“听力学和神经病学”为发表与听觉和前庭系统以及耳部疾病的基础科学和临床方面相关的最先进和最严谨的科学研究提供了一个论坛。该杂志寻求提交前沿研究，开辟新的和创新的研究领域，这可能会提高我们对听觉和前庭系统疾病患者的理解和治疗，他们的中枢连接和他们在中枢神经系统中的感知。除了原创论文外，该杂志还提供由该领域领先专家撰写的关于当前主题的受邀评论文章。该杂志对所有对听力学、耳科和神经病学、听觉神经科学和相关学科感兴趣的科学家和从业者都至关重要。

"Audiology and Neurotology" provides a cutting-edge academic forum for fundamental and clinical research related to the auditory and vestibular systems, as well as ear diseases. The journal aims to publish innovative studies that explore new research areas, enhancing our understanding and treatment of patients with auditory and vestibular system disorders, particularly regarding their central connections and perceptions within the central nervous system. In addition to original research articles, the journal features invited review articles written by leading experts in the field, discussing current topics of interest. This journal is essential for all scientists and practitioners interested in audiology, otology, neurology, auditory neuroscience, and related disciplines.

《Audiology and Neurotology》为听觉和前庭系统以及耳部疾病的基础科学和临床研究提供了一个前沿的学术论坛。该杂志致力于发表创新性研究，探索新的研究领域，以增进我们对听觉和前庭系统疾病患者的理解和治疗，特别是他们的中枢连接及其在中枢神经系统中的感知。此外，杂志还刊登由该领域顶尖专家撰写的受邀评论文章，讨论当前的研究主题。对于所有关注听力学、耳科、神经病学、听觉神经科学及相关学科的科学家和从业者来说，该杂志具有重要的学术价值。

Audiology and Neurotology

The excessive storage of mucopolysaccharide in Hunter syndrome leads to various otologic manifestations. We interviewed 19 patients with Hunter syndrome to assess their otologic problems, and conducted audiologic tests and temporal bone CT. Patients with the intermediate or severe form exhibited severe speech delay by more than 2 years (12/14 patients). However, in patients with the mild form (5/5), speech development was not much disturbed (2/5), although otoscopic findings were similar. The hearing threshold determined by the auditory brainstem response differed significantly between the mild and intermediate/severe forms (p &lt; 0.05). Therefore, patients with the mild form may benefit from active otologic intervention such as VT insertion, amplification, and speech therapy.

Yang-Sun Cho

Joon Ho Kim

Tae Wook Kim

Soo Chan Chung

Son-A Chang

Dong-Kyu Jin

Otologic Manifestations of Hunter Syndrome and Their Relationship with Speech Development

亨特综合征的耳科表现及其与语言发展的关系

Gaze stabilization during head movements is provided by the vestibulo-ocular reflex (VOR). Clinical assessment of this reflex is performed using the video Head Impulse Test (vHIT). To date, the influence of different fixation distances on VOR gain using the vHIT has not been explored. We assessed the effect of target proximity on the horizontal VOR using the vHIT. Firstly, we assessed the VOR gain in 18 healthy subjects with 5 viewing target distances (150, 40, 30, 20, and 10 cm). The gain increased significantly as the viewing target distance decreased. A second experiment on 10 subjects was performed in darkness whilst the subjects were imagining targets at different distances. There were significant inverse relationships between gain and distance for both the real and the imaginary targets. There was a statistically significant difference between light and dark gains for the 20- and 40-cm distances, but not for the 150-cm distance. Theoretical VOR gains for different target distances were calculated and compared with those found in light and darkness. The increase in gain observed for near targets was lower than predicted by geometrical calculations, implying a physiological ceiling effect on the VOR. The VOR gain in the dark, as assessed with the vHIT, demonstrates an enhancement associated with a reduced target distance.

