AJOG Global Reports

Autoimmune thyroid disease, one of the main risk factors for hypothyroidism, is associated with adverse pregnancy outcomes. The burden of autoimmune thyroid disease in pregnancy and its association with thyroid function among normotensive pregnant women and pregnant women with hypertension in South Africa are not known.This study aimed to establish the magnitude of thyroid peroxidase autoantibodies in pregnancy in the Eastern Cape of South Africa and its relationship with iodine nutrition status and preeclampsia.Overall, 60 randomly selected normotensive pregnant controls at term and 120 pregnant participants with preeclampsia in the third trimester of pregnancy going to the Mthatha Regional Hospital and the Nelson Mandela Academic Hospital in the Eastern Cape Province who had complete data on thyroid peroxidase antibody titers, urinary iodine concentrations, serum thyroid-stimulating hormones, and free triiodothyronine, free thyroxine, and thyroglobulin levels were enrolled in this unmatched case-control study.The cases and controls had similar mean chronological age (23.8 vs 24.0 years), body mass index (29.4 vs 28.8 kg/m2), and median parity (both 1) (P>.05). The controls had a higher mean gestational age than participants with preeclampsia (38.5 vs 33.7 weeks, respectively; P<.001). Both participants with preeclampsia and normotensive participants had median thyroid peroxidase antibody levels consistent with a negative thyroid autoimmune status. Participants with preeclampsia had higher but nonstatistically significant median thyroid peroxidase antibody (2.14 vs 1.77 IU/L), thyroglobulin (25.9 vs 21.3 µg/L), and thyroid-stimulating hormone (2.4 vs 2.3 mIU/L) levels (P>.05) and significantly lower median urinary iodine concentration (123.4 vs 188.6 µg/L), free thyroxine (13.2 vs 14.1 pmol/L), and free triiodothyronine (4.3 vs 4.6 pmol/L) levels (P<.05) than normotensive controls. Thyroid peroxidase antibodies were positively correlated with thyroglobulin, urinary iodine concentration, and thyroid-stimulating hormone.In the rural Eastern Cape of South Africa, pregnant women in the third trimester of pregnancy have thyroid peroxidase antibody titers that show negative thyroid autoimmune status. Insufficient iodine intake, other than thyroid autoimmune disease, seems to be the underlying cause of the lower free triiodothyronine and free thyroxine levels observed among women with preeclampsia.

Charles Bitamazire Businge

Keletso Phohlo

Constance Sewani-Rusike

Thyroid peroxidase antibody titers, thyroid function, and iodine nutrition status of pregnant normotensive and preeclamptic women in Eastern Cape South Africa

In vitro fertilization is the most used assisted reproductive technology in the United States that is increasing in efficiency and in demand. Certain states have mandated coverage that enable individuals with low income to undergo in vitro fertilization treatment. This study aimed to evaluate if socioeconomic status has an impact on the perinatal outcomes in in vitro fertilization pregnancies. We hypothesized that with greater coverage there may be an alleviation of the financial burden of in vitro fertilization that can facilitate the application of evidence-based practices. This was a retrospective, population-based, observational study that was conducted in accordance with the Healthcare Cost and Utilization Project–Nationwide Inpatient Sample database over the 6-year period from 2008 to 2014 during which period 10,000 in vitro fertilization deliveries were examined. Maternal outcomes of interest included preterm prelabor rupture of membranes, preterm birth (ie, before 37 weeks of gestation), placental abruption, cesarean delivery, operative vaginal delivery, spontaneous vaginal delivery, maternal infection, chorioamnionitis, hysterectomy, and postpartum hemorrhage. Neonatal outcomes included small for gestational age neonates, defined as birthweight <10th percentile, intrauterine fetal death, and congenital anomalies. Our study found that the socioeconomic status did not have a statistically relevant effect on the perinatal outcomes among women who underwent in vitro fertilization to conceive after adjusting for the potential confounding effects of maternal demographic, preexisting clinical characteristics, and comorbidities. The literature suggests that in states with mandated in vitro fertilization coverage, there are better perinatal outcomes because, in part, of the increased use of best in vitro fertilization practices, such as single-embryo transfers. Moreover, the quality of medical care in states with coverage is in the highest quartile in the country. Therefore, our findings of equivalent perinatal outcomes in in vitro fertilization care irrespective of socioeconomic status possibly suggests that a lack of access to quality medical care may be a factor in the health disparities usually seen among individuals with lower socioeconomic status.

