The journal "Problems of Cryobiology and Cryomedicine" publishes reviews and original research papers on cryobiological and cryomedical studies. It focuses on elucidating the mechanisms of injuries occurring in biological entities due to the influence of low and ultra-low temperatures, the natural resistance of biologicals to cold, and their recovery post-exposure. The journal also covers the development of effective cryoprotection methods and technologies for storing biological resources under hypothermic and ultra-low temperatures. Additionally, it explores the application of hypothermia, cryotherapy, and cryopreserved biologicals in treating various pathologies, as well as cell and tissue-based therapies and other issues related to low-temperature biology and medicine. The journal addresses all topics related to low-temperature biology, medicine, and engineering, including but not limited to: low-temperature storage of biologicals (human, animal, or plant cells, tissues, and organs), preparation for storage, thawing/warming, and cell and tissue culturing; the response of biologicals to low temperatures; cold adaptation in animals and plants; the utilization of low temperatures in medicine; experimental and clinical transplantation; cell and tissue-based therapies; the development of cryobiological and cryomedical devices; and the organization and functioning of low-temperature banks.