Archives of Breast Cancer

Objectives: Breast cancer is a major public health in Algeria. Tamoxifen has been approved in the treatment of ER+ breast cancer. Some of negative side effects of tamoxifen are frequently a reason for discontinuation of therapy during treatment, which would otherwise be potentially lifesaving. In the current study, we assessed the association between CYP2D6 polymorphisms and tamoxifen efficacy in Algerian population receiving tamoxifen as adjuvant therapy in ER+ breast cancer. Methods: A total of 76 Algerian hormone receptor-positive premenopausal breast cancer patients with adjuvant tamoxifen treatment were investigated (45.36±6.13). DNA genotyping was performed by TaqMan Open Array technology. Tamoxifen and its metabolites levels were measured by ultra-high-performance liquid chromatography (UHPLC) followed by electro spray tandem mass spectrometry (LC-MS/MS). Results: A significant association between the presence of deficit copy of enzyme activity and development of adverse effect after the commencement of tamoxifen therapy. Low plasma endoxifen were observed in patients categorized as (NM/PM), (IM/ IM), (IM/PM) and (PM/PM). Patients with increased plasma endoxifen concentrations were significantly more likely than patients with reduced or null activity to not report recurrences (P&lt;0.05). We realized that the combination genotypes NM/PM, IM/IM, IM/PM, with PM/PM were more strongly associated with disease recurrence and adverse effects than NM carries of CYP2D6*1 allele (P&lt;0.05). Conclusion: Our results affirm that CYP2D6 polymorphism should be considered in predicting the occurrence of adverse effect fatty liver in women treated with tamoxifen. Thus, alternative treatment can be intended and lifestyle modifications can be implemented

Amira Boucenna

Ahmed Hirech

Rezgoune Mohamed Larbi

Dalila Satta

IMPACT OF CYP2D6 POLYMORPHISMS IN PREDUCTING OCCURRENCE OF ADVERSE EFFECT TO TAMOXIFEN AND DEVELOPING RECCURENCE IN ER+ BREAST CANCER PATIENETS:

CYP2D6多态性在预测ER+乳腺癌患者对他莫昔芬不良反应发生及复发中的影响：

Bасkgrоunds: Аll оf thе еlеmеnts оf thе mеtаbоliс sуndrоmе(MS) саn аffесt thе dеvеlорmеnt оf brеаst саnсеr(BC) аnd its mаnifеstаtiоns thrоugh diffеrеnt mесhаnisms. This studу аims tо еvаluаtе thе mаnifеstаtiоn оf раthоmоrрhоlоgiсаl fеаturеs оf саnсеr in BC wоmеn with MS аnd еvаluаtе relationship between serum level of IL-6 and hystological characteristics of tumor in BC. Mеthоds: Thе рrеsеnt cross sectional studу inсludеd 55 раtiеnts with а diаgnоsis оf рrеmеnораusаl BC in thе Dераrtmеnt оf Brеаst Саnсеr, Rерubliсаn Cancer Сеntеr of Uzbеkistаn, frоm Осtоbеr 2022 tо Nоvеmbеr 2023. Wе dеtеrminеd thе еffесt оf MS to сliniсораthоlоgiсаl fеаturеs оf brеаst саnсеr. We determined serum level of IL-6 with method of IFA. Rеsults: 31 patients(56.36%) were with MS, аnd 24(43.63%) wеrе withоut MS of all BC patients. Thе rеsults оf оur studу suggеst thаt MS mау аffесt thе histоlоgiсаl mаnifеstаtiоns оf BC in рrеmеnораusаl wоmеn. Sеrum IL-6 lеvеls in рrеmеnораusаl BС wоmеn with MS аrе роsitivеlу соrrеlаtеd with сlаssiс сliniсораthоlоgiсаl раrаmеtеrs indiсаtivе оf саnсеr-аggrеssivе рhеnоtуре. Соnсlusiоn: Thеrе is а signifiсаnt соrrеlаtiоn bеtwееn thе рrеsеnсе оf MS аnd рrеmеnораusаl BC. Sеrum lеvеl of IL-6 саn bе аn indереndеnt indiсаtоr in еvаluаting сliniсаl and раthоmоrрhоlоgiсаl fеаturеs оf thе disеаsе in wоmеn with MS.

