ALLERGOLOGY INTERNATIONAL 是日本过敏学会的官方期刊，发表有关过敏及相关疾病的病因、诊断和治疗的原创论文。论文可能包括控制过敏反应的方法、超敏反应的人类和动物模型以及最广泛意义上的基本和应用临床过敏的其他方面的研究。该杂志旨在鼓励结果的国际交流，并鼓励来自所有国家的作者提交以下三类论文：原创文章、评论文章和致编辑的信。

Allergology International is the official journal of the Japanese Society of Allergology, dedicated to publishing original research papers on the etiology, diagnosis, and treatment of allergies and related diseases. The papers may include methods for controlling allergic reactions, human and animal models of hypersensitivity, and other aspects of basic and applied clinical allergy research in the broadest sense. The journal aims to promote international exchange of research findings and encourages authors from all countries to submit three types of papers: original articles, review articles, and letters to the editor.

《Allergology International》是日本过敏学会的官方期刊，专注于发表关于过敏及相关疾病的原创研究论文。这些论文涵盖了过敏反应的控制方法、超敏反应的人类和动物模型，以及基础和应用临床过敏研究的其他广泛领域。该期刊旨在促进国际间的研究成果交流，并鼓励来自各国的作者提交三类论文：原创研究文章、评论文章和致编辑的信件。

Allergology International

Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder mostly associated with IgE elevation and skin barrier dysfunction due to decreased filaggrin expression. The lesional skin of AD exhibits Th2- and Th22-deviated immune reactions that are progressive during disease chronicity. Th2 and Th22 cytokines further deteriorate the skin barrier by inhibiting filaggrin expression. Some IgEs are reactive to self-antigens. The IgE autoreactivity may precipitate the chronicity of AD. Upon activation of the ORAI1 calcium channel, atopic epidermis releases large amounts of thymic stromal lymphopoietin (TSLP), which initiates the Th2 and Th22 immune response. Th2-derived interleukin-31 and TSLP induce an itch sensation. Taken together, TSLP/Th2/Th22 pathway is a promising target for developing new therapeutics for AD. Enhancing filaggrin expression using ligands for the aryl hydrocarbon receptor may also be an adjunctive measure to restore the disrupted barrier function specifically for AD.

Masutaka Furue

Takahito Chiba

Gaku Tsuji

Dugarmaa Ulzii

Makiko Kido-Nakahara

Takeshi Nakahara

Takafumi Kadono

Atopic dermatitis: immune deviation, barrier dysfunction, IgE autoreactivity and new therapies

特应性皮炎：免疫偏离、屏障功能障碍、IgE自身反应性与新疗法

Mucus provides a protective barrier that is crucial for host defense in the lungs. However, excessive or abnormal mucus can have pathophysiological consequences in many pulmonary diseases, including asthma. Patients with asthma are treated with agents that relax airway smooth muscle and reduce airway inflammation, but responses are often inadequate. In part, this is due to the inability of existing therapeutic agents to directly target mucus. Accordingly, there is a critical need to better understand how mucus hypersecretion and airway plugging are affected by the epithelial cells that synthesize, secrete, and transport mucus components. This review highlights recent advances in the biology of mucin glycoproteins with a specific focus on MUC5AC and MUC5B, the chief macromolecular components of airway mucus. An improved mechanistic understanding of key steps in mucin production and secretion will help reveal novel potential therapeutic strategies.

Ana M. Jaramillo

Eszter K. Vladar

Fernando Holguin

Burton F. Dickey

Christopher M. Evans

Emerging cell and molecular targets for treating mucus hypersecretion in asthma

哮喘中黏液高分泌治疗的新兴细胞和分子靶点

Leukotrienes (LTs), both LTB4 and the cysteinyl LTs (CysLTs) LTC4, LTD4 and LTE4, are implicated in a wide variety of inflammatory disorders. These lipid mediators are generated from arachidonic acid via multistep enzymatic reactions through which arachidonic acid is liberated from membrane phospholipids through the action of phospholipase A2. LTB4 and CysLTs exert their biological effects by binding to cognate receptors, which belong to the G protein-coupled receptor superfamily. LTB4 is widely considered to be a potent chemoattractant for most subsets of leukocytes, whereas CysLTs are potent bronchoconstrictors that have effects on airway remodeling. LTs play a central role in the pathogenesis of asthma and many other inflammatory diseases. This review will provide an update on the synthesis, biological function, and relevance of LTs to the pathobiology of allergic diseases, and examine the current and future therapeutic prospects of LT modifiers.

