The journal "Circulation. Genomic and Precision Medicine" encompasses all types of original research articles, including studies conducted in human subjects, experimental animals, in vitro, and computational settings. Articles may cover the following research areas: clinical genetics applications in the diagnosis and management of single-gene or polygenic cardiovascular diseases; the molecular basis of complex cardiovascular diseases, including genome-wide association studies, exome and genome sequencing association studies, coding variant association studies, genetic linkage studies, epigenomics, transcriptomics, proteomics, metabolomics, and metagenomics; integration of electronic health record data or patient-generated data with any of the aforementioned methods (including phenotype association studies) or environmental and lifestyle factors; pharmacogenomics; gene expression regulation; gene therapy and therapeutic genome editing; systems biology approaches to the diagnosis and management of cardiovascular diseases; novel methods for conducting any of the above research; and new applications of precision medicine. Importantly, we seek research related to human cardiovascular biology and disease.