Alcohol, Clinical and Experimental Research

Abstract Background To investigate the trends in alcohol‐associated liver disease (ALD), liver cancer from alcohol, and alcohol use disorder (AUD) burden among older adults in the United States (US). Methods We gathered the ALD, liver cancer from alcohol, and AUD prevalence, mortality, and age‐standardized rates (ASRs) from the Global Burden of Disease (GBD) Study 2021 between 2010 and 2021. We estimated the annual percent change (APC) with confidence intervals (CIs) for the burden of ALD, liver cancer from alcohol, and AUD in older adults (&gt;70 years) in the United States. The findings were contrasted with global estimates and categorized by sex and state. Results In 2021, there were approximately 512,340 cases of AUD, 56,990 cases of ALD, and 4490 cases of primary liver cancer from alcohol among older adults in the United States. In contrast to declining ASRs of prevalence and mortality in the global burden, these parameters were increased in older adults in the United States. From 2000 to 2021, prevalence from AUD (APC: 0.54%, 95% CI 0.43% to 0.65%), ALD (APC + 0.54%, 95% CI 0.22% to 0.86%), and primary liver cancer from alcohol (APC 2.93%, 95% CI 2.76% to 3.11%) increased. Forty states in the United States exhibited a rise in the prevalence rates of ALD in older adults. Conclusion Our findings highlighted the increased prevalence and mortality of AUD, ALD, and primary liver cancer from alcohol among older adults in the United Sates, contrasting with the decline in global trends. Public health strategies on ALD, AUD, and primary liver cancer from alcohol, which targets older adults, are urgently needed.

Pojsakorn Danpanichkul

Kwanjit Duangsonk

Ethan Kai Jun Tham

Primrose Tothanarungroj

Thanida Auttapracha

Vitchapong Prasitsumrit

Benedix Sim

Daniel Tung

Romelia Barba

Robert J. Wong

Lorenzo Leggio

Ju Dong Yang

Vincent L. Chen

Mazen Noureddin

Luis Antonio Díaz

Juan Pablo Arab

Karn Wijarnpreecha

Suthat Liangpunsakul

Alcohol Clinical and Experimental Research

Increased mortality from alcohol use disorder, alcohol‐associated liver disease, and liver cancer from alcohol among older adults in the United States: 2000 to 2021

2000年至2021年美国老年人因酒精使用障碍、酒精相关性肝病及酒精所致肝癌的死亡率上升

Abstract Background Setting rules about alcohol use and minimizing its availability in the home are known effective parent‐level strategies for reducing underage drinking risk. However, parents' restrictions and their perceptions of their child's alcohol access have rarely been considered in combination (e.g., determining if rule‐setting consistently accompanies perceived easy access), despite the potential to inform targeted prevention. The current study identified patterns in six parent‐reported indicators of their child's alcohol restrictions and access and characterized them with respect to race/ethnicity, socioeconomic status, community type (urban, suburban, or rural), and neighborhood (dis)advantage. Methods Latent profile analysis was applied to Follow‐up Year 2 data from the parents of Black, Latinx, and White participants in the Adolescent Brain Cognitive Development Study ( n = 9586; youth mean age = 12.05; 47.50% girl, 51.32% boy, 0.32% other gender; 14.29% Black, 25.97% Latinx, and 59.74% White) to derive distinct profiles. Results Four profiles (subgroups) emerged: High Restrictions/No Drinkers in Household (32.18%), Low Restrictions/High Access (29.58%), High Restrictions/High Access (26.38%), and High Restrictions/Low Access (11.86%). Black and Latinx youth and parents with relatively low educational attainment and income were overrepresented in the High Restrictions/No Drinkers in Household and High Restrictions/Low Access subgroups. By contrast, the low restrictions subgroups were composed primarily of parents of White youth living in advantaged neighborhoods. Conclusions Findings support the notion that parents' perspectives and behaviors around youth alcohol access cannot be divided simply into restrictive and permissive. Further, the observed differences by demographic and neighborhood factors suggest the value of tailoring parent‐level prevention approaches to consider community norms.

