Annals of Hepato-Biliary-Pancreatic Surgery

In the last two decades, pancreatic cancer has been undergoing important changes in its perioperative management due to the great interest in multidisciplinary management and preoperative multimodal therapy, which in numerous studies have shown promising clinical results.Although the standard of treatment for resectable pancreatic ductal adenocarcinoma (PDAC) today is surgery followed by adjuvant therapy, as it is a biologically aggressive disease, even with complete resection, it has high rates of local and distant relapse.Several retrospective and prospective phase I/II studies have opened the window for neoadjuvant therapy with chemotherapy (CT), chemoradiotherapy (CRT), or both, as an alternative treatment for resectable pancreatic cancer, with promising results.Neoadjuvant therapy could has some advantages, including early administration of systemic treatment, in vivo assessment of response to treatment, increase resectability rate in borderline patients, increase resection rate with negative margin and survival benefit.While it seems clear that even potentially resectable disease would benefit from preoperative multimodal therapy, the optimal neoadjuvant therapeutic strategy is still controversial and currently there are only recommendations for neoadjuvant treatment, in clinical guidelines such as the NCCN and ESMO, for borderline and/or locally advanced PDAC.This review provides an overview of recent studies available and how they relate to systemic treatment of resectable PDAC in the neoadjuvant setting.(

Alvaro Gregorio Morales Taboada

Pablo Lozano Lominchar

Lorena Martin Roman

Pilar García-Alfonso

Andres Jesús Muñoz Martin

Jose Antonio Blanco Rodriguez

Jose Manuel Asencio Pascual

Advances in neoadjuvant therapy for resectable pancreatic cancer over the past two decades

过去二十年可切除胰腺癌新辅助治疗的进展

Intrahepatic cholangiocarcinoma is an aggressive, often fatal, malignancy that arises from the bile ducts. As it often presents with metastatic disease, surgery has limited utility. However, in some cases, neoadjuvant chemotherapy has provided the necessary reduction in tumor burden to allow for adequate resection. Consequently, new advances in neoadjuvant chemoradiation and targeted therapy are of interest with numerous case reports and small series published routinely; it is challenging to present a large case series or study given the overall rare frequency with which this malignancy is seen. Herein, we aim to summarize the newest advances in both neoadjuvant chemotherapy and targeted immunotherapy.

Michael Ghio

Adarsh Vijay

Intrahepatic cholangiocarcinoma: Evolving role of neoadjuvant and targeted therapy

肝内胆管癌：新辅助治疗与靶向治疗的演变作用

Backgrounds/Aims: Endoscopic retrograde cholangiopancreatography (ERCP) combined with laparoscopic cholecystectomy (LC) remains the most common therapeutic strategy used for cholecystocholedocholithiasis (CCL).Recently, single-stage ERCP + LC has gained popularity for treating CCL due to patient satisfaction and financial considerations.In this study, we aimed to compare the feasibility and efficacy of the two variants of single-stage ERCP + LC (starting with ERCP followed by LC versus starting with LC followed by ERCP) for treatment of CCL.Methods: A total of 115 patients who underwent single-stage ERCP + LC for CCL from January 2021 to December 2023 were enrolled in a retrospective comparative cohort study.These patients were divided into two groups: Group A (ERCP-first approach) and Group B (LC-first approach).Results: Patients in Group A had a common bile duct clearance rate of 88.2%, which was comparable to the 95.7% observed in Group B (p = 0.163).The mean duration of the ERCP procedure was comparable between the two groups (43.3 ± 11.8 vs 39.5 ± 13.5 minutes; p = 0.112).However, the mean duration of the LC procedure was significantly longer in Group A than in Group B (41.2 ± 8.98 vs 37.2 ± 12.2 minutes; p = 0.045).The mean total operative time for the combined ERCP + LC was significantly longer in Group A compared to Group B (81.9 ± 16.7 vs 75.1 ± 19.3 minutes; p = 0.046).Post-ERCP pancreatitis occurred in 4 patients in Group A and in 2 patients in Group B (p = 0.701).Conclusions: Both LC-1st approach and ERCP-1st approach are feasible and highly effective for treating CCL through single-stage ERCP + LC.However, the LC-1st approach has the advantage of a shorter operative time.

Mostafa M. Sayed

Ahmed Shawkat Abdelmohsen

Mostafa Ibrahim

Mohamad Raafat

Single-stage laparoendoscopic management of cholecystocholedocholithiasis: A retrospective study comparing starting with ERCP versus with laparoscopic cholecystectomy

单阶段腹腔镜内镜联合治疗胆囊胆总管结石：一项比较ERCP先行与腹腔镜胆囊切除术先行的回顾性研究

Bile duct injuries are a serious issue, and their surgical treatment carries the risk of morbidity and mortality.In selected cases, non-surgical treatments are possible, even for total strictures.We outline the technique and results of using magnetic compression anastomosis (MCA) to treat post-cholecystectomy bile duct stricture (PCBDS), in two female patients.Initially, a bilio-cutaneous tract was established via external biliary drainage, followed by the positioning of both endoscopic and percutaneous biliary magnets.After their approximation and subsequent removal, a fully covered self-expandable metal stent (FCSEMS) was deployed across the stricture.The magnet coupling was successfully achieved within the first two weeks of placement.The FCSEMS was maintained for durations of 12 and 16 months.Follow-up durations were 28 and 15 months post-FCSEMS removal.Both patients remain asymptomatic, with normal laboratory and imaging studies, and no adverse events were reported.MCA proves to be a safe and effective method for treating selected cases of total PCBDS.However, further studies and long-term follow-up are required to fully assess the efficacy of this technique.

