运动免疫学评论 (EIR) 是国际运动与免疫学学会和德国运动医学与预防学会的官方出版物。它致力于发展和丰富与急性运动和定期体育活动相关的免疫学各个方面的知识。 EIR 发表评论文章和具有新的原始数据的论文，包括扩展的、类似评论的讨论。鉴于有助于理解免疫功能的广泛学科，该杂志采用了跨学科重点。这允许传播来自运动科学、医学、免疫学、生理学、行为科学、内分泌学、药理学和心理学等学科的研究成果。

Exercise Immunology Review is the official publication of the International Society of Exercise and Immunology and the German Society of Sports Medicine and Prevention. It is dedicated to advancing and enriching knowledge related to immunology in the context of acute exercise and regular physical activity. The journal publishes review articles and original research papers with new data, including extended discussions similar to reviews. Given the broad disciplines that contribute to understanding immune function, the journal adopts an interdisciplinary focus, allowing for the dissemination of research findings from fields such as exercise science, medicine, immunology, physiology, behavioral science, endocrinology, pharmacology, and psychology.

《Exercise Immunology Review》是国际运动与免疫学学会和德国运动医学与预防学会的官方出版物，致力于发展和丰富与急性运动和定期体育活动相关的免疫学知识。该期刊发表评论文章和包含新原始数据的研究论文，内容涵盖广泛的学科，以帮助理解免疫功能。期刊采用跨学科的重点，传播来自运动科学、医学、免疫学、生理学、行为科学、内分泌学、药理学和心理学等领域的研究成果。

Exercise Immunology Review

To determine the effects of an exercise-based comprehensive rehabilitation program on the physiological, health, and cost benefit in medically complex patients.Case seriesComprehensive rehabilitation centers.Elderly chronically ill men (n = 39, age = 75.3 +/- 1.4) and women (n = 74, age = 76.5 +/- 0.9 years).Patients participated in individualized physical therapy with therapeutic exercises (stretching, strengthening, endurance, balance, sitting and standing dynamic exercises) three times/week for three months under the supervision of a physician.Upper (back) and lower (leg flexors) extremity strength, aerobic power as measured by metabolic equivalents (METS) at 80% of age predicted maximal heart rate (APMHR), physical functioning and mental health as assessed by the Short Form-36 (SF-36) questionnaire, and medical events (falls, physician visits, and hospitalizations) questionnaire was collected at baseline and after three months of the program.Strength measures improved by approximately 30% (P < 0.05) as well as aerobic power improved by approximately 25% (P < 0.05) over the three-month period. There were significant improvements in two of the SF-36 Physical Component Scales: Physical Functioning (P < 0.05) and Role Physical (P < 0.05); plus, there were significant improvements in all four of the Mental Component Scales: Vitality (P < 0.05), Social Functioning (P < 0.05), Role Emotional (P < 0.05), and Mental Health (P < 0.05). There were significant reductions in fall rate (P < 0.05), physician visits (P < 0.05), and hospitalizations (P < 0.05).Patients improve physical capacity, which result in improvements in health status with concurrent reductions in healthcare utilization during a comprehensive rehabilitation program.

Taro P Smith

Sarah L Kennedy

Marci Smith

Sander Orent

Monika Fleshner

Exercise immunology review

Physiological improvements and health benefits during an exercise-based comprehensive rehabilitation program in medically complex patients.

