Analytica

Saquinavir is a drug used as an HIV treatment, with recent reports of new uses. It has poor aqueous solubility and very low oral bioavailability. However, when prepared in a eutectic mixture with the natural bioenhancer, piperine, it demonstrated improvements in these drawbacks. Therefore, considering that EMs can be easily produced and scaled-up, it could potentially be used in new pharmaceutical formulations. For this purpose, an analytical method capable of quantifying SQV in the presence of PIP is required for quality control purposes. In this context, UV–Vis equipment is simpler to use and cheaper than HPLC, and it is commonly available in most laboratories. Therefore, a derivative spectrophotometry method at 245 nm was developed and validated to quantify SQV. The method showed good linearity from 0.5 to 100.0 mg/L, with a limit of detection and limit of quantification of 0.331 mg/L and 0.468 mg/L, respectively. Furthermore, it was precise, accurate, and demonstrated good specificity up to a 1:4.3 SQV:PIP ratio. Consequently, the results demonstrate that the method can be employed for SQV quantification in the presence of PIP as an economical and simple technique. This contribution could be the basis for a quality control technique for these types of products.

Tamara Quesada-Soto

Luis Felipe Vargas-Huertas

José Roberto Vega-Baudrit

Mirtha Navarro-Hoyos

Andrea Mariela Araya-Sibaja

Analytica—A Journal of Analytical Chemistry and Chemical Analysis

A First-Order Derivative Spectrophotometric Method for the Quantification of Saquinavir in the Presence of Piperine in a Eutectic Mixture

一种用于在共晶混合物中定量测定沙奎那韦的一阶导数分光光度法，同时存在胡椒碱

Substituted phenols, including chlorophenols, are important analytes, particularly in the context of environmental analysis. Chlorophenols are formed during the disinfection of drinking water by chlorination and are important water pollutants. Gas chromatography–mass spectrometry (GC-MS) is an important method for the analysis of chlorophenols. Retention indices are used in GC-MS analysis to improve the accuracy of identification. Our research reveals that the retention indices currently available for substituted phenols are erroneous in a number of cases. We report reliable retention index values for pentafluorophenol, 5-methoxy-2-nitrophenol, 4-cyanophenol (stationary phase: 5%-phenyl-polymethylsiloxane), 3-methoxyphenol, 2-chlorophenol, 3-chlorophenol, 4-chlorophenol, 2,3-dichlorophenol, 2,5-dichlorophenol, 2,6-dichlorophenol, 3,4-dichlorophenol, 3,5-dichlorophenol, 2,3,5-trichlorophenol, 2,3,6-trichlorophenol, 2,4,5-trichlorophenol, and 2,4,6-trichlorophenol (stationary phase: polyethylene glycol modified with 2-nitroterephthalic acid). The structures of the standard samples were confirmed, and measurements were performed under various conditions. The analysis of the causes of the incorrect records appearing in the well-known NIST database was also carried out.

Anastasia Yu. Sholokhova

Svetlana A. Borovikova

Dmitriy D. Matyushin

Refinement of Retention Indices in Gas Chromatography for a Number of Substituted Phenols

气相色谱中多种取代酚保留指数的优化

We report a workflow and a software description for digital image colorimetry aimed at obtaining a quantitative dose–response curve and the minimal inhibitory concentration in the Resazurin Microtiter Assay (REMA) test of the activity of antimycobacterial drugs. The principle of this analysis is based on the newly established correspondence between the intensity of the a* channel of the CIE L*a*b* colour space and the concentration of resorufin produced in the course of this test. The whole procedure can be carried out using free software. It has sufficiently mild requirements for the quality of colour images, which can be taken by a typical smartphone camera. Thus, the approach does not impose additional costs on the medical examination points and is widely accessible. Its efficiency is verified by applying it to the case of two representatives of substituted 2-(quinolin-4-yl) imidazolines. The direct comparison with the data on the indicator’s fluorescence obtained using a commercial microplate reader argues that the proposed approach provides results of the same range of accuracy on the quantitative level. As a result, it would be possible to apply the strategy not only for new low-cost studies but also for expanding databases on drug candidates by quantitatively reprocessing existing data, which were earlier documented by images of microplates but analysed only qualitatively.