Matluba Mirzaeva

Bakhtiyor Iriskulov

Lola Alimkhodjaeva

Potential of Serum IL-6 as a Predictor of Tumоr Histоlоgiсаl Mаnifеstаtiоns in Prеmеnораusаl Brеаst Cаnсеr with Mеtаbоliс Sуndrоmе

血清IL-6作为绝经前乳腺癌合并代谢综合征患者肿瘤组织学表现的预测因子的潜力

Background : Locally advanced breast cancers are nowadays treated with neoadjuvant chemotherapy (NAC) to downstage the tumor. One way to assess the NAC response is to use “Residual cancer burden index (RCB).” The aim of the study was to assess inter-pathologist reproducibility of residual cancer burden index and to evaluate different clinico-pathological parameters that determine the pathological response. Methods: In this retrospective cohort study, surgically excised specimens of 49 NAC treated breast cancer were examined by histopathology and immunohistochemistry over a period of one and half years. Four pathologists with different level of experience reviewed the reports (unaware of original RCB index) and slides and assigned the RCB indices for each case. Clinical, histopathological and immunohistochemical parameters were evaluated.. Fleiss- Kappa statistics was applied to assess interobserver reproducibility of RCB index. Results: No significant relationship was observed between RCB index (of original report) with age, largest tumor dimension and number of chemotherapy cycles . The RCB index of 49 cases as assigned by four pathologists was calculated by Fleiss-kappa statistics and it showed good overall agreement (82.6%). Conclusion: It has been observed that there is no significant relation between pathological response to NAC with age, largest tumor dimension and number of chemotherapy cycles of breast carcinoma. It can also be concluded that RCB can be reliably used to report neoadjuvant chemotherapy treated specimens of breast cancer.

Nilanjana Mondal

Ambalika Mondal

Ratnaprabha Maji

Anup Kumar Roy

Anis Bandyopadhyay

Gopinath Barui

Arghya Bandyopadhyay

Assessment of Inter-observer Reproducibility of the Residual Cancer Burden Index and Neoadjuvant Chemotherapy Response in Breast Carcinoma

乳腺癌新辅助化疗反应及残余癌症负荷指数观察者间可重复性评估

Background: Breast cancer is among the most prevalent cancers which can effectively be screened by mammography. The spatial distribution of grey levels of the mammogram known as first-order statistical features (FOSFs) contain higher dimensional data which describe the breast composition. We aim to test these basic measures to differentiate density categories in breast cancer patients, and use them as covariates to investigate the relationship between radiologic and pathologic features of the tumor. Methods: Data from Eighty-five breast cancer subjects, their BI-RADS breast density category (a to d), percentage density (PD), and FOSFs of the mammogram including median, mean, interquartile range, kurtosis, maximum, minimum, standard deviation, skewness, and energy, were extracted. The tumor grade and the percentage of Ki67, ER, PR, and Her2 status were recorded. A linear discriminant analysis, and a support vector machine (SVM) were used to discriminate each density category from others. Then, the relation between variables were investigated using ANCOVA and regression analysis. Results: Density categories a and d were classified by SVM with high accuracy. The key feature of a and d were interquartile range and maximum intensities respectively. Reported tumor margins were related to Her2 overexpression and PR positivity. Spiculated tumor margin predicted percentage of PR expression, with a cumulative odds ratio of 7.85 (CI 2.5- 24.78), when adjusted for age, area of breast, density, and FOSFs, (p=0.0004). Conclusion: The findings of this study suggest that FOSFs can be incorporated in computer-aided systems to adjust for differences in breast composition and to refine risk profiles.

