BME Frontiers

Objective. The goal is to increase the precision of radiation delivery during radiotherapy by tracking the movements of the tumor and other surrounding normal tissues due to respiratory and other body motions. Introduction. This work presents the recent advancement of X-ray-induced radiation acoustic imaging (xRAI) technology and the evaluation of its feasibility for real-time monitoring of geometric and morphological misalignments of the X-ray field with respect to the target tissue by combining xRAI with established ultrasound (US) imaging, thereby improving radiotherapy tumor eradication and limiting treatment side effects. Methods. An integrated xRAI and B-mode US dual-modality system was established based on a clinic-ready research US platform. The performance of this dual-modality imaging system was evaluated via experiments on phantoms and ex vivo and in vivo rabbit liver models. Results. This system can alternatively switch between the xRAI and the US modes, with spatial resolutions of 1.1 mm and 0.37 mm, respectively. 300 times signal averaging was required for xRAI to reach a satisfactory signal-to-noise ratio, and a frame rate of 1.1 Hz was achieved with a clinical linear accelerator. The US imaging frame rate was 22 Hz, which is sufficient for real-time monitoring of the displacement of the target due to internal body motion. Conclusion. Our developed xRAI, in combination with US imaging, allows for mapping of the dose deposition in biological samples in vivo, in real-time, during radiotherapy. Impact Statement. The US-based image-guided radiotherapy system presented in this work holds great potential for personalized cancer treatment and better outcomes.

Wei Zhang

Ibrahim Oraiqat

Hao Lei

Paul L. Carson

Issam EI Naqa

Xueding Wang

Dual-Modality X-Ray-Induced Radiation Acoustic and Ultrasound Imaging for Real-Time Monitoring of Radiotherapy

Ultrasound is extensively studied for biomedical engineering applications. As the core part of the ultrasonic system, the ultrasound transducer plays a significant role. For the purpose of meeting the requirement of precision medicine, the main challenge for the development of ultrasound transducer is to further enhance its performance. In this article, an overview of recent developments in ultrasound transducer technologies that use a variety of material strategies and device designs based on both the piezoelectric and photoacoustic mechanisms is provided. Practical applications are also presented, including ultrasound imaging, ultrasound therapy, particle/cell manipulation, drug delivery, and nerve stimulation. Finally, perspectives and opportunities are also highlighted.

Jiapu Li

Yuqing Ma

Tao Zhang

K. Kirk Shung

Benpeng Zhu

BME Front

Recent Advancements in Ultrasound Transducer: From Material Strategies to Biomedical Applications

超声换能器近期进展：从材料策略到生物医学应用

Changxiang Huan

Jinze Li

Yingxue Li

Shasha Zhao

Qi Yang

Zhiqi Zhang

Chuanyu Li

Shuli Li

Zhen Guo

Jia Yao

Lianqun Zhou

Spatially resolved multiomics: data analysis from monoomics to multiomics

空间解析多组学：从单组学到多组学的数据分析

Yanyan Liu

Meijiao Li

Hao Zhang

Le Gao

Jitao Liu

Xuetong Zhu

Chenzhong Li

Shan Liu

Yue Hou

Jiancheng Xu

Preparation and characterization of CRP dual particle latex enhanced immunoturbidimetric reagent

CRP双粒子乳胶增强免疫比浊试剂的制备与表征

Priyankan Datta

Sreejesh Moolayadukkam

Dhrubajyoti Chowdhury

Adnan Rayes

Nan Sook Lee

Rakesh P. Sahu

Qifa Zhou

Ishwar K. Puri

Recent advances and future directions in sonodynamic therapy for cancer treatment

声动力疗法在癌症治疗中的最新进展与未来方向

Yifeng Xu

Bao Jiang

Fangfang Liu

Hua Zhang

Dan Li

Xiaohui Tang

Xiuming Yang

Yan Sheng

Xuanye Wu

Nan Shi

A Novel System for Fabricating Microspheres with MEMS based Bioprinting Technology(MBT)

基于MEMS生物打印技术制备微球的新型系统

Shikha Jain

Monika Nehra

Neeraj Dilbaghi

Ganga Ram Chaudhary

Sandeep Kumar

Detection of Hg2+ using a dual-mode biosensing probe based on CuNCs@Zr-MOF@G-quadruplex structure

基于CuNCs@Zr-MOF@G四链体结构的双模生物传感探针用于Hg²⁺检测

Abbreviation	BME Front
Journal Impact	4.97
Quartiles(Global)	ENGINEERING, BIOMEDICAL(Q1)

Publication Information	Publisher: American Association for the Advancement of Science，Publishing cycle: ，Journal Type: journal，Open Access Journals: Yes
Basic data	Year of publication: 2020，Proportion of original research papers: 0.00%，Self Citation Rate:2.00%， Gold OA Rate: 98.48%
Average review cycle	网友分享经验：16 Weeks

BME Frontiers

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Dual-Modality X-Ray-Induced Radiation Acoustic and Ultrasound Imaging for Real-Time Monitoring of Radiotherapy

Recent Advancements in Ultrasound Transducer: From Material Strategies to Biomedical Applications

Spatially resolved multiomics: data analysis from monoomics to multiomics

Preparation and characterization of CRP dual particle latex enhanced immunoturbidimetric reagent

Recent advances and future directions in sonodynamic therapy for cancer treatment

Spatially resolved multiomics: data analysis from monoomics to multiomics

Preparation and characterization of CRP dual particle latex enhanced immunoturbidimetric reagent

Recent advances and future directions in sonodynamic therapy for cancer treatment

A Novel System for Fabricating Microspheres with MEMS based Bioprinting Technology(MBT)

Detection of Hg2+ using a dual-mode biosensing probe based on CuNCs@Zr-MOF@G-quadruplex structure