Min Liu

Takehiko Yokomizo

The role of leukotrienes in allergic diseases

白三烯在过敏性疾病中的作用

Steroid hormones, especially glucocorticoids, androgens, and estrogens, have profound influence on immunity. Recent studies using cell-type specific steroid hormone receptor-deficient mice have revealed the precise roles of some of these hormones in the immune system. Glucocorticoids are known to have strong anti-inflammatory and immunosuppressive effects and pleiotropic effects on innate and adaptive immune responses. They suppress the production of inflammatory cytokines by macrophages and DCs and the production of IFN-γ by NK cells, thus inhibiting innate immunity. By contrast, glucocorticoids enhance the immune response by inducing the expression of IL-7R and CXCR4 in T cells and the accumulation of T cells in lymphoid organs in accordance with the diurnal change of the glucocorticoid concentration. Thus, glucocorticoids suppress innate immunity but enhance adaptive immunity. Androgens suppress the homeostasis and activation of ILC2s and the differentiation of Th2 and Th17 cells and enhance the suppressive function of Tregs, thereby alleviating allergic airway inflammation. Thus, these steroid hormones have pleiotropic functions in the immune system. Further investigations are awaited on the regulation of immunity and allergy by estrogens using cell-specific steroid hormone receptor-deficient mice.

Koichi Ikuta

Aki Ejima

Shinya Abe

Akihiro Shimba

Control of immunity and allergy by steroid hormones

类固醇激素对免疫和过敏的调控

Interleukin-33 (IL-33) is an alarmin cytokine that binds to the interleukin 1 receptor-like 1 protein ST2. Clock is a key circadian gene that is essential for endogenous clockworks in mammals. This study investigated whether Clock temporally regulated IL-33-mediated responses in mast cells. The kinetics of IL-33-mediated IL-6, IL-13, and TNF-α productions were compared between bone marrow-derived mast cells (BMMCs) from wild-type and Clock-mutated mice (ClockΔ19/Δ19 mice). The kinetics of the neutrophil influx into the peritoneal cavity or expression of IL-13 and Gob-5 in the lung in response to IL-33 were compared between wild-type and ClockΔ19/Δ19 mice. We also examined the kinetics of ST2 expression in mast cells and its association with Clock expression. There was a time-of-day-dependent variation in IL-33-mediated IL-6, IL-13, and TNF-α production in wild-type BMMCs, which was absent in Clock-mutated BMMCs. IL-33-induced neutrophil infiltration into the peritoneal cavity also showed a time-of-day-dependent variation in wild-type mice, which was absent in ClockΔ19/Δ19 mice. Furthermore, IL-33-induced IL-13 and Gob-5 expression in the lung exhibited a time-of-day-dependent variation in wild-type mice. These temporal variations in IL-33-mediated mast cell responses were associated with temporal variations of ST2 expression in mast cells. In addition, CLOCK bound to the promoter region of ST2 and Clock deletion resulted in down-regulation of ST2 expression in mast cells. CLOCK temporally gates mast cell responses to IL-33 via regulation of ST2 expression. Our findings provide novel insights into IL-33/mast cell-associated physiology and pathologies.