Hoda Mahdavi

Vahid Kaveh

Fatemeh Karami

Mohammad Amin Rahimi

Association between Radiological and First-Order Statistical Features of the Mammogram, and the Tumor Phenotype in Breast Cancer Patients

乳腺X线摄影的放射学特征与一阶统计特征及乳腺癌患者肿瘤表型的关联

Background: Different reports have shown that prostate and breast cancers are the most common cancers worldwide. Lupeol, a dietary triterpene, provides various beneficial effects including anti-cancer properties. The current study aims to investigate the anti-proliferative and antioxidant effects of lupeol, in line with the effects of lupeol on the expression of estrogen and androgen receptors in breast (MCF-7) and prostate (LNCaP) cancer cell lines. Methods: MCF-7 and LNCaP cells were incubated with increasing concentrations of the lupeol (1, 10, and 100 µM) for 24h. The cytotoxicity of the lupeol was assessed by MTT and Neutral Red assays. Moreover, TAC (total antioxidant capacity), and gene expression of androgen and estrogen receptors were measured by spectrophotometric and qPCR methods, respectively. Overall, 17 beta-estradiol (E2) (9 nM) and dehydroepiandrosterone (DHEA) (5 µM) were selected as positive controls. Results: The highest concentration of the lupeol induced cytotoxic effects on MCF-7 and LNCaP cells. Various levels of lupeol at specified time intervals increased TAC levels in comparison with the control group. Moreover, the expression levels of estrogen receptors (α and β) and androgen receptors were negatively affected by lupeol. Conclusion: The findings of our study indicate that lupeol could serve as a promising, and accessible multi-functional anti-tumor agent against hormone-positive breast and prostate cancers.

Mahdieh Nezami Majd

Arash Alizadeh

Elham Zadeh Hashem

Effects of Lupeol on Estrogen and Androgen Receptor-Positive Breast and Prostate Cancer Cells

羽扇豆醇对雌激素和雄激素受体阳性乳腺癌和前列腺癌细胞的影响

出版信息	出版商: Farname Scientific Publishing Inc.，出版周期: ，期刊类型: journal，开源期刊: 否
基本数据	创刊年份: 2019，原创研究文献占比: ，自引率:， Gold OA占比:

Archives of Breast Cancer

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IMPACT OF CYP2D6 POLYMORPHISMS IN PREDUCTING OCCURRENCE OF ADVERSE EFFECT TO TAMOXIFEN AND DEVELOPING RECCURENCE IN ER+ BREAST CANCER PATIENETS:

Potential of Serum IL-6 as a Predictor of Tumоr Histоlоgiсаl Mаnifеstаtiоns in Prеmеnораusаl Brеаst Cаnсеr with Mеtаbоliс Sуndrоmе

Assessment of Inter-observer Reproducibility of the Residual Cancer Burden Index and Neoadjuvant Chemotherapy Response in Breast Carcinoma

Association between Radiological and First-Order Statistical Features of the Mammogram, and the Tumor Phenotype in Breast Cancer Patients

Effects of Lupeol on Estrogen and Androgen Receptor-Positive Breast and Prostate Cancer Cells

IMPACT OF CYP2D6 POLYMORPHISMS IN PREDUCTING OCCURRENCE OF ADVERSE EFFECT TO TAMOXIFEN AND DEVELOPING RECCURENCE IN ER+ BREAST CANCER PATIENETS:

Potential of Serum IL-6 as a Predictor of Tumоr Histоlоgiсаl Mаnifеstаtiоns in Prеmеnораusаl Brеаst Cаnсеr with Mеtаbоliс Sуndrоmе

Assessment of Inter-observer Reproducibility of the Residual Cancer Burden Index and Neoadjuvant Chemotherapy Response in Breast Carcinoma

Association between Radiological and First-Order Statistical Features of the Mammogram, and the Tumor Phenotype in Breast Cancer Patients

Effects of Lupeol on Estrogen and Androgen Receptor-Positive Breast and Prostate Cancer Cells

ISSN	2383-0425, 2383-0433
h-index	6