APMIS，前身为 ACTA PATHOLOGICA, MICROBIOLOGICA ET IMMUNOLOGICA SCANDINAVICA，自 1924 年以来一直由斯堪的纳维亚医学微生物学和病理学会作为非营利性科学期刊出版。

APMIS, formerly known as ACTA PATHOLOGICA, MICROBIOLOGICA ET IMMUNOLOGICA SCANDINAVICA, has been published as a non-profit scientific journal by the Scandinavian Society for Medical Microbiology and Pathology since 1924.

APMIS（前身为 ACTA PATHOLOGICA, MICROBIOLOGICA ET IMMUNOLOGICA SCANDINAVICA）自1924年以来由斯堪的纳维亚医学微生物学和病理学会以非营利性科学期刊的形式出版。

APMIS

This study was performed to explore the antifungal and antibiofilm effects of polyphyllin I (PPI) on Candida albicans. Microdilution assay was performed to determine the minimal inhibitory concentrations (MIC) of PPI against Candida species. Adhesion assay, hyphal growth assay, biofilm formation, and development were used to test the impacts of PPI on C. albicans virulence factors. Propidium iodide staining was performed to test whether the permeability of cell membrane was influenced by PPI. PPI showed significant antifungal activities against several Candida species, with MIC below or equal to 6.25 μM. PPI also inhibited the adhesion to polystyrene surfaces, hyphal growth, and biofilm formation. PPI significantly increased the permeability of C. albicans cell membrane. In sum, PPI can suppress the planktonic growth and biofilm of C. albicans and its mechanism involves the increased permeability of cell membrane.

Yu Zhang

Jingxiao Zhang

Jian Sun

Min Zhang

Xin Liu

Longfei Yang

Yongjie Yin

Apmis

Polyphyllin I, a strong antifungal compound against Candida albicans

岩白菜素I，一种对白色念珠菌具有强抗真菌作用的化合物

Syrjänen S. Current concepts on human papillomavirus infections in children. APMIS 2010; 118: 494–509. Current evidence is strong enough to conclude that human papillomavirus (HPV) can be transmitted both sexually and non‐sexually. The debate on HPV infections in children still continues but it is more focused on HPV prevalence than on transmission modes. HPV DNA detection in amniotic fluid, foetal membranes, cord blood and placental trophoblastic cells all suggest HPV infection in utero , i.e. prenatal transmission. Based on recent meta‐analysis, vertical transmission occurs in approximately 20% of cases. Most of the mucosal HPV infections in infants are incident, persistent infections in oral and genital mucosa being found in less than 10% and 2% respectively. The mother seems to be the main transmitter of HPV to her newborn, but subsequent HPV infections are acquired horizontally via saliva or other contacts. Bimodal peak prevalence is seen for skin warts, oral papillomas and recurrent respiratory papillomatosis (RRP) in younger and older age groups, suggesting similar epidemiology. Of the clinical HPV diseases, juvenile‐onset‐RRP and genital condylomata are problematic; the former because of its life‐threatening potential and the latter because of possible sexual abuse. HPV6 and 11 are the most common genotypes in both the lesions. Early in life, infections by the high‐risk HPV genotypes may also remain persistent for a considerable period, and should be of considerable importance for HPV vaccination strategies.

STINA SYRJÄNEN

Current concepts on human papillomavirus infections in children

儿童人乳头瘤病毒感染的最新概念

The effect of rhinovirus on airway epithelium is very well described. However, its influence on the vascular endothelium is unknown. The current study assesses the effect of rhinovirus HRV16 on the antiviral and inflammatory response in the human vascular endothelial cells (ECs). HRV16 increased IFN‐β, RANTES, and IP‐10 mRNA expression and protein release. HRV16 copy number in ECs reached maximal value 10 h after incubation. Increase in virus copies was accompanied by the enhancement of Toll‐ and RIG‐I‐like receptors: TLR3, RIG‐I, and MDA5. Additionally, HRV16 increased OAS‐1 and PKR mRNA expression, enzymes responsible for virus degradation and inhibition of replication. ICAM‐1 blockade decreased HRV16 copy number in ECs and inhibited IFN‐β, RANTES, IP‐10, OAS1, PKR, TLR3, RIG‐I, and MDA5 mRNA expression increase upon subsequent induction with HRV16. The vascular endothelium may be infected by human rhinovirus and generate antiviral and inflammatory innate response. Results of the study indicate the possible involvement of the vascular endothelium in the immunopathology of rhinoviral airway infections.

Maciej Chałubiński

Aleksandra Szulc

Małgorzata Pawełczyk

Adrian Gajewski

Mateusz Gawrysiak

Aleksandra Likońska

Marek L. Kowalski

Human rhinovirus 16 induces antiviral and inflammatory response in the human vascular endothelium

人鼻病毒16在人血管内皮细胞中诱导抗病毒和炎症反应

Acta Pathologica Microbiologica ScandinavicaVolume 46, Issue 3 p. 217-222 STRAINS OF COXSACKIE VIRUS TYPE A-9 AND ECHO VIRUS TYPE 9 RECOVERED FROM CEREBROSPINAL FLUIDS Annelise Godtfredsen, Annelise Godtfredsen STATENS SERUMINTSTITUTSearch for more papers by this author Annelise Godtfredsen, Annelise Godtfredsen STATENS SERUMINTSTITUTSearch for more papers by this author First published: September 1959 https://doi.org/10.1111/j.1699-0463.1959.tb00332.xCitations: 8AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume46, Issue3September 1959Pages 217-222 RelatedInformation

Annelise Godtfredsen

Acta Pathologica Microbiologica Scandinavica

STRAINS OF COXSACKIE VIRUS TYPE A‐9 AND ECHO VIRUS TYPE 9 RECOVERED FROM CEREBROSPINAL FLUIDS

从脑脊液中分离出的柯萨奇病毒A-9型和埃可病毒9型株

Enterovirus is a common viral infection, which can affect multiple organ systems with an array of clinical presentation such as meningitis, encephalitis, myocarditis, and disseminated infections. The illness is usually asymptomatic and self‐limited but few cases can be severe and life‐threatening especially when associated with hemophagocytosis. We discuss a fatal case of disseminated enterovirus infection and the histomorphological features of the infection.

Manoj Gopal Madakshira

Sunny Bhardwaj

Kirti Gupta

Yogesh Chander

Ashish Bhalla

A fatal case of enterovirus infection with secondary hemophagocytosis—case report with review of literature

肠道病毒感染致死合并继发性噬血细胞综合征——病例报告及文献回顾

Staphylococcus aureus is a multi‐host pathogen that can colonize and infect both humans and livestock in a tissue‐specific manner. This amazing feature of the pathogen is mainly facilitated by the surplus virulence agents produced upon necessity and favorable environmental factors. These factors are adept at damaging cellular barriers, manipulating host immune factors, and circumventing the host complement system. The delicate balance between the timely release of virulent factors and the regulation of their production underscores the significance of the exoenzyme network. Moreover, the intricate relationship between the pathogen and host tissue highlights the importance of understanding tissue‐specific phenotypes for effective therapeutic strategies. Here, we provide a review on the diverse role played by the extracellular enzymes of S. aureus in tissue‐specific infection and systemic colonization leading to distinctive diseased conditions. The article highlights the need to study the role of staphylococcal exoenzymes in various systemic invasions, their impact on the deterioration of host tissue, and the regulation of S. aureus virulence factors.

Atlanta Borah

Anand Srivastava

Impact of extracellular enzymes on Staphylococcus aureus host tissue adaptation and infection

胞外酶对金黄色葡萄球菌宿主组织适应及感染的影响

Several in vivo and in vitro studies have shown that Helicobacter pylori can invade epithelial cells and the lamina propria, potentially leading to underdiagnosis due to its subepithelial location. This retrospective study investigated H. pylori infection patterns and their impact on clinical improvement. Gastric tissue biopsies from 346 patients (August to December 2021) were studied using four commercially available immunohistochemical antibodies (TMDU, BioGenex, Cell Marque, and DAKO). The bacteria were graded based on their surface epithelial and subepithelial locations and then combined to establish an overall pattern. BioGenex, the antibody with the highest diagnostic performance due to its superior detection of surface and subepithelial cases, was selected as the gold standard for determining study outcomes. The isolated subepithelial H. pylori pattern was found to be an independent unfavorable prognostic feature. Patients with this pattern had the worst clinical outcomes compared to groups with isolated surface epithelial or other mixed patterns, which did not significantly differ. Subepithelial H. pylori should be included in pathological reports alongside the updated Sydney System. Further research should explore whether its eradication could improve treatment outcomes.

Chalermpak Supakatitham

Kongsak Loharamtaweethong

Prognostic impact of subepithelial Helicobacter pylori infection on clinical outcomes in patients with dyspepsia

胃上皮下幽门螺杆菌感染对消化不良患者临床结局的预后影响

The SARS‐CoV‐2 is the causative agent of COVID‐19 whose evolutionary path with geographical context forms the focus of present study. The first reported sequence from each of the 161 countries was downloaded from the GISAID database. Multiple sequence alignment was performed using MAFFT v.7, and a TCS‐based network was constructed using PopART v.1.7. A total of 27 proteins were analyzed including structural and non‐structural proteins. NSP3 and NSP12, responsible for viral replication and RNA synthesis, respectively, had the highest mutation incidence and frequency among non‐structural proteins. The spike (S) protein, critical for viral attachment and entry, had the highest prevalence and frequency of mutations. ORF3a had the highest mutation incidence and frequency among accessory proteins. The phylogeogenomic network identified six haplogroups containing 35 sequences, while the remaining sequences belonged to different haplotypes. The virus's genetic distinctiveness was higher in European genomes, with four haplogroups dominated by Europe‐linked sequences. The triangular‐shaped pattern observed in the virus's evolutionary path suggests that it spread to different continents from Asia. Multiple transmission pathways connecting different countries affirm the virus's ability to emerge in multiple countries by early 2020. The possibility of new species emergence through “saltation” due to the pandemic is also discussed.

Rezwanuzzaman Laskar

Mehboob Hoque

Safdar Ali

Phylogeogenomic analysis of the earliest reported sequences of SARS‐CoV‐2 from 161 countries

来自161个国家的最早报告的SARS-CoV-2序列的系统发育基因组分析

Dental caries is a multifactorial disease, which is the result of a complex interplay between the diet, the host, the saliva, and dental biofilms. Although the prevalence of dental caries has decreased dramatically since 1950 in many countries, it continues to be one of the most common health conditions globally. The aim of the present review is to summarize the investigations on dental caries performed by the late Noble prize winner Henrik Dam and his colleagues in the middle of the 20th century, and to relate the knowledge and state of the art at the time to current concepts on dental caries. Henrik Dam is mostly known for his discovery of Vitamin K, but he also conducted experimental studies on dental caries that focused on the role of Vitamin K, the diet, and saliva in the development of dental caries. The discoveries of Henrik Dam contributed to our understanding of the role of saliva and different dietary components, such as fat and proteins, in caries development and prevention.

Merete Markvart

Christiane E. Sørensen

Kim R. Ekstrand

Sebastian Schlafer

Daniel Belstrøm

Historical concepts and contemporary perspectives of dental caries—a tribute to Henrik Dam (1895–1976)

龋齿的历史概念与当代视角——纪念亨里克·达姆（1895-1976）

This review aimed to summarize the current literature on antibiotic distribution in orthopedically relevant tissues and settings where dynamic sampling methods have been used. PubMed and Embase databases were systematically searched. English-published studies between 2004 and 2024 involving systemic antibiotic administration in orthopedically relevant tissues and settings based on dynamic measurements were included. In total, 5385 titles were identified. After title and abstract screening, 97 eligible studies (43 different antibiotic drugs) were included. The studies covered both preclinical (42%) and clinical studies including healthy and infected tissues (21%) and prophylactic and steady-state situations (35%). Microdialysis emerged as the predominant sampling method in 98% of the studies. Most of the presented antibiotics (80%) were only assessed once or twice. Among the most extensively studied antibiotics were cefuroxime (18 studies), linezolid (9 studies) and vancomycin (9 studies). This review presents valuable insights into the microenvironmental distribution of antibiotics in orthopedically relevant target tissues and settings and seeks to provide a basis for improving dosing recommendations and treatment outcomes. However, it is important to acknowledge that our findings are limited to the specific drug, dosing regimens, administration method and target tissue, and are crucially linked to the selected PK/PD target.

Maria Bech Damsgaard Nielsen

Andrea René Jørgensen

Maiken Stilling

Mads Kristian Duborg Mikkelsen

Nis Pedersen Jørgensen

Mats Bue

Dynamic distribution of systemically administered antibiotics in orthopeadically relevant target tissues and settings

全身给药抗生素在骨科相关靶组织和环境中的动态分布

Abbreviation	Apmis
Journal Impact	2.32
Quartiles(Global)	PATHOLOGY(Q3)

ISSN	0365-5555, 0903-4641, 1600-0463
h-index	99

Publication Information	Publisher: Blackwell Munksgaard，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 1988，Proportion of original research papers: ，Self Citation Rate:， Gold OA Rate:

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