基于运动的全面康复计划对复杂病情患者生理改善和健康益处的研究。

This study investigated the association between the basal (rest) insulin-signaling proteins, Akt, and the Akt substrate AS160, metabolic risk factors, inflammatory markers and aerobic fitness, in middle-aged women with varying numbers of metabolic risk factors for type 2 diabetes.Sixteen women (n=16) aged 51.3 +/- 5.1 (mean +/- SD) years provided muscle biopsies and blood samples at rest. In addition, anthropometric characteristics and aerobic power were assessed and the number of metabolic risk factors for each participant was determined (IDF criteria).The mean number of metabolic risk factors was 1.6 +/- 1.2. Total Akt was negatively correlated with IL-1beta (r = -0.45, p = 0.046), IL-6 (r = -0.44, p = 0.052) and TNF-alpha (r = -0.51, p = 0.025). Phosphorylated AS160 was positively correlated with HDL (r = 0.58, p = 0.024) and aerobic fitness (r = 0.51, p = 0.047). Furthermore, a multiple regression analysis revealed that both HDL (t = 2.5, p = 0.032) and VO2peak (t = 2.4, p = 0.037) were better predictors for phosphorylated AS160 than TNF-alpha or IL-6 (p > 0.05).Elevated inflammatory markers and increased metabolic risk factors may inhibit insulin-signaling protein phosphorylation in middle-aged women, thereby increasing insulin resistance under basal conditions. Furthermore, higher HDL and fitness levels are associated with an increased AS160 phosphorylation, which may in turn reduce insulin resistance.

Itamar Levinger

Kirsten F Howlett

Jonathan Peake

Andrew Garnham

David L Hare

George Jerums

Steve Selig

Craig Goodman

Akt, AS160, metabolic risk factors and aerobic fitness in middle-aged women.

中年女性中的Akt、AS160、代谢风险因素与有氧健身。

The purpose of this study was to examine the influence of vitamin D status on mucosal and systemic immunity and the incidence, severity and duration of upper respiratory tract illness (URTI) episodes in endurance athletes during a 16-week winter training period. Blood was collected from 225 subjects at the start of the study and plasma was analysed for total 25-hydroxy vitamin D (25(OH)D) and cathelicidin concentration. Blood was also collected at the end of the study and analysed for 25(OH)D and antigen-stimulated cytokine production. Unstimulated saliva samples were obtained at the start and at 4-week intervals during the study period. Saliva samples were analysed for salivary antimicrobial peptides and proteins (AMPs). Weekly training and daily illness logs were kept. At the start and end of the study 38% and 55%, respectively, of the athlete cohort had inadequate (plasma 25(OH)D 30-50 nmol/L) or deficient (plasma 25(OH)D 120 nmol/L) and the total number of URTI symptom days and the median symptom-severity score in the vitamin D deficient group was signifi- cantly higher than in the other groups. The plasma cathelicidin concentration positively correlated with the plasma 25(OH)D concentration and the saliva secretory immunoglobulin A (SIgA) secretion rate in the optimal vitamin D status group was significantly higher than in the other groups. Low vitamin D status was associated with lower pro-inflammatory cytokine production by monocytes and lymphocytes. Low vitamin D status could be an important determinant of URTI risk in endurance athletes and mucosal as well as systemic immunity may be modified via vitamin D-dependent mechanisms.

Cheng-Shiun He

Michal Handzlik

William D Fraser

Ayu Muhamad

Hannah Preston

Andrew Richardson

Michael Gleeson

Influence of vitamin D status on respiratory infection incidence and immune function during 4 months of winter training in endurance sport athletes.

维生素D水平对耐力运动员冬季训练4个月期间呼吸道感染发生率和免疫功能的影响。

BACKGROUND Toll-like receptors (TLRs) are a family of transmembrane pattern recognition receptors that are mainly expressed on immune cells. Recognition of various exogenous and endogenous molecular patterns activates the TLR signalling cascade, which orchestrates an inflammatory immune response. Dysfunctional immune responses, including aberrant TLR signalling, are increasingly implicated in the associations between sedentarism, chronic low-grade systemic inflammation and various non-communicable diseases. Conversely, exercise exerts anti-inflammatory effects, which could be conferred through its immunomodulatory properties, potentially affecting TLRs. This study aims to systematically review the effects of exercise on human TLR expression. METHOD A systematic literature search of Pubmed, Embase, The Cochrane Library and SPORTDiscus for articles addressing the impact of exercise (as isolated intervention) on TLRs in humans was conducted, ending in February 2020. RESULTS A total of 66 articles were included. The publications were categorised according to exercise modality and duration: acute resistance exercise (4 studies), acute aerobic exercise (26 studies), resistance training program (9 studies), aerobic training program (16 studies), combined (i.e. resistance and aerobic) training program (8 studies) and chronic exercise not otherwise classifiable (9 studies). Five articles investigated more than one of the aforementioned exercise categories. Several trends could be discerned with regard to the TLR response in the different exercise categories. Acute resistance exercise seemed to elicit TLR upregulation, whereas acute aerobic exercise had less activating potential with the majority of responses being neutral or, especially in healthy participants, downregulatory. Chronic resistance and combined exercise programs predominantly resulted in unaltered or decreased TLR levels. In the chronic aerobic exercise category, mixed effects were observed, but the majority of measurements demonstrated unchanged TLR expression. CONCLUSION Currently published research supports an interplay between exercise and TLR signalling, which seems to depend on the characteristics of the exercise. However, there was large heterogeneity in the study designs and methodologies. Therefore, additional research is required to further corroborate these findings, to define its pathophysiological implications and to elucidate the mechanism(s) linking exercise to TLR signalling.

