Aging Medicine

Abstract Objective To investigate the factors associated with hypercholesterolemia in older adults residing in a small municipality in northeastern Brazil. Methods This is a population‐based cross‐sectional epidemiological study conducted with 232 older adults (women: 58.60%; men: 41.40%) in Aiquara, Bahia, Brazil. Independent variables included socioeconomic, behavioral, and health‐related factors. The outcome was self‐reported hypercholesterolemia (yes or no). Poisson regression with a robust estimator was used to calculate Prevalence Ratios (PR) and their respective 95% Confidence Intervals (CI) in the inferential analysis. Gross models were initially developed, followed by a hierarchical multiple explanatory model (Level 1: socioeconomic variables; Level 2: behavioral aspects; Level 3: health conditions). Results The observed prevalence of hypercholesterolemia was 34.50% (men: 21.90%; women: 43.40%). Additionally, a higher probability of hypercholesterolemia was observed in women (PR: 1.94; 95% CI: 1.27–2.97); participants with high sedentary behavior (PR: 1.47; 95% CI: 1.03–2.09); those with abdominal obesity (PR: 1.65; 95% CI: 1.06–2.57); and those with diabetes mellitus (PR: 1.54; 95% CI: 1.04–2.29). Conclusion The main results showed that female sex, high sedentary behavior, abdominal obesity, and diabetes mellitus were positively associated with hypercholesterolemia in the older population of the study.

Maria Clara Alves de Oliveira

Júlia Perfeito Andrade

Ana Carolina Souza Porto

Gizelly Maria Torres Martins

Nurielly Monteiro Campos

Paulo da Fonseca Valença Neto

Claudio Bispo De Almeida

Saulo Sacramento Meira

Beatriz Cardoso Roriz

Débora Jesus da Silva

Victor Giovannino Accetta

Cezar Augusto Casotti

Lucas dos Santos

Factors associated with hypercholesterolemia in older adults: A cross‐sectional investigation

与老年人高胆固醇血症相关的因素：一项横断面调查

Abstract Objectives Attaining castration resistance in metastatic prostate cancer (mCRPC) represents a pivotal juncture in the progression of the patient's illness and treatment regimen. Within this therapeutic context, novel hormonal agents (NHA) constitute a fundamental component of pharmacological intervention. However, the efficacy of NHA therapy remains uncertain for patients with a compromised general condition, as indicated by an Eastern Cooperative Oncology Group Performance Status (ECOG PS) score of ≥2. Notably, most clinical trials excluded individuals with an ECOG PS ≥2, leaving a gap in our understanding of the potential benefits of NHA therapy for this specific patient cohort. Methods We conducted an analysis of fifty‐three NHA‐naïve men characterized by attaining mCRPC at an ECOG PS of ≥2 subsequent to androgen deprivation monotherapy between 2008 and 2023. Patients were then treated with either NHA or Best Supportive Care (BSC) based on individual decisions. Survival and adverse event (AE) analysis was performed to assess the outcomes of NHA therapy compared to BSC. Results Among the patients, 30 (56.6%) received NHA, whereas the remaining 23 (43.4%) choose BSC. No significant differences in baseline characteristics were observed between the NHA and BSC group. Median overall survival (OS) was 9.1 months in the BSC group and 7.0 months in the NHA group, with no significant OS benefits associated with NHA treatment. AEs and severe AEs commonly occurred, but remained indifferent between treatment groups. Conclusions Our findings suggest that NHA therapy may confer reduced survival benefits in mCRPC patients with ECOG PS ≥2. While hope for NHA treatment persists, particularly given its oral administration and tolerability, careful consideration and discussion with patients regarding treatment expectations and palliative care goals are warranted in this challenging patient population.

Thomas Büttner

Philipp Lossin

Stefan Latz

Carolin Jacobs

Philipp Krausewitz

Stefan Hauser

Novel hormonal agents in men with metastatic castration resistant prostate cancer and reduced performance status: Experiences of a specialized single center

