Insights into docking in megasynthases from investigation of the toblerol <i>trans</i>-AT polyketide synthase: many α-helical means to an end

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Contents list

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Contents list

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Front cover

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Back cover

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Access to capped RNAs by chemical ligation

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Cationic dextrin nanoparticles for effective intracellular delivery of cytochrome <i>C</i> in cancer therapy

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Contents list

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Biosynthesis of the corallorazines, a widespread class of antibiotic cyclic lipodipeptides

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Introduction to ‘Medicinal Chemistry Small Molecule Probes’

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Back cover

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Harnessing acetogenic bacteria for one-carbon valorization toward sustainable chemical production

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Metabolically activated proteostasis regulators that protect against erastin-induced ferroptosis

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The Mycobacterium lipid transporter MmpL3 is dimeric in detergent solution, SMALPs and reconstituted nanodiscs

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Peptide dendrimers transfecting CRISPR/Cas9 plasmid DNA: optimization and mechanism

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Affinity enhancement of polo-like kinase 1 polo box domain-binding ligands by a bivalent approach using a covalent kinase-binding component

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Sialic acids in infection and their potential use in detection and protection against pathogens

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Genetically Encodable Biosensors for Ras Activity

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Ancient and modern mechanisms compete in progesterone receptor activation

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Introduction to the themed collection on ‘Molecular and Nanotheranostics’

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Tracking the cellular uptake and phototoxicity of Ru(<scp>ii</scp>)-polypyridyl-1,8-naphthalimide Tröger's base conjugates

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Molecularly imprinted nanoparticles reveal regulatory scaffolding features in Pyk2 tyrosine kinase

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[⁶⁸Ga]Ga-THP-Tetrazine for bioorthogonal click radiolabelling: Pretargeted PET imaging of liposomal nanomedicines

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Inside front cover

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Front cover

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Engineered triphenylphosphonium-based, mitochondrial-targeted liposomal drug delivery system facilitates cancer cell killing actions of chemotherapeutics

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A cell-permeable probe for the labelling of a bacterial glycosyltransferase and virulence factor

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Redox-neutral, metal-free tryptophan labeling of polypeptides in hexafluoroisopropanol (HFIP)

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A minimal RNA substrate with dual fluorescent probes enables rapid kinetics and provides insight into bacterial RNase P active site interactions

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Front cover

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Biomedical applications, perspectives and tag design concepts in the cell - silent Raman window

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Why pyridoxal phosphate could be a functional predecessor of thiamine pyrophosphate and speculations on a primordial metabolism

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Site-specific RNA modification <i>via</i> initiation of <i>in vitro</i> transcription reactions with m⁶A and isomorphic emissive adenosine analogs

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Cell penetration of oxadiazole-containing macrocycles

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Enhancement of tryptophan 2-monooxygenase thermostability by semi-rational enzyme engineering: A strategic design to minimize experimental investigation

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Front cover

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Advanced piperazine-containing inhibitors target microbial β-glucuronidases linked to gut toxicity

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Discovery of a New Inhibitor for the YTH Domain-containing m6A RNA Readers

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Novel strategy for activating gene expression through triplex DNA formation targeting epigenetically suppressed genes

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Superoxide-responsive quinone methide precursors (QMP-SOs) to study superoxide biology by proximity labeling and chemoproteomics

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Bioluminescent detection of viral surface proteins using branched multivalent protein switches

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Evaluating Riboglow-FLIM probes for RNA sensing

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Target identification of usnic acid in bacterial and human cells

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Carbohydrate-active enzyme (CAZyme) Discovery and Engineering via (Ultra)High-throughput Screening

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Click chemistry in the development of PROTACs

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A covalent compound selectively inhibits RNA demethylase ALKBH5 rather than FTO

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