CHEM 是 CELL 的姊妹期刊，为开创性和有见地的研究提供了场所，并展示了化学及其子学科的基础研究如何帮助找到应对未来全球挑战的潜在解决方案。

CHEM is a sister journal of CELL, dedicated to providing a platform for groundbreaking and insightful research. The journal showcases how fundamental research in chemistry and its sub-disciplines can help identify potential solutions to future global challenges.

CHEM 是 CELL 的姊妹期刊，致力于为开创性和有见地的研究提供一个平台。该期刊展示了化学及其子学科的基础研究如何为应对未来全球挑战提供潜在解决方案。

Chem

The Bigger PictureFluorine is regarded as a vital element in drug design. Nowadays, a variety of organofluorine compounds are available as pharmaceuticals and agrochemicals. The Earth's crust bears relatively large amounts of fluoride (relative abundance, 0.03%; close to that of nitrogen). In contrast, resources of naturally occurring organofluorine compounds are limited to a small number of examples, such as monofluoroacetic acid and ω-fluorinated fatty acids. We cannot seek fluorinated drug candidates in nature. Thus, the development of synthetic methodologies for organofluorine compounds is an important topic. Recently, photoredox catalysis with metal and organic dye catalysts has expanded rapidly in the field of synthetic chemistry and has emerged as a powerful synthetic tool for radical fluoromethylation, giving rise to facile syntheses of diverse organofluorine compounds as well as discovery of new drugs and functional materials.SummaryRadical tri- and difluoromethylation (fluoromethylation) by photoredox catalysis has emerged as a new synthetic methodology over the past several years. In particular, the strategy is useful for the introduction of a fluoromethyl group (CF2X, X = F or H) and a different functional group across a carbon-carbon double bond via a single operation. Step-economical synthesis of diverse organofluorine compounds bearing a C(sp3)–CF2X bond has been achieved. In this review, the discussion focuses on recent representative examples of photoredox-catalyzed fluoromethylative difunctionalization of alkenes through redox-neutral processes. Close attention is paid to the choice of the fluoromethylating reagent and the photocatalyst. The basic concept, reaction design, and the prospects for this research area are also discussed.Graphical abstract

Takashi Koike

Munetaka Akita

New Horizons of Photocatalytic Fluoromethylative Difunctionalization of Alkenes

光催化氟甲基化二官能化烯烃的新视野

Jiaqi Zhao

Li-Zhu Wu

Tierui Zhang

Enhanced oxidation potential of holes under visible light for organic photo-oxidation

Qi Zheng

Yang-Kun Qu

Peng Zuo

Hai-Tian Yuan

Yue-Jian Yang

Yu-Chen Qiu

Liang-Sheng Liao

Dong-Ying Zhou

Zuo-Quan Jiang

Enhancing multi-resonance thermally activated delayed fluorescence emission via through-space heavy-atom effect

通过空间重原子效应增强多共振热活化延迟荧光发射

Owing to its simplicity, ethylene, as the most abundant organic feedstock, only finds limited applications in fine chemical synthesis, resulting in molecules of modest complexity. Ethylene difunctionalization allows for the synthesis of much more complex chemicals, but it is rare and almost always relies on transition-metal catalysis. Herein, we report an unprecedented metal-free radical difunctionalization of ethylene through a functional group migration strategy. The use of sulfone-based bifunctional reagents enables straightforward access to a wide range of diheteroarylated compounds under mild conditions in a highly selective manner. The precise modulation of radical polarity and kinetic preference arising from intramolecular functional group migration guarantee the success of the cascade three-bond forming process in a controllable manner.

Jiajia Yu

Xu Zhang

Xinxin Wu

Tao Liu

Zhi-Qi Zhang

Jie Wu

Chen Zhu

Metal-free radical difunctionalization of ethylene

The direct allylic C–H amination of alkenes, especially internal ones, with aliphatic amines remains a major challenge in chemical synthesis. Recently in Science, Gevorgyan et al. reported a robust strategy for this process with photoinduced palladium catalysis, which accommodates different olefin substitution patterns and offers excellent selectivities. The direct allylic C–H amination of alkenes, especially internal ones, with aliphatic amines remains a major challenge in chemical synthesis. Recently in Science, Gevorgyan et al. reported a robust strategy for this process with photoinduced palladium catalysis, which accommodates different olefin substitution patterns and offers excellent selectivities.