Misha Fotovati

Ahmad M. Badeghiesh

Haitham A. Baghlaf

Michael H. Dahan

The relationship between socioeconomic status and perinatal outcomes in in vitro fertilization conceptions

社会经济地位与体外受精妊娠围产期结局的关系

Sarah Hansen

Monica Lauridsen Kujabi

Rikke Damkjær Maimburg

Anna Macha

Luzango Maembe

Idrissa Kabanda

Hudson Manyanga

Rukia Juma Msumi

Sangalala Mtingele

Natasha Housseine

Brenda Sequeira Dmello

Kidanto Hussein

Thomas van den Akker

Dan Wolf Meyrowitsch

Nanna Maaløe

Disclosing possible non-medically indicated caesarean sections in five high-volume urban maternity units in Tanzania: A criterion-based clinical audit

坦桑尼亚五家高容量城市产科单位中可能非医学指征剖宫产的披露：基于标准的临床审计

Kadek A. Kurniawan

Sri Winarsih

Nurdiana Nurdiana

Sri Andarini

Wiwit Nurwidyaningtyas

The primiparous IgA and IL-5 colostrum concentration based on maternal factor: corroborate the inflammation pathways to IgA colostrum synthesis

基于母体因素的首胎初乳中IgA和IL-5浓度：验证炎症通路对IgA初乳合成的影响

Greg Marchand

Ahmed Massoud

Hollie Ulibarri

Amanda Arroyo

Daniela Gonzalez Herrera

Brooke Hamilton

Kate Ruffley

Mckenna Robinson

Marissa Dominick

Ali Azadi

Non-Inferiority of Single Incision Laparoscopy Versus Conventional Laparoscopy in Salpingectomy or Salpingotomy for Ectopic Pregnancy, a Meta Analysis

单孔腹腔镜与传统腹腔镜在异位妊娠输卵管切除术或输卵管切开术中的非劣效性：一项Meta分析

Hassine Saber ABOUDA

Haithem ALOUI

Eya AZOUZ

Sofiene Ben MARZOUK

Hatem FRIKHA

Rami HAMMAMI

Sana MINJLI

Rachid HENTATI

Mehdi KHILA

Badis Mohamed CHANOUFI

Abir KAROUI

Maghrebi HAYEN

New Surgical Technique for Managing Placenta Accreta Spectrum and Pilot Study of the "CMNT PAS" Study

管理胎盘植入谱的新手术技术及“CMNT PAS”研究的初步研究

Md. Nawal Sarwer

Effat Ara Jahan

Akibul Islam Chowdhury

Does Women Empowerment alone Influence Contraception utilization in Bangladesh perspective? Findings from demographic health survey 2017-18 using A SEM analysis

女性赋权本身是否影响孟加拉国的避孕措施使用？基于2017-18年人口健康调查的结构方程模型分析结果

Publication Information	Publisher: Elsevier Inc.，Publishing cycle: ，Journal Type: journal，Open Access Journals: Yes
Basic data	Year of publication: 2021，Proportion of original research papers: ，Self Citation Rate:， Gold OA Rate:
Journal Fees	$2000Details
Average review cycle	21 weeks

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Thyroid peroxidase antibody titers, thyroid function, and iodine nutrition status of pregnant normotensive and preeclamptic women in Eastern Cape South Africa

The relationship between socioeconomic status and perinatal outcomes in in vitro fertilization conceptions

Disclosing possible non-medically indicated caesarean sections in five high-volume urban maternity units in Tanzania: A criterion-based clinical audit

The primiparous IgA and IL-5 colostrum concentration based on maternal factor: corroborate the inflammation pathways to IgA colostrum synthesis

Non-Inferiority of Single Incision Laparoscopy Versus Conventional Laparoscopy in Salpingectomy or Salpingotomy for Ectopic Pregnancy, a Meta Analysis

Disclosing possible non-medically indicated caesarean sections in five high-volume urban maternity units in Tanzania: A criterion-based clinical audit

The primiparous IgA and IL-5 colostrum concentration based on maternal factor: corroborate the inflammation pathways to IgA colostrum synthesis

Non-Inferiority of Single Incision Laparoscopy Versus Conventional Laparoscopy in Salpingectomy or Salpingotomy for Ectopic Pregnancy, a Meta Analysis

New Surgical Technique for Managing Placenta Accreta Spectrum and Pilot Study of the "CMNT PAS" Study

Does Women Empowerment alone Influence Contraception utilization in Bangladesh perspective? Findings from demographic health survey 2017-18 using A SEM analysis

ISSN	2666-5778
h-index	7