Bulletin of the Karaganda University Chemistry Series

The possibility of using the copolymers based on unsaturated polyesters with acrylic acid (AA) as the main component (polymeric basis) for the creation of novel highly effective sealants and glues of domestic produc-tion was demonstrated. Polyethylene glycol maleate (p-EGM) was synthesized by step-growth polymeriza-tion of maleic anhydride with ethylene glycol using the catalyst, which shortened the process duration. A number of solutions of p-EGM with AA were obtained. Physicochemical characteristics of initial solutions were determined. Some rheological properties of the solutions of p-EGM in unsaturated carboxylic acid were studied. Radical polymerization — the process of “cold curing” of the solutions of p-EGM with AA at room temperature was carried out. The combination of initiating a system of cold curing consisting of initiator (benzoyl peroxide) and promoter (dimethylaniline) was selected and their optimal content in the initial mon-omer mixture was established. The main parameters of curing, namely gelation time and curing time, were determined. Identification of the copolymers was performed using IR-spectroscopy. The morphology of the surfaces of cured samples of p-EGM with AA was studied using SEM. The optimal composition requiring further studies as highly filled compositional polymeric materials for using as sealants and glue basis was es-tablished.

G.K. Burkeyeva

Ye.M. Tazhbayev

D.M. Muslimova

G.D. Nurseiit

L.Zh. Zhaparova

Bulletin of the Karaganda University Chemistry series

“Cold Curing” of Polyethylene Glycol Maleate with Acrylic Acid and Some Physicochemical Properties of Their Solutions

聚乙二醇马来酸与丙烯酸的“冷固化”及其溶液的某些物理化学性质

The interaction of the superoxide radical ion O2– with the active site of Cu, Zn-superoxide dismutase is stud-ied by computer simulation using the ORCA software package version 5.0.2 at the level of density functional theory using the PBE functional and the basis sets of functions def2-SVP, def2-SVPD and def2-TZVPD. The main characteristics for two processes of electron transfer in the catalytic cycle of radical ion deactivation are obtained: reaction potential ΔG0, total reorganization energy λtot, activation energy ΔG≠, overlap matrix ele-ment HDA, and transfer rate constant k according to Marcus. The variable factor in the modeling is the pres-ence of the Zn2+ ion at the active site of the enzyme. Two variants of the electron transfer mechanism are con-sidered: one carried out through ligands and another occurring in the immediate vicinity of an oxygen-containing particle and a copper ion. It has been established that the presence of the Zn2+ ion contributes to a large extent only to the second electron transfer from the Cu+ ion to the protonated form of the radical ion, to the hydroperoxide radical HO2. Other things being equal, the zinc ion increases the electron transfer rate con-stant by five times through specific interactions.

A.V. Ryabykh

O.A. Maslova

S.A. Beznosyuk

A.S. Masalimov

The Role of Zinc Ion in the Active Site of Copper-Zinc Superoxide Dismutase

锌离子在铜锌超氧化物歧化酶活性位点中的作用

The paper presents the results of a physicochemical analysis of a coke sample from “Euromet” LLP (Kara-ganda, Kazakhstan), which is carbonaceous material with high carbon content, the absence of volatiles matter and low ash content. Carbon sorbents were obtained from low-value fractions of carbonized materials of the Karaganda region coke production by the steam-gas activation. An important advantage of using screenings (coke breeze class 0–10 mm, which was crushed and fractionated to a particle size of 2–5 mm.) is the exclu-sion of the energy-intensive carbonization stage from the technological process, which releases a large amount of environmentally harmful substances (phenols, cresols, gaseous emissions etc.). The optimal condi-tions for obtaining a sorbent from low-value coke breeze are a temperature of 850 °C and an activation time of 2 hours. The physicochemical properties (ash content, bulk density, sorption capacity for iodine and meth-ylene blue, total pore volume for water) of carbon sorbents were determined.