Eugene B. Postnikov

Alexander V. Sychev

Anastasia I. Lavrova

Dose–Response Curve in REMA Test: Determination from Smartphone-Based Pictures

REMA测试中的剂量-反应曲线：基于智能手机图片的确定

Boron nitride nanostructures (BNNs), including nanotubes, nanosheets, and nanoribbons, are renowned for their exceptional thermal stability, chemical inertness, mechanical strength, and high surface area, making them suitable for advanced material applications. Metal–organic frameworks (MOFs), characterized by their porous crystalline structures, high surface area, and tunable porosity, have emerged as excellent candidates for gas adsorption and storage applications, particularly in the context of hydrogen. This paper explores the synthesis and properties of BNNs and MOFs, alongside the innovative approach of integrating BNNs within MOFs to create composite materials with synergistic properties. The integration of BNNs into MOFs enhances the overall thermal and chemical stability of the composite while improving hydrogen sensing and storage performance. Various synthesis methods for both BNNs and MOFs are discussed, including chemical vapor deposition, solvothermal synthesis, and in situ growth, with a focus on their scalability and reproducibility. Furthermore, the mechanisms underlying hydrogen sensing and storage are examined, including physisorption, chemisorption, charge transfer, and work function modulation. Electrochemical characterization techniques, such as cyclic voltammetry, electrochemical impedance spectroscopy, and galvanostatic charge–discharge, are used to analyze the performance of BNN-MOF systems in hydrogen storage and sensing applications. These methods offer insights into the material’s electrochemical behavior and its potential to store hydrogen efficiently. Potential industrial applications of BNN-MOF composites are highlighted, particularly in fuel cells, hydrogen-powered vehicles, safety monitoring in hydrogen production and distribution networks, and energy storage devices. The integration of these materials can contribute significantly to the development of more efficient hydrogen energy systems. Finally, this study outlines key recommendations for future research, which include optimizing synthesis techniques, improving the hydrogen interaction mechanisms, enhancing the stability and durability of BNN-MOF composites, and performing comprehensive economic and environmental assessments. BNN-MOF composites represent a promising direction in the advancement of hydrogen sensing and storage technologies, offering significant potential to support the transition toward sustainable energy systems and hydrogen-based economies.

Azizah Alamro

Thanih Balbaied

Boron Nitride Nanostructures (BNNs) Within Metal–Organic Frameworks (MOFs): Electrochemical Platform for Hydrogen Sensing and Storage

金属有机框架中的氮化硼纳米结构(BNNs)：用于氢传感与存储的电化学平台

This study describes the development of an optical-based surface plasmon resonance (SPR) aptasensor for the detection of cocaine. The aptasensor was prepared by first attaching gold nanoparticles to a clean SPR chip surface, followed by the addition of an aptamer to create a modified surface. This surface was characterized using contact angle and atomic force microscopy, revealing surface roughness values of 0.28 nm and 28.12 nm for the blank and modified surfaces, respectively. The detection of cocaine was carried out in the concentration range of 1 ng/mL to 1000 ng/mL, with a detection time of approximately 8 min and a cocaine limit of detection (LOD) of 0.43 ng/mL. Repeatability studies were conducted, and the stability of the signal response was examined at a concentration of 200 ng/mL. Adsorption isotherm models, including Scatchard, Langmuir, and Freundlich models, were calculated to assess the surface homogeneity of the SPR aptasensor chip, with the results indicating compatibility with the Langmuir isotherm model.

Gül Keklik Şah

Aybüke A. Isbir Turan

Innovative Surface Plasmon Resonance Aptasensor for Detecting Cocaine in Human Urine

用于检测人尿中可卡因的创新表面等离子体共振适配体传感器

Publication Information	Publisher: Multidisciplinary Digital Publishing Institute (MDPI)，Publishing cycle: ，Journal Type: journal，Open Access Journals: Yes
Basic data	Year of publication: 2020，Proportion of original research papers: ，Self Citation Rate:， Gold OA Rate:
Journal Fees	$Details
Average review cycle	6 weeks

Analytica

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A First-Order Derivative Spectrophotometric Method for the Quantification of Saquinavir in the Presence of Piperine in a Eutectic Mixture

Refinement of Retention Indices in Gas Chromatography for a Number of Substituted Phenols

Dose–Response Curve in REMA Test: Determination from Smartphone-Based Pictures

Boron Nitride Nanostructures (BNNs) Within Metal–Organic Frameworks (MOFs): Electrochemical Platform for Hydrogen Sensing and Storage

Innovative Surface Plasmon Resonance Aptasensor for Detecting Cocaine in Human Urine

A First-Order Derivative Spectrophotometric Method for the Quantification of Saquinavir in the Presence of Piperine in a Eutectic Mixture

Refinement of Retention Indices in Gas Chromatography for a Number of Substituted Phenols

Dose–Response Curve in REMA Test: Determination from Smartphone-Based Pictures

Boron Nitride Nanostructures (BNNs) Within Metal–Organic Frameworks (MOFs): Electrochemical Platform for Hydrogen Sensing and Storage

Innovative Surface Plasmon Resonance Aptasensor for Detecting Cocaine in Human Urine

ISSN	2673-4532
h-index	6