Advances in Redox Research

Manikandan Vani Raju

Meenakshi Kaniyur Chandrasekaran

Rathi Muthaiyan Ahalliya

Gopalakrishnan Velliyur Kanniappan

Reconnoitering the role of Lipid Metabolites in Ferroptosis

探究脂质代谢物在铁死亡中的作用

Raju Rana

Dr. Shobha U Kamath

Dr. B Ananthakrishna Shastri

Dr. Shashikiran U

Dr. G Arun Maiya

Dr. Ullas Kamath

Dr. Raghavendra Rao S

Dr. Vani Lakshmi R

Evaluation of thiol/disulfide homeostasis and ischemia-modified albumin in metabolic syndrome patients

代谢综合征患者硫醇/二硫化物稳态及缺血修饰白蛋白的评估

Karina Ricart

Kyle S. McCommis

David A. Ford

Rakesh P. Patel

2-Chloro- and 2-Bromopalmitic Acids Inhibit Mitochondrial Function in Airway Epithelial Cells

2-氯和2-溴棕榈酸抑制气道上皮细胞的线粒体功能

Amyloid aggregates are responsible for the development of oxidative stress and neurotoxicity in the brain. Several amino acid residues of amyloid beta (Aβ) 42 establish different molecular interactions to form and stabilize these aggregates, which can be targeted to prevent the aggregation. Resveratrol (Res) has inhibitory properties against Aβ 42 aggregation but studies elucidating its interactions with different residues of Aβ 42 aggregates are scarce. In the present study, we have discerned the molecular interactions of Res with different amino acid residues of Aβ 42 peptide and fibril during in-vitro Aβ 42 aggregation. Inhibitory properties of Res against amyloid aggregation were established through ANS and Thioflavin-T fluorescence assay, congo red assay and CD spectroscopy. The molecular interactions were established through molecular docking and 100 ns molecular dynamics simulations. The hydrophobic regions of Aβ 42 peptide, responsible for the formation of aggregates, were better protected in the presence of Res as indicated by ANS assay. Th-T and congo red assay suggested that Res prevented the formation of cross β-sheet structures. CD spectra analysis revealed that in the presence of Res, the secondary structure content was significantly decreased. MD simulation analysis revealed that Res formed strong molecular interactions with hydrophobic and secondary structure forming amino acid residues, which are involved in the amyloid aggregation and stabilization of aggregates. In conclusion, these interactions might have led to the decline in secondary structure content, formation of unordered nontoxic aggregates and prevention of the formation of sufuranyl free radical.

Sheetal Sharma

Hemant Goyal

Shubhi Joshi

Bimla Nehru

Avneet Saini

Molecular interactions of resveratrol with Aβ 42 peptide and fibril during in-vitro Aβ 42 aggregation

白藜芦醇与Aβ 42肽及其纤维在体外Aβ 42聚集过程中的分子相互作用

Oxidative stress (OS) is a phenomenon caused by an imbalance between free-radical production and antioxidant activity within the body. Status of endogenous antioxidants is not always sufficient to mitigate the oxidative damage. In this case, exogenous antioxidants could help to minimize free-radical production and subsequent OS. Green tea is rich in several phenolic compounds that have strong antioxidant properties. However, their mechanism of action is still unclear. Hence, the present study aims to investigate binding affinities of six green tea polyphenols such as catechin, epicatechin, epicatechin gallate, epigallocatechin, epigallocatechin gallate, and gallocatechin for common ROS producers such as Lipoxygenase (LOX), CYP2C9, and NAD(P)H oxidase (NOX). Results indicated that polyphenols interacted with binding pockets of these enzymes through hydrogen bonds and other stable interactions such as van der waals, Pi-Pi, Pi-alkyl, and alkyl. All polyphenols showed varied binding affinities. Among them, epigallocatechin gallate and epigallocatechin showed the highest binding affinities for the ROS producers. Findings of the present study suggest that, apart from free radical scavenging activity, green tea polyphenols may directly interact with binding pockets of LOX, CYP2C9, and NOX to dampen ROS production and OS. However, studies involving animal models are required for additional validation of results.

Prem Rajak

Abhratanu Ganguly

Moutushi Mandi

Anik Dutta

Saurabh Sarkar

Sayantani Nanda

Kanchana Das

Siddhartha Ghanty

Gopal Biswas

In silico targeting of lipoxygenase, CYP2C9, and NAD(P)H oxidase by major green tea polyphenols to subvert oxidative stress

主要绿茶多酚通过计算机模拟靶向脂氧合酶、CYP2C9和NAD(P)H氧化酶以逆转氧化应激

Sarah E. Lacher

Tessa Schumann

Ryan Peters

Christopher Migliaccio

Andrij Holian

Matthew Slattery

NRF2 Protects Lung Epithelial Cells from Wood Smoke Particle Toxicity

NRF2保护肺上皮细胞免受木材烟雾颗粒毒性

Jibon Kumar Paul

Mahir Azmal

ANM Shah Newaz Been Haque

Omar Faruk Talukder

Meghla Meem

Ajit Ghosh

Phytochemical-Mediated Modulation of Signaling Pathways: A Promising Avenue for Drug Discovery

植物化学介导的信号通路调控：药物发现的新途径

Publication Information	Publisher: Elsevier Inc.，Publishing cycle: ，Journal Type: journal，Open Access Journals: Yes
Basic data	Year of publication: 2021，Proportion of original research papers: ，Self Citation Rate:， Gold OA Rate:
Journal Fees	$1500Details
Average review cycle	19 weeks

Advances in Redox Research

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Reconnoitering the role of Lipid Metabolites in Ferroptosis

Evaluation of thiol/disulfide homeostasis and ischemia-modified albumin in metabolic syndrome patients

2-Chloro- and 2-Bromopalmitic Acids Inhibit Mitochondrial Function in Airway Epithelial Cells

Molecular interactions of resveratrol with Aβ 42 peptide and fibril during in-vitro Aβ 42 aggregation

In silico targeting of lipoxygenase, CYP2C9, and NAD(P)H oxidase by major green tea polyphenols to subvert oxidative stress

Reconnoitering the role of Lipid Metabolites in Ferroptosis

Evaluation of thiol/disulfide homeostasis and ischemia-modified albumin in metabolic syndrome patients

2-Chloro- and 2-Bromopalmitic Acids Inhibit Mitochondrial Function in Airway Epithelial Cells

NRF2 Protects Lung Epithelial Cells from Wood Smoke Particle Toxicity

Phytochemical-Mediated Modulation of Signaling Pathways: A Promising Avenue for Drug Discovery