Kasper Favere

Matthias Bosman

Peter L Delputte

Herman W Favoreel

Emeline M Van Craenenbroeck

Johan De Sutter

Isabel Witvrouwen

Guido R Y De Meyer

Hein Heidbuchel

Pieter-Jan D F Guns

A systematic literature review on the effects of exercise on human Toll-like receptor expression.

运动对人类Toll样受体表达影响的系统文献综述

Atherosclerosis is a chronic inflammatory cardiovascular disease, which results from lipid accumulation in the blood vessel wall, forming a plaque, and ultimately restricting blood flow. The immune system plays a vital role in progression to plaque rupture. While recent evidence clearly indicates the anti-inflammatory function of regular exercise, the mechanisms by which regular exercise can modulate its pathophysiology is not well understood. In this review, we discuss how regular exercise can lower systemic inflammation directly via modulation of the immune system or indirectly via altered myokine concentrations and metabolites. We describe the exercise-induced responses of various myokines (such as IL-6, adiponectin, and FGF21), and how cell function in the innate immune system can be modulated via regular exercise, with the aim to modulate plaque formation in atherosclerosis.

André F do Brito Valente

Richard T Jaspers

Rob Ci Wüst

Regular physical exercise mediates the immune response in atherosclerosis.

规律体育锻炼介导动脉粥样硬化中的免疫反应。

Despite evidence that monocyte migration is accentuated by central adiposity, the impact of physical activity (PA) and exercise, particularly in the post-prandial state, on limiting migration are not established. We hypothesised that PA and a single bout of walking exercise would be associated with reduced ex vivo monocyte tethering and migration in middleaged males with central obesity (CO). Objective levels of PA were measured for 7 days in lean males (LE, N=12, mean (SD) age 39 (10) years, waist circumference 81.0 (6.3) cm) and males with CO (N=12, mean (SD) age 40 (9) years, waist circumference 115.3 (13.9) cm), followed by donation of a fasted blood sample. On the same day, CO undertook a bout of walking exercise, before donation of a second fasted blood sample. An ex vivo assay, coupled to flow cytometry, determined tethering and migration of classical, intermediate, and non-classical monocytes. C-C and CXC chemokine receptor (CCR2, CCR5 and CX3CR1) expression were also determined on total and classical monocytes. Monocyte subsets (total, classical, intermediate and CCR2+ monocytes), metabolic (glucose and lipids) and inflammatory (C-reactive protein) markers were greater in CO vs. LE (lower highdensity lipoprotein); however, adjustments for PA mitigated group differences for glucose, lipids, and monocyte subsets. Ex vivo tethering and migration (absolute and relative) of most monocyte subsets was greater in CO vs LE. Relative monocyte tethering and migration was largely not influenced by PA; however, higher PA was associated with reduced absolute migration and tethering of CD16 expressing monocytes in CO. Prior walking had no impact on these variables. These results highlight that regular PA, not single exercise bouts may limit the migration of pro-inflammatory monocytes in CO. These changes may relate to physiological parameters in blood (i.e. number of cells and their adhesion), rather than differences in chemokine receptor expression.