Z.M. Muldakhmetov

A.T. Ordabaeva

M.G. Meiramov

A.M. Gazaliev

Zh.S. Shaikenova

G.K. Mukusheva

T.S. Zhivotova

Obtaining Carbon Sorbent from “Euromet” LLP Coke Breeze

从“Euromet”LLP焦粉中获取碳吸附剂

This paper presents the results of an ESR spectroscopic study of the intermolecular proton exchange kinetics with some isomers of aminocaproic acid, such as 2-aminohexanoic and 6-aminohexanoic acids in the toluene indifferent medium. A stable semiquinone radical, namely 3,6-di-tert-butyl-2-hydroxyphenoxyl, is used as a spin probe. The ESR spectra have been recorded on a RE-1306 spectrometer. The article provides the ob-tained dynamic spectra of the intermolecular proton exchange process. Modeling of the proton exchange ESR spectra has been carried out using a previously developed program, which is based on a four-jump model of this reaction and modified Bloch equations. The kinetic parameters of the process of acid-base interaction of the spin probe with amino acids and the activation barrier of the reaction have been estimated with a mini-mum error based on a comparison of the model spectra with the experimental ones. The obtained data have been analyzed and compared with previous studies. It has been found that the reaction rate of the intermo-lecular proton exchange between 3,6-di-tert-butyl-2-hydroxyphenoxy and studied aliphatic amino acids is comparable to the same with aliphatic carboxylic acids. Hoewever, in our case, there is an increase in the ac-tivation barrier, which apparently is associated with a negative effect on the intramolecular hydrogen bonding process between the amino and the carboxyl groups in the amino acid molecule.

I.L. Stadnik

F.Zh. Abilkanova

Ye.V. Kudryavtseva

S.N. Nikolskiy

ESR-Study of the Proton Exchange with Aliphatic Amino Acids in Toluene

甲苯中脂肪族氨基酸与质子交换的ESR研究

The article is dedicated to the 90th anniversary of Academician Esen Abikenovich Bekturov, a prominent Ka-zakhstani chemist who has made an outstanding world contribution to the physical chemistry of polymers. His scientific interests focused on the study of water-soluble and water-swelling polymers, interpolymer and polymer-metal complexes, polymeric catalysts and associates, polymeric hydrogels, molecular complexes of polymers, nanomaterials and nanotechnology are summarized in numerous monographs published in Japan, Germany, Poland, and Kazakhstan. The essay briefly reflects the life path, creativity, scientific and pedagogi-cal activity of Professor Esen Bekturov, as well as the most important and prominent publications. His role in the transfer of knowledge, training of high-qualified specialists, his contribution to Research and Develop-ment (R&amp;D), recognized by numerous International and Republican awards and participation at International Conferences and Symposiums, are highlighted.

S.E. Kudaibergenov

The Contribution of Professor Esen Bekturov to Physical Chemistry of Polymers

埃森·贝克图罗夫教授对聚合物物理化学的贡献

The thermal decomposition of low-temperature coal tar (LTCT) obtained from the coals of Shubarkol Komir JSC of the Republic of Qazaqstan in the presence of nanocatalysts with metal oxides (iron, cobalt and nickel) supported on microsilicate was studied for the first time. Microsilicate acts as a carrier and catalyst. Microsil-icate is a product of the Karaganda silicon plant of “Tau-Ken.temir” LLP. The main chemical component of the original microsilicate is silicon oxide. The individual and chemical phase composition of the microsilicate was determined using X-ray spectral analysis. The particle size of the initial microsilicate and the mixture of microsilicate with metal oxide catalysts (nickel, cobalt, and iron) was determined using a nanosizer. Stages of thermal decomposition of LTCT and a mixture of LTCT with catalysts under conditions of programmed heat-ing up to 640 °С in a nitrogen atmosphere have been established. On the basis of thermogravimetric analysis, the kinetic parameters (activation energy, mass loss rate, and pre-exponential factor) of LTCT pyrolysis and mixture with added catalysts were determined. The modeless integral isoconversion Ozawa–Flynn–Wall method was used to determine the kinetic parameters. The values of the activation energy for the thermal de-struction of the LTCT in the absence and presence of the nanocatalyst ranged from 54.04 to 297.5 kJ/mol. A kinetic compensation effect was revealed, probably due to the multicomponent composition of the LTCT and the influence of added catalysts to the LTCT. The thermogravimetry method showed a high effect of the sup-ported catalysts on the thermal degradation of LTCT. This method was used to determine the values of the ac-tivation energy and the pre-exponential degradation factor for the LTCT and the mixture with catalysts at dif-ferent heating rates, which allows a detailed interpretation of the thermal analysis data. The obtained results of the kinetics of decomposition of LTCT can be used to create a database for mathematical modeling of the process of processing this type of raw material.

