Aging Medicine

Abstract Objectives To understand how psychosocial factors associated with physical activity differ based on disease severity in people with dementia, and how these factors are associated with physical activity participation. Methods Eighty‐seven people with dementia, alongside their family carer were asked to complete a series of questions related to physical activity participation, including barriers, motivators, and facilitators. Regression models were developed to understand how psychosocial factors were associated with physical activity participation in the cohort. Results In the final models, only the absence of intrapersonal barriers was associated with overall physical activity and regular moderate‐to‐vigorous physical activity. Feelings of relatedness were associated with regular moderate‐to‐vigorous physical activity only. Conclusion Reducing intrapersonal barriers would appear to be a potentially useful strategy to promote physical activity in people with dementia. However, a tailored approach is needed depending on the desired physical activity outcome.

Nicolas Farina

Uzma Niazi

Riona Mc Ardle

Johanna Eronen

Ruth Lowry

Sube Banerjee

Psychosocial factors associated with physical activity in people with dementia: A pilot cross‐sectional study

痴呆患者身体活动相关的心理社会因素：一项初步的横断面研究

Abstract The geriatric vision of palliative care is based on a multidisciplinary, patient‐centered approach, looking for a balance between human dignity and medical treatments with a particular focus on the social and ethical aspects. In order to develop the best care models, there is a rising need for a tighter collaboration of all the involved players (i.e., doctors, nurses, social workers). Indeed, the idea of a fragmented system without considering the patient or his/her family is not at all applicable to older patients with chronic disease. The causes of death, the phase of death changes, and the extend of last period of life could be a long phase characterized by complicated treatment decisions, difficult management of symptoms, multiple psychosocial problems, and complex spiritual distress. Recently, Italian guidelines on Comprehensive Geriatric Assessment (CGA) have been published. However, none of the identified studies on patients in hospice and other palliative care facilities met the criteria for inclusion. These findings underscore the need for further research to determine the potential benefits of a multidimensional approach for patients in hospice and other palliative care settings. Our reflections and suggestions on the CGA use for older persons in palliative care may be a starting point for an open and continuous dialogue with all the operators concerned.

Alberto Castagna

Vincenzo Militano

Carmen Ruberto

Ciro Manzo

Giovanni Ruotolo

Comprehensive geriatric assessment and palliative care

综合老年评估与姑息治疗

Abstract Alzheimer's disease (AD) is a neurodegenerative disease that is characterized by amyloid plaques, neurofibrillary tangles, and neuronal loss. Early cerebral and body iron dysregulation and accumulation interact with AD pathology, particularly in the precuneus, a crucial functional hub in cognitive functions. Quantitative susceptibility mapping (QSM), a novel post‐processing approach, provides insights into tissue iron levels and cerebral oxygen metabolism and reveals abnormal iron accumulation early in AD. Increased iron deposition in the precuneus can lead to oxidative stress, neuroinflammation, and accelerated neurodegeneration. Metabolic disorders (diabetes, non‐alcoholic fatty liver disease (NAFLD), and obesity), genetic factors, and small vessel pathology contribute to abnormal iron accumulation in the precuneus. Therefore, in line with the growing body of literature in the precuneus region of patients with AD, QSM as a neuroimaging method could serve as a non‐invasive biomarker to track disease progression, complement other imaging modalities, and aid in early AD diagnosis and monitoring.

Sana Mohammadi

Sadegh Ghaderi

Farzad Fatehi

Iron accumulation/overload and Alzheimer's disease risk factors in the precuneus region: A comprehensive narrative review

楔前叶区域铁积累/过载与阿尔茨海默病风险因素：一项综合叙述性综述

Yi‐Xuan Liao

Yang Ju

He Wang

Xiao‐Man Du

Jing Wang

Fan Zhang

Yan‐Ming Li

Respiratory medical quality control system construction in China

中国呼吸医学质量控制体系建设

Abstract Objectives Excess dietary salt causes increased urinary calcium and this may lead to bone loss. We proposed to study the association between dietary salt intake and bone health in postmenopausal women from southern India. Methods An observational study in which community‐dwelling postmenopausal women were recruited. Daily salt intake and urine calcium/creatinine ratio were assessed. Bone biochemistry and densitometric parameters such as bone mineral density (BMD), trabecular bone score (TBS) vertebral fractures, and bone strain index (BSI) were assessed using Dual Energy X‐Ray Absorptiometry (DXA). Results A total of 383 postmenopausal women with a mean ± SD age of 59.8 ± 7.2 years and BMI of 25.2 ± 4.6 kg/m 2 were recruited. Among the participants, 165/383(43.1%) had osteoporosis at any site and 21% had moderate–severe vertebral fractures. The BMD at lumbar spine and femoral neck, TBS and BSI were significantly ( p &lt; 0.001) lower and the CTx was significantly ( p = 0.008) higher among women with high salt intake (7.2 g/day) as compared to those with salt intake of &lt;7.2 g/day. The prevalence of osteoporosis, low TBS, high BSI, and moderate–severe vertebral fractures significantly increased across low to high salt‐intake categories. An ROC analysis showed that excess dietary salt was significantly associated with osteoporosis at any site with an AUC of 0.870 (95% CI: 0.832–0.907). On a multivariate analysis, excess salt intake conferred the highest odds of osteoporosis (OR: 2.296; 95% CI: 1.909–2.761). Conclusions Excess dietary salt is associated with high urinary calcium and compromised bone health among postmenopausal women from southern India. This may be a modifiable risk factor in osteoporosis and warrants further research.