Alex J Wadley

Matthew J Roberts

Jade Creighton

Alice E Thackray

David J Stensel

Nicolette C Bishop

Higher levels of physical activity are associated with reduced tethering and migration of pro-inflammatory monocytes in males with central obesity.

较高水平的体力活动与中心性肥胖男性中促炎性单核细胞的粘附和迁移减少相关。

Numerous epidemiological studies have shown the existence of a relationship between exercise and reduced risk of different types of cancer. In vitro studies have identified a direct effect of exercise-conditioned human serum on cancer cell lines of the lung, breast, prostate, and colon. The aim of this systematic review with meta-analysis (SRM) was to estimate the magnitude of the effect that exercise-conditioned human serum produced on the viability of cancer cell cultures. The design followed the PRISMA guidelines and the TREND statement to assess the quality of information (QoI) in each study. Nine in vitro studies were included in the SRM, involving a total of nine cancer cell lines and serum from 244 individuals from different countries, including namely healthy sedentary individuals, at risk of prostate cancer individuals and cancer patients, with ages ranging from 18 to 73 years. The impact of exerciseconditioned human serum on the viability of cancer cell cultures was analysed by a variety of assays, using pre-exercise human serum for comparison purposes. Globally, cultures of cancer cell lines exposed to human serum conditioned by exercise of various intensities exhibited a reduced viability, when compared with control cultures, with an overall effect size of -1.126 (95% CI; -1.300 to -0.952; p < 0.001). When the analysis only included human serum conditioned by high intensity exercise, the effect became more pronounced (ES -1.350; -1.522 to -1.179 (95% CI); p < 0.001). These results are in line with the hypothesis that changes in human serum induced by exercise might play a role in the beneficial effects of physical activity in cancer prevention and management and that these effects depend on exercise intensity.

Carlos M Soares

Ana M Teixeira

Hugo Sarmento

Fernanda M Silva

Marcio C Rusenhack

Meirielly Furmann

Paulo R Nobre

Miguel A Fachada

Ana M Urbano

José P Ferreira

Effect of exercise-conditioned human serum on the viability of cancer cell cultures: A systematic review and meta-analysis.

运动条件化人血清对癌细胞培养存活率的影响：系统综述与Meta分析。

Abbreviation	Exerc. Immunol. Rev.
Journal Impact	3.44
Quartiles(Global)	SPORT SCIENCES(Q1)

ISSN	1077-5552, 2959-9555
h-index	63

Publication Information	Publisher: Human Kinetics Publishers Inc.，Publishing cycle: Annual，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 1996，Proportion of original research papers: 0.00%，Self Citation Rate:5.70%， Gold OA Rate: 0.00%
Average review cycle	网友分享经验：约稿?周期不定
Average recruitment ratio	网友分享经验：较难

Exercise Immunology Review

Journal Citation Format

A journal article with 1 author

A journal article with 2 authors

A journal article with 3 authors

A journal article with 5 or more authors

Books Citation Format

Thesis Citation Format

Web sites Citation Format

Patent Citation Format

Staying up late manually editing references? ivySCI automatically matches journals and helps you generate references with a single click.

Share Submission Experience

Physiological improvements and health benefits during an exercise-based comprehensive rehabilitation program in medically complex patients.

Akt, AS160, metabolic risk factors and aerobic fitness in middle-aged women.

Influence of vitamin D status on respiratory infection incidence and immune function during 4 months of winter training in endurance sport athletes.

A systematic literature review on the effects of exercise on human Toll-like receptor expression.

Regular physical exercise mediates the immune response in atherosclerosis.

Higher levels of physical activity are associated with reduced tethering and migration of pro-inflammatory monocytes in males with central obesity.

A systematic literature review on the effects of exercise on human Toll-like receptor expression.

Regular physical exercise mediates the immune response in atherosclerosis.

Effect of exercise-conditioned human serum on the viability of cancer cell cultures: A systematic review and meta-analysis.

Influence of vitamin D status on respiratory infection incidence and immune function during 4 months of winter training in endurance sport athletes.