Clinical Hematology International

Helen Cashman

Andrew J Wilson

Ke Xu

Elisabeth Nacheva

Robert Baker

Rajeev Gupta

Untangling the clonal architecture in a case of acute myeloid leukaemia with multiple cytogenetically unrelated clones

解析一例急性髓系白血病中多个细胞遗传学上不相关的克隆的克隆结构

Background Advanced Therapy Medicinal Products (ATMPs) for human use have advanced globally with the rapid adoption of Chimeric Antigen Receptor T-cell (CAR-T) therapies in haemato-oncology. CAR-T cell therapy and ATMPs have unique, significant acute and chronic toxicities, and appropriate patient care is crucial. Significant challenges, including the need for nurse education and training, accompany optimal patient success and benefits. Objectives This study aimed to describe nurses’ training needs in relation to ATMP management and patient care. Methods A cross-sectional online survey was performed by the European Society for Blood and Marrow Transplantation, based on a previously tested questionnaire developed in the UK. Findings 109 complete responses from 86 different centers from 24 countries were returned (1207 distributed). Over 1/3 reported experience delivering licensed ATMPs (CAR-T). High-priority training areas included a general introduction to ATMPs, toxicity management, product-specific information, and regulatory frameworks for ATMPs. A clear need for ATMP-specific training exists and is regarded as important. Training prior to implementation is key and should be supported by ongoing competency maintenance. Counseling, patient support, and long-term follow-up are identified for future training and opportunities for nurse experience sharing in this rapidly evolving field.

Michelle Kenyon

Sarah Jayne Liptrott

Annika Kisch

Jarl Mooyaart

Brian Piepenbroek

Daphna Hutt

Isabel Salcedo

Annalisa Ruggeri

Cristian Chabannon

Rose Ellard

John Murray

Nurses’ reported training needs for advanced cell therapies: a survey on behalf of the Nurses Group of the EBMT

护士对高级细胞疗法培训需求的报告：欧洲血液与骨髓移植学会护士组的一项调查

Chronic graft-versus-host disease (cGVHD) represents a common long-term complication after allogeneic hematopoietic stem cell transplantation (HSCT). It imposes a significant morbidity burden and is the leading cause of non-relapse mortality among long-term HSCT survivors. cGVHD can manifest in nearly any organ, severely affecting the quality of life of a transplant survivor. While the mainstay of treatment has remained systemic immunosuppression with glucocorticoids, progress has been made within the last few years with approvals of three oral agents to treat steroid-refractory cGVHD: ibrutinib, ruxolitinib, and belumosudil. Iatrogenesis contributes a significant portion of the morbidity experienced by patients with cGVHD, primarily from glucocorticoids. This review highlights the myriad impacts of cGVHD, including and beyond the traditional organ systems captured by the National Institutes of Health Consensus Criteria, including iatrogenic complications of long-term immunosuppression. It presents the implications of cGVHD and its treatment on cardiovascular and metabolic health, bone density, endocrine function, sexual health, and ocular and pulmonary disease and outlines a framework around the comprehensive multidisciplinary approach for its evaluation and management.

Rahul Shah

Danielle Murphy

Melissa Logue

James Jerkins

Andrew Jallouk

Kassim Adetola

Olalekan Oluwole

Reena Jayani

Eden Biltibo

Tae K. Kim

Salyka Sengsayadeth

Wichai Chinratanalab

Carrie Kitko

Bipin Savani

Bhagirathbhai Dholaria

Multidisciplinary Management of Morbidities Associated with Chronic Graft-Versus-Host Disease

慢性移植物抗宿主病相关并发症的多学科管理

Abstract not included as this is letter to the editor.

Khushnuma Mullanfiroze

Charlotte Jones

David Williams

Matias Vieira

Ashutosh Wechalekar

Xenofon Papanikolaou

Rakesh Popat

Charalampia Kyriakou

Management of multiple myeloma presenting as malignant spinal cord compression during pregnancy: a case report

妊娠期间表现为恶性脊髓压迫的多发性骨髓瘤管理：一例报告

Shakthi T Bhaskar

Bipin N Savani

Overview of approved CAR-T products and utility in clinical practice

已批准CAR-T产品及其在临床实践中的应用概述

涉及主题	医学生物内科学病理遗传学免疫学外科疾病细胞生物学移植干细胞肿瘤科化学化疗生物化学造血干细胞移植数学物理
出版信息	出版商: Saabron Press，出版周期: ，期刊类型: journal，开源期刊: 是
基本数据	创刊年份: 2022，原创研究文献占比: 0.00%，自引率:N.A.， Gold OA占比: 0.00%
平均审稿周期	网友分享经验：20 Weeks

Clinical Hematology International

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Untangling the clonal architecture in a case of acute myeloid leukaemia with multiple cytogenetically unrelated clones

Nurses’ reported training needs for advanced cell therapies: a survey on behalf of the Nurses Group of the EBMT

Multidisciplinary Management of Morbidities Associated with Chronic Graft-Versus-Host Disease

Management of multiple myeloma presenting as malignant spinal cord compression during pregnancy: a case report

Overview of approved CAR-T products and utility in clinical practice

Nurses’ reported training needs for advanced cell therapies: a survey on behalf of the Nurses Group of the EBMT

Untangling the clonal architecture in a case of acute myeloid leukaemia with multiple cytogenetically unrelated clones

Management of multiple myeloma presenting as malignant spinal cord compression during pregnancy: a case report

Overview of approved CAR-T products and utility in clinical practice

Multidisciplinary Management of Morbidities Associated with Chronic Graft-Versus-Host Disease

ISSN	2590-0048
h-index	5