Historically, essential oils (Eos) have been applied in diverse ways, with modern science confirming their antimicrobial, antioxidant, anti-inflammatory, and neuroprotective properties. &lt;italic&gt;Origanum vulgare&lt;/italic&gt; (oregano) is a notable source of EOs, being particularly rich in compounds like thymol, carvacrol, and β-caryophyllene, which contribute to its potent antibacterial effects. These include disruption of bacterial cell membranes, interference with quorum sensing, and inhibition of biofilm formation. Oregano EO has shown effectiveness against both antibiotic-resistant and non-resistant bacterial strains, such as &lt;italic&gt;Escherichia coli&lt;/italic&gt;, &lt;italic&gt;Staphylococcus aureus&lt;/italic&gt;, and &lt;italic&gt;Pseudomonas aeruginosa&lt;/italic&gt;. The components of this EO disrupt membrane integrity, ion transport, membrane surface charge, biofilm formation, and other biophysical parameters, eventually leading to cell death. Research highlights its potential in combatting antibiotic resistance, either alone or in synergy with traditional antibiotics. Additionally, oregano EO holds promise as a natural therapeutic agent. Continued study of its complex chemical interactions will further elucidate its full potential in antimicrobial therapy. This review article presents the possible mechanisms of the antimicrobial action of oregano essential oil and its application prospects.&lt;/p&gt;

Armenuhi Moghrovyan

Naira Sahakyan

Antimicrobial activity and mechanisms of action of &lt;i&gt;Origanum vulgare&lt;/i&gt; L. essential oil: effects on membrane-associated properties

牛至精油的抗菌活性及其作用机制：对膜相关特性的影响

&lt;p&gt;Nanomedicine, which is blazing new trails in modern healthcare, exploits the distinctive attributes of nanoparticles (NPs) to reimagine diagnosis and therapy. With imaging, this “magic ammunition” enhances the capability of MRI, a noninvasive, high-resolution technology that can pinpoint cancers with astonishing precision. Unlike traditional treatments, which muddle the distinction between diseased and healthy tissue, gold nanoparticles (AuNPs) directly target tumors, using increased permeability and retention (EPR) effects for crystal-clear, early-stage detection. While gadolinium (Gd (III)) T1 agents are the most widely used in clinical practice, iron oxide T2 agents have fallen out of favor due to failing to perform. Beyond imaging, NPs offer a “one-two punch” in the treatment of complicated disorders by enabling photothermal (PTT), photodynamic (PDT), and multimodal therapies (MMT), as well as nano drug delivery systems (NDDS). This nanotechnology-based technique personalizes medicines for diseases such as tuberculosis (TB) and cardiovascular disease (CVD), focusing on damaged tissues to improve therapeutic response. In tuberculosis, NPs circumvent medication resistance by delivering medicines directly to infected cells, thus avoiding biological barriers that impede standard treatments. Similarly, in CVD, NPs target arterial plaques to improve treatment accuracy while reducing systemic adverse effects. Furthermore, the genomic “blueprint” is evolving parallel to nanotechnology, with India's “Genome India” initiative mapping 10,000 genomes, lighting the path for genetic chips suited for specific disorders and moment tests. The convergence of nanotechnology and genomes is an arcade modification, bringing accuracy and personalization to the forefront of cancer and tuberculosis treatment.&lt;/p&gt;