新型激素药物在转移性去势抵抗性前列腺癌且体能状态下降患者中的应用：一家专科中心的经验

Abstract Objective Evaluating the change trajectories of triglyceride‐glucose (TyG) index calculated after multiple tests in elderly heart failure (HF) patients may have clinical implications for predicting long‐term adverse cardiovascular events (MACEs). Methods This retrospective study included 1184 elderly HF (LVEF ≥50%) patients with diabetes admitted to our center between January 2015 and January 2020. Based on the multiple TyG levels detected during the exposure period with annual measurements, three distinct TyG trajectories were determined using latent mixture modeling: low‐stable group (TyG index &lt;8.26, n = 367), medium‐stable group (TyG index 8.26–9.06, n = 613), and high‐increasing group (TyG index &gt;9.06, n = 204). The primary endpoint was the composite outcome of MACEs. Results There were significant increases in the prevalence of several cardiovascular risk factors and conditions, such as male gender, BMI, current smoker, hyperlipidemia, atrial fibrillation, old myocardial infarction, fasting glucose, triglycerides, and uric acid levels, from the Low‐Stable Group to the High‐Increasing Group (all P &lt; 0.05). During a median follow‐up of 29 months (range, 18–46 months), 181 MACEs occurred. Kaplan–Meier analyses curve showed a significantly increased risk of MACEs in the medium‐stable and high‐increasing groups compared to the low‐stable group ( HR = 2.528, 95% CI : 1.665–3.838; HR = 2.706, 95% CI : 1.722–4.255, respectively). Furthermore, the rates of heart failure‐related hospitalizations, nonfatal myocardial infarctions and non‐fatal stroke were significantly increased in the medium‐stable and high‐increasing groups. Multivariable Cox regression analyses revealed that age ( HR = 1.728), current smoker ( HR = 1.385), old myocardial infarction ( HR = 1.593), chronic renal disease ( HR = 1.682), HbA1c ( HR = 1.816), NT‐proBNP ( HR = 2.471), TyG trajectory ( HR = 2.112) and SGLT2 inhibitors ( HR = 0.841) were independently associated with the occurrence of MACEs during follow‐up ( P &lt; 0.05). Conclusions The TyG trajectory is strongly associated with the risk of MACEs during follow‐up in elderly patients with T2DM, suggesting that TyG trajectories may further optimize risk stratification model of cardiovascular events.

Hong Liu

Jian Wang

Zhi Luo

Ding Jia

Shixing Feng

Zhufang Yang

Zeyu Wang

Triglyceride‐glucose index trajectories predict adverse cardiovascular outcomes in elderly heart failure patients with Diabetes: A retrospective cohort study

甘油三酯-葡萄糖指数轨迹预测老年糖尿病心力衰竭患者不良心血管结局：一项回顾性队列研究

Abstract Objectives To outline the design of the P3 study and serve as a summary of the interim baseline patient characteristics. Methods P3 study is a multicenter, prospective cohort study targeting 1000 acute ischemic stroke (AIS) and cerebral small vessel disease (CSVD) patients with a 2‐year follow‐up from 80 participating hospitals across China. Comprehensive multimodal imaging, neuropsychological tests, and biological samples were collected prospectively on admission and follow‐up visits. Patients were interviewed face to face for 2 years and followed up. Results Until 30 December 2023, 642 patients were enrolled from 67 centers. In the AIS cohort, 219 patients (72.5%) were diagnosed with acute post‐stroke cognitive impairment (PSCI). Compared to those without PSCI, the acute PSCI group exhibited significantly lower levels of education and a history of stroke (all P &lt; 0.05). In the CSVD cohort, 53 patients (41.4%) were diagnosed with cognitive impairment. Compared to those with normal cognitive function, the impaired cognitive function group had a significantly higher prevalence of hypertension and diabetes history (all P &lt; 0.05). All 642 patients completed 20 tests, as well as clinical information and blood sample collection. Nearly 95% of the patients underwent structural MRI and ASL, and 60% of patients completed fMRI and DKI or DTI. Conclusions P3 study aims to establish a comprehensive spatiotemporal profile of VCI. Through multidimensional analysis of clinical information, radiomics, proteomics, metabolomics, microbiomics, and genetics, provide a more comprehensive understanding of VCI trajectories and individual variability, enhancing early detection and prognosis management.

Linlin Wang

Jiwei Jiang

Yanli Wang

Gaifen Liu

Wenyi Li

Qiwei Ren

Shirui Jiang

Min Zhao

Huiying Zhang

Tianlin Jiang

Shiyi Yang

Mei Cui

Qiang Dong

Jun Xu

Predictive, preventive and personalized project of vascular cognitive impairment in China (<scp>P3</scp>): Study design and interim baseline patient characteristics of a Nationwide multicenter prospective registry

中国血管性认知障碍的预测、预防和个性化项目（P3）：全国多中心前瞻性注册研究的设计及中期基线患者特征

Abstract Objective Denture use has been shown to improve nutritional intake and diet quality in people with tooth loss. Despite evidence linking tooth loss and dementia, few studies have examined the association between denture use and cognitive decline. We investigated the relationship between denture use and cognitive decline among Chinese older adults with tooth loss. Methods We analyzed data from the Chinese Longitudinal Healthy Longevity Survey 2008–2018, including 27,708 community‐dwelling dentate and edentulous (i.e., who have lost all natural teeth) older adults aged 65 and older. Cognitive function was assessed using the Mini‐Mental State Examination from 2008 to 2018. Linear mixed‐effect models were employed to assess the association of denture use with baseline cognitive function and rate of cognitive decline, adjusting for sociodemographic characteristics, health‐related behavior, and health status. Subgroup analyses evaluated differences in associations among dentate participants with varying degrees of tooth loss (1–9, 10–19, 20–31). Results Compared to non‐denture users, dentate participants who used dentures had better baseline cognitive function ( β , 1.032; 95% CI, 0.813–1.251; p &lt; 0.001) and a slower annual decline in cognitive function ( β , 0.127; 95% CI, 0.047–0.206; p &lt; 0.01). For edentulous participants, denture use was associated with higher baseline cognitive function ( β , 3.063; 95% CI, 2.703–3.423; p &lt; 0.001) but not with the rate of cognitive decline ( β , 0.011; 95% CI, –0.082 to 0.105; p = 0.818). Results remained consistent across subgroups of dentate participants with various degrees of missing teeth. Conclusions Denture use may help protect against cognitive decline in older adults with partial tooth loss. This study highlights the potential importance of prosthodontic rehabilitation in preserving cognitive health. Further research is needed to establish a causal relationship between denture use and cognitive function.

