Journal of Basic and Clinical Health Sciences

Purpose: The aim of the study was to compare the kinesiophobia, pain catastrophizing, physical activity, anxiety, and depression in patients with or without MI. &#x0D; Methods: A cross-sectional prospective case-control study was conducted with a total of 100 participants (50 myocardial infarction, 50 age-sex matched controls). Participants were evaluated with the Tampa Scale of Kinesiophobia for Heart (TSK Heart), Pain Catastrophizing Scale (PCS), International Physical Activity Questionnaire-Short Form (IPAQ-SF), Hospital Anxiety And Depression Scale (HADS). &#x0D; Results: There was significant difference between two groups in all subscales of IPAQ-SF (except sitting time) (p

Fatih ÖZDEN

Mehmet ÖZKESKİN

İsmet TÜMTÜRK

Eda ÖZLEK

Bülent ÖZLEK

The Investigation of Kinesiophobia, Pain Catastrophizing, Physical Activity, Anxiety, and Depression in Patients with Myocardial Infarction

心肌梗死患者中运动恐惧、疼痛灾难化、身体活动、焦虑和抑郁的调查研究

Purpose: In recent years, the medical use of smartphones has increased with the development of hardware. The study aims to evaluate the reliability and concurrent validity of iPhone® measurement application to measure ITB tightness. Methods: This was a cross-sectional study. Thirty athletes with ITB tightness (17 males, 13 females) between 20 and 45 years old were included and assessed in this study. The intraclass correlation coefficient (ICC) was used to evaluate the reliability of each smartphone measurement, and Bland–Altman analysis was used to examine measurement errors. The ITB tightness was measured with Ober test using a bubble inclinometer and iPhone® measurement application and evaluated by two experienced physiotherapists. The researchers carried out three measurements for both extremities, using both the bubble inclinometer and the iPhone® measurement application. Measurement values were recorded by a third physiotherapist. Results: The iPhone® measurement application has strong inter-rater (ICC=0.941) and intra-rater (ICC=0.986) reliability and concurrent validity (r=0.945) in measuring ITB tightness. Conclusion: From the cross-sectional study’s results, it can be concluded that the iPhone® measurement application possesses strong intra-rater and inter-rater reliability and concurrent validity and can be used for measuring ITB tightness.

Bayram Sönmez Ünüvar

Hasan Gerçek

Ertuğrul Demirdel

The Concurrent Validity and Reliability of the Smartphone Measurement Application to Evaluate Iliotibial Band Tightness: A Cross-Sectional Study

智能手机测量应用程序评估髂胫束紧张度的同时效度和可靠性：一项横断面研究

Background and Purpose: The most significant pathogen hypothesized to be causing the formation of Acute lung injury (ALI) in sepsis is thought to be lipopolysaccharide (LPS), a key endotoxin component of gram-negative bacteria. The main objective of this study is to determine possible anti-inflammatory effects of crocin (CRO) which has many biological properties such as anti-inflammatory, antioxidant, and anti-apoptotic in LPS-induced ALI. Methods: 40 Wistar albino rats were divided into four groups: Control (no treatment), CRO (given 50 mg/kg crocin for 9 days), LPS (given 30 mg/kg LPS at 9th day), LPS+CRO (given 50 mg/kg crocin for 9 days and 30 mg/kg LPS at 9th day). After experimental, rats were sacrificed and lungs were extracted. Histological examinations were performed in the lung tissue and the changes in the HMGB1 and TLR4 expressions were determined via immunohistochemical staining. Results and Conclusion: Hemorrhage, mononuclear cell infiltration and HMGB1 and TLR4 expressions significantly increased in the LPS group. However, CRO administrations exerted a strong protective effect on the lungs in terms of these parameters in LPS+CRO group. According to our results, we suggest that CRO can be considered as a protective agent against LPS induced ALI via inhibition of HMGB1/TLR4 pathway-mediated inflammatory response.

Tayfun Ceylan

Ali Akın

Emin Kaymak

Şaban Varinli

Ayşe Toluk

Crocin Suppresses Inflammatory Response in LPS-Induced Acute Lung Injury (ALI) Via Regulation of HMGB1/TLR4 Inflammation Pathway

藏红花素通过调控HMGB1/TLR4炎症通路抑制LPS诱导的急性肺损伤（ALI）中的炎症反应

Purpose: This study aimed to examine the use of graduated compression stockings after surgery. Methods: Employing a descriptive research design, the study was conducted on a sample of 173 patients admitted to the surgical departments of a university hospital. Results: Among all the patients, 80.9% of them did not lift their feet up for a while when they were in bed before wearing stockings; 72.3% did not wear stockings before getting out of bed. The researchers observed that 50.9% of the patients placed the stockings properly on the heel and 79.2% of them had folds in the stockings they wore. Additionally, upon removing the stockings for observations, 59.5% of the patients exhibited redness in the corresponding area. The use of stockings was more accurate and the damage to the tissue was less in the patients who received information (p