S. Tyanakh

M.I. Baikenov

A.M. Gulmaliev

Feng-Yun Ma

G. Musina

T.O. Khamitova

A.N. Bolatbay

Kinetics of Thermolysis of a Low-Temperature Tar in the Presence of a Catalyzer Agent with Deposited Metals

催化剂金属负载下低温焦油热解动力学

The electrochemical behavior of methionine at an electrode modified with vitamin B12 and multi-walled car-bon nanotubes has been studied in this work. A possible mechanism of redox processes occurring on the modified electrode is proposed. When the electrode is formed, vitamin B12 is fixed on the surface of a carbon-containing electrode modified with multi-walled carbon nanotubes due to adsorption. In the process of ca-thodic polarization, cobalt(III) in cobalamin is reduced to cobalt(II) to which a partially negatively-charged sulfur atom in the methionine molecule is attached due to electrostatic interactions. During anodic polariza-tion, cobalt(II) in the complex is oxidized up to Co3+, the methyl group from methionine is transferred to co-balamin, and homocysteine passes into the solution, which is proved by Raman spectra. Based on the study of the dependence of current and potential on the sweep speed, it was found that the oxidation process is not re-versible, the limiting stage is adsorption, and one proton and one electron participate in the electrochemical stage. The following optimal conditions for recording an analytical signal were selected: the background elec-trolyte is a tartrate buffer solution with pH = 4.01; the electrolysis potential is 1.6 V; the accumulation time is up to 180 s. The metrological characteristics of the procedure for determining methionine were estimated. The accuracy index did not exceed 29 %, the repeatability and intermediate precision indices did not exceed 14 % and 16 %, respectively. The range of detectable contents was (1–50)×10–7; the detection limit was 5.0×10–8 M. It was shown that a 10-fold excess of ascorbic acid, tryptophan, glycine, cysteine and tyrosine does not have a noticeable distorting effect on the procedure for determining methionine.

V.V. Shelkovnikov

A.M. Altyev

M.S. Fryanova

Study of the Methionine Electrooxidation at an Electrode Modified with Vitamin B12 and Multi-Walled Carbon Nanotubes

维生素B12和多壁碳纳米管修饰电极上蛋氨酸电氧化的研究

The novel corona virus infection had become a global epidemic due to its rapid spread. So, there is an urgent need to treat COVID-19 patients. The aim of this research was to hypothesize and examine vitamin drug con-jugate as targeted moiety. The present scaffold may have potential role to fight against COVID-19 infection due to its antimicrobial, antioxidants and immunomodulatory activities. Here, we've highlighted the term Vit-amin Drug Conjugate as possible therapy approach for SARS-COV-2 infection. As a result, we synthesize, characterized, and evaluated a Hydroxychloroquine — Folic Acid conjugate (HCQ-FA) by esterification mechanism to provide effective treatment against SARS-CoV-2 infection by enhancing therapeutic effect through synergistic mechanism, masking undesired side effects, and improving cellular internalization. By us-ing prodrug, the efficacy and bioavailability of existing antiviral drugs could be improved. The structure of the conjugate was determined by spectroscopic data like IR, NMR, and mass spectra, which indicates that HCQ-FA conjugate formed by esteric conjugation. Molecular docking studies revealed that HCQ-FA conju-gate shows good level of docking as well as binding interaction with main protease moiety. Molecular dy-namic stimulation revealed that this conjugate shows good stability at the binding site of SARS main protease moiety and exhibits inhibitory activity against COVID-19 infection.

R.P. Bhole

P.M. Karche

Y. Shinde

P.R. Kute

S.S. Gurav

R.D. Wavhale

Design and Synthesis of Vitamin Drug Conjugate for its Probable Potential Against SARS-COV-2 Infections