Patricia Castro

Sara Sena Esteves

Florencia Lerchundi

David Buckwell

Michael A. Gresty

Adolfo M. Bronstein

Qadeer Arshad

Audiol Neurotol

Viewing Target Distance Influences the Vestibulo-Ocular Reflex Gain when Assessed Using the Video Head Impulse Test

观察目标距离影响使用视频头脉冲测试评估的前庭眼反射增益

Introduction: Current clinical practice considers the vestibulo-ocular reflex (VOR) gain as registered by the video head impulse test (vHIT) as the primary measure for semicircular canal function, while the role of the re-fixation saccades (RSs) is still under evaluation. The goal of the study was to appraise the added benefit of RS towards the improvement of vHIT diagnostic accuracy in cases of suspected left horizontal semicircular canal dysfunction. Methods: The vHIT recordings of 40 patients with left-sided horizontal VOR gains &lt;0.8 were retrospectively evaluated for the presence of RS. The study groups included 20 patients with a final diagnosis of left horizontal semicircular canal dysfunction and 20 patients for whom vestibular dysfunction was ruled out. Results: Gain values &gt;0.72 were found in all patients with no vestibular disease and in 4 (20%) patients having vestibulopathy. Significantly higher average left-sided RS velocity and frequency were found among the vestibular patients. VOR gain &lt;0.72 was found to be highly specific for the diagnosis of vestibular dysfunction. However, for gain values in the range of 0.72–0.79, the presence of RS with frequency &gt;80% largely improved vHIT diagnostic accuracy. Conclusions: Although VOR gain &lt;0.8 is considered to reflect dysfunction, a significant false-positive rate for left-sided horizontal vHIT was found for gains in the range of 0.72–0.79. The presence of RS with frequency &gt;80% could improve vHIT diagnostic ability in these patients.

Nabil Faranesh

Khaldon Abo-Saleh

Margalith Kaminer

Avi Shupak

Refining the Video Head Impulse Test Diagnostic Accuracy: A Case-Control Study

精炼视频头脉冲试验诊断准确性：一项病例对照研究

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; Recently, the role of neural modulation in nonauditory cortices via repetitive transcranial magnetic stimulation (rTMS) for tinnitus control has been emphasized. It is now more compelling to consider these nonauditory cortices and the whole “tinnitus network” as targets for tinnitus treatment to achieve a better outcome. &lt;b&gt;&lt;i&gt;Objective:&lt;/i&gt;&lt;/b&gt; We aimed to investigate the effects of active dual-site rTMS treatment in tinnitus reduction using a double-blind randomized controlled trial. &lt;b&gt;&lt;i&gt;Method:&lt;/i&gt;&lt;/b&gt; In study 1, the dual-site rTMS treatment group (&lt;i&gt;n&lt;/i&gt; = 17) was treated daily for 4 consecutive days. The sham group (&lt;i&gt;n&lt;/i&gt; = 13) also visited the clinic for 4 days; they received sham treatment for the same duration as the dual-site rTMS treatment group. In study 2, the rTMS treatment protocol was exactly the same as in study 1. Magnetoencephalography recordings were performed before and 1 week after the last rTMS treatment. The outcome measure was the Tinnitus Handicap Inventory (THI) score and the visual analog scale score. The effects of treatment were assessed 1, 2, 4, and 8 weeks after rTMS treatment in study 1. Then the mean band power and network changes were compared between pre- and post-treatment values after rTMS in study 2. &lt;b&gt;&lt;i&gt;Result:&lt;/i&gt;&lt;/b&gt; Patients in the dual-site rTMS treatment group exhibited significantly improved THI scores at 2, 4, and 8 weeks after rTMS treatment compared with the pretreatment scores. However, the sham group did not show any significant reduction in THI scores. When the mean band power changes were compared between pre- and post-treatment assessments, an increased oscillation power was observed in the alpha band after rTMS. &lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; A beneficial effect of rTMS on tinnitus suppression was found in the dual-site active rTMS group, but not in the sham rTMS group.

