Rheumatology and Autoimmunity

Abstract Background Autoimmune diseases are immune disorders in which the immune system mistakenly targets and attacks the normal cells, tissues, and organs of the patients. The etiology of autoimmune diseases is complex and multifactorial. Objective This review aims to provide a general introduction to the immunological functions of inflammasomes and describe the role of inflammasomes in disorders characterized by self‐directed inflammation, with a particular focus on several common autoimmune diseases. Methods We reviewed current research on the mechanisms of inflammasome activation and inflammasomes' contribution to autoimmune diseases. Inhibitors targeting inflammasome components were also explored for their potential in therapeutic applications. Results With increasing research on mechanisms of inflammation of the pathologic conditions, accumulated evidence suggests that the aberrant or uncontrolled activation of inflammasomes contributes to the pathogenesis and development of autoimmune diseases. Additionally, inflammasome‐targeting drugs have shown promise in treating autoimmune diseases. Conclusion Insights into the mechanisms governing inflammasome activation and their roles in autoimmune diseases could contribute to the development of novel anti‐inflammatory drugs for the prevention and treatment of autoimmune diseases with enhanced targeting precision and reduced adverse reactions.

Minghui Pan

Jie Yang

Zhengfan Jiang

Rheumatology & autoimmunity

Inflammasomes and their roles in autoimmune diseases

炎症小体及其在自身免疫疾病中的作用

Haojie Xu

Wenwen Pei

Ruyu Liang

Ranran Yao

Yin Su

Successful treatment with upadacitinib for Sjögren's syndrome complicated by atopic dermatitis

乌帕达西替尼成功治疗合并特应性皮炎的干燥综合征

Abstract Introduction Idiopathic retroperitoneal fibrosis (IRPF) is a rare fibro‐inflammatory disease characterized by fibrous sclerosis of the retroperitoneal area and may be accompanied by other autoimmune diseases. Herein, we report an unusual case of IRPF with compression of retroperitoneal vessels, then diagnosed with antiphospholipid syndrome (APS), evidenced by multiple venous thrombosis and persistent positivity of antiphospholipid antibodies (aPLs). Along with literature reviews, we highlighted the important of screening for all possible causes in case of thrombosis secondary to IRPF. Case Description A 46‐year‐old male patient was admitted in 2010 due to hypogastralgia and low back pain. The initial laboratory findings showed elevated inflammatory indicators, but negative results of immunology screening. Abdominal computed tomography (CT) revealed diffuse soft tissue in the retroperitoneal area. IRPF was first diagnosed and initially treated with glucocorticoids and immunosuppressants. Along the process of tapering the drugs, IRPF relapsed again. Reexamination of CT scan showed newly developed thrombus in the retroperitoneal vessels. APLs were evaluated and persistently positive with the interval of six months. The diagnosis of APS was confirmed. Glucocorticoids and immunosuppressants were prescribed again accompanied with warfarin. During 17‐month follow‐up periods, there was no relapse of symptoms again. Conclusion When IRPF is accompanied by venous thrombosis, in addition to blood flow stasis due to venous compression, other potential causes of thrombophilia should also be considered.

Wanki Ho

Weihao Li

Wenchang Nie

Yunshan Zhou

Chun Li

Yuzhou Gan

Hua Ye

Antiphospholipid syndrome followed idiopathic retroperitoneal fibrosis in the same patient: A case report and review of literature

同一患者继发抗磷脂综合征的特发性腹膜后纤维化：病例报告与文献综述

Ruiling Feng

Xia Zhang

Jing He

Combination therapy with belimumab and low‐dose interleukin‐2 in a patient with anti‐MDA5 antibody dermatomyositis overlapping with systemic lupus erythematosus

贝利尤单抗与低剂量白细胞介素-2联合治疗抗MDA5抗体阳性皮肌炎合并系统性红斑狼疮患者的疗效

Raida Ben Salah

Rim Kallel

Oumaima Chouchene

Tahia Boudawara

Zouhir Bahloul

Submandibular mucosa‐associated lymphoid tissue lymphoma in a primary Sjögren's syndrome

原发性干燥综合征中颌下黏膜相关淋巴组织淋巴瘤

短名
Journal Impact	1.10
国际分区	RHEUMATOLOGY(Q4)

涉及主题	immunologyrheumatologypharmacologyarthritisautoimmunity
出版信息	出版商: John Wiley & Sons Inc.，出版周期: ，期刊类型: journal，开源期刊: 是
基本数据	创刊年份: 2021，原创研究文献占比: ，自引率:， Gold OA占比:
期刊费用	$3000详情
平均审稿周期	11 weeks

Rheumatology and Autoimmunity

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Inflammasomes and their roles in autoimmune diseases

Successful treatment with upadacitinib for Sjögren's syndrome complicated by atopic dermatitis

Antiphospholipid syndrome followed idiopathic retroperitoneal fibrosis in the same patient: A case report and review of literature

Combination therapy with belimumab and low‐dose interleukin‐2 in a patient with anti‐MDA5 antibody dermatomyositis overlapping with systemic lupus erythematosus

Submandibular mucosa‐associated lymphoid tissue lymphoma in a primary Sjögren's syndrome

Inflammasomes and their roles in autoimmune diseases

Successful treatment with upadacitinib for Sjögren's syndrome complicated by atopic dermatitis

Antiphospholipid syndrome followed idiopathic retroperitoneal fibrosis in the same patient: A case report and review of literature

Combination therapy with belimumab and low‐dose interleukin‐2 in a patient with anti‐MDA5 antibody dermatomyositis overlapping with systemic lupus erythematosus

Submandibular mucosa‐associated lymphoid tissue lymphoma in a primary Sjögren's syndrome

ISSN	2767-1410, 2767-1429
h-index	5