Carolyn E. Sartor

Shawn J. Latendresse

Kristina M. Jackson

Mai‐Ly N. Steers

Sharon Lipperman‐Kreda

Tim Slade

Tammy Chung

Parents' perspectives and behaviors regarding their child's access to alcohol: Variation by race/ethnicity, socioeconomic status, and neighborhood

父母对孩子接触酒精的看法与行为：基于种族/民族、社会经济地位和社区的差异

Early midlife individuals (ages 30-40) experience demographic shifts that may influence the remainder of adult life. Although new or persistent alcohol misuse is common during this period, early midlife is understudied in alcohol use literature. We examined the heritability of alcohol misuse; the associations between alcohol misuse and sociodemographic factors, physical health, and well-being; and whether these associations were robust in cotwin comparisons.

Erin Lumpe

Angela Pascale

Mallory Stephenson

Peter Barr

Megan E. Cooke

Antti Latvala

Hermine H. M. Maes

Sari Aaltonen

Maarit Piirtola

Richard Viken

Richard J. Rose

Pyry N. Sipilä

Anna Keski‐Rahkonen

Eero Vuoksimaa

Jaakko Kaprio

Danielle M. Dick

Jessica E. Salvatore

Etiology and correlates of alcohol misuse in early midlife

中年早期酒精滥用的病因及相关因素

Abstract In recent years, there have been significant advances in pathological research on alcoholic liver disease (ALD), with suitable animal models making a significant contribution. However, the currently established animal ALD models still have some significant drawbacks, especially the inability to induce the entire human ALD lineage, which may be related to physiological differences between animals and humans. This review comprehensively summarized the most widely used experimental models of ALD, including voluntary drinking, Lieber–DeCarli, Meadows–Cook, Tsukamoto–French, NIAAA, and the “second hit” model. “Second hit” refers to an additional factor that damages the liver. There are various “second hit” models that fall into two main categories: particular diets and drugs. These models can either simulate human drinking patterns more accurately or produce varying degrees of ALD without significantly increasing animal mortality. We introduced the established method of the original models, discussed the advantages and disadvantages of the existing models from the aspects of operability and practicality, and provided existing improvement methods, hoping to provide a reference for future researchers.

Mengsi Liu

Mingying Zhou

Xueyi Ren

Yandi Xie

Establishment and application of murine models of alcoholic liver disease: A narrative review

酒精性肝病小鼠模型的建立与应用：叙述性综述

Abstract Fetal alcohol spectrum disorders (FASD) are among the most common neurodevelopmental disabilities. Individuals with FASD experience postnatal adversity (PA; i.e., child maltreatment or other potentially traumatic events) at exceedingly high rates. This adversity is connected to increased internalizing and externalizing symptomatology. The current systematic review aimed to synthesize the literature regarding the intersectionality of FASD/prenatal alcohol exposure (PAE) and postnatal adversity utilizing the developmental psychopathology (DP) framework. Adhering to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) standards, systematic identification of studies through PsycInfo, PubMed, and Web of Science was conducted. Primary data on PAE, postnatal adversity, individual functioning (biological, cognitive, and affective), external systems, and familial and cultural contexts were extracted. Furthermore, quality assessment information was extracted for all studies. Thirty‐one studies met the inclusion criteria. Overall, individuals with FASD experience a weighted mean of 4.44 adverse childhood experiences. Multifinality in developmental outcomes was evident, as FASD and postnatal exposure impact mental health, cognitive ability, and biological processes. Cultural context and familial settings contribute to risk and resilience factors. The quality assessment points to unique strengths and areas for improvement within the literature. Aligning with the DP framework, the intersection of FASD and postnatal adversity is complex and impacts various developmental processes. Systems and cultural context add to this complexity. Intervention development taking into consideration these multiple factors is necessary.

Madeline N. Rockhold

Elizabeth D. Handley

Christie L. M. Petrenko

Understanding the intersection of prenatal alcohol exposure and postnatal adversity: A systematic review from a developmental psychopathology lens