Rebecca John

Kripa Elizabeth Cherian

Nitin Kapoor

Thomas Vizhalil Paul

Excess dietary salt is associated with an altered bone strain index, degraded bone microarchitecture, vertebral fractures, and increased prevalence of osteoporosis in postmenopausal women—A study from a teaching hospital in southern India

过量饮食盐与绝经后女性骨应变指数改变、骨微结构退化、椎体骨折及骨质疏松症患病率增加相关——来自印度南部一家教学医院的调查研究

Abstract Objective The objective of this study is to examine the epidemiological characteristics of very elderly patients (aged over 80 years) with cancer admitted to the intensive care unit (ICU), and to elucidate the association between Acute Physiology Score III (APS‐III) and 28‐day mortality. Method A retrospective analysis was conducted using data extracted from the Medical Information Mart for Intensive Care IV (MIMIC‐IV) database. Patients aged 80 years and above were assigned to three groups: non‐cancer group, non‐metastatic cancer group, and metastatic cancer group, based on their cancer diagnosis and its extent, Kaplan–Meier curves were constructed among these patient groups. Furthermore, patients were divided into a survival group and a non‐survival group based on their 28‐day survival status after ICU admission. Univariate and multivariate logistic regression analyses were performed to detect the risk factors for 28‐day mortality among these patients. Additionally, this investigation sought to establish a dose–response relationship by exploring the graded association between APS‐III scores and the 28‐day mortalities among patients diagnosed with cancer. Results A total of 42,037 medical records were screened, from which 11,461 elderly patients aged over 80 years were included, comprising 1020 (8.90%) with non‐metastatic cancer, 537 (4.68%) with metastatic cancer, and 9904 (86.41%) without cancer. Significant differences in 28‐day mortality were observed between both the non‐metastatic and metastatic cancer groups compared to the non‐cancer group (20.98% and 22.35% vs. 15.75%, p &lt; 0.001). However, no statistically significant difference was detected in the 28‐day mortality rate when comparing the non‐metastatic cancer group directly with the metastatic cancer group (20.98% vs. 22.35%, p = 0.576). Univariate analysis revealed significant differences ( p &lt; 0.001) in age, gender, BMI, aCCI excluding cancer point, ventilation, presence of cancer, and status of metastatic cancer between the survival and non‐survival groups. In the multivariate logistic regression, the odds ratio (OR) for ventilation was found to be 2.154 (95% CI: 1.799–2.578), cancer conferred an OR of 1.499 (95% CI: 1.137–1.975), metastatic cancer showed an OR of 1.171 (95% CI: 0.745–1.841), APS‐III showed an OR of 1.038 (95% CI: 1.034–1.042). A dose–response relationship was observed, demonstrating that when the APS‐III score exceeded 80 points, the 28‐day mortality rate surpassed 50% among the very elderly cancer patients in ICU. Conclusions More than one‐tenth of critically ill very elderly patients admitted to the ICU are diagnosed with cancer. Among ICU patients, those with cancer face a short‐term mortality risk approximately 1.5 times higher than those without a cancer diagnosis. Interestingly, while our findings do not indicate an escalated mortality risk due to metastasis within the cancer patient cohort, the presence of cancer itself remains a significant factor influencing ICU mortality rates in this very elderly population.

Taotao Liu

Runyu Ding

Short‐term mortality among very elderly cancer patients in the intensive care unit: A retrospective cohort study based on the Medical Information Mart for Intensive Care <scp>IV</scp> database

基于重症监护医学信息集市<scp>IV</scp>数据库的回顾性队列研究：重症监护病房中非常老年癌症患者的短期死亡率

短名	Aging Medicine
Journal Impact	2.08
国际分区	GERIATRICS & GERONTOLOGY(Q3)

ISSN	2475-0360
h-index	16

涉及主题	医学内科学生物病理心理学精神科遗传学计算机科学疾病化学数学社会学老年学内分泌学生物化学人口学环境卫生政治学法学人口外科
出版信息	出版商: John Wiley and Sons Inc，出版周期: ，期刊类型: journal，开源期刊: 是
基本数据	创刊年份: 2018，原创研究文献占比: 0.00%，自引率:0.00%， Gold OA占比: 75.21%
期刊费用	$2000详情
平均审稿周期	网友分享经验：12 Weeks

Aging Medicine

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Psychosocial factors associated with physical activity in people with dementia: A pilot cross‐sectional study

Comprehensive geriatric assessment and palliative care

Iron accumulation/overload and Alzheimer's disease risk factors in the precuneus region: A comprehensive narrative review

Respiratory medical quality control system construction in China

Excess dietary salt is associated with an altered bone strain index, degraded bone microarchitecture, vertebral fractures, and increased prevalence of osteoporosis in postmenopausal women—A study from a teaching hospital in southern India

Psychosocial factors associated with physical activity in people with dementia: A pilot cross‐sectional study

Respiratory medical quality control system construction in China

Iron accumulation/overload and Alzheimer's disease risk factors in the precuneus region: A comprehensive narrative review

Short‐term mortality among very elderly cancer patients in the intensive care unit: A retrospective cohort study based on the Medical Information Mart for Intensive Care IV database

Comprehensive geriatric assessment and palliative care