Tae-Soo Noh

Jeong-Sug Kyong

Moo Kyun Park

Jun Ho Lee

Seung Ha Oh

Chun Kee Chung

June Sic Kim

Myung-Whan Suh

Treatment Outcome of Auditory and Frontal Dual-Site rTMS in Tinnitus Patients and Changes in Magnetoencephalographic Functional Connectivity after rTMS: Double-Blind Randomized Controlled Trial

耳鸣患者听觉和额叶双部位重复经颅磁刺激治疗效果及经颅磁刺激后脑磁图功能连接变化：双盲随机对照试验

Research suggests deaf children who receive cochlear implants (CIs) at an early age can achieve age-appropriate language. Recent studies suggest age at full-time CI use is a better predictor of language outcomes than age at implant. The aim of this study was to investigate whether there are correlations between age at implantation, establishing consistent device use, and language outcomes in a cohort of young children in Aotearoa New Zealand.

Matthew McCall

Janitha Jayawardana

Jill Mustard

Joanne Lake

John Pearson

Philip Bird

The Correlation between Age at Implant, Consistent Device Use, and Language Outcomes for Children Implanted under 18 Months

18个月以下植入儿童的植入年龄、持续设备使用与语言结果的相关性

Objective: We investigated the accuracy of imaging modalities in diagnosis and outcome of otitis media with effusion by correlating the imaging findings with the preoperative otomicroscopic examinations, tympanometric results, and intra-operative findings in patients who undergone cochlear implant surgery. Methods: The results of the preoperative physical examination, and intra-operative findings of patients younger than 18 years who underwent cochlear implant surgery at a single tertiary instution were recorded from their medical charts. Tympanometries, which were performed in maximum 1 week prior to imaging modalities, were analyzed. The high resolution computed tomography of temporal bone and magnetic resonance imaging of internal acoustic meati findings were reviewed. The mastoid cavity and middle ears were evaluated separately. Results: The data comprising of 280 ears were evaluated. The correlation between imaging findings and both physical examination and tympanometries were statistically significant (p=0.000). The intra-operative findings supported this correlation. Conclusions: Our study showed that imaging modalities might detect the middle ear and mastoid cavity effusions. The severity of these changes may differ according to the severity of disease.

Ela Araz Server

Cigdem Kalaycik Ertugay

Ahmet Ahmet Volkan

Ozgur Yigit

Muhammed Ture

Eda Sunnetci

THE ROLE OF IMAGING MODALITIES IN DIAGNOSIS AND OUTCOME OF OTITIS MEDIA WITH EFFUSION IN COCHLEAR IMPLANT CANDIDATES

影像学模式在耳蜗植入候选者中耳积液诊断及预后中的作用

Introduction: The totally implantable active middle ear implant Esteem® may be considered an effective alternative to conventional hearing aids (cHAs) to manage moderate-to-severe forms of sensorineural hearing loss. This study aimed to provide long-term comparative data of Esteem performances with those achieved by cHA. Methods: From a total of 46 subjects who received unilateral application of Esteem®, and were followed up over the years, ten underwent an audiological assessment that compared the outcomes with those achieved in the contralateral ear by a cHA, considering the initially symmetric auditory thresholds in both ears. Other than pure tone audiometry and speech audiometry in quiet, the assessment was performed by using the adaptive speech in noise, i.e., Matrix test. Results: The mean speech intelligibility in quiet shows in the unaided situation a recognition of 50.7% at 71 dBHL, 71% at 69 dBHL with only contralateral cHA, 92% at 66 dBHL with only Esteem device and 94% at 61 dBHL with Esteem® device and contralateral cHA. The mean speech intelligibility in noise shows in the unaided situation a recognition of 36% at 71 dBHL, 56% at 69 dBHL with only contralateral cHA, 79% at 66 dBHL with only Esteem® device and 84% at 61 dBHL with Esteem® device and contralateral cHA. At Matrix test in the unaided condition, 4 patients reached 50% of intelligibility and the 50% threshold was obtained with a mean sound/noise ratio of +10 dBHL. In the contralaterally aided condition, 10 patients reached a 50% threshold in a condition of mean S/N ratio of +10.6 dBHL. In the Esteem® only and Esteem® plus cHA condition, all patients reached the 50% threshold with a mean S/N ratio of +3.4 dBHL with the Esteem® device and +0.92 dBHL with Esteem® plus a contralateral cHA, with a statistically nonsignificant difference. The mean deviation from the reference value (7.1 dB in the normal hearing population) was 17.1 dBHL, in unaided situation; this condition did not change with only the contralateral cHA (17.6 dBHL), whilst a significant improvement could be identified with only Esteem® device, where the mean deviation was 10.5 dBHL, and mostly with Esteem® device associated with the contralateral cHA, with a value of 8.02 dBHL. Conclusions: The adaptive speech audiometry in noise (Matrix Test) showed that binaural stimulation provides greater benefits in the speech recognition in noise test in comparison to monaural stimulation, especially when this is carried out only by the cHA. However, the Esteem® device allowed to obtain audiological benefits that are significantly superior to those offered by cHAs, especially in cases where the hearing loss is severe and, in some cases, profound, achieving performances almost comparable to those of a cochlear implant.