维生素药物偶联物的设计与合成及其对SARS-COV-2感染潜在疗效的研究

This review considers recent work on the synthesis of transition metal ferrites (Co, Cu, Ni, Mn) by sol-gel method with combustion, as well as the effect of microwave radiation. Ferrites are interesting not only for magnetic and optical properties, but also for their catalytic ones. In recent years, there has been an increasing amount of literature, which investigates the catalytic properties of transition metal ferrites in various reac-tions, including oxidative reactions. Given the fact that various organic components are used as complexing agents and as a fuel in the sol-gel method with combustion, the review considers the influence of the organic reagent nature, its ratio to precursors, the pH of the medium, the power and time of microwave exposure to the process of ferrite formation as factors influencing the size of formed particles and their textural character-istics, which are of great importance in the catalysis. Recently, the attention of chemists working in the field of catalysis has been attracted by studies of the effect of physical fields, to which the microwave field be-longs, on various chemical processes, including the nanocatalysts synthesis. The use of microwave radiation in sol-gel synthesis of ferrite allows obtaining nanoferrites with high specific surface area. From this point of view, this paper considers the works of recent years devoted to the study of microwave sol-gel synthesis of ferrite.

S.M. Zulfugarova

G.R. Azimova

Z.F. Aleskerova

Yu.N. Litvishkov

D.B. Tagiyev

Synthesis of Transition Metal Ferrites (Co, Cu, Ni, Mn) by the Sol-Gel Method with Combustion and the Use of Microwave Processing

通过溶胶-凝胶法和燃烧技术合成过渡金属铁氧体（Co、Cu、Ni、Mn）及微波处理的应用

Three different nanogels possessing anionic, cationic and amphoteric character were synthesized via conven-tional redox initiated free radical copolymerization of N-isopropylacrylamide (NIPAM), 2-acrylamido-2-methyl-1-propanesulfonic acid sodium salt (AMPS) and (3-acrylamidopropyl) trimethylammonium chloride (APTAC). The negatively charged [NIPAM]:[AMPS] = 90:10 mol.%, positively charged [NIPAM]:[APTAC] = = 90:10 mol.%, and charge-balanced amphoteric nanogels [NIPAM]:[APTAC]:[AMPS] = 90:5:5 mol.% ab-breviated as NIPAM90-AMPS10, NIPAM90-APTAC10, and NIPAM90-APTAC5-AMPS5, respectively, were characterized by FTIR spectroscopy, TGA, UV-Vis spectroscopy and DLS measurements. The temperature and salt responsive properties of nanogels in aqueous and aqueous-salt solutions were studied in the tempera-ture range of 25–60 °C and ionic strength (μ) of 0.001–1.0 M NaCl. Anionic NIPAM90-AMPS10 and cationic NIPAM90-APTAC10 nanogels, exhibit a pronounced polyelectrolyte effect in aqueous-salt solution due to screening of the negative or positive charges by low-molecular-weight salt. Whereas the charge-balanced amphoteric nanogel NIPAM90-APTAC5-AMPS5 exhibits an antipolyelectrolyte effect due to the screening of electrostatic attraction between opposite charges by low-molecular-weight salt. The difference between the temperature-dependent behaviors of anionic, cationic and amphoteric nanogels is explained by shrinking (polyelectrolyte effect) and expanding (antipolyelectrolyte effect) of macromolecular chains in aqueous-salt solutions.

A.Ye. Ayazbayeva

A.V. Shakhvorostov

Temperature and Salt Responsivity of Anionic, Cationic and Amphoteric Nanogels Based on N-Isopropylacrylamide, 2-Acrylamido-2-Methyl-1-Propanesulfonic Acid Sodium Salt and (3-Acrylamidopropyl) Trimethylammonium Chloride

基于N-异丙基丙烯酰胺、2-丙烯酰胺-2-甲基-1-丙磺酸钠和(3-丙烯酰胺丙基)三甲基氯化铵的阴离子、阳离子和两性纳米凝胶的温度和盐响应性

Abbreviation	Bull. of the Kar. Univ. "Chem". Ser.
Journal Impact	0.71
Quartiles(Global)	CHEMISTRY, MULTIDISCIPLINARY(Q4)

Publication Information	Publisher: E.A.Buketov Karaganda State University Publish House，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2021，Proportion of original research papers: 92.54%，Self Citation Rate:0.00%， Gold OA Rate: 0.00%

Bulletin of the Karaganda University Chemistry Series

Journal Citation Format

A journal article with 1 author

A journal article with 2 authors

A journal article with 3 authors

A journal article with 5 or more authors

Books Citation Format

Thesis Citation Format

Web sites Citation Format

Patent Citation Format

Staying up late manually editing references? ivySCI automatically matches journals and helps you generate references with a single click.

Share Submission Experience