Yi Wei

Fen-Ya Xiong

Liang-Qiu Lu

Wen-Jing Xiao

Photoinduced palladium-catalyzed asymmetric allylic C–H amination

光诱导钯催化不对称烯丙基C-H胺化

Till L. Kalkuhl

Israel Fernández

Terrance J. Hadlington

Cooperative hydrogenation catalysis at a constrained gallylene-nickel(0) interface

受限的二价镓-镍(0)界面上的协同氢化催化作用

Julie Yi-Hsuan Chen

Qing Shi

Xue Peng

Jean de Dieu Habimana

James Wang

William Sobolewski

Andy Hsien-Wei Yeh

De novo luciferases enable multiplexed bioluminescence imaging

从头设计的发光酶实现多重生物发光成像

Linh Duy Thai

Jochen A. Kammerer

Dmitri Golberg

Hatice Mutlu

Christopher Barner-Kowollik

Sequence-defined main-chain photoswitching macromolecules with odd-even effect-controlled properties

奇偶效应调控的序列定义主链光开关大分子

The bigger pictureWithin the rich and multifaceted field of boron chemistry, ring compounds with electron-precise boron–boron bonds are still a curiosity. In the past isolated only as trace amounts from complex reaction mixtures, the properties of these boron rings are poorly understood, limiting the exploration of their potential uses.Here, we present a simple and efficient method for the preparation of the cyclic tetraborane B4(NCy2)4. Strikingly, its puckered tetraborane ring structure is unaffected by redox processes and is conserved across four different charge states. While one-electron reduction events involved the B4π-system and produced stable radical anionic and aromatic dianionic species, the latter being isoelectronic with elusive cyclobutadiene dications, one-electron oxidation resulted in the removal of an electron from the σ-bonds within the tetraborane core without altering its basic geometry.Highlights•Selective synthesis of an electron-precise cyclic tetraborane, B4(NCy2)4•Puckered B4 structure persistent in redox chemistry across four charge states•One-electron oxidation generates a stable electron-deficient radical cation•One- and two-electron reductions yield stable radical monoanions and aromatic dianionsSummaryBoron rings with electron-precise (i.e., non-cluster) bonds represent a largely untapped area in boron chemistry, and investigating their properties could potentially open up exciting new research avenues. In this work, we present an efficient method for synthesizing the cyclic tetraborane B4(NCy2)4 by reduction of the amino(dihalo)borane (Cy2N)BCl2 (Cy, cyclohexyl). This puckered, covalently bonded compound features unprecedented stability across four charge states, highlighting the capacity of the B4 ring to adapt to varying σ- and π-electron counts. Density functional theory (DFT) calculations elucidate the electronic structure of all species, revealing how electron delocalization is modulated.Graphical abstract

Eva Beck

Ivo Krummenacher

Thomas Kupfer

Maximilian Dietz

Maximilian Michel

Kai Hammond

Holger Braunschweig

Structural stability of a bent tetra(amino)tetraborane ring across four charge states

四氨基四硼烷环在四种电荷态下的结构稳定性

短名
Journal Impact	19.29
国际分区	CHEMISTRY, MULTIDISCIPLINARY(Q1)
期刊索引	SCI Q1中科院 1 区

ISSN	2451-9294, 2451-9308
h-index	144
国内分区	化学(1区)化学化学综合(1区)
Top 期刊	是

涉及主题	化学有机化学材料科学生物物理工程类量子力学纳米技术生物化学催化作用计算机科学化学工程复合材料物理化学冶金
出版信息	出版商: Elsevier Inc.，出版周期: ，期刊类型: journal，开源期刊: 否
基本数据	创刊年份: 2016，原创研究文献占比: 81.82%，自引率:1.00%， Gold OA占比: 72.86%

Chem

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New Horizons of Photocatalytic Fluoromethylative Difunctionalization of Alkenes

Enhanced oxidation potential of holes under visible light for organic photo-oxidation

Enhancing multi-resonance thermally activated delayed fluorescence emission via through-space heavy-atom effect

Metal-free radical difunctionalization of ethylene

Photoinduced palladium-catalyzed asymmetric allylic C–H amination

Enhancing multi-resonance thermally activated delayed fluorescence emission via through-space heavy-atom effect

Cooperative hydrogenation catalysis at a constrained gallylene-nickel(0) interface

De novo luciferases enable multiplexed bioluminescence imaging

Sequence-defined main-chain photoswitching macromolecules with odd-even effect-controlled properties

Structural stability of a bent tetra(amino)tetraborane ring across four charge states