Maurizio Barbara

Chiara Filippi

Silvia Tarentini

Giorgio Bandiera

Simonetta Monini

Edoardo Covelli

Esteem® Active Middle Ear Implant versus Conventional Hearing Aids: Long-Term Performance

Esteem®主动式中耳植入与传统助听器：长期性能比较

Introduction: We were conducting this study to evaluate the effects of different hearing aid adaptation formulas on middle latency responses (MLR) in adult hearing aid users. Methods: The study included 72 participants: those with moderate hearing loss using hearing aids with two different formulas for the last year, those with moderate hearing loss not using hearing aids, and those without hearing loss. Sixteen participants using NAL-NL1 and NAL-RP formulas were Group 1; twenty using NAL-NL2 and DSL formulas were Group 2; fifteen with hearing loss not using devices were Group 3; and twenty-one without hearing loss were Group 4. We obtained and compared MLR responses, including Na latency, Pa latency, and Na-Pa amplitude. Results: Group 1 mean Na-Pa amplitude value was found to be higher than Group 2 (p = 0.001). No significant difference was observed between Group 1 and Group 2 in terms of Na latency and Pa latency values (p = 0.001; p = 0.035). It was observed that the mean Na-Pa amplitude values in Group 1 and Group 2 were higher than Group 3 (p = 0.001), but this elevation reached the level of statistical significance only in Group 1. No difference was observed between Group 1, Group 2, and Group 3 in terms of Na latency and Pa latency values (p = 0.001; p = 0.035). Compared with those without hearing loss (Group 4), participants with hearing loss (Group 1, Group 2, and Group 3) had longer Na latency and Pa latency values (p = 0.001; p = 0.035), and Na-Pa amplitudes were lower (p = 0.001). The effect of current (tested) hearing aid usage time on Na latency, Pa latency, and Na-Pa amplitude values of Group 1 and Group 2 was not observed. In all groups, there was a positive correlation between audiometric airway/bone conduction pure tone averages and speech acquisition threshold values, Na latency and Pa latency values, and a negative correlation between Na-Pa amplitude values. In all groups, there was a negative correlation between speech discrimination scores and Na and Pa latency values, as well as a positive correlation between Na and Pa amplitude values. There was a positive correlation between age and Pa latency values in all groups, as well as a negative correlation between Na and Pa amplitude values. Conclusion: Middle latency responses are affected by the presence of hearing loss, the use of hearing aids, and different hearing aid adaptation formulas. MLR measurements with a hearing aid can be used as an objective test to evaluate the benefit of hearing aid use.