Filiz Salman

Altun Baksi

Faruk Durna

Nida Nur Yurt

Examining Patients’ Use of Graduated Compression Stockings in Postoperative Period

术后患者使用分级加压袜的情况研究

Background and Purpose: To evaluate the effect of the Hospital Recycling Program conducted for the wastes generated during the practice of nurses on the recycling behavior and waste amounts of the nurses. Methods: A quasi-experimental study with a pre-test and post-test control group was conducted with 64 nurses. Data were collected by the Nurse Descriptive Characteristics Form, Recycling Scale for Sustainable Hospital, and Unit Waste Registration Form. The Hospital Recycling Program based on the Theory of Planned Behaviour was applied to the intervention group. Results: The Hospital Recycling Program had a positive effect on attitudes/behavior intention, and recycling behavior scores of nurses in the intervention group; the amount of recyclable waste was significantly increased compared to the control group (p

Hatice Gürgen Şimşek

Süheyla Altuğ Özsoy

Evaluation of the Effectiveness of Hospital Recycling Program for Improving Nurses' Recycling Behaviours

医院回收计划对改善护士回收行为有效性的评估

Purpose: Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. Accurate survival prediction is crucial for advanced-stage patients to optimize treatment strategies and improve clinical outcomes. This study aimed to develop an artificial intelligence-assisted clinical decision support system (CDSS) for survival prediction in CRC patients using clinical and genomic data from the Cancer Genome Atlas Colon Adenocarcinoma Collection (TCGA-COAD) dataset. Methods: Machine learning algorithms, including C4.5 Decision Tree, Support Vector Machines (SVM), Random Forest, and Naive Bayes, were employed to create survival prediction models. Clinical parameters and genomic data from key pathways, such as glycolysis/gluconeogenesis and mTORC1, were integrated into the models. The models were evaluated based on accuracy and performance. Results: The Random Forest algorithm achieved the highest accuracy (82.3%) when only clinical parameters were used. When clinical data were combined with gene expression data, the model’s accuracy increased further. The resulting models were incorporated into a user-friendly web interface, SurvCOCA, for clinical use. Conclusions: This study demonstrates the potential of AI-based tools to improve prognosis predictions in CRC patients. Further research is needed, with larger datasets and additional machine learning algorithms, to enhance clinical decision-making and optimize treatment strategies.

Hüseyin Koray Mısırlıoğlu

Asım Leblebici

Gizem Çalıbaşı Koçal

Hülya Ellidokuz

Yasemin Başbınar

AI-Assisted Survival Prediction in Colorectal Cancer: A Clinical Decision Support Tool

人工智能辅助结直肠癌生存预测：一种临床决策支持工具

Purpose: Colorectal cancer (CRC) is one of the most common cancer types globally, with a high mortality rate. The FAK-Rho-ROCK successive signaling cascade promotes growth, migration and invasion of cancer cells. Focal adhesions are major sites of interactions between extracellular mechanical environments and intracellular biochemical signaling molecules/cytoskeleton and therefore focal adhesion proteins have been proposed to play important roles in mechanotransduction. This study aims to evaluate the effects of combination treatments with Focal Adhesion Kinase (FAK), Rho-ROCK, and YAP/TAZ inhibitors on the proliferative and epithelial-mesenchymal transition (EMT)-related metastatic characteristics of colorectal cancer cells. Material and Methods: In vitro experiments were performed using the HCT-116 colon cancer cell line. The effects of Y-15 (FAK inhibitor), ROCK inhibitor-2, and YAP/TAZ inhibitor-2, either applied alone or in combination, on cell proliferation were analyzed using the WST-1 cell viability assay. Epithelial-mesenchymal transition (EMT) markers, E-cadherin and N-cadherin, were evaluated via immunofluorescence staining, and fluorescent intensity was analyzed using ImageJ software. Results: Y-15, when applied alone or in combination with other inhibitors, significantly reduced cell proliferation (p≤0.005). Moreover, the combination of Y-15 and ROCK inhibitor-2 increased E-cadherin levels while decreasing N-cadherin levels (p≤0.0159, p≤0.0286). While the effect of YAP/TAZ inhibitor-2 alone was limited, specific effects were observed in combination treatments. Conclusion: This study demonstrates the potential of FAK-Rho-ROCK pathway inhibitors in the treatment of colorectal cancer. The ability of Y-15, in particular, to inhibit cell viability/proliferation and metastatic processes suggests that combination strategies targeting these pathways could contribute to the development of new therapeutic approaches for CRC.