Freddy Pereira Graterol

Francisco Salazar Marcano

Yajaira Venales Barrios

Yeisson Rivero-Moreno

Dong Ki Lee

Post-cholecystectomy total bile duct strictures: Cases for magnetic compression anastomosis

胆囊切除术后胆总管狭窄：磁压吻合术的病例分析

Giovanni D. Tebala, Paolo Pietro Bianchi, Giles Bond-Smith, Andrea Coratti, Fabrizio Panaro, Graziano Pernazza, Davide Cavaliere. Ann Hepatobiliary Pancreat Surg -0001;0:. https://doi.org/10.14701/ahbps.24-192

Giovanni D. Tebala

Paolo Pietro Bianchi

Giles Bond-Smith

Andrea Coratti

Fabrizio Panaro

Graziano Pernazza

Davide Cavaliere

Robotic versus laparoscopic cholecystectomy: Can they be compared? A narrative review and personal considerations disproving low-level evidence

机器人与腹腔镜胆囊切除术：它们能被比较吗？一篇反驳低水平证据的叙述性综述及个人思考

Backgrounds/Aims: Pancreatic texture is difficult to predict without palpation.Soft pancreatic texture is associated with increased post-operative complications, including postoperative pancreatic fistula (POPF), cardiac, and respiratory complications.We aimed to develop a calculator predicting pancreatic texture using patient factors and to illustrate complications from soft pancreatic texture following pancreaticoduodenectomy.Methods: Data was collected from the 2016 to 2021 American College of Surgeons National Surgical Quality Improvement database including 17,706 pancreaticoduodenectomy cases.Patients were categorized into two cohorts based on pancreatic texture (9,686 hard, 8,020 soft).Multivariable modeling assessed the impact of patient factors on complications, mortality, and pancreatic texture.These preoperative factors were integrated into a risk calculator (preoperative soft pancreas risk score [PSPRS]) that predicts pancreatic texture.Results: Patients with a soft pancreas had higher rates of postoperative complications compared to those with a hard pancreas (56.5% vs 42.2%; p < 0.001), particularly a threefold increase in POPF rate, and at least a twofold increase in rates of acute kidney injury, deep organ space infection, septic shock, and prolonged length of stay.Female sex (odds ratio [OR]: 1.14, confidence interval [CI]: 1.06-1.22,p < 0.001) and higher body mass index (OR: 1.12, CI: 1.09-1.16,p < 0.001) were independently associated with a soft pancreas.PSPRS ≥6 correctly identified >40% of patients preoperatively as having a hard pancreas (68.9% specificity).Conclusions: A soft pancreas was independently associated with serious postoperative complications.Our results were integrated into a risk calculator predicting pancreatic texture from preoperative patient factors, potentially enhancing preoperative counseling and surgical decision-making.

Zofia Czarnecka

Kevin Verhoeff

David Bigam

Khaled Dajani

James Shapiro

Blaire Anderson

Impact of soft pancreas on pancreaticoduodenectomy outcomes and the development of the preoperative soft pancreas risk score

软胰腺对胰十二指肠切除术后结果的影响及术前软胰腺风险评分的建立

Ana Duarte, Vasyl Katerenchuk, Rita Poeira, Paula Rocha, Filipe Pissarra, Margarida Canas, Sandra Dias, Diogo Andrade, Hugo Pinto Marques, Susana Cadilha, José Silva Pinto. Ann Hepatobiliary Pancreat Surg -0001;0:. https://doi.org/10.14701/ahbps.24-170

Ana Duarte

Vasyl Katerenchuk

Rita Poeira

Paula Rocha

Filipe Pissarra

Margarida Canas

Sandra Dias

Diogo Andrade

Hugo Pinto Marques

Susana Cadilha

José Silva Pinto

Anesthesia management for total robotic liver transplantation: Inaugural case series in Europe

欧洲首例全机器人肝移植麻醉管理：系列病例报告

Abbreviation	Ann Hepatobiliary Pancreat Surg
Journal Impact	1.13
Quartiles(Global)	SURGERY(Q3)

Publication Information	Publisher: Korean Association of Hepato-Biliary-Pancreatic Surgery，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2021，Proportion of original research papers: ，Self Citation Rate:， Gold OA Rate:

Annals of Hepato-Biliary-Pancreatic Surgery

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Advances in neoadjuvant therapy for resectable pancreatic cancer over the past two decades

Intrahepatic cholangiocarcinoma: Evolving role of neoadjuvant and targeted therapy

Single-stage laparoendoscopic management of cholecystocholedocholithiasis: A retrospective study comparing starting with ERCP versus with laparoscopic cholecystectomy

Post-cholecystectomy total bile duct strictures: Cases for magnetic compression anastomosis

Robotic versus laparoscopic cholecystectomy: Can they be compared? A narrative review and personal considerations disproving low-level evidence

Single-stage laparoendoscopic management of cholecystocholedocholithiasis: A retrospective study comparing starting with ERCP versus with laparoscopic cholecystectomy

Post-cholecystectomy total bile duct strictures: Cases for magnetic compression anastomosis

Robotic versus laparoscopic cholecystectomy: Can they be compared? A narrative review and personal considerations disproving low-level evidence

Impact of soft pancreas on pancreaticoduodenectomy outcomes and the development of the preoperative soft pancreas risk score

Anesthesia management for total robotic liver transplantation: Inaugural case series in Europe

ISSN	2508-5778, 2508-5859
h-index	9