理解产前酒精暴露与产后逆境的交叉影响：基于发展精神病理学视角的系统综述

Abstract Background Adolescent alcohol use is the norm, but only some develop a substance use disorder. The increased risk might reflect heightened mesocorticolimbic responses to reward‐related cues but results published to date have been inconsistent. Methods Young social drinkers (age 18.5 ± 0.6 y.o.) who have been followed since birth were recruited from high‐ versus low‐risk trajectories based on externalizing (EXT) behavioral traits. All had functional magnetic resonance imaging (fMRI) scans to measure mesocorticolimbic responses to alcohol, juice, and water cues (High EXT: 20F/10M; Low EXT: 15F/12M). Most had positron emission tomography (PET) [ 18 F]fallypride scans to measure brain regional dopamine D2 receptor availabilities ( n = 47). Results Compared with the low EXT group, high EXT participants reported larger subjective responses to the alcohol and juice cues (vs. water). Despite this, a main effect of group was not seen for brain activation responses to the alcohol and juice cues. Instead, low EXT participants exhibited higher mesocorticolimbic activations to alcohol than juice, whereas these activations did not differ in the high EXT group. Across all participants, alcohol (vs. water) blood oxygen level‐dependent (BOLD) responses in the striatum and amygdala were associated with midbrain [ 18 F]fallypride BP ND values. Conclusion Young social drinkers at high versus low risk for substance use disorders did not exhibit larger mesocorticolimbic BOLD activations to alcohol‐related cues and their responses poorly differentiated alcohol from juice. These observations raise the possibility that (i) diminished mesocorticolimbic BOLD differentiations between reward‐related cues might be a marker of increased risk for substance use disorders, and (ii) previously reported large BOLD responses to drug‐related cues in people with substance use disorders might better identify the disease than pre‐existing vulnerability.

Maja Nikolic

Sylvia M. L. Cox

Natalia Jaworska

Natalie Castellanos‐Ryan

Alain Dagher

Frank Vitaro

Mara Brendgen

Sophie Parent

Michel Boivin

Sylvana Côté

Richard E. Tremblay

Jean R. Séguin

Marco Leyton

A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [<scp><sup>18</sup>F</scp>]fallypride positron emission tomography

一项针对有物质使用障碍风险的青少年的多模态神经影像学研究：功能磁共振成像与[<sup>18</sup>F]fallypride正电子发射断层扫描

Abbreviation
Journal Impact	3.12
Quartiles(Global)	SUBSTANCE ABUSE(Q2)

ISSN	2993-7175
h-index	171

Publication Information	Publisher: John Wiley and Sons Inc，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2023，Proportion of original research papers: ，Self Citation Rate:， Gold OA Rate:

Alcohol, Clinical and Experimental Research

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Increased mortality from alcohol use disorder, alcohol‐associated liver disease, and liver cancer from alcohol among older adults in the United States: 2000 to 2021

Parents' perspectives and behaviors regarding their child's access to alcohol: Variation by race/ethnicity, socioeconomic status, and neighborhood

Etiology and correlates of alcohol misuse in early midlife

Establishment and application of murine models of alcoholic liver disease: A narrative review

Understanding the intersection of prenatal alcohol exposure and postnatal adversity: A systematic review from a developmental psychopathology lens

A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [¹⁸F]fallypride positron emission tomography

Understanding the intersection of prenatal alcohol exposure and postnatal adversity: A systematic review from a developmental psychopathology lens

Establishment and application of murine models of alcoholic liver disease: A narrative review

Etiology and correlates of alcohol misuse in early midlife

Alcohol, Clinical and Experimental Research

Journal Citation Format

A journal article with 1 author

A journal article with 2 authors

A journal article with 3 authors

A journal article with 5 or more authors

Books Citation Format

Thesis Citation Format

Web sites Citation Format

Patent Citation Format

Staying up late manually editing references? ivySCI automatically matches journals and helps you generate references with a single click.

Share Submission Experience

Increased mortality from alcohol use disorder, alcohol‐associated liver disease, and liver cancer from alcohol among older adults in the United States: 2000 to 2021

Parents' perspectives and behaviors regarding their child's access to alcohol: Variation by race/ethnicity, socioeconomic status, and neighborhood

Etiology and correlates of alcohol misuse in early midlife

Establishment and application of murine models of alcoholic liver disease: A narrative review

Understanding the intersection of prenatal alcohol exposure and postnatal adversity: A systematic review from a developmental psychopathology lens

A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [18F]fallypride positron emission tomography

Understanding the intersection of prenatal alcohol exposure and postnatal adversity: A systematic review from a developmental psychopathology lens

Establishment and application of murine models of alcoholic liver disease: A narrative review

Etiology and correlates of alcohol misuse in early midlife

A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [¹⁸F]fallypride positron emission tomography