Advances in Ophthalmology Practice and Research

Dry eye disease (DED) is a commonly reported ocular complaint that has garnered significant attention in recent research. The global occurrence of DED ranges from 5% to 50%, impacting a substantial proportion of individuals worldwide with increasing frequency. Although topical administration remains the mainstream drug delivery method for ocular diseases, it suffers from drawbacks such as low bioavailability, rapid drug metabolism, and frequent administration requirements. Fortunately, the advancements in nanomedicine offer effective solutions to address the aforementioned issues and provide significant assistance in the treatment of DED.

Zeen Lv

Su Li

Guixiang Zeng

Ke Yao

Haijie Han

Recent progress of nanomedicine in managing dry eye disease

纳米医学在干眼病管理中的最新进展

In the last two decades, electrical stimulation (ES) has been tested in patients with various eye diseases and shows great treatment potential in retinitis pigmentosa and optic neuropathy. However, the clinical application of ES in ophthalmology is currently limited. On the one hand, optimization and standardization of ES protocols is still an unmet need. On the other hand, poor understanding of the underlying mechanisms has hindered clinical exploitation. Numerous experimental studies have been conducted to identify the treatment potential of ES in eye diseases and to explore the related cellular and molecular mechanisms. In this review, we summarized the in vitro and in vivo evidence related to cellular and tissue response to ES in eye diseases. We highlighted several pathways that may be utilized by ES to impose its effects on the diseased retina. Therapeutic effect of ES in retinal degenerative diseases might through preventing neuronal apoptosis, promoting neuronal regeneration, increasing neurotrophic factors production in Müller cells, inhibiting microglial activation, enhancing retinal blood flow, and modulating brain plasticity. Future studies are suggested to analyse changes in specific retinal cells for optimizing the treatment parameters and choosing the best fit ES delivery method in target diseases.

Jinfeng Liu

Andre K.H. Ma

Kwok Fai So

Vincent W.H. Lee

Kin Chiu

Mechanisms of electrical stimulation in eye diseases: A narrative review

眼病电刺激机制：叙述性综述

Sen Ma

Ruben V. Huis In’t Veld

Elisabet de los Pinos

Ferry A. Ossendorp

Martine J. Jager

Targeting ocular malignancies using a novel light-activated virus-like drug conjugate

利用新型光激活病毒样药物偶联物靶向眼部恶性肿瘤

Yuyu Cao

Wei Lu

Runhan Shi

Fuying Liu

Steven Liu

Xinwei Xu

Jin Yang

Guangyu Rong

Changchang Xin

Xujiao Zhou

Xinghuai Sun

Jiaxu Hong

Performance of Popular Large Language Models in Glaucoma Patient Education: a randomized controlled study

流行大型语言模型在青光眼患者教育中的表现：一项随机对照研究

Lan Ma

Xue Jiang

Zhijia Hou

Dongmei Li

Causal association between non-thyroidal autoimmune diseases and Graves' ophthalmopathy: a mendelian randomization study

非甲状腺自身免疫疾病与格雷夫斯眼病之间的因果关联：一项孟德尔随机化研究

Publication Information	Publisher: Elsevier Inc.，Publishing cycle: ，Journal Type: journal，Open Access Journals: Yes
Basic data	Year of publication: 2021，Proportion of original research papers: ，Self Citation Rate:， Gold OA Rate:
Journal Fees	$1600Details
Average review cycle	14 weeks

Advances in Ophthalmology Practice and Research

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Recent progress of nanomedicine in managing dry eye disease

Mechanisms of electrical stimulation in eye diseases: A narrative review

Targeting ocular malignancies using a novel light-activated virus-like drug conjugate

Performance of Popular Large Language Models in Glaucoma Patient Education: a randomized controlled study

Causal association between non-thyroidal autoimmune diseases and Graves' ophthalmopathy: a mendelian randomization study

Targeting ocular malignancies using a novel light-activated virus-like drug conjugate

Performance of Popular Large Language Models in Glaucoma Patient Education: a randomized controlled study

Causal association between non-thyroidal autoimmune diseases and Graves' ophthalmopathy: a mendelian randomization study

Nano-based drug delivery systems for the treatment of non-infectious uveitis

Decline in US–China science: Can ophthalmology remain collaborative?