Takahiro Kawauchi

Kayoko Ishimaru

Yuki Nakamura

Nobuhiro Nakano

Mutsuko Hara

Hideoki Ogawa

Ko Okumura

Shigenobu Shibata

Atsuhito Nakao

Clock-dependent temporal regulation of IL-33/ST2-mediated mast cell response

依赖于时钟的IL-33/ST2介导的肥大细胞反应的时间调控

Naotomo Kambe

Mayuko Yamamoto

Koji Takemura

Shin-ichiro Kagami

Yoshie Kawahara

Hajime Yoshifuji

Tomoyasu Jo

Kazushi Izawa

Satoshi Nakamizo

Norimitsu Inoue

Tatsuya Ito

Yoko Amino

Yumiko Ibi

Satoshi Morita

Nobuo Kanazawa

Investigator-initiated, multi-center, single-arm, open-label study of the effectiveness of canakinumab in Japanese patients with Schnitzler syndrome

研究者发起的多中心、单臂、开放标签研究：卡那单抗在日本Schnitzler综合征患者中的疗效

Patients with asthma-COPD overlap (ACO) have a greater symptom burden, worse respiratory function, and more frequent exacerbations than those with asthma alone. However, only a few studies have investigated the prevalence and clinical course of ACO in severe asthma. This study aimed to examine the comorbid rate of ACO and its clinical impact on severe asthma.

Miho Wakazono

Hirokazu Kimura

Ichizo Tsujino

Nobuyasu Wakazono

Michiko Takimoto-Sato

Munehiro Matsumoto

Kaoruko Shimizu

Houman Goudarzi

Hironi Makita

Masaharu Nishimura

Satoshi Konno

Prevalence and clinical impact of asthma-COPD overlap in severe asthma

重度哮喘中哮喘-慢阻肺重叠的患病率及临床影响

Non-esophageal eosinophilic gastrointestinal diseases (non-EoE EGIDs) are allergic conditions where Th-2-predominant inflammation causes symptoms related to gastrointestinal tract dysfunction. No studies have reported the incidence of non-EoE EGIDs. In addition, little is known about the influence of lifestyle factors on the condition.

Akinari Sawada

Takumi Imai

Yasutaka Ihara

Fumio Tanaka

Yasuhiro Fujiwara

Epidemiology and risk factors of non-esophageal eosinophilic gastrointestinal diseases in Japan: A population-based study

日本非食管嗜酸性胃肠疾病流行病学及风险因素：一项基于人群的研究

Katsunori Masaki

Maho Suzukawa

Hitoshi Sasano

Norihiro Harada

Yasunari Miyazaki

Hideki Katsura

Etsuko Tagaya

Junko Terada

Masayuki Hojo

Naoya Sugimoto

Hiroyuki Nagase

Yuta Kono

Hisato Hiranuma

Yasuhiro Gon

Ryo Takemura

Misato Irie

Reina Nakamura

Hiroki Kabata

Jun Miyata

Koichi Fukunaga

Effectiveness of benralizumab in the Tokyo Asthma Study (TOAST): A real-world prospective interventional trial

东京哮喘研究中贝那利珠单抗的有效性（TOAST）：一项真实世界的前瞻性干预试验

Ayumi Shimamura

Ryoji Shinohara

Megumi Kushima

Sanae Otawa

Hideki Yui

Tomokazu Matsuoka

Daisuke Watanabe

Hiroshi Yokomichi

Kunio Miyake

Reiji Kojima

Zentaro Yamagata

Daiju Sakurai

Association of Japanese cedar pollen sensitization in children with Dermatophagoides pteronyssinus sensitization and maternal sensitization: Insights from the Yamanashi adjunct study within the Japan Environment and Children’s Study (JECS)

日本柳杉花粉致敏儿童与屋尘螨致敏及母亲致敏的关联：来自日本环境与儿童研究（JECS）山梨补充研究的启示

Abbreviation	Allergol. Int.
Journal Impact	6.36
Quartiles(Global)	IMMUNOLOGY(Q1)

ISSN	1323-8930, 1440-1592
h-index	77

Publication Information	Publisher: Japanese Society of Allergology，Publishing cycle: ，Journal Type: journal，Open Access Journals: Yes
Basic data	Year of publication: 1996，Proportion of original research papers: 61.82%，Self Citation Rate:4.80%， Gold OA Rate: 95.73%
Journal Fees	$Details
Average review cycle	网友分享经验：29 Weeks

Allergology International

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