Xiang Qi

Zheng Zhu

Yaolin Pei

Bei Wu

Denture use and a slower rate of cognitive decline among older adults with partial tooth loss in China: A 10‐year prospective cohort study

中国部分牙齿缺失老年人使用义齿与认知衰退速度减缓的关系：一项为期10年的前瞻性队列研究

Abstract Objectives Comorbidity prediction models have been demonstrated to offer more comprehensive and accurate predictions of death risk compared to single indices. However, their application in China has been limited, particularly among maintenance hemodialysis (MHD) patients. Therefore, the objective of this study was to evaluate the utility of comorbidity index models in predicting mortality risk among Chinese MHD patients. Methodology The MHD patients in the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine were taken as the subjects. Claims‐based disease‐specific refinements matching translation to ICD‐10 and flexibility (CDMF‐CCI) model and Liu model were selected as the candidate models for this verification research. Univariate and multivariate Cox regression calculations were used to analyze the independent predictive effect of the models on survival rate. Results Annually, nearly 500 patients undergo hemodialysis treatment. From January 2019 to June 2022, a total of 199 patients succumbed, with a mean age of 65.2 years. During these 4 years, the mortality rates were 13.04%, 9.68%, 11.69%, and 6.39%, respectively. The leading causes of death were sudden demise (82 patients, 41.2%), cardiovascular disease (48 patients, 24.1%), pulmonary infection (33 patients, 16.5%), and stroke (19 patients, 9.5%). When compared to individual indices, the CDMF‐CCI model displayed more accurate and predictive results, with an HR of 1.190 ( P = 0.037). Conversely, the Liu model failed to identify high‐risk individuals. Conclusion The MHD patients face a significant risk of mortality. When compared to univariate parameters and the Liu model, the CDMF‐CCI model exhibits superior predictive accuracy for mortality in MHD patients.

Yanna Yu

Fen Li

Zhan Wang

Zhibin Ni

Shu Zhang

Weihong Zhao

Xiaohua Pei

Predictive accuracy of comorbidity index models in assessing mortality risk among hemodialysis patients: A comprehensive single‐center observational cohort study

合并症指数模型在评估血液透析患者死亡风险中的预测准确性：一项全面的单中心观察性队列研究

Cuiping Wang

Junhong Ren

Ultrasound blood–brain barrier opening: A new era of treatment for Alzheimer's disease?

超声血脑屏障开放：阿尔茨海默病治疗的新时代？

Abbreviation	Aging Medicine
Journal Impact	2.08
Quartiles(Global)	GERIATRICS & GERONTOLOGY(Q3)

ISSN	2475-0360
h-index	16

Publication Information	Publisher: John Wiley and Sons Inc，Publishing cycle: ，Journal Type: journal，Open Access Journals: Yes
Basic data	Year of publication: 2018，Proportion of original research papers: 0.00%，Self Citation Rate:0.00%， Gold OA Rate: 75.21%
Journal Fees	$2000Details
Average review cycle	网友分享经验：12 Weeks

Aging Medicine

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Factors associated with hypercholesterolemia in older adults: A cross‐sectional investigation

Novel hormonal agents in men with metastatic castration resistant prostate cancer and reduced performance status: Experiences of a specialized single center

Triglyceride‐glucose index trajectories predict adverse cardiovascular outcomes in elderly heart failure patients with Diabetes: A retrospective cohort study

Predictive, preventive and personalized project of vascular cognitive impairment in China (P3): Study design and interim baseline patient characteristics of a Nationwide multicenter prospective registry

Denture use and a slower rate of cognitive decline among older adults with partial tooth loss in China: A 10‐year prospective cohort study

Predictive accuracy of comorbidity index models in assessing mortality risk among hemodialysis patients: A comprehensive single‐center observational cohort study

Predictive, preventive and personalized project of vascular cognitive impairment in China (P3): Study design and interim baseline patient characteristics of a Nationwide multicenter prospective registry

Denture use and a slower rate of cognitive decline among older adults with partial tooth loss in China: A 10‐year prospective cohort study

Ultrasound blood–brain barrier opening: A new era of treatment for Alzheimer's disease?

Factors associated with hypercholesterolemia in older adults: A cross‐sectional investigation