Serap Türkmen

Caner Karaca

Hasan Kurter

Nurçin Kayacık

Combined inhibition of the FAK-Rho-ROCK signaling cascade, one of the important players in mechanotransduction, in colorectal cancers

结直肠癌中机械转导重要角色之一FAK-Rho-ROCK信号级联的联合抑制

Background and Purpose: Aconitine, a potent alkaloid from Aconitum plants, has shown promising anticancer properties. The aim of the study is to investigate the effects of aconitine on lateral migration, and matrix metalloproteinase (MMP) activity in MDA-MB-231 triple-negative breast cancer cells. Methods: For this purpose, a WST-1 viability assay was first conducted to determine the effect of aconitine on the viability of MDA-MB-231 cells. Following treatment with non-cytotoxic doses of aconitine, lateral migration was evaluated through wound healing assays. Additionally, gelatin zymography was conducted to analyze MMP-2 and MMP-9 activity and secretion levels. Results: Aconitine concentrations up to 200 μM did not significantly affect cell viability for up to 72 hours. However, higher doses (400-600 μM) reduced viability in a time-dependent manner. Aconitine (200 μM) showed a trend towards decreased lateral motility, with a significant reduction at 9 hours post-treatment. Gelatin zymography revealed no alterations in MMP-2 and MMP-9 activity and secretion levels following aconitine treatment. Conclusion: Aconitine demonstrates limited efficacy in modulating the migratory capacity of MDA-MB-231 cells and does not affect gelatinase activity. The observed resistance to aconitine's cytotoxic effects warrants further investigation into underlying mechanisms, potentially leading to novel therapeutic strategies for triple-negative breast cancer.

Didem Keleş Bartık

Murat Sipahi

Şeniz İnanç-sürer

Gülgün Oktay

Aconitine Impedes Cell Motility in MDA-MB-231 Breast Cancer Cells: A Potential Therapeutic Avenue

乌头碱抑制MDA-MB-231乳腺癌细胞迁移：潜在的治疗途径

Purpose: This study aim to determine the occurrence of gestational diabetes mellitus (GDM) in pregnancies after IVF treatment and to evaluate the factors that reduce this risk. Methods: This retrospective cohort study was conducted using the medical records of pregnant women who conceived following IVF at the in-vitro fertilization center between 2002–2019. The data were obtained from medical records and phone interviews. Univariate and multivariate logistic regression analyses were performed. Results: The incidence of GDM was found to be 16.7%. The regression model indicated that the risk of GDM was 4.57 times higher in the age group 36–40 at conception during the IVF cycle than the age group 31–35 (95% CI = 1.18–17.73, p = .028). Furthermore, women who conceived after the second IVF trial had a risk of GDM 3.464 times higher than those that conceived after their first IVF trial (95% CI = 1.07–11.23, p= .038). Conclusion: As age and number of IVF trials increase in infertile women, the risk of GDM increases after IVF treatment.

Nuran Nur Aypar Akbağ

Merlinda Aluş Tokat

Sevcan Özöztürk

Elif Ünsal Avdal

Recep Emre Okyay

Ömer Erbil Doğan

Is the occurrence of Gestational Diabetes Mellitus in pregnancies higher following In Vitro Fertilization treatment? Why? A retrospective cohort study

妊娠期糖尿病在体外受精治疗后妊娠中的发生率是否更高？为什么？一项回顾性队列研究

Purpose: To investigate the relationship between trunk control, upper and lower extremity function with functional activity, activities of daily living and quality of life in patients with Parkinson’s Disease (PwPD). Materials and Methods: The study was completed with 52 PwPD. Trunk control was evaluated with the Trunk Impairment Scale (TIS); upper extremity function with 9-Hole Peg Test (9-HPT) bilaterally; lower extremity function with 30-Second Sit-To-Stand Test (30STS); functional activity level with The Parkinson Activity Scale (PAS); activities of daily living with Barthel Index (BI); quality of life with The Parkinson's Disease Quality of Life Questionnaire (PDQ-39) Results: 30STS and right-left 9-HPT results was correlated with PAS and PDQ-39, but not with BI in PwPD. All TIS scores except the coordination sub-parameter were found to be associated with PAS, all TIS scores except the static sitting balance sub-parameter were found to be associated with BI, and all TIS scores were found to be associated with PDQ-39 in PwPD (ρ between 0.293 and 0.689; p

Taşkın Özkan

Yasemin Ateş Sarı

Aybike Erkoç

Yeşim Sücüllü Karadağ

Nezehat Özgül Ünlüer

Effects of trunk control, upper and lower extremity functions on functional activity, activities of daily living and quality of life in Parkinson's Disease

躯干控制、上下肢功能对帕金森病患者功能活动、日常生活活动及生活质量的影响

Abbreviation	J Basic Clin Health Sci
Journal Impact	0.40
Quartiles(Global)	HEALTH CARE SCIENCES & SERVICES(Q4)

Publication Information	Publisher: Dokuz Eyul Universitesi Saglik Bilimleri Enstitusu，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: ，Proportion of original research papers: 90.91%，Self Citation Rate:0.00%， Gold OA Rate: 98.95%

Journal of Basic and Clinical Health Sciences

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