Shruti Shukla

Nano-technological advancements in multimodal diagnosis and treatment

多模态诊断与治疗中的纳米技术进展

&lt;p&gt;Increasing interest in biopolymers moves their knowledge frontiers. One area undergoing this development is polysaccharides. The practical and theoretical significance of studying polysaccharides lies in the numerous essential functions these macromolecules fulfill in living organisms, and the important industrial and technological purposes they serve. Polysaccharides are thought to be abundant in marine microalgae; nevertheless, little is known about their sulfated polysaccharides. We studied &lt;italic&gt;Chaetoceros muelleri&lt;/italic&gt; sulfated polysaccharide (CMSP) chain conformation, physical characteristics, and morphology. The CMSP spectrum generated from Fourier-transform infrared analysis displayed distinctive bands for these macromolecules. S=O and C–O–S signals were detected at 1225 and 820 cm&lt;sup&gt;−1&lt;/sup&gt;, respectively, confirming the presence of sulfate in the molecules. The biopolymer registered weight-average molar mass, intrinsic viscosity ([&lt;italic&gt;η&lt;/italic&gt;]), radius of gyration (RG), hydrodynamic radius (Rh), and sulfate degree of substitution of 1933 kDa, 577 mL/g, 62 nm, 44 nm, and 0.5 (sulfates per disaccharide repeat unit), respectively. The exponent α and the coefficient K in the Mark-Houwink-Sakurada (MHS) equation were 0.76 and 9.76 x 10&lt;sup&gt;−3&lt;/sup&gt; mL/g, respectively. These values suggest a flexible and compact random coil structure in CMSP. The sample's zeta potential (ζ), conductivity, and diffusion coefficient (D) were −26.43 mV, −2.07 µm cm/s V, 1.25 mS/cm, and 1.8 × 10&lt;sup&gt;−8&lt;/sup&gt; cm&lt;sup&gt;2&lt;/sup&gt;/s, correspondingly. The negative charge in the molecules is related to the sulfate groups contained. The CMSP surface was coarse and craggy, according to scanning electron microscopy (SEM). The information generated in this present study contributes to elucidating characteristics as fundamental knowledge to understand the macromolecule functionality.&lt;/p&gt;

Valeria Miranda-Arizmendi

Jorge Marquez-Escalante

Agustin Rascon-Chu

Karla Martínez-Robinson

Francisco Brown-Bojorquez

Elizabeth Carvajal-Millan

&lt;i&gt;Chaetoceros muelleri&lt;/i&gt; sulfated polysaccharides: chain conformation, physical characteristics, and morphology

<i>Chaetoceros muelleri</i>硫酸化多糖：链构象、物理特性和形态

&lt;p&gt;To analyze thermal effects caused by mobile phones on the human auricle region, we performed an experiment with controlled exposure to mobile phones operating in different modes for a group of 40 men. Temperature changes were measured with the use of infrared thermography. Thermograms were taken before and after a standardized 15-minute phone call when the mobile phone was placed lightly against the skin surface in the auricle region. The measurements were performed in three modes: OFF, ON, and FLIGHT. Statistically significant differences (p = 0.03) were observed between the experimental temperature increase of the auricle region in OFF mode (average temperature rise = 1.1 °C ± 0.2 °C) and in ON mode (average temperature rise = 1.9 °C ± 0.3 °C), while between FLIGHT (average temperature rise = 1.4 °C ± 0.2 °C) and ON modes, no statistical differences were observed (p = 0.20). Based on thermographic measurements and the model of heat transfer between the ear and the phone, it was shown that the human ear is the largest heat source in the system and that the increase in skin temperature is mainly caused by the handheld mobile phone restricting heat dissipation from the skin surface.&lt;/p&gt;

Tomasz Rok

Artur Kacprzyk

Eugeniusz Rokita

Dorota Kantor

Grzegorz Tatoń

Quantitative assessment of thermal effects on the auricle region caused by mobile phones operating in different modes

不同模式下手机操作对耳廓区域热效应的定量评估

Abbreviation	AIMS Biophys.
Journal Impact	1.00
Quartiles(Global)	BIOPHYSICS(Q4)

ISSN	2377-9098
h-index	18

Publication Information	Publisher: AIMS Press，Publishing cycle: ，Journal Type: journal，Open Access Journals: Yes
Basic data	Year of publication: 2014，Proportion of original research papers: 88.89%，Self Citation Rate:27.30%， Gold OA Rate: 96.05%
Journal Fees	$500Details
Average review cycle	网友分享经验：8 Weeks

AIMS Biophysics

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Mechanisms and applications of the anti-inflammatory effects of photobiomodulation

Microfluidic technology for cell hydrodynamic manipulation

Advancements in nanosensors for cancer detection

Antimicrobial activity and mechanisms of action of <i>Origanum vulgare</i> L. essential oil: effects on membrane-associated properties

Nano-technological advancements in multimodal diagnosis and treatment

Advancements in nanosensors for cancer detection

Antimicrobial activity and mechanisms of action of <i>Origanum vulgare</i> L. essential oil: effects on membrane-associated properties

Nano-technological advancements in multimodal diagnosis and treatment

<i>Chaetoceros muelleri</i> sulfated polysaccharides: chain conformation, physical characteristics, and morphology

Quantitative assessment of thermal effects on the auricle region caused by mobile phones operating in different modes