Nedim Ugur Kaya

Emine Aydin

F. Ceyda Akin Ocal

Bulent Satar

The Effect of Different Adaptation Formulas on Mid-Latency Auditory Evoked Potentials in Adults with Hearing Aids

不同适应公式对成人助听器中潜伏期听觉诱发电位的影响

Introduction: We aimed to investigate electrophysiologically and histopathologically, the protective effects of intratympanic memantine, an N-methyl-D-aspartate receptor antagonist, on ototoxicity caused by cisplatin, an anti-neoplastic agent used in many types of cancer. Methods: Thirty-seven guinea pigs with a normal auditory function were randomly allocated to group 1 (Cisplatin; n=8), group 2 (Memantine; n=8), group 3 (Cisplatin+Memantine; n=8), group 4 (Cisplatin+Physiological Serum [PS]; n=8), and group 5 (Control; n=5). Auditory assessments were conducted using distortion product otoacoustic emissions (DPOAE) within a frequency range of 1-32 kHz, and auditory brainstem responses (ABR) within 8-32 kHz. A single dose of cisplatin (12 mg/kg) was administered intraperitoneally, followed by intratympanic administration of 0.2 mL of either memantine or PS to both ears at least half an hour before cisplatin administration. Subsequent auditory evaluations were conducted 72 h after cisplatin administration. Histopathological analyses were performed using light microscopy of the right ear and scanning electron microscopy (SEM) of the left ear. Results: Auditory evaluations conducted before and after treatment revealed significant findings. Specifically, within groups 3 and 4, ABR thresholds were elevated at all frequencies (p=0.00), whereas the DPOAE signal-to-noise ratios were reduced at frequencies of 8, 12, 16, and 24 kHz (p=0.001, p=0.01, p=0.01, and p=0.00, respectively). Histopathologically, both light microscopy and SEM revealed that the cisplatin+memantine group exhibited fewer hair cells and nuclear degeneration in the spiral ganglion than the cisplatin and cisplatin+PS groups. Additionally, the stria vascularis thickness was greater in the cisplatin+memantine group than in cisplatin and cisplatin+PS groups. Conclusion: Despite the negative electrophysiological findings, the histopathological outcomes suggest that intratympanic memantine may have a potential protective effect against cisplatin-induced ototoxicity. However, further investigations are warranted to corroborate these findings and elucidate the underlying mechanisms of action of memantine.

Abbreviation	Audiol Neurotol
Journal Impact	1.78
Quartiles(Global)	OTORHINOLARYNGOLOGY(Q2)

ISSN	1420-3030, 1421-9700
h-index	90

Publication Information	Publisher: S. Karger AG，Publishing cycle: Bimonthly，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 1996，Proportion of original research papers: 92.86%，Self Citation Rate:N.A.， Gold OA Rate: 22.15%
Average review cycle	网友分享经验：>12周，或约稿
Average recruitment ratio	网友分享经验：较易

Audiology and Neurotology

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Otologic Manifestations of Hunter Syndrome and Their Relationship with Speech Development

Viewing Target Distance Influences the Vestibulo-Ocular Reflex Gain when Assessed Using the Video Head Impulse Test

Refining the Video Head Impulse Test Diagnostic Accuracy: A Case-Control Study

Treatment Outcome of Auditory and Frontal Dual-Site rTMS in Tinnitus Patients and Changes in Magnetoencephalographic Functional Connectivity after rTMS: Double-Blind Randomized Controlled Trial

The Correlation between Age at Implant, Consistent Device Use, and Language Outcomes for Children Implanted under 18 Months

The Correlation between Age at Implant, Consistent Device Use, and Language Outcomes for Children Implanted under 18 Months

THE ROLE OF IMAGING MODALITIES IN DIAGNOSIS AND OUTCOME OF OTITIS MEDIA WITH EFFUSION IN COCHLEAR IMPLANT CANDIDATES

Esteem® Active Middle Ear Implant versus Conventional Hearing Aids: Long-Term Performance

The Effect of Different Adaptation Formulas on Mid-Latency Auditory Evoked Potentials in Adults with Hearing Aids

The Effects of Memantine on Cisplatin-induced Ototoxicity