家畜内分泌学发表关于家畜内分泌生理学研究的科学论文。也欢迎那些利用其他物种作为与家畜相关的临床或生产问题模型的手稿。涵盖的主题包括：经典和生殖内分泌学-临床和应用内分泌学-激素分泌的调节-激素作用-分子生物学-细胞因子-生长因子

The journal "Domestic Animal Endocrinology" focuses on research in the endocrinology of domestic animals. It welcomes manuscripts that utilize other species as models for clinical or production issues related to domestic animals. Topics covered include classical and reproductive endocrinology, clinical and applied endocrinology, regulation of hormone secretion, hormone action, molecular biology, cytokines, and growth factors.

《Domestic Animal Endocrinology》期刊专注于家畜内分泌生理学的研究，欢迎与家畜相关的临床或生产问题模型的手稿，尤其是那些利用其他物种的研究。期刊涵盖的主题包括经典和生殖内分泌学、临床和应用内分泌学、激素分泌的调节、激素作用、分子生物学、细胞因子和生长因子等。

Domestic Animal Endocrinology

The measurement of progesterone (P4) and estradiol (E2) is essential for monitoring reproductive cycles and can aid in diagnosing the cause of poor reproductive performance in dairy cattle. Readily available, reproducible, accurate, non-radioactive assays are needed for the assessment of P4 and E2 in bovine serum. The gold standard for hormone assessment, radioimmunoassay (RIA), was compared with enzyme-linked immunoassay (EIA). Serum collected from various points in the estrous cycle was extracted with radiolabeled P4 (ie, 3H-P4; HE) and without 3H-P4 (CE) before being used in the assay. For the assessment of P4, there is a great degree of correlation between the RIA and EIA (adjusted R-square = 0.95; Pearson correlation coefficient (PCC) = 0.98, P < 0.001). A difference between the RIA and EIA methods was not detected for E2 concentrations (P = 0.16), but the correlation between techniques was poor (adjusted R-squared = 0.73; PCC = 0.87, P = 0.002). There was no difference in the serum extraction efficiency as measured with 3H-P4 as opposed to without (P = 0.94). The two methods for the measurement of serum extraction efficiency were highly correlated (adjusted R-square = 0.83; PCC = 0.92, P < 0.001). The concordance correlation coefficient (CCC) showed an excellent agreement between RIA and EIA for P4 determination (0.89) and between HE and CE methods (0.90). Although the 95% limits of agreement of the Bland-Altman plots encompassed 89% (8/9) and 92% (12/13) of the differences between methods for P4 quantification and extraction respectively, the CCC indicated an excellent agreement among them. The CCC between RIA and EIA for E2 quantification was 0.68 which corresponds with a fair agreement; however, the 95% limits of agreement of the Bland-Altman plot encompassed 100% (9/9) of differences between methods. The EIA and CE methods are comparable alternatives to the RIA and HE methods, respectively and can be used to quantify P4 and E2 for bovine serum.

C S Skenandore

A Pineda

J M Bahr

A E Newell-Fugate

F C Cardoso

Domestic animal endocrinology

Domest Anim Endocrinol

Evaluation of a commercially available radioimmunoassay and enzyme immunoassay for the analysis of progesterone and estradiol and the comparison of two extraction efficiency methods.

商业化放射免疫分析和酶免疫分析法对孕酮和雌二醇分析的评估及两种提取效率方法的比较。

Glucagon-like peptide 2 (GLP-2) is a member of family of peptides derived from the proglucagon gene expressed in the intestines, pancreas and brain. Tissue-specific posttranslational processing of proglucagon leads to GLP-2 and GLP-1 secretion from the intestine and glucagon secretion from the pancreas. GLP-2 and GLP-1 are co-secreted from the enteroendocrine L-cells located in distal intestine in response to enteral nutrient ingestion, especially carbohydrate and fat. GLP-2 secretion is mediated by direct nutrient stimulation of the L-cells and indirect action from enteroendocrine and neural inputs, including GIP, gastrin-releasing peptide (GRP) and the vagus nerve. GLP-2 is secreted as a 33-amino acid peptide and is rapidly cleaved by dipeptidylpeptidase IV (DPP-IV) to a truncated peptide which acts as a weak agonist with competitive antagonistic properties. GLP-2 acts to enhance nutrient absorption by inhibiting gastric motility and secretion and stimulating nutrient transport. GLP-2 also suppresses food intake when infused centrally. The trophic actions of GLP-2 are specific for the intestine and occur via stimulation of crypt cell proliferation and suppression of apoptosis in mucosal epithelial cells. GLP-2 reduces gut permeability, bacterial translocation and proinflammatory cytokine expression under conditions of intestinal inflammation and injury. The effects of GLP-2 are mediated by a G-protein-linked receptor that is localized to the intestinal mucosa and hypothalamus. The intestinal localization of the GLP-2R to neural and endocrine cells, but not enterocytes, suggests that its actions are mediated indirectly via a secondary signaling mechanism. The implications of GLP-2 in domestic animal production are largely unexplored. However, GLP-2 may have therapeutic application in treatment of gastrointestinal injury and diarrheal diseases that occur in developing neonatal and weanling animals.

D G Burrin

B Stoll

X Guan

Glucagon-like peptide 2 function in domestic animals.

家养动物中胰高血糖素样肽-2的功能。

Growth hormone (GH) plays a specific role to inhibit apoptosis in the bovine mammary gland through the insulin-like growth factor (IGF)-I system, however, the mechanism of GH action is poorly understood. In this study, we show that GH dramatically inhibits the expression of IGFBP-5, and GH along with IGF-I enhanced the phosphorylation of Akt through the reduction of IGF binding protein (IGFBP)-5. To determine how GH affects Akt through IGF-I in bovine mammary epithelial cells (BMECs), we examined the phosphorylation of Akt in GH treated BMECs and found that IGF-I induced phosphorylation of Akt was significantly enhanced by the treatment with GH. We demonstrated that GH reduces mRNA and protein expression of IGFBP-5 in BMECs, but it does not affect the expression of IGFBP-3. To determine that the enhanced effect of the Akt phosphorylation by the treatment of GH is due to the inhibition of the expression of IGFBP-5, we examined the effect of IGFBP-3 and -5 on the phosphorylation of Akt through IGF-I in the GH-treated BMECs. The phosphorylation of Akt was inhibited in a dose-dependent manner when IGFBP-5 was added at varying concentrations and was also inhibited in the presence of IGFBP-3. The results of this study suggest that GH plays an important role on mammary gland involution in bovine mammary epithelial cells.

Kazuhito Sakamoto

Tomoki Yano

Takuya Kobayashi

Akihiko Hagino

Hisashi Aso

Yoshiaki Obara

Growth hormone suppresses the expression of IGFBP-5, and promotes the IGF-I-induced phosphorylation of Akt in bovine mammary epithelial cells

生长激素抑制IGFBP-5表达，并促进IGF-I诱导的牛乳腺上皮细胞中Akt磷酸化

Malgorzata Szczesna

Katarzyna Kirsz

Dorota A. Zieba

Pregnancy-induced mechanisms regulating central and peripheral leptin sensitivity: lessons from sheep

妊娠诱导的调节中枢和外周瘦素敏感性的机制：来自绵羊的启示

Rongyu Yao

Peidi Zhao

Haiyu Ma

Wanhong Li

Xiuxiu Weng

Fadi Li

Xiangpeng Yue

Analyses of widely targeted metabolic profiling reveal enhanced energy metabolism in well-developed testicular tissue of Hu sheep

广泛靶向代谢组学分析揭示湖羊发育良好睾丸组织中能量代谢增强

Copper is a vital micronutrient necessary for the maintenance of physiological functions. However, excessive amounts can lead to organ damage. Porcine ovarian granulosa cells are damaged by a high concentration of CuSO

Nannan Qi

Binbin Wang

Wenwen Xing

Mengxuan Li

Jiying Liu

Impact of Quercetin on Autophagy and Apoptosis Induced by High a concentration of CuSO4 in Porcine Ovarian Granulosa Cells

槲皮素对高浓度CuSO4诱导的猪卵巢颗粒细胞自噬和凋亡的影响

Moyan Di

Xinbao Gong

Yanyun Zhu

Shibao Guo

Zhihao Pan

Mengxian Li

Zhuoya Wu

Wei Zhang

Xuelan Liu

Ya Liu

Yunsheng Li

Jian Li

Fugui Fang

Active immunization with a novel recombinant GnRH vaccine inhibits reproductive function in male goats

新型重组促性腺激素释放激素疫苗的主动免疫抑制雄性山羊的生殖功能

Junyuan Ma

Yanmei Yang

Lin He

Chongfa Yang

Yahua Yang

Yang Li

Wen He

Xiaoying Niu

Zhou Chen

Songming Hu

Jin'e Wang

Yingpai Zhaxi

Shengdong Huo

17β-Estradiol inhibits lipopolysaccharide-induced inflammation and pyroptosis of Leydig cells of the domestic yak (Bos grunniens) via the SIRT1/Nox4/ROS pathway

17β-雌二醇通过SIRT1/Nox4/ROS通路抑制脂多糖诱导的家牦牛（Bos grunniens）睾丸间质细胞炎症和细胞焦亡

Abbreviation	Domest. Anim. Endocrinol.
Journal Impact	1.77
Quartiles(Global)	ENDOCRINOLOGY & METABOLISM(Q3)

ISSN	0739-7240, 1879-0054
h-index	82

Publication Information	Publisher: Elsevier Inc.，Publishing cycle: Bimonthly，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 1984，Proportion of original research papers: 97.22%，Self Citation Rate:5.30%， Gold OA Rate: 21.61%
Average review cycle	网友分享经验：较慢,9-18周来源Elsevier官网：平均9.7周
Average recruitment ratio	网友分享经验：较易

Domestic Animal Endocrinology

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Evaluation of a commercially available radioimmunoassay and enzyme immunoassay for the analysis of progesterone and estradiol and the comparison of two extraction efficiency methods.

Glucagon-like peptide 2 function in domestic animals.

Growth hormone suppresses the expression of IGFBP-5, and promotes the IGF-I-induced phosphorylation of Akt in bovine mammary epithelial cells

Pregnancy-induced mechanisms regulating central and peripheral leptin sensitivity: lessons from sheep

Analyses of widely targeted metabolic profiling reveal enhanced energy metabolism in well-developed testicular tissue of Hu sheep

Impact of Quercetin on Autophagy and Apoptosis Induced by High a concentration of CuSO4 in Porcine Ovarian Granulosa Cells

Pregnancy-induced mechanisms regulating central and peripheral leptin sensitivity: lessons from sheep

Analyses of widely targeted metabolic profiling reveal enhanced energy metabolism in well-developed testicular tissue of Hu sheep

Active immunization with a novel recombinant GnRH vaccine inhibits reproductive function in male goats

17β-Estradiol inhibits lipopolysaccharide-induced inflammation and pyroptosis of Leydig cells of the domestic yak (Bos grunniens) via the SIRT